Evaluation of the mechanism of epithelial-mesenchymal transition in human ovarian cancer stem cells transfected with a WW domain-containing oxidoreductase gene

Oncology Letters

Volumn 8, Issue 1, 2014, Pages 426-430

  Yan, Hongchao ^a   Sun, Yuping ^b  

^a SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b JINAN CENTRAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Epithelial mesenchymal transition; Ovarian cancer stem cells; WW domain containing oxidoreductase gene

Indexed keywords

BETA CATENIN; FIBRONECTIN; NERVE CELL ADHESION MOLECULE; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

AMINO ACID ANALYSIS; ARTICLE; CANCER STEM CELL; CELL INVASION ASSAY; CELL PROLIFERATION; CELL VIABILITY ASSAY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MTT ASSAY; OVARY CANCER; PROTEIN EXPRESSION; RECOMBINANT PLASMID; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WW DOMAIN CONTAINING OXIDOREDUCTASE GENE;

EID: 84901196333     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2063     Document Type: Article

References (17)

1. Ishii H, Iwatsuki M, Ieta K, et al: Cancer stem cells and chemoradiation resistance. Cancer Sci 99: 1871-1877, 2008.
2. Cioce M and Ciliberto G: On the connections between cancer stem cells and EMT. Cell Cycle 11: 4301-4302, 2012.
3. Yan HC, Yu N and Tong JY: Isolation of cancer stem cells from ovarian cancer cell line HO9810 and identification of their biological characteristics. Jiang Su Yi Yao 38: 431-435, 2012 (In Chinese).
4. Yan HC, Xue JQ, Lu XY, et al: Effects of WWOX gene transfection on cell growth of epithelial ovarian cancer. Zhonghua Fu Chan Ke Za Zhi 5: 361-365, 2008 (In Chinese).
5. Jordan NV, Johnson GL and Abell AN: Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer. Cell Cycle 10: 2865-2873, 2011.
6. Jing Y, Han Z, Zhang S, et al: Epithelial-mesenchymal transition in tumor microenvironment. Cell Biosci 1: 29, 2011.
7. Jiang J, Tang YL and Liang XH: EMT: a new vision of hypoxia promoting cancer progression. Cancer Biol Ther 11: 714-723, 2011.
8. Scheel C and Weinberg RA: Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol 22: 396-403, 2012.
9. Lee HJ and Ormandy CJ: Elf5, hormones and cell fate. Trends Endocrinol Metab 23: 292-298, 2012.
10. Chakrabarti R, Hwang J, Andres Blanco M, et al: Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. Nat Cell Biol 14: 1212-1222, 2012.
11. Bednarek AK, Laflin KJ, Daniel RL, et al: WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res 60: 2140-2145, 2000.
12. Yan HC, Lu XY and Han QY: WWOX mRNA expression in epithelial ovarian cancer and its clinical significance. Acta Academiae Medicinae Xuzhou 2: 126-128, 2007 (In Chinese).
13. Zuo HC, Lu XZ and Han QY and Jin XS: Construction and Identification of WWOX gene eukaryotic expression vector. Jiang Su Yi Yao 3: 287-288, 2008 (In Chinese).
14. Zuo HC, Zhang ZZ and Wu XY, et al: Effects of wwox gene transfection on control mechanism of cell cycle of epithelial ovarian cancer. Zhonghua Fu Chan Ke Za Zhi 5: 383-385, 2010.
15. Yan H, Yu N and Tong J: Effects of 5-Aza-2' deoxycytidine on the methylation state and function of the WWOX gene in the HO-8910 ovarian cancer cell line. Oncol Lett 6: 845-849, 2013.
16. Yan HC and Zhang J: Effects of sodium valproate on the growth of human ovarian cancer cell line HO8910. Asian Pac J Cancer Prev 13: 6429-6433, 2012.
17. Yan HC and Sun J: Methylation status of WWOX gene promoter CpG islands in epithelial ovarian cancer and its clinical significance. Biomedical Reports 1: 375-378, 2013.