Determination of mutagenic and cytotoxic effects of Limonium globuliferum aqueous extracts by Allium, Ames, and MTT tests

Revista Brasileira de Farmacognosia

Volumn 24, Issue 1, 2014, Pages 51-59

  Erena, Yasin ^a   Özatab, Ahmet ^b  

^a SULEYMAN DEMIREL UNIVERSITY   (Turkey)

^b ANADOLU UNIVERSITY   (Turkey)

Author keywords

Allium test; Ames test; Limonium globuliferum; MTT test

Indexed keywords

2 AMINOANTHRACENE; 2 FLUORENYLAMINE; 4 NITRO 1, 2 PHENYLENEDIAMINE; CYTOTOXIC AGENT; LIMONIUM GLOBULIFERUM EXTRACT; MUTAGENIC AGENT; PLANT EXTRACT; SODIUM AZIDE; UNCLASSIFIED DRUG;

ALLIUM TEST; AMES TEST; ANIMAL CELL; ARTICLE; BIOASSAY; CELL PROLIFERATION; CHROMOSOME DAMAGE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DOSE COMPARISON; ENZYME LINKED IMMUNOSORBENT ASSAY; GROWTH INHIBITION; MITOSIS INDEX; MTT ASSAY; MUTAGENIC ACTIVITY; NONHUMAN; PLANT LEAF; PLANT ROOT; PLANT STEM; SALMONELLA TYPHIMURIUM;

EID: 84901247922     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/0102-695X20142413322     Document Type: Article

References (49)

