Ex vivo lung perfusion to improve donor lung function and increase the number of organs available for transplantation

Transplant International

Volumn 27, Issue 6, 2014, Pages 553-561

  Valenza, Franco ^a,b   Rosso, Lorenzo ^a   Coppola, Silvia ^a   Froio, Sara ^a   Palleschi, Alessandro ^a   Tosi, Davide ^a   Mendogni, Paolo ^a   Salice, Valentina ^a   Ruggeri, Giulia M ^a   Fumagalli, Jacopo ^a   Villa, Alessandro ^a   Nosotti, Mario ^a,b   Santambrogio, Luigi ^a,b   Gattinoni, Luciano ^a,b  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

brain death; ex vivo lung perfusion organ regeneration; lung transplantation; marginal donor criteria; outcome

Indexed keywords

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BRAIN DEATH; CADAVER DONOR; COMPARATIVE STUDY; EX VIVO STUDY; EXTRACORPOREAL OXYGENATION; HEART OUTPUT; HUMAN; INTENSIVE CARE UNIT; LUNG ARTERY PRESSURE; LUNG FUNCTION; LUNG PERFUSION; LUNG VASCULAR RESISTANCE; ORGAN DONOR; ORGAN TRANSPLANTATION; OUTCOME ASSESSMENT; OVERALL SURVIVAL; POSITIVE END EXPIRATORY PRESSURE; PRIMARY GRAFT DYSFUNCTION; PRIORITY JOURNAL; THORAX RADIOGRAPHY; ADVERSE EFFECTS; ANALYSIS OF VARIANCE; CONTROLLED STUDY; DONOR; EXTRACORPOREAL CIRCULATION; FEMALE; FOLLOW UP; GRAFT REJECTION; GRAFT SURVIVAL; KAPLAN MEIER METHOD; LUNG FUNCTION TEST; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; NONPARAMETRIC TEST; ORGAN PRESERVATION; PERFUSION; POSTOPERATIVE CARE; PROCEDURES; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; TIME; TRANSPLANTATION; TREATMENT OUTCOME;

ADULT; ANALYSIS OF VARIANCE; EXTRACORPOREAL CIRCULATION; FEMALE; FOLLOW-UP STUDIES; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; KAPLAN-MEIER ESTIMATE; LINEAR MODELS; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; ORGAN PRESERVATION; PERFUSION; POSTOPERATIVE CARE; PROSPECTIVE STUDIES; RESPIRATORY FUNCTION TESTS; RISK ASSESSMENT; STATISTICS, NONPARAMETRIC; TIME FACTORS; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; TREATMENT OUTCOME;

EID: 84901234656     PISSN: 09340874     EISSN: 14322277     Source Type: Journal    
DOI: 10.1111/tri.12295     Document Type: Article

References (44)

