Cellular signaling by antiphospholipid antibodies

Journal of Thrombosis and Haemostasis

Volumn 12, Issue 5, 2014, Pages 773-775

  De Groot, P G ^a   Urbanus, R T ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1; BETA2 GLYCOPROTEIN 1 ANTIBODY; GLYCOPROTEIN IB ALPHA; PHOSPHOLIPID ANTIBODY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NFKB1 PROTEIN, HUMAN; TOLL LIKE RECEPTOR;

ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CELL ACTIVATION; CELL INTERACTION; CELL STRUCTURE; CELL TRANSPORT; CONFORMATIONAL TRANSITION; ENDOCYTOSIS; ENDOSOME; HUMAN; INTERNALIZATION; INTRACELLULAR SIGNALING; LYSOSOME; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SECOND MESSENGER; THROMBOEMBOLISM; CHEMISTRY; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM;

ANTIBODIES, ANTIPHOSPHOLIPID; ENDOSOMES; GENE EXPRESSION REGULATION; HUMANS; MONOCYTES; NF-KAPPA B P50 SUBUNIT; TOLL-LIKE RECEPTORS;

EID: 84901196339     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12540     Document Type: Article

References (11)

1. Giannakopoulos B, Krilis SA. The pathogenesis of the antiphospholipid syndrome. N Engl J Med 2013; 368: 1033-44.
2. 2-glycoprotein I is complement dependent and requires a priming factor. Blood 2005; 106: 2340-6.
3. Arad A, Proulle V, Furie RA, Furie BC, Furie B. β-Glycoprotein-1 autoantibodies from patients with antiphospholipid syndrome are sufficient to potentiate arterial thrombus formation in a mouse model. Blood 2001; 117: 3453-9.
4. 2-glycoprotein I. Blood 2012; 120: 266-74.
5. 2-Glycoprotein I can exist in two conformations: implications for our understanding of the antiphospholipid syndrome. Blood 2010; 116: 1336-43.
6. 2-glycoprotein I cause LAC and their presence correlates strongly with thrombosis. Blood 2005; 105: 1540-5.
7. Brandt KJ, Boehlen F, Fickentscher C, Kruithof E, de Moerloose P. NF-κB is activated from endosomal compartments in antiphospholipid antibodies-treated human monocytes. J Thromb Haemost 2014; 12: 779-91.
8. Sorkin A, von Zastrow M. Endocytosis and signalling: intertwining molecular networks. Nat Rev Mol Cell Biol 2009; 10: 609-22.
9. Benzing C, Rossy J, Gaus K. Do signaling endosomes play a role in T cell activation? FEBS J 2013; 280: 5164-76.
10. Fraser ID, Germain RN. Navigating the network: signaling cross-talk in hematopoietic cells. Nat Immunol 2009; 10: 327-33.
11. 2-glycoprotein 1 antibodies. Thromb Haemost 2002; 88: 851-7.