1. Aithal, B.K., Kumar, M.R., Rao, B.N., Udupa, N., Rao, B.S., 2009. Juglone, a naphthoquinone from walnut, exerts cytotoxic and genotoxic effects against cultured melanoma tumor cells. Cell. Biol. Int. 33, 1039-1049.
2. Alade, A., Olufunsho, A., Gbenga, A., Herbert, A.B.C., 2009. Mutagenic screening of some commonly used medicinal plants in Nigeria. J. Ethnopharmacol. 125, 461-470.
3. Ali, N.A.A., Mothana, R., Ghaleb, N., Lindequist, U., 2007. Screening of traditionally used endemic soqotraen plants for cytotoxic activity. Afr. J. Trad. Complement. Altern. Med. 4, 529-531.
4. Al-Moaruf, O.A., Muibat, O.B., Asiata, O.I., Isiaka, A.O., Nureni, O.O., 2004. Heavy trace metals and macronutrients status in herbal plants. J. Food. Chem. 85, 67-71.
5. Avaz, S., 2010. Afyonkarahisar'da doǧal olarak yetişen Limonium Mill. türlerinin antimikrobiyal aktiviteleri, Master Thesis, Afyon Kocatepe University, Science Institute, Afyonkarahisar.
6. Babatunde, B.B., Bakare, A.A., 2006. Genotoxicity screening of wastewaters from Agbara Industrial estate Nigeria evaluated with the Allium test. Pollut. Res. 25, 227-234.
7. Babula, P., Adam, V., Kizek, R., Sladky, Z., Havel, L., 2009. Naphthoquinones as allelochemical triggers of programmed cell death. Environ. Exp. Bot. 65, 330-337.
8. Bakare, A.A., Wale-Adeyemo, A.R. 2004. The potential mutagenic and cytotoxic effects of leachates from domesticwastes and Aba-Eku landfill Nigeria on Allium cepa. J. Nat. Environ. Pollut. Technol. 3, 455-462.
9. Bayor, M.T., Ayim, J.S.K., Phillips, R.M., Shnyder, S.M., Wright, C.W., 2007. The evaluation of selected Ghanaian medicinal plants for cytotoxic activities. J. Sci. Technol. 27, 16-24.
10. Betancur-Galvis, A., Saez, J., Granados, H., Salazar, A., 1999. Antitumor and antiviral activity of Colombian medicinal plant extracts. Mem. I. Oswaldo Cruz 94, 531-535.
11. Bingwen, W., Rong, Z., Si-qing, S., 1994. Limonium bicolor Mechanism of hemostatic effect. J. Xi'an Medical Univ. 15, 59-63.
12. Boroffice, R.A., 1990. Cytogenetic effects of zinc and chromium on the of onion (Allium cepa) root tip. Niger J. Nat. Sci. 1, 75-79.
13. Davis, P.H., Mill, R.R., Tan, K., 1982. Limonium Miller In: Davis, P.H., Mill, R.R., Tan, K. (eds.), Flora of Turkey and the East Aegean Islands. (Supplement) Edinburgh Univ. Press, Edinburgh.
14. Dean, B.J., Brooks, T.M., Hodson-Walker, G., Hutson, D.H., 1985. Genetic toxicology testing of 41 industrial chemicals. Mutat. Res. 153, 57-77.
15. Durga, R., Sridhar, P., Polasa, H. 1992. Antimutagenic activity of plumbagin in Ames Salmonella typhimurium test. Ind. J. Med. Res. Sect. B 96, 143-145.
16. Edenharder, R., Tang, X., 1997. Inhibition of the mutagenicity of 2-nitrofluorene, 3-nitrofluoranthene and 1-nitropyrene by flavonoids, coumarins, quinones and other phenolic compounds. Food Chem. Toxicol. 35, 357-372.
17. Farr, S.B., Natvig, D.O., Kogoma, T., 1985. Toxicity and mutagenicity of plumbagin and the induction of a possible new DNA repair pathway in Escherichia coli. J. Bacteriol. 164, 1309-1316.
18. Fasola, T.R., Egunyomi, A., 2005. Nigerian usage of bark in phytomedicine. Ethnobotany Res. Appl. 3, 73-78.
19. Fiskesjö, G., 1985. The Allium as a standard in environmental monitoring. Hereditas 102, 99-102.
20. Fiskesjö, G., 1997. Allium test for screening chemicals; evaluation of cytologic parameters. In: Wang, W., Gorsuch, J.W., Hughes, J.S. (Eds.) Plants for Environmental Studies. CRC Lewis Publishers, Boca Raton, New York.
21. Gadano, A.B., Gumi, A.A., Carballo, M.A., 2006. Argentine folk medicine: genotoxic effects of Chenopodiaceae family. J. Ethnopharmacol. 103, 246-251.
22. Haider, S., Naithani, V., Barthwal, J., Kakkar, P., 2004. Heavy metal content in some therapeutically important medicinal plants. Bull. Environ. Contam. Tox. 72, 119-127.
23. Hakura, A., Mochida, H., Tsutsui, Y., Yamatsu, K., 1994. Mutagenicity and cytotoxicity of naphthoquinones for Ames Salmonella tester strains. Chem. Res. Toxicol. 7, 559-567.
24. Higashimoto, M., Purintrapiban, J., Kataoka, K., Kinouchi, T., Vinitketkumnuen, U., Akimoto, S., Matsumoto, H., Ohnishi, Y., 1993. Mutagenicity and antimutagenicity of extracts of three species and a medicinal plant in Thailand. Mutat. Res. 303, 135-142.
