Quantitative proteomic analysis of amphotericin B resistance in Leishmania infantum

International Journal for Parasitology: Drugs and Drug Resistance

Volumn 4, Issue 2, 2014, Pages 126-132

  Brotherton, Marie Christine ^a   Bourassa, Sylvie ^b   Légaré, Danielle ^a   Poirier, Guy G ^b   Droit, Arnaud ^b   Ouellette, Marc ^a  

^a LAVAL UNIVERSITY   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Amphotericin B; Drug resistance; Leishmania; Quantitative proteomics; Stable isotope labeling of amino acids in cell culture (SILAC)

Indexed keywords

ACONITATE HYDRATASE; AMPHOTERICIN B; CHAPERONIN; CHAPERONIN CONTAINING TCP1; DIHYDROLIPOAMIDE DEHYDROGENASE; ELONGATION FACTOR 1ALPHA; ENOLASE; FLAVOPROTEIN; FRUCTOSE BISPHOSPHATE ALDOLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GLYCOLYTIC ENZYME; HEAT SHOCK PROTEIN; HEXOKINASE; INITIATION FACTOR 4A; INOSITOL PHOSPHATE; MALATE DEHYDROGENASE; MEMBRANE PROTEIN; METHIONINE ADENOSYLTRANSFERASE; METHIONINE SYNTHASE; MUTANT PROTEIN; MYOINOSITOL 1 PHOSPHATE SYNTHASE; PEROXIDASE; REACTIVE OXYGEN METABOLITE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; SERINE TRANSFER RNA LIGASE; SUCCINATE DEHYDROGENASE; TRYPANOTHIONE REDUCTASE;

ANTIFUNGAL RESISTANCE; ARTICLE; BACTERIUM MUTANT; CELL CULTURE; CELL FUNCTION; CELL MEMBRANE POTENTIAL; CITRIC ACID CYCLE; CYTOPLASM; GLYCOLYSIS; HUMAN; IN VITRO STUDY; ISOTOPE LABELING; LEISHMANIA INFANTUM; LEISHMANIASIS; MAJOR CLINICAL STUDY; MEMBRANE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEOMICS; QUANTITATIVE PROTEOMIC; SENSITIVITY ANALYSIS; STABLE ISOTOPE LABELING OF AMINO ACIDS IN CELL CULTURE; UPREGULATION;

EID: 84901243708     PISSN: 22113207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpddr.2014.05.002     Document Type: Article

References (34)

