Leishmania aethiopica Field Isolates Bearing an Endosymbiontic dsRNA Virus Induce Pro-inflammatory Cytokine Response

PLoS Neglected Tropical Diseases

Volumn 8, Issue 4, 2014, Pages

  Zangger, Haroun ^a   Hailu, Asrat ^b   Desponds, Chantal ^a   Lye, Lon Fye ^c   Akopyants, Natalia S ^c   Dobson, Deborah E ^c   Ronet, Catherine ^a   Ghalib, Hashim ^a   Beverley, Stephen M ^c   Fasel, Nicolas ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b ADDIS ABABA UNIVERSITY   (Ethiopia)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSID PROTEIN; RNA DIRECTED RNA POLYMERASE; TOLL LIKE RECEPTOR 3; VIRUS RNA;

ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DOT HYBRIDIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FRAMESHIFT MUTATION; IMMUNOFLUORESCENCE MICROSCOPY; INFLAMMATION; LEISHMANIA; LEISHMANIA AETHIOPICA; LEISHMANIA RNA VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA SEQUENCE; RNA VIRUS;

ANIMALS; CYTOKINES; ETHIOPIA; HUMANS; LEISHMANIA; LEISHMANIASIS; MICE; MOLECULAR SEQUENCE DATA; RNA VIRUSES; RNA, VIRAL; SEQUENCE ANALYSIS, DNA;

EID: 84901246751     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0002836     Document Type: Article

References (43)

1. Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, et al. (2012) Leishmaniasis Worldwide and Global Estimates of Its Incidence. PloS one 7: e35671.
2. Schonian G, Akuffo H, Lewin S, Maasho K, Nylen S, et al. (2000) Genetic variability within the species Leishmania aethiopica does not correlate with clinical variations of cutaneous leishmaniasis. Molecular and biochemical parasitology 106: 239-248.
3. Acestor N, Masina S, Ives A, Walker J, Saravia NG, et al. (2006) Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. J Infect Dis 194: 1160-1167.
4. Alvar J, Aparicio P, Aseffa A, Den Boer M, Canavate C, et al. (2008) The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334-359 table of contents.
5. Arevalo I, Tulliano G, Quispe A, Spaeth G, Matlashewski G, et al. (2007) Role of imiquimod and parenteral meglumine antimoniate in the initial treatment of cutaneous leishmaniasis. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America 44: 1549-1554.
6. Castellucci L, Jamieson SE, Almeida L, Oliveira J, Guimaraes LH, et al. (2012) Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil. Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases 12: 1102-1110.
7. Castellucci L, Jamieson SE, Miller EN, Menezes E, Oliveira J, et al. (2010) CXCR1 and SLC11A1 polymorphisms affect susceptibility to cutaneous leishmaniasis in Brazil: a case-control and family-based study. BMC Med Genet 11: 10.
8. Castellucci L, Menezes E, Oliveira J, Magalhaes A, Guimaraes LH, et al. (2006) IL6 -174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. J Infect Dis 194: 519-527.
9. de Jesus Fernandes Covas C, Cardoso CC, Gomes-Silva A, Santos Oliveira JR, Da-Cruz AM, et al. (2013) Candidate gene case-control and functional study shows macrophage inhibitory factor (MIF) polymorphism is associated with cutaneous leishmaniasis. Cytokine 61: 168-172.
10. Liarte DB, Murta SM, (2010) Selection and phenotype characterization of potassium antimony tartrate-resistant populations of four New World Leishmania species. Parasitology research 107: 205-212.
11. Ramasawmy R, Menezes E, Magalhaes A, Oliveira J, Castellucci L, et al. (2010) The -2518 bp promoter polymorphism at CCL2/MCP1 influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. Infect Genet Evol 10: 607-613.
12. Sakthianandeswaren A, Foote SJ, Handman E, (2009) The role of host genetics in leishmaniasis. Trends in parasitology 25: 383-391.
13. Salhi A, Rodrigues V Jr, Santoro F, Dessein H, Romano A, et al. (2008) Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis. Journal of immunology 180: 6139-6148.
14. Machado-Coelho GL, Caiaffa WT, Genaro O, Magalhaes PA, Mayrink W, (2005) Risk factors for mucosal manifestation of American cutaneous leishmaniasis. Trans R Soc Trop Med Hyg 99: 55-61.
15. Ives A, Ronet C, Prevel F, Ruzzante G, Fuertes-Marraco S, et al. (2011) Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science 331: 775-778.
16. Stuart KD, Weeks R, Guilbride L, Myler PJ, (1992) Molecular organization of Leishmania RNA virus 1. Proc Natl Acad Sci U S A 89: 8596-8600.
17. Tarr PI, Aline RF Jr, Smiley BL, Scholler J, Keithly J, et al. (1988) LR1: a candidate RNA virus of Leishmania. Proc Natl Acad Sci U S A 85: 9572-9575.
18. Hartley M-A, Ronet C, Zangger H, Beverley SM, Fasel N, (2012) Leishmania RNA virus: when the host pays the toll. Front Cell Infect Microbiol 2: 99.
19. Martinez JE, Valderrama L, Gama V, Leiby DA, Saravia NG, (2000) Clonal diversity in the expression and stability of the metastatic capability of Leishmania guyanensis in the golden hamster. J Parasitol 86: 792-799.
20. Ronet C, Beverley SM, Fasel N, (2011) Muco-cutaneous leishmaniasis in the New World: the ultimate subversion. Virulence 2: 547-552.
21. Scheffter SM, Ro YT, Chung IK, Patterson JL, (1995) The complete sequence of Leishmania RNA virus LRV2-1, a virus of an Old World parasite strain. Virology 212: 84-90.
22. Widmer G, Dooley S, (1995) Phylogenetic analysis of Leishmania RNA virus and Leishmania suggests ancient virus-parasite association. Nucleic Acids Res 23: 2300-2304.
23. Naitow H, Tang J, Canady M, Wickner RB, Johnson JE, (2002) L-A virus at 3.4 A resolution reveals particle architecture and mRNA decapping mechanism. Nature structural biology 9: 725-728.
24. Lee SE, Suh JM, Scheffter S, Patterson JL, Chung IK, (1996) Identification of a ribosomal frameshift in Leishmania RNA virus 1-4. J Biochem 120: 22-25.
25. Ro YT, Scheffter SM, Patterson JL, (1997) Specific in vitro cleavage of a Leishmania virus capsid-RNA-dependent RNA polymerase polyprotein by a host cysteine-like protease. J Virol 71: 8983-8990.
26. Li H, Havens WM, Nibert ML, Ghabrial SA, (2011) RNA sequence determinants of a coupled termination-reinitiation strategy for downstream open reading frame translation in Helminthosporium victoriae virus 190S and other victoriviruses (Family Totiviridae). J Virol 85: 7343-7352.
27. Lye LF, Owens K, Shi H, Murta SM, Vieira AC, et al. (2010) Retention and loss of RNA interference pathways in trypanosomatid protozoans. PLoS pathogens 6: e1001161.
28. Zangger H, Ronet C, Desponds C, Kuhlmann FM, Robinson J, et al. (2013) Detection of Leishmania RNA virus in Leishmania parasites. PLoS neglected tropical diseases 7: e2006.
29. Atayde VD, Shi H, Franklin JB, Carriero N, Notton T, et al. (2013) The structure and repertoire of small interfering RNAs in Leishmania (Viannia) braziliensis reveal diversification in the trypanosomatid RNAi pathway. Mol Microbiol 87: 580-593.
30. van Luenen HG, Farris C, Jan S, Genest PA, Tripathi P, et al. (2012) Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania. Cell 150: 909-921.
31. Hyde JL, Sosnovtsev SV, Green KY, Wobus C, Virgin HW, et al. (2009) Mouse norovirus replication is associated with virus-induced vesicle clusters originating from membranes derived from the secretory pathway. J Virol 83: 9709-9719.
32. Lukacs N, (1994) Detection of virus infection in plants and differentiation between coexisting viruses by monoclonal antibodies to double-stranded RNA. J Virol Methods 47: 255-272.
33. Asato Y, Oshiro M, Myint CK, Yamamoto Y, Kato H, et al. (2009) Phylogenic analysis of the genus Leishmania by cytochrome b gene sequencing. Exp Parasitol 121: 352-361.
34. Bruenn JA, (1993) A closely related group of RNA-dependent RNA polymerases from double-stranded RNA viruses. Nucleic Acids Res 21: 5667-5669.
35. Ribas JC, Wickner RB, (1992) RNA-dependent RNA polymerase consensus sequence of the L-A double-stranded RNA virus: definition of essential domains. Proc Natl Acad Sci U S A 89: 2185-2189.
36. Routhier E, Bruenn JA, (1998) Functions of conserved motifs in the RNA-dependent RNA polymerase of a yeast double-stranded RNA virus. Journal of virology 72: 4427-4429.
37. Akuffo HO, Walford C, Nilsen R, (1990) The pathogenesis of Leishmania aethiopica infection in BALB/c mice. Scand J Immunol 32: 103-110.
38. Childs GE, Lightner LK, McKinney L, Groves MG, Price EE, et al. (1984) Inbred mice as model hosts for cutaneous leishmaniasis. I. Resistance and susceptibility to infection with Leishmania braziliensis, L. mexicana, and L. aethiopica. Ann Trop Med Parasitol 78: 25-34.
39. Humber DP, Hetherington CM, Atlaw T, Eriso F, (1989) Leishmania aethiopica: infections in laboratory animals. Exp Parasitol 68: 155-159.
40. Firth AE, Brierley I, (2012) Non-canonical translation in RNA viruses. J Gen Virol 93: 1385-1409.
41. Goodman RP, Ghabrial SA, Fichorova RN, Nibert ML, (2011) Trichomonasvirus: a new genus of protozoan viruses in the family Totiviridae. Arch Virol 156: 171-179.
42. Wickner RB, Fujimura T, Esteban R, (2013) Viruses and prions of Saccharomyces cerevisiae. Adv Virus Res 86: 1-36.
43. Pereira Lde O, Maretti-Mira AC, Rodrigues KM, Lima RB, de Oliveira-Neto MP, et al. (2013) Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil. Mem Inst Oswaldo Cruz 108: 665-667.