25. Kassie, F., Parzefall, W., Musk, S., Johnson, I., Lamprecht, G., Sontag, G., Knasmueller, S., 1996. Genotoxic effects of crude juices from Brassica vegetables and juices and extracts from phytopharmaceutical preparations and spices of cruciferous plants origin in bacterial and mammalian cells. Chem. Biol. Interact. 102, 1-16.
26. Krishnaswamy, M., Purushothaman, K.K., 1980. Plumbagin: A study of its anticancer, antibacterial and antifungal properties. Ind. J. Exp. Biol. 18, 876-877.
27. Kuo, Y., Lin, L.C., Tsai, W.J., 2002. Samarangenin B from Limonium sinense suppresses herpes simplex virus type-l. J. Antimicrob Agents Chemother. 46, 2854-2864.
28. Lerda, D., 1992. The effect of lead on Allium cepa L. Mutat. Res. 281, 89-92.
29. Lin, L.C., Chou, C.J. 2000. Flavonoids and phenolics from Limonium sinense. Planta Med. 66, 382-383.
30. Lin LC, Kuo YC, Chou CJ 2000. Anti-herpes simplex virus type-l flavonoids a new flavanone from the root of Limonium sinense. Planta Med. 66, 333-336.
31. Mahavorasirikul, W., Viyanant, V., Chaijaroenkul, W., Itharat, A., Na-Bangchang, K., 2010. Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro. BMC Complem. Altern. Med., DOI: 10.1186/1472-6882-10-55.
32. Maron, D.M., Ames, B.N., 1983. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173-215.
33. Matsushima, T., Muramatsu, M., Yagame, O., Araki, A., Tikkanen, L., Natori, S., 1986. Mutagenicity and chemical structure relations of naturally occurring mutagens from plants. In: Ramel, C., Lambert, B., Magnusson, J. (eds.) Progress in Clinical and Biological Research. Genetic Toxicology of Environmental Chemicals, Part B: Genetic Effects and Applied Mutagenesis; 4th International Conference on Environmental Mutagens, New York, Alan R. Liss, Inc.
34. Mortelmans, K., Zeiger, E., 2000. The Ames Salmonella/ microsome mutagenicity assay. Mutat. Res. 455, 29-60.
35. Mosmann, T., 1983. Rapid colonmetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
36. Santhakumari, G., Saralamma, P.G., Radhakrishnan, N., 1980. Effect of plumbagin on cell growth and mitosis. Indian J. Exp. Biol. 18, 215-218.
37. Schimmer, O., Haefele, F., Kruger, A., 1988. The mutagenic potencies of plant extracts containing quercetin in Salmonella typhimurium TA98 and TA100. Mutat. Res. 206, 201-208.
38. Seo, Y., Lee, H., Ah, Kim, Y., Youn, H.J., Lee, B., 2005. Effects of several salt marsh plants on mouse spleen and thymus cell proliferation using MTT assay. Ocean Sci. J. 40, 209-212.
39. Sharma, C.B.S.R., 1983. Plant meristems as monitors of genetic toxicity of environmental chemicals. Cur. Sci. 52, 1000-1002.
40. Simaan, J.A., 2009. Herbal medicine, what physicians need to know. Lebanese Med. J. 57, 215-217.
41. Sofowora, A., 1999. The state of medicinal plants research in Nigeria. In: Proceeding of workshop held at Ile-Ife, Nigeria.
42. Taylor, R.S.L., Manandhar, N.P., Hudson, J.B., Towers, G.H.N., 1996. Antiviral activities of nepalese medicinal plants. J. Ethnopharmacol. 52, 157-163.
43. Watanabe, K., Sakamoto, K., Sasaki, T., 1998. Comparisons on chemically-induced mutation among four bacterial strains, Salmonella typhimurium TA102 and TA2638, and Escherichia coli WP2/pKM101 and WP2 uvrA/pKM101: Collaborative study II. Mutat. Res. 412, 17-31.
44. WHO, 2013. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine, World Health Organization, 41.
45. William, S.B., Edward, J.K., 1978. Testing the environment for dispersed mutagens: use of plant bioconcentrators coupled with microbial mutagen assays. Environ. Health Persp. 27, 61-67.
46. Xiuyun, L., Xian, Y.J., 1991. Limonium bicolor and other four kinds of herbal medicine to stop bleeding in the determination of trace elements. J. Northwest. Pharma. 6, 16-21.
47. Zeiger, E., 2001. Mutagens that are not carcinogenic: faulty theory or faulty tests. Mutat. Res. 492, 29-38.
48. Zhen-fa, X., Liang, Z., 1991. Limonium sinense in mice with hemorrhagic anemia-Limonium sinense main component analysis. J. Shantou. Univ. 6, 78-83.
49. Zia, S., Khan, M.A., 2004. Effect of light, salinity, and temperature on seed germination of Limonium stocksii. Can. J. Bot. 82, 151-157.