1. Jirsch DW, Fisk RL, Couves CM,. Ex vivo evaluation of stored lungs. Ann Thorac Surg 1970; 10: 163.
2. Steen S, Ingemansson R, Eriksson L, et al,. First human transplantation of a nonacceptable donor lung after reconditioning ex vivo. Ann Thorac Surg 2007; 83: 2191.
3. Cypel M, Yeung JC, Liu M, et al,. Normothermic ex vivo lung perfusion in clinical lung transplantation. N Engl J Med 2011; 364: 1431.
4. Aigner C, Slama A, Hotzenecker K, et al,. Clinical ex vivo lung perfusion-pushing the limits. Am J Transplant 2012; 12: 1839.
5. Cypel M, Yeung JC, Machuca T, et al,. Experience with the first 50 ex vivo lung perfusions in clinical transplantation. J Thorac Cardiovasc Surg 2012; 144: 1200.
6. Ingemansson R, Eyjolfsson A, Mared L, et al,. Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo. Ann Thorac Surg 2009; 87: 255.
7. Wallinder A, Ricksten SE, Hansson C, et al,. Transplantation of initially rejected donor lungs after ex vivo lung perfusion. J Thorac Cardiovasc Surg 2012; 144: 1222.
8. Wallinder A, Ricksten SE, Silverborn M, et al,. Early results in transplantation of initially rejected donor lungs after ex vivo lung perfusion: a case-control study. Eur J Cardiothorac Surg 2014; 45: 40.
9. Zych B, Popov AF, Stavri G, et al,. Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning. J Heart Lung Transplant 2012; 31: 274.
10. Valenza F, Rosso L, Pizzocri M, et al,. The consumption of glucose during ex vivo lung perfusion correlates with lung edema. Transplant Proc 2011; 43: 993.
11. Valenza F, Rosso L, Coppola S, et al,. Beta-adrenergic agonist infusion during extracorporeal lung perfusion: effects on glucose concentration in the perfusion fluid and on lung function. J Heart Lung Transplant 2012; 31: 524.
12. Oto T, Levvey BJ, Whitford H, et al,. Feasibility and utility of a lung donor score: correlation with early post-transplant outcomes. Ann Thorac Surg 2007; 83: 257.
13. Christie JD, Carby M, Bag R, et al,. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction part II: definition. A consensus statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant 2005; 24: 1454.
14. Orens JB, Boehler A, de Perrot M, et al,. A review of lung transplant donor acceptability criteria. J Heart Lung Transplant 2003; 22: 1183.
15. Van Raemdonck D, Neyrinck A, Verleden GM, et al,. Lung donor selection and management. Proc Am Thorac Soc 2009; 6: 28.
16. Aigner C, Winkler G, Jaksch P, et al,. Extended donor criteria for lung transplantation-a clinical reality. Eur J Cardiothorac Surg 2005; 27: 757.
17. Bhorade SM, Vigneswaran W, McCabe MA, Garrity ER,. Liberalization of donor criteria may expand the donor pool without adverse consequence in lung transplantation. J Heart Lung Transplant 2000; 19: 1199.
18. Kron IL, Tribble CG, Kern JA, et al,. Successful transplantation of marginally acceptable thoracic organs. Ann Surg 1993; 217: 518.
19. Meers C, Van Raemdonck D, Verleden GM, et al,. The number of lung transplants can be safely doubled using extended criteria donors; a single-center review. Transpl Int 2010; 23: 628.
20. Botha P, Trivedi D, Weir CJ, et al,. Extended donor criteria in lung transplantation: impact on organ allocation. J Thorac Cardiovasc Surg 2006; 131: 1154.
21. Kawut SM, Reyentovich A, Wilt JS, et al,. Outcomes of extended donor lung recipients after lung transplantation. Transplantation 2005; 79: 310.
22. Pierre AF, Sekine Y, Hutcheon MA, Waddell TK, Keshavjee SH,. Marginal donor lungs: a reassessment. J Thorac Cardiovasc Surg 2002; 123: 421.
23. Schiavon M, Falcoz PE, Santelmo N, Massard G,. Does the use of extended criteria donors influence early and long-term results of lung transplantation? Interact Cardiovasc Thorac Surg 2012; 14: 183.
24. Whitson BA, Nath DS, Johnson AC, et al,. Risk factors for primary graft dysfunction after lung transplantation. J Thorac Cardiovasc Surg 2006; 131: 73.
25. Pego-Fernandes PM, Samano MN, Fiorelli AI, et al,. Recommendations for the use of extended criteria donors in lung transplantation. Transplant Proc 2011; 43: 216.
26. Avlonitis VS, Fisher AJ, Kirby JA, Dark JH,. Pulmonary transplantation: the role of brain death in donor lung injury. Transplantation 2003; 75: 1928.
27. Pennefather SH, Bullock RE, Dark JH,. The effect of fluid therapy on alveolar arterial oxygen gradient in brain-dead organ donors. Transplantation 1993; 56: 1418.
28. Venkateswaran RV, Dronavalli V, Patchell V, et al,. Measurement of extravascular lung water following human brain death: implications for lung donor assessment and transplantation. Eur J Cardiothorac Surg 2013; 43: 1227.
29. Porro GA, Valenza F, Coppola S, et al,. Use of the Oto lung donor score to analyze the 2010 donor pool of the Nord Italia Transplant program. Transplant Proc 2012; 44: 1830.
30. Mascia L, Pasero D, Slutsky AS, et al,. Effect of a lung protective strategy for organ donors on eligibility and availability of lungs for transplantation: a randomized controlled trial. JAMA 2010; 304: 2620.
31. Broccard AF, Vannay C, Feihl F, Schaller MD,. Impact of low pulmonary vascular pressure on ventilator-induced lung injury. Crit Care Med 2002; 30: 2183.
32. Petak F, Habre W, Hantos Z, Sly PD, Morel DR,. Effects of pulmonary vascular pressures and flow on airway and parenchymal mechanics in isolated rat lungs. J Appl Physiol 1985; 2002: 169.
33. Schutte H, Hermle G, Seeger W, Grimminger F,. Vascular distension and continued ventilation are protective in lung ischemia/reperfusion. Am J Respir Crit Care Med 1998; 157: 171.
34. Cypel M, Yeung JC, Hirayama S, et al,. Technique for prolonged normothermic ex vivo lung perfusion. J Heart Lung Transplant 2008; 27: 1319.
35. Sanchez PG, D'Ovidio F,. Ex-vivo lung perfusion. Curr Opin Organ Transplant 2012; 17: 490.
36. Hsia CC,. Respiratory function of hemoglobin. N Engl J Med 1998; 338: 239.
37. 2 affinity and tissue hypoxia. J Appl Physiol 1985; 1989: 2163.
38. Aigner C,. Growing experience with ex vivo lung perfusion: many ways leading to the same goal. Eur J Cardiothorac Surg 2014; 45: 45.
39. Yeung JC, Cypel M, Machuca TN, et al,. Physiologic assessment of the ex vivo donor lung for transplantation. J Heart Lung Transplant 2012; 31: 1120.
40. Baskurt OK, Meiselman HJ,. Blood rheology and hemodynamics. Semin Thromb Hemost 2003; 29: 435.
41. Bucens D, Pain MC,. Influence of hematocrit, blood gas tensions, and pH on pressure-flow relations in the isolated canine lung. Circ Res 1975; 37: 588.
42. Pries AR, Secomb TW, Sperandio M, Gaehtgens P,. Blood flow resistance during hemodilution: effect of plasma composition. Cardiovasc Res 1998; 37: 225.
43. Lee SS, Antaki JF, Kameneva MV, et al,. Strain hardening of red blood cells by accumulated cyclic supraphysiological stress. Artif Organs 2007; 31: 80.
44. Watanabe N, Sakota D, Ohuchi K, Takatani S,. Deformability of red blood cells and its relation to blood trauma in rotary blood pumps. Artif Organs 2007; 31: 352.