Unambiguous characterization of N-glycans of monoclonal antibody cetuximab by integration of LC-MS/MS and 1H NMR spectroscopy

Analytical Chemistry

Volumn 86, Issue 10, 2014, Pages 4807-4814

  Wiegandt, Alena ^a   Meyer, Bernd ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DATA HANDLING; DISEASES; ESTERIFICATION; GLYCOSYLATION; LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SINGULAR VALUE DECOMPOSITION;

BIOPHARMACEUTICALS; CHROMATOGRAPHIC SEPARATIONS; CROSS CORRELATIONS; H NMR SPECTROSCOPY; HUMAN COMPATIBILITY; N-GLYCOLYLNEURAMINIC ACID; RECOMBINANT ANTIBODY; THERAPEUTIC ANTIBODIES;

POLYSACCHARIDES;

ANTINEOPLASTIC AGENT; CETUXIMAB; MONOCLONAL ANTIBODY; POLYSACCHARIDE;

CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TANDEM MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL, HUMANIZED; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MAGNETIC RESONANCE SPECTROSCOPY; POLYSACCHARIDES; TANDEM MASS SPECTROMETRY;

EID: 84901247842     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/ac404043g     Document Type: Article

References (30)

1. Reichert, J. mAbs 2012, 4, 413-415
2. Beck, A.; Wurch, T.; Bailly, C.; Corvaia, N. Nat. Rev. Immunol. 2010, 10, 345-352
3. Davis, J.; Deng, R.; Boswell, C.; Zhang, Y.; Li, J.; Fielder, P.; Joshi, A.; Kenkare-Mitra, S. Pharmaceutical Biotechnology; Springer: New York, 2013; p 143.
4. Reichert, J. mAbs 2010, 2, 84-100
5. Ledford, H. Nature 2010, 468, 18-19
6. Ayoub, D.; Jabs, W.; Resemann, A.; Evers, W.; Evans, C.; Main, L.; Baessmann, C.; Wagner-Rousset, E.; Suckau, D.; Beck, A. mAbs 2013, 5, 699-710
7. Lis, H.; Sharon, N. Eur. J. Biochem./FEBS 1993, 218, 1-27
8. Berger, E.; Buddecke, E.; Kamerling, J.; Kobata, A.; Paulson, J.; Vliegenthart, J. Experientia 1982, 38, 1129-1258
9. Rademacher, T.; Parekh, R.; Dwek, R. Annu. Rev. Biochem. 1988, 57, 785-838
10. Chan, A.; Carter, P. Nat. Rev. Immunol. 2010, 10, 301-316
11. Chung, C.; Mirakhur, B.; Chan, E.; Le, Q.-T.; Berlin, J.; Morse, M.; Murphy, B.; Satinover, S.; Hosen, J.; Mauro, D.; Slebos, R.; Zhou, Q.; Gold, D.; Hatley, T.; Hicklin, D.; Platts-Mills, T. New Engl. J. Med. 2008, 358, 1109-1117
12. Dell, A.; Morris, H. Science 2001, 291, 2351-2356
13. Fellenberg, M.; Coksezen, A.; Meyer, B. Angew. Chem., Int. Ed. 2010, 49, 2630-2633
14. Humblet, Y. Expert Opin. Pharmacother. 2004, 5, 1621-1633
15. Cunningham, D.; Humblet, Y.; Siena, S.; Khayat, D.; Bleiberg, H.; Santoro, A.; Bets, D.; Mueser, M.; Harstrick, A.; Verslype, C.; Chau, I.; Van Cutsem, E. New Engl. J. Med. 2004, 351, 337-345
16. Qian, J.; Liu, T.; Yang, L.; Daus, A.; Crowley, R.; Zhou, Q. Anal. Biochem. 2007, 364, 8-18
17. Wuhrer, M.; Catalina, M.; Deelder, A.; Hokke, C. J. Chromatogr., B 2007, 849, 115-128
18. Fridriksson, E.; Beavil, A.; Holowka, D.; Gould, H.; Baird, B.; McLafferty, F. Biochemistry 2000, 39, 3369-3376
19. Han, X.; Jin, M.; Breuker, K.; McLafferty, F. Science 2006, 314, 109-112
20. Rahul, R.; Raguram, S.; Ganesh, V.; James, C. P.; Ram, S. Nat. Methods 2005, 2, 817-824
21. Fellenberg, M.; Behnken, H.; Nagel, T.; Wiegandt, A.; Baerenfaenger, M.; Meyer, B. Anal. Bioanal. Chem. 2013, 405, 7291-7305
22. Behnken, H.; Fellenberg, M.; Koetzler, M.; Jirmann, R.; Nagel, T.; Meyer, B. Anal. Bioanal. Chem. 2012, 404, 1427-1437
23. Ruhaak, L.; Deelder, A.; Wuhrer, M. Anal. Bioanal. Chem. 2009, 394, 163-174
24. König, S.; Leary, J. J. Am. Soc. Mass Spectrom. 1998, 9, 1125-1134
25. Viseux, N.; de Hoffmann, E.; Domon, B. Anal. Chem. 1998, 70, 4951-4959
26. Weiskopf, A.; Vouros, P.; Harvey, D. Anal. Chem. 1998, 70, 4441-4447
27. Domon, B.; Costello, C. E. Glycoconjugate J. 1988, 5, 397-409
28. Harvey, D. Proteomics 2005, 5, 1774-1786
29. Vliegenthart, J. F. G.; Dorland, L.; van Halbeek, H. Adv. Carbohydr. Chem. Biochem. 1983, 41, 209-374
30. Press, W.; Flannery, B.; Teukolsky, S.; Vetterling, W. Numerical recipes: The art of scientific computing; Cambridge University Press: New York, 1986; p 818.