Specific in vitro cleavage of a Leishmania virus capsid-RNA-dependent RNA polymerase polyprotein by a host cysteine-like protease

Journal of Virology

Volumn 71, Issue 12, 1997, Pages 8983-8990

  Ro, Young Tae ^a   Scheffter, Scott M ^a   Patterson, Jean L ^a  

^a SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; HYBRID PROTEIN; RNA DIRECTED RNA POLYMERASE; VIRUS CAPSID ANTIGEN;

ARTICLE; ENZYME DEGRADATION; LEISHMANIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RNA VIRUS; VIRUS PARTICLE;

EID: 0030730227     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.12.8983-8990.1997     Document Type: Article

References (39)

1. Baker, E. N., and J. Drenth. 1987. The thiol proteases: structure and mechanism, p. 313-368. In F. A. Jurnak and A. McPherson (ed.), Biological macromolecules and assemblies. Wiley, New York, N.Y.
2. Bhattacharya, J., R. Dey, and S. C. Datta. 1993. Calcium dependent thiol protease caldonopain and its specific endogenous inhibitor in Leishmania donovani. Mol. Cell. Biochem. 126:9-16.
3. Bruenn, J. A. 1991. Relationships among the positive strand and double-strand RNA viruses as viewed through their RNA-dependent RNA polymerases. Nucleic Acids Res. 19:217-226.
4. Cadd, T. L., and J. L. Patterson. 1994. Synthesis of viruslike particles by expression of the putative capsid protein of Leishmania RNA virus in a recombinant baculovirus expression system. J. Virol. 68:358-365.
5. Cadd, T. L., M. C. Keenan, and J. L. Patterson. 1993. Detection of Leishmania RNA virus 1 proteins. J. Virol. 67:5647-5650.
6. Carrion, R., Jr., Y. T. Ro, and J. L. Patterson. Unpublished data.
7. Diamond, M. E., J. J. Dowhanick, M. E. Nemeroff, D. F. Pietras, C. Tu, and J. A. Bruenn. 1989. Overlapping genes in a yeast double-stranded RNA virus. J. Virol. 63:3983-3990.
8. Dougherty, W. G., and B. L. Semler. 1993. Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol. Rev. 57:781-822.
9. Dubay, J. W., S. R. Dubay, H.-J. Shin, and E. Hunter. 1995. Analysis of the cleavage site of the human immunodeficiency virus type 1 glycoprotein: requirement of precursor cleavage for glycoprotein incorporation. J. Virol. 69:4675-4682.
10. Fujimura, T., and R. B. Wickner. 1988. Replicase of L-A virus-like particles of Saccharomyces cerevisiae. J. Biol. Chem. 263:454-460.
11. Heidner, H. W., K. L. McKnight, N. L. Davis, and R. E. Johnston. 1994. Lethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2. J. Virol. 68:2683-2692.
12. Howard, M. K., M. M. Pharoah, F. Ashall, and M. A. Miles. 1991. Human urine stimulates growth of Leishmania in vitro. Trans. R. Soc. Trop. Med. Hyg. 85:477-479.
13. Huang, S., and S. A. Ghabrial. 1996. Organization and expression of the double-stranded RNA genome of Helminthosporium victoriae 190S virus, a totivirus infecting a plant pathogenic filamentous fungus. Proc. Natl. Acad. Sci. USA 93:12541-12546.
14. Jacks, T., H. D. Madhani, F. R. Masiarz, and H. E. Varmus. 1988. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell 55: 447-458.
15. Jacks, T., M. D. Power, F. R. Masiarz, P. A. Luciw, P. J. Barr, and H. E. Varmus. 1988. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature 331:280-283.
16. Kay, J., and B. M. Dunn. 1990. Viral proteinases: weakness in strength. Biochim. Biophys. Acta 1048:1-18.
17. Kozak, M. 1986. Bifunctional messenger RNAs in eukaryotes. Cell 47:481-483.
18. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15:8125-8148.
19. Krausslich, H.-G., and E. Wimmer. 1988. Viral proteinases. Annu. Rev. Biochem. 57:701-754.
20. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
21. Lee, S. E., J. M. Suh, S. Scheffter, J. L. Patterson, and I. K. Chung. 1996. Identification of a ribosomal frameshift in Leishmania RNA virus 1-4. J. Biochem. 120:22-25.
22. MacBeth, K. J., and J. L. Patterson. 1995. The short transcript of Leishmania RNA virus is generated by RNA cleavage. J. Virol. 69:3458-3464.
23. McKerrow, J. H., E. Sun, P. J. Rosenthal, and J. Bouvier. 1993. The proteases and pathogenicity of parasitic protozoa. Annu. Rev. Microbiol. 47: 821-853.
24. Moulard, M., L. Montagnier, and E. Bahraoui. 1994. Effects of calcium ions on proteolytic processing of HIV-1 gp160 precursor and on cell fusion. FEBS Lett. 338:281-284.
25. Patterson, J. L. 1993. The current status of Leishmania RNA virus 1. Parasitol. Today 9:135-136.
26. Patterson, J. L., S. A. Ghabrial, J. A. Bruenn, K. W. Buck, R. B. Wickner, K. D. Stuart, A. L. Wang, and C. C. Wang. 1995. Virus taxonomy: sixth report of the International Committee on Taxonomy of Viruses. Arch. Virol. 1995(Suppl. 10):245-252.
27. Robertson, C. D., and G. H. Coombs. 1993. Cathepsin B-like cysteine proteases of Leishmania mexicana. Mol. Biochem. Parasitol. 62:271-280.
28. Sakanari, J. A., S. A. Nadler, V. J. Chan, J. C. Engel, C. Leptak, and J. Bouvier. 1997. Leishmania major: comparison of the cathepsin L-and B-like cysteine protease genes with those of other trypanosomatids. Exp. Parasitol. 85:63-76.
29. Scheffter, S., G. Widmer, and J. L. Patterson. 1994. Complete sequence of Leishmania RNA virus 1-4 and identification of conserved sequences. Virology 199:479-483.
30. Scheffter, S., Y. T. Ro, I. K. Chung, and J. L. Patterson. 1995. The complete sequence of Leishmania RNA virus LRV2-1, a virus of an Old World parasite strain. Virology 212:84-90.
31. Shaw, E. 1990. Cysteinyl proteinases and their selective inactivation. Adv. Enzymol. 63:271-347.
32. Skalka, A. M. 1989. Retroviral proteases: first glimpses at the anatomy of a processing machine. Cell 56:911-913.
33. Soldevila, A. I., S. Huang, B. A. Webb, and S. A. Ghabrial. 1997. Expression, assembly and proteolytic processing of Helminthosporium victoriae 190S totivirus capsid protein in insect cells, abstr. W1-11, p. 96. In Abstracts of the 16th General Meeting of the American Society for Virology 1997. American Society for Virology, Bozeman, Mont.
34. Stuart, K. D., R. Weeks, L. Guilbride, and P. J. Myler. 1992. Molecular organization of Leishmania RNA virus 1. Proc. Natl. Acad. Sci. USA 89: 8596-8600.
35. Summers, M. D., and G. E. Smith. 1987. A manual of methods for baculovirus vectors and insect cell culture procedures, p. 1-48. Texas Agricultural Experiment Station, Texas A & M University, College Station, Tex.
36. Tarr, P. I., R. F. Aline, Jr., B. L. Smiley, J. Scholler, J. Keithly, and K. Stuart. 1988. LR1: a candidate RNA virus of Leishmania. Proc. Natl. Acad. Sci. USA 85:9572-9575.
37. Wang, A. L., H.-M. Yang, K. A. Shen, and C. C. Wang. 1993. Giardiavirus double-stranded RNA genome encodes a capsid polypeptide and a gag-pol-like fusion protein by a translation frameshift. Proc. Natl. Acad. Sci. USA 90:8595-8599.
38. Widmer, G., and J. L. Patterson. 1991. Genomic structure and RNA polymerase activity in Leishmania virus. J. Virol. 65:4211-4215.
39. Yu, D., C. C. Wang, and A. L. Wang. 1995. Maturation of giardiavirus capsid protein involves posttranslational proteolytic processing by a cysteine protease. J. Virol. 69:2825-2830.