1. Alscher R.G., Erturk N., Heath L.S. Role of superoxide dismutases (SODs) in controlling oxidative stress in plants. J. Exp. Bot. 2002, 53:1331-1341.
2. Alvar J., Croft S., Olliaro P. Chemotherapy in the treatment and control of leishmaniasis. Adv. Parasitol. 2006, 61:223-274.
3. Bern C., Adler-Moore J., Berenguer J., Boelaert M., den Boer M., Davidson R.N., Figueras C., Gradoni L., Kafetzis D.A., Ritmeijer K., Rosenthal E., Royce C., Russo R., Sundar S., Alvar J. Liposomal amphotericin B for the treatment of visceral leishmaniasis. Clin. Infect. Dis. 2006, 43:917-924.
4. Biyani N., Singh A.K., Mandal S., Chawla B., Madhubala R. Differential expression of proteins in antimony-susceptible and -resistant isolates of Leishmania donovani. Mol. Biochem. Parasitol. 2011, 179:91-99.
5. Blum G., Hortnagl C., Jukic E., Erbeznik T., Pumpel T., Dietrich H., Nagl M., Speth C., Rambach G., Lass-Florl C. New insight into amphotericin B resistance in Aspergillus terreus. Antimicrob. Agents Chemother. 2013.
6. Blum G., Kainzner B., Grif K., Dietrich H., Zelger B., Sonnweber T., Lass-Florl C. In vitro and in vivo role of heat shock protein 90 in amphotericin B resistance of Aspergillus terreus. Clin. Microbiol. Infect. 2013, 19:50-55.
7. Brotherton M.C., Racine G., Foucher A.L., Drummelsmith J., Papadopoulou B., Ouellette M. Analysis of stage-specific expression of basic proteins in Leishmania infantum. J. Proteome Res. 2010, 9:3842-3853.
8. Brotherton M.C., Racine G., Ouameur A.A., Leprohon P., Papadopoulou B., Ouellette M. Analysis of membrane-enriched and high molecular weight proteins in Leishmania infantum promastigotes and axenic amastigotes. J. Proteome Res. 2012, 11:3974-3985.
9. Brotherton M.C., Bourassa S., Leprohon P., Legare D., Poirier G.G., Droit A., Ouellette M. Proteomic and genomic analyses of antimony resistant Leishmania infantum mutant. PLoS One 2013, 8:e81899.
10. Chappuis F., Sundar S., Hailu A., Ghalib H., Rijal S., Peeling R.W., Alvar J., Boelaert M. Visceral leishmaniasis: what are the needs for diagnosis, treatment and control?. Nat. Rev. Microbiol. 2007, 5:873-882.
11. Coelho A.C., Boisvert S., Mukherjee A., Leprohon P., Corbeil J., Ouellette M. Multiple mutations in heterogeneous miltefosine-resistant Leishmania major population as determined by whole genome sequencing. PLoS Negl. Trop. Dis. 2012, 6:e1512.
12. Cohen B.E., Ramos H., Gamargo M., Urbina J. The water and ionic permeability induced by polyene antibiotics across plasma membrane vesicles from Leishmania sp. Biochim. Biophys. Acta 1986, 860:57-65.
13. Havlis J., Thomas H., Sebela M., Shevchenko A. Fast-response proteomics by accelerated in-gel digestion of proteins. Anal. Chem. 2003, 75:1300-1306.
14. Hoehamer C.F., Cummings E.D., Hilliard G.M., Rogers P.D. Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents. Antimicrob. Agents Chemother. 2010, 54:1655-1664.
15. Lachaud L., Bourgeois N., Plourde M., Leprohon P., Bastien P., Ouellette M. Parasite susceptibility to amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV type 1 and Leishmania infantum. Clin. Infect. Dis. 2009, 48:e16-22.
16. Lira R., Sundar S., Makharia A., Kenney R., Gam A., Saraiva E., Sacks D. Evidence that the high incidence of treatment failures in Indian kala-azar is due to the emergence of antimony-resistant strains of Leishmania donovani. J. Infect. Dis. 1999, 180:564-567.
17. Mbongo N., Loiseau P.M., Billion M.A., Robert-Gero M. Mechanism of amphotericin B resistance in Leishmania donovani promastigotes. Antimicrob. Agents Chemother. 1998, 42:352-357.
18. Moreira W., Leprohon P., Ouellette M. Tolerance to drug-induced cell death favours the acquisition of multidrug resistance in Leishmania. Cell Death Dis. 2011, 2:e201.
19. Morsomme P., Slayman C.W., Goffeau A. Mutagenic study of the structure, function and biogenesis of the yeast plasma membrane H(+)-ATPase. Biochim. Biophys. Acta 2000, 1469:133-157.
20. Murray H.W., Berman J.D., Davies C.R., Saravia N.G. Advances in leishmaniasis. Lancet 2005, 366:1561-1577.
21. Olliaro P., Sundar S. Anthropometrically derived dosing and drug costing calculations for treating visceral leishmaniasis in Bihar, India. Trop. Med. Int. Health 2009, 14:88-92.
22. Prinz W.A., Hinshaw J.E. Membrane-bending proteins. Crit. Rev. Biochem. Mol. Biol. 2009, 44:278-291.
23. Purkait B., Kumar A., Nandi N., Sardar A.H., Das S., Kumar S., Pandey K., Ravidas V., Kumar M., De T., Singh D., Das P. Mechanism of amphotericin B Resistance in Clinical Isolates of Leishmania donovani. Antimicrob. Agents Chemother. 2012, 56:1031-1041.
24. Ritt J.F., Raymond F., Leprohon P., Legare D., Corbeil J., Ouellette M. Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum. PLoS Negl. Trop. Dis. 2013, 7:e2564.
25. Saha A.K., Mukherjee T., Bhaduri A. Mechanism of action of amphotericin B on Leishmania donovani promastigotes. Mol. Biochem. Parasitol. 1986, 19:195-200.
26. Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem. 1996, 68:850-858.
27. Shilov I.V., Seymour S.L., Patel A.A., Loboda A., Tang W.H., Keating S.P., Hunter C.L., Nuwaysir L.M., Schaeffer D.A. The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra. Mol. Cell. Proteomics 2007, 6:1638-1655.
28. Sokol-Anderson M.L., Brajtburg J., Medoff G. Amphotericin B-induced oxidative damage and killing of Candida albicans. J. Infect. Dis. 1986, 154:76-83.
29. Srivastava P., Prajapati V.K., Rai M., Sundar S. Unusual case of resistance to amphotericin B in visceral leishmaniasis in a region in India where leishmaniasis is not endemic. J. Clin. Microbiol. 2011, 49:3088-3091.
30. Sundar S., Rosenkaimer F., Makharia M.K., Goyal A.K., Mandal A.K., Voss A., Hilgard P., Murray H.W. Trial of oral miltefosine for visceral leishmaniasis. Lancet 1998, 352:1821-1823.
31. Sundar S. Drug resistance in Indian visceral leishmaniasis. Trop. Med. Int. Health 2001, 6:849-854.
32. Sundar S., Jha T.K., Thakur C.P., Sinha P.K., Bhattacharya S.K. Injectable paromomycin for visceral leishmaniasis in India. N. Engl. J. Med. 2007, 356:2571-2581.
33. Thakur C.P., Dedet J.P., Narain S., Pratlong F. Leishmania species, drug unresponsiveness and visceral leishmaniasis in Bihar, India. Trans. R. Soc. Trop. Med. Hyg. 2001, 95:187-189.
34. Wyllie S., Vickers T.J., Fairlamb A.H. Roles of trypanothione S-transferase and tryparedoxin peroxidase in resistance to antimonials. Antimicrob. Agents Chemother. 2008, 52:1359-1365.