The relationship between neurocognition and symptomatology in people with schizophrenia: Social cognition as the mediator

BMC Psychiatry

Volumn 14, Issue 1, 2014, Pages

  Lam, Bess Y H ^a   Raine, Adrian ^b   Lee, Tatia M C ^a,c  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Cognition; Emotion; Eyes test; Faux pas; Schizophrenia; Theory of mind

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; FAUX PAS TEST; FEMALE; HUMAN; INTERPERSONAL REACTIVITY INDEX; JUDGMENT OF LINE ORIENTATION TEST; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; OBSERVATION; PARANOID SCHIZOPHRENIA; POSITIVE AND NEGATIVE SYNDROME SCALE; RANDOMIZED CONTROLLED TRIAL; RAVEN PROGRESSIVE MATRICES TEST; SOCIAL COGNITION; SYMPTOMATOLOGY; TOWER OF LONDON TEST; CHINA; COGNITION; MIDDLE AGED; PSYCHOLOGY; SCHIZOPHRENIA, PARANOID; SOCIAL BEHAVIOR; UNITED STATES;

ADULT; CHINA; COGNITION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA, PARANOID; SOCIAL BEHAVIOR; UNITED STATES;

EID: 84901234926     PISSN: None     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-14-138     Document Type: Article

References (57)

