7-difluoromethoxyl-5,4'-di-n-octyl genistein inhibits ovarian cancer stem cell characteristics through the downregulation of FOXM1

Oncology Letters

Volumn 8, Issue 1, 2014, Pages 295-300

  Ning, Ying Xia ^a   Li, Qing Xiu ^a   Ren, Kai Qun ^b   Quan, Mei Fang ^b   Cao, Jian Guo ^b  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b HUNAN NORMAL UNIVERSITY   (China)

Author keywords

7 difluoromethoxyl 5,4' di n octylgenistein; Cancer stem cells; Ovarian cancer; Therapeutic action

Indexed keywords

7 DIFLUOROMETHOXYL 5,4' DI N OCTYL GENISTEIN; ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE ISOENZYME 1; CD133 ANTIGEN; FORKHEAD BOX PROTEIN M1; FORKHEAD TRANSCRIPTION FACTOR; GENISTEIN; HERMES ANTIGEN; PLASMID DNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; CANCER STEM CELL; CARCINOGENICITY; CELL PROLIFERATION; CELL RENEWAL; CELL VIABILITY; CONTROLLED STUDY; DNA TRANSFECTION; DOWN REGULATION; HUMAN; HUMAN CELL; MALE; MOUSE; MTT ASSAY; NONHUMAN; OVARIAN CANCER CELL LINE; OVARIAN CANCER STEM CELL; OVARY CANCER; PROTEIN EXPRESSION; SPHERE FORMATION ASSAY; STEM CELL CULTURE; WESTERN BLOTTING;

EID: 84901200269     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2080     Document Type: Article

References (26)

1. Jelovac D and Armstrong DK: Role of farletuzumab in epithelial ovarian carcinoma. Curr Pharm Des 18: 3812-3815, 2012.
2. Wang Y, Yu Y, Tsuyada A, Ren X, Wu X, Stubblefield K, Rankin-Gee EK and Wang SE: Transforming growth factor-β regulates the sphere-initiating stem cell-like feature in breast cancer through miRNA-181 and ATM. Oncogene 30: 1470-1480, 2011.
3. Bhola NE, Balko JM, Dugger TC, Kuba MG, Sanchez V, Sanders M, Stanford J, Cook RS and Arteaga CL: TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer. J Clin Invest 123: 1348-1358, 2013.
4. Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, Chang HY, Shurtleff SA, Downing JR and Cleary ML: Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 4: 129-140, 2009.
5. Achilleos A and Trainor PA: Neural crest stem cells: discovery, properties and potential for therapy. Cell Res 22: 288-304, 2012.
6. Huang FT, Zhuan-Sun YX, Zhuang YY, Wei SL, Tang J, Chen WB and Zhang SN: Inhibition of hedgehog signaling depresses self-renewal of pancreatic cancer stem cells and reverses chemoresistance. Int J Oncol 41: 1707-1714, 2012.
7. Latifi A, Luwor RB, Bilandzic M, Nazaretian S, Stenvers K, Pyman J, Zhu H, Thompson EW, Quinn MA, Findlay JK and Ahmed N: Isolation and characterization of tumor cells from the ascites of ovarian cancer patients: molecular phenotype of chemoresistant ovarian tumors. PLoS One 7: e46858, 2012.
8. Ponnusamy MP, Seshacharyulu P, Vaz A, Dey P and Batra SK: MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells. J Ovarian Res 4: 7, 2011.
9. Myatt SS and Lam EW: The emerging roles of forkhead box (Fox) proteins in cancer. Nat Rev Cancer 7: 847-859, 2007.
10. Wierstra I and Alves J: FOXM1, a typical proliferation-associated transcription factor. Biol Chem 388: 1257-1274, 2007.
11. Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H and Teh MT: Induction of human epithelial stem/progenitor expansion by FOXM1. Cancer Res 70: 9515-9526, 2010.
12. Bao B, Wang Z, Ali S, Kong D, Banerjee S, Ahmad A, Li Y, Azmi AS, Miele L and Sarkar FH: Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells. J Cell Biochem 112: 2296-2306, 2011.
13. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, Shibuya M and Fukami Y: Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 262: 5592-5595, 1987.
14. Hillman GG, Wang Y, Kucuk O, Che M, Doerge DR, Yudelev M, Joiner MC, Marples B, Forman JD and Sarkar FH: Genistein potentiates inhibition of tumor growth by radiation in a prostate cancer orthotopic model. Mol Cancer Ther 3: 1271-1279, 2004.
15. Barnes S: Effect of genistein on in vitro and in vivo models of cancer. J Nutr 125 (3 Suppl): 777S-783S, 1995.
16. Wang Z, Ahmad A, Banerjee S, Azmi A, Kong D, Li Y and Sarkar FH: FoxM1 is a novel target of a natural agent in pancreatic cancer. Pharm Res 27: 1159-1168, 2010.
17. Ning Y, Li Q, Xiang H, Liu F and Cao J: Apoptosis induced by 7-difluoromethoxyl-5,4'-di-n-octyl genistein via the inactivation of FoxM1 in ovarian cancer cells. Oncol Rep 27: 1857-1864, 2012.
18. Xiang HL, Liu F, Quan MF, Cao JG and Lv Y: 7-difluoromethoxyl-5,4'-di-n-octylgenistein inhibits growth of gastric cancer cells through downregulating forkhead box M1. World J Gastroenterol 18: 4618-4626, 2012.
19. Reynolds BA and Weiss S: Clonal and population analyses demonstrate that an EGF-responsive mammalian embryonic CNS precursor is a stem cell. Dev Biol 175: 1-13, 1996.
20. Shi X, Gipp J and Bushman W: Anchorage-independent culture maintains prostate stem cells. Dev Biol 312: 396-406, 2007.
21. Zhang S, Balch C, Chan MW, Lai HC, Matei D, Schilder JM, Yan PS, Huang TH and Nephew KP: Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res 68: 4311-4320, 2008.
22. Van den Broeck A, Gremeaux L, Topal B and Vankelecom H: Human pancreatic adenocarcinoma contains a side population resistant to gemcitabine. BMC Cancer 12: 354, 2012.
23. Penumatsa K, Edassery SL, Barua A, Bradaric MJ and Luborsky JL: Differential expression of aldehyde dehydrogenase 1a1 (ALDH1) in normal ovary and serous ovarian tumors. J Ovarian Res 3: 28, 2010.
24. Creighton CJ, Chang JC and Rosen JM: Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J Mammary Gland Biol Neoplasia 15: 253-260, 2010.
25. Wang Z, Ahmad A, Li Y, Banerjee S, Kong D and Sarkar FH: Forkhead box M1 transcription factor: a novel target for cancer therapy. Cancer Treat Rev 36: 151-156, 2010.
26. Wang Z, Li Y, Ahmad A, Banerjee S, Azmi AS, Kong D, Wojewoda C, Miele L and Sarkar FH: Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells. J Cell Biochem 112: 78-88, 2011.