1. Hoff AL, Kremen WS. Is there a cognitive phenotype for schizophrenia: The nature and course of the disturbance in cognition?. Curr Opin Psychiatry 2002, 15(1):43-48.
2. Caspi A, Reichenberg A, Weisera M, Rabinowitz J, Kaplan Z, Knobler H, Sagi ND, Davidson M. Cognitive performance in schizophrenia patients assessed before and following the first psychotic episode. Schizophr Res 2003, 65:87-94. 10.1016/S0920-9964(03)00056-2, 14630301.
3. Hardoy MC, Cart MG, Catena M, Hardoy MJ, Cadeddu M, Dell'Osso L, Hugdahl K, Carpiniello B. Impairment in visual and spatial perception in schizophrenia and delusional disorder. Psychiat Res 2004, 127:163-166.
4. Hughes C, Kumari V, Soni W, Das M, Binneman B, Drozd S, O'Neil S, Mathew V, Sharma T. Longitudinal study of symptoms and cognitive function in chronic schizophrenia. Schizophr Res 2002, 59:137-146.
5. Brüne M, Schaub D, Juckel G, Langdon R. Social skills and behavioral problems in schizophrenia: The role of mental state attribution, neurocognition and clinical symptomatology. Psychiatry Res 2011, 190(1):9-17. 10.1016/j.psychres.2010.03.015, 20417974.
6. Fett AK, Viechtbauer W, Dominguez MD, Penn DL, van Os J, Krabbendam L. The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 2011, 35(3):573-588. 10.1016/j.neubiorev.2010.07.001, 20620163.
7. Green MF, Kern RS, Braff DL, Mintz J. Neurocognitive deficits and functional outcome in schizophrenia: are we measuring the " right stuff" ?. Schizophr Bull 2000, 26(1):119-136. 10.1093/oxfordjournals.schbul.a033430, 10755673.
8. Tolman AW, Kurtz MM. Neurocognitive predictors of objective and subjective quality of life in individuals with schizophrenia: a meta-analytic investigation. Schizophr Bull 2012, 38(2):304-315. 10.1093/schbul/sbq077, 3283161, 20624752.
9. Schmidt SJ, Mueller DR, Roder V. Social cognition as a mediator variable between neurocognition and functional outcome in schizophrenia: empirical review and new results by structural equation modeling. Schizophr Bull 2011, 37(Suppl 2):S41-S54. 10.1093/schbul/sbr079, 3160114, 21860046.
10. Hovington CL, Lepage M. Neurocognition and neuroimaging of persistent negative symptoms of schizophrenia. Expert Rev Neurother 2012, 12(1):53-69. 10.1586/ern.11.173, 22243045.
11. Ventura J, Hellemann GS, Thames AD, Koellner V, Nuechterleina KH. Symptoms as mediators of the relationship between neurocognition and functional outcome in schizophrenia: a meta-analysis. Schizophr Res 2009, 113(2-3):189-199. 2825750, 19628375.
12. Berman I, Viegner B, Merson A, Allan E, Pappas D, Green AI. Differential relationships between positive and negative symptoms and neuropsychological deficits in schizophrenia. Schizophr Res 1997, 25(1):1-10. 10.1016/S0920-9964(96)00098-9, 9176922.
13. Brazo P, Delamillieure P, Morello R, Halbecq L, Marié RM, Dollfus S. Impairments of executive/attentional functions in schizophrenia with primary and secondary negative symptoms. Psychiatry Res 2005, 133(1):45-55. 10.1016/j.psychres.2004.10.001, 15698676.
14. Carlsson R, Nyman H, Ganse G, Cullberg J. Neuropsychological functions predict 1- and 3-year outcome in first-episode psychosis. Acta Psychiatr Scand 2006, 113:102-111. 10.1111/j.1600-0447.2005.00661.x, 16423161.
15. Johnson-Selfridge M, Zalewski C. Moderator variables of executive functioning in schizophrenia: meta-analytic findings. Schizophr Bull 2001, 27(2):305-316. 10.1093/oxfordjournals.schbul.a006876, 11354597.
16. Norman RMG, Malla AK, Morrison-Stewart SL, Helmes E, Williamson PC, Thomas J, Cortese L. Neuropsychological correlates of syndromes in schizophrenia. Br J Psychiatry 1997, 170:134-139. 10.1192/bjp.170.2.134, 9093501.
17. Fulford D, Niendam TA, Floyd EG, Carter CS, Mathalon DH, Vinogradov S, Stuart BK, Loewy RL. Symptom dimensions and functional impairment in early psychosis: more to the story than just negative symptoms. Schizophr Res 2013, 147(1):125-131. 10.1016/j.schres.2013.03.024, 23587696.
18. Rabinowitz J, Levine SZ, Garibaldi G, Bugarski-Kirola D, Berardo CG, Kapur S. Negative symptoms have greater impact on functioning than positive symptoms in schizophrenia: analysis of CATIE data. Schizophr Res 2013, 137(1-3):147-150.
19. Brewer WJ, Wood SJ, Phillips LJ, Francey SM, Pantelis C, Yung AR, Cornblatt B, McGorry PD. Generalized and specific cognitive performance in clinical high-risk cohorts: a review highlighting potential vulnerability markers for psychosis. Schizophrenia Bull 2006, 32(3):538-555.
20. Wood SJ, Pantelis C, Proffitt T, Phillips LJ, Stuart GW, Buchanan JA, Mahony K, Brewer W, Smith DJ, McGorry PD. Spatial working memory ability is a marker of risk-for-psychosis. Psychol Med 2003, 33:1239-1247. 10.1017/S0033291703008067, 14580078.
21. Comblatt BA, Keilp JG. Impaired attention, genetics and the pathophysiology of schizophrenia. Schizophrenia Bull 1994, 20(l):31-46.
22. Addington J, Saeedi H, Addington D. Facial affect recognition: a mediator between cognitive and social functioning in psychosis?. Schizophr Res 2006, 85:142-150. 10.1016/j.schres.2006.03.028, 16678388.
23. Billeke P, Aboitiz F. Social cognition in schizophrenia: from social stimuli processing to social engagement. Front Psychiatry 2013, 4:4. 3580762, 23444313.
24. Zhu CY, Lee TMC, Li XS, Jing SC, Wang YG, Wang K. Impairments of social cues recognition and social functioning in Chinese people with schizophrenia. Psychiatry Clin Neurosci 2007, 61:149-158. 10.1111/j.1440-1819.2007.01630.x, 17362432.
25. Brunet-Gouet E, Decety J. Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Res 2006, 148:75-92. 10.1016/j.pscychresns.2006.05.001, 17088049.
26. Pijnenborg GHM, Withaar FK, Evans JJ, Van Den Bosch RJ, Timmerman ME, Brouwer WH. The predictive value of measures of social cognition for community functioning in schizophrenia: implications for neuropsychological assessment. J Int Neuropsych Soc 2009, 15:239-247.
27. Hirao K, Miyata J, Fujiwara H, Yamada M, Namiki C, Shimizu M, Sawamoto N, Fukuyama H, Hayashi T, Murai T. Theory of mind and frontal lobe pathology in schizophrenia: a voxel-based morphometry study. Schizophr Res 2008, 105(1-3):165-174.
28. Corbera S, Wexler BE, Ikezawa S, Bell MD. Factor structure of social cognition in Schizophrenia: is empathy preserved?. Schizophr Res and Treatment 2013, 2013:1-13.
29. Couture SM, Penn DL, Roberts DL. The functional significance of social cognition in schizophrenia: a review. Schizophrenia Bull 2006, 32(1):44-63.
30. Tas C, Brown E, Cubukcuoglu Z, Aydemir O, Danaci AE, Brüne M. Towards an integrative approach to understanding quality of life in schizophrenia: the role of neurocognition, social cognition and psychopathology. Compr Psychiat 2013, 54(3):262-268. 10.1016/j.comppsych.2012.08.001, 22998842.
31. Sergi MJ, Rassovsky Y, Widmark C, Reist C, Erhart S, Braff D, Marder SR, Green MF. Social cognition in schizophrenia: relationships with neurocognition and negative symptoms. Schizophr Res 2007, 90:316-324. 10.1016/j.schres.2006.09.028, 17141477.
32. Kerr SL, Neale JM. Emotion perception in schizophrenia: specific deficit or further evidence of generalized poor performance?. J Abnorm Psychology 1993, 102:312-318.
33. Ambady N, Hallahan M, Rosenthal R. On judging and being judged accurately in zero-acquaintance situations. J Pers Soc Psychol 1995, 69:519-529.
34. Barbato M, Liu L, Penn DL, Keefe RS, Perkins DO, Woods SW, Addigton J. Social Cognition as a mediator between neurocognition and functional outcome in individuals at clinical high risk for psychosis. Schizophr Res 2013, 150(2-3):542-546.
35. Corcoran R, Mercer G, Frith CD. Schizophrenia, symptomatology and social inference: Investigating " theory of mind" in people with schizophrenia. Schizophr Res 1995, 17:5-13. 10.1016/0920-9964(95)00024-G, 8541250.
36. Tibi-Elhanany Y, Shamay-Tsoory SG. Social cognition in social anxiety: first evidence for increased empathic abilities. Isr J Psychiatry Relat Sci 2011, 48(2):98-106.
37. Haker H, Rossler W. Empathy in schizophrenia: impaired resonance. Eur Arch Psychiatry Clin Neurosci 2009, 259(6):352-361. 10.1007/s00406-009-0007-3, 19377866.
38. Sparks A, McDonald S, Lino B, O'Donnell M, Green MJ. Social cognition, empathy and functional outcome in schizophrenia. Schizophr Res 2010, 122(1-3):172-178.
39. Achim AM, Ouellet R, Roy MA, Jackson PL. Assessment of empathy in first episode psychosis and meta-analytic comparison with previous studies in schizophrenia. Psychiatry Res 2011, 190(1):3-8. 10.1016/j.psychres.2010.10.030, 21131057.
40. Smith MJ, Horan WP, Karpouzian TM, Abram SV, Cobia DJ, Csernansky JG. Self-reported empathy deficits are uniquely associated with poor functioning in schizophrenia. Schizophr Res 2012, 137:196-202. 10.1016/j.schres.2012.01.012, 22321668.
41. McCabe DP, Roediger HL, McDaniel MA, Balota DA, Hambrick DZ. The relationship between working memory capacity and executive functioning: evidence for a common executive attention construct. Neuropsychology 2010, 24(2):222-243. 2852635, 20230116.
42. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 4th edn (text revision) 2000, Washington, DC: American Psychiatric Association, American Psychiatric Association.
43. Shallice T. Specific impairments of planning philosophical transactions of the royal society of London. Series B, Biological Sciences 1982, 298(1089):199-209.
44. Baker SC, Rogers RD, Owen AM, Frith CD, Dolan RJ, Frackowiak RSJ, Robbins TW. Neural systems engaged in planning: a PET study of the tower of London task. Neuropsychologia 1996, 34:515-526. 10.1016/0028-3932(95)00133-6, 8736565.
45. Benton AL, Sivan AB, Hamsher K, Varney NR, Spreen O. Contributions to neuropsychological assessment 1983, New York: Oxford University Press.
46. Raven J, Raven JC, Court JH. Manual for Raven's progressive matrices and vocabulary scales 2003, Harcourt Assessment: San Antonio, TX.
47. Stone VE, Baron-Cohen S, Knight RT. Frontal lobe contributions to theory of mind. J Cogn Neurosci 1998, 10:640-656. 10.1162/089892998562942, 9802997.
48. Baron-Cohen S, Wheelwright S, Hill J, Raste Y, Plumb I. The " Reading the Mind in the Eyes" test, revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. J Child Psychol Psychiatry 2001, 42:241-251. 10.1111/1469-7610.00715, 11280420.
49. Wimmer H, Perner J. Beliefs about beliefs: representation and constraining function of wrong beliefs in young children's understanding of deception. Cogn 1983, 13(1):103-128.
50. Davis MH. Measuring individual differences in empathy: evidence for a multidimensional approach. J Pers Soc Psychol 1983, 44(1):113-126.
51. Kay SR, Opler LA, Lindenmayer JP. The positive and negative syndrome scale (PANSS): rationale and standardisation. Br J Psychiatry 1989, 155(Suppl 7):59-65.
52. Hayes AF. An introduction to mediation, moderation, and conditional process analysis: a regression-based Approach 2013, New York: Guilford Press.
53. Shrout PE, Bolger N. Mediation in experimental and nonexperimental studies: new procedures and recommendations. Psychol Meth 2002, 7:422-445.
54. Bora E, Eryavuz A, Kayahan B, Sungu G, Veznedaroglu B. Social functioning, theory of mind and neurocognition in outpatients with schizophrenia; mental state decoding may be a better predictor of social functioning than mental state reasoning. Psychiat Res 2006, 145:95-103.
55. Derntl B, Seidel EM, Schneider F, Habel U. How specific are emotional deficits? A comparison of empathic abilities in schizophrenia, bipolar and depressed patients. Schizophr Res 2012, 142(1-3):58-64. 3514634, 23116884.
56. Bartholomeusz CF, Allott K. Neurocognitive and social cognitive approaches for improving functional outcome in early psychosis: theoretical considerations and current state of evidence. Schizophrenia Res Treatment 2012, doi:10.1155/2012/815315.
57. Lincoln TM, Mehl S, Kesting M, Rief W. Negative symptoms and social cognition: identifying targets for psychological interventions. Schizophr Bull 2011, 37(Suppl 2):S23-S32. 10.1093/schbul/sbr066, 3160122, 21860044.