Hepatitis C virus NS5A competes with PI4KB for binding to ACBD3 in a genotype-dependent manner

Antiviral Research

Volumn 107, Issue 1, 2014, Pages 50-55

  Hong, Zhi ^a   Yang, Xiaojie ^a   Yang, Guangbo ^a   Zhang, Leiliang ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

ACBD3; HCV; NS5A; PI4KB; PI4P

Indexed keywords

ACYL COENZYME A BINDING DOMAIN CONTAINING PROTEIN 3; BINDING PROTEIN; NONSTRUCTURAL PROTEIN 5A; PHOSPHATIDYLINOSITOL 4 KINASE B; PHOSPHATIDYLINOSITOL KINASE; RENILLA LUCIFERIN 2 MONOOXYGENASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VIRUS RNA; ACBD3 PROTEIN, HUMAN; MEMBRANE PROTEIN; NS-5 PROTEIN, HEPATITIS C VIRUS; PHOSPHATIDYLINOSITOL PHOSPHATE 4-KINASE; PHOSPHOTRANSFERASE; PROTEIN BINDING; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CELL LYSATE; CELL VIABILITY; CONTROLLED STUDY; GENE TARGETING; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GENOTYPE; HEPATITIS C VIRUS; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA REPLICATION; VIRUS REPLICATION; ENZYMOLOGY; HEPACIVIRUS; HOST PATHOGEN INTERACTION; METABOLISM; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; GENOTYPE; HEPACIVIRUS; HOST-PATHOGEN INTERACTIONS; MEMBRANE PROTEINS; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; VIRAL NONSTRUCTURAL PROTEINS;

EID: 84901056076     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.04.012     Document Type: Article

References (18)

1. I.U. Ansari, and R. Striker Subtype specific differences in NS5A domain II reveals involvement of proline at position 310 in cyclosporine susceptibility of hepatitis C virus Viruses 4 2012 3303 3315
2. M. Arita, H. Kojima, T. Nagano, T. Okabe, T. Wakita, and H. Shimizu Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity J. Virol. 85 2011 2364 2372
3. K.L. Berger, S.M. Kelly, T.X. Jordan, M.A. Tartell, and G. Randall Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication J. Virol. 85 2011 8870 8883
4. A. Bianco, V. Reghellin, L. Donnici, S. Fenu, R. Alvarez, C. Baruffa, F. Peri, M. Pagani, S. Abrignani, P. Neddermann, and R. De Francesco Metabolism of phosphatidylinositol 4-kinase IIIalpha-dependent PI4P Is subverted by HCV and is targeted by a 4-anilino quinazoline with antiviral activity PLoS Pathog. 8 2012 e1002576
5. J. Borawski, P. Troke, X. Puyang, V. Gibaja, S. Zhao, C. Mickanin, J. Leighton-Davies, C.J. Wilson, V. Myer, I. Cornellataracido, J. Baryza, J. Tallarico, G. Joberty, M. Bantscheff, M. Schirle, T. Bouwmeester, J.E. Mathy, K. Lin, T. Compton, M. Labow, B. Wiedmann, and L.A. Gaither Class III phosphatidylinositol 4-kinase alpha and beta are novel host factor regulators of hepatitis C virus replication J. Virol. 83 2009 10058 10074
6. C.M. Dorobantu, H.M. van der Schaar, L.A. Ford, J.R. Strating, R. Ulferts, Y. Fang, G. Belov, and F.J. van Kuppeveld Recruitment of PI4KIIIbeta to coxsackievirus B3 replication organelles is independent of ACBD3, GBF1, and Arf1 J. Virol. 88 2014 2725 2736
7. F. Fernandes, I.U. Ansari, and R. Striker Cyclosporine inhibits a direct interaction between cyclophilins and hepatitis C NS5A PLoS ONE 5 2010 e9815
8. A.L. Greninger, G.M. Knudsen, M. Betegon, A.L. Burlingame, and J.L. Derisi The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta J. Virol. 86 2012 3605 3616
9. N.Y. Hsu, O. Ilnytska, G. Belov, M. Santiana, Y.H. Chen, P.M. Takvorian, C. Pau, H. van der Schaar, N. Kaushik-Basu, T. Balla, C.E. Cameron, E. Ehrenfeld, F.J. van Kuppeveld, and N. Altan-Bonnet Viral reorganization of the secretory pathway generates distinct organelles for RNA replication Cell 141 2010 799 811
10. K. Kumthip, P. Chusri, N. Jilg, L. Zhao, D.N. Fusco, H. Zhao, K. Goto, D. Cheng, E.A. Schaefer, L. Zhang, C. Pantip, S. Thongsawat, A. O'Brien, L.F. Peng, N. Maneekarn, R.T. Chung, and W. Lin Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling J. Virol. 86 2012 8581 8591
11. H. Li, X. Yang, G. Yang, Z. Hong, L. Zhou, P. Yin, Y. Xiao, L. Chen, R.T. Chung, and L. Zhang Hepatitis C virus NS5A hijacks ARFGAP1 to maintain a PI4P-enriched microenvironment J. Virol. 88 2014 5956 5966
12. Y.S. Lim, and S.B. Hwang Hepatitis C virus NS5A protein interacts with phosphatidylinositol 4-kinase type IIIalpha and regulates viral propagation J. Biol. Chem. 286 2011 11290 11298
13. S. Reiss, I. Rebhan, P. Backes, I. Romero-Brey, H. Erfle, P. Matula, L. Kaderali, M. Poenisch, H. Blankenburg, M.S. Hiet, T. Longerich, S. Diehl, F. Ramirez, T. Balla, K. Rohr, A. Kaul, S. Buhler, R. Pepperkok, T. Lengauer, M. Albrecht, R. Eils, P. Schirmacher, V. Lohmann, and R. Bartenschlager Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment Cell Host Microbe 9 2011 32 45
14. J. Sasaki, K. Ishikawa, M. Arita, and K. Taniguchi ACBD3-mediated recruitment of PI4KB to picornavirus RNA replication sites EMBO J. 31 2012 754 766
15. D.B. Smith, J. Bukh, C. Kuiken, A.S. Muerhoff, C.M. Rice, J.T. Stapleton, and P. Simmonds Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource Hepatology 59 2014 318 327
16. A.W. Tai, and S. Salloum The role of the phosphatidylinositol 4-kinase PI4KA in hepatitis C virus-induced host membrane rearrangement PLoS ONE 6 2011 e26300
17. F. Teoule, C. Brisac, I. Pelletier, P.O. Vidalain, S. Jegouic, C. Mirabelli, M. Bessaud, N. Combelas, A. Autret, F. Tangy, F. Delpeyroux, and B. Blondel The Golgi protein ACBD3, an interactor for poliovirus protein 3A, modulates poliovirus replication J. Virol. 87 2013 11031 11046
18. L. Zhang, Z. Hong, W. Lin, R.X. Shao, K. Goto, V.W. Hsu, and R.T. Chung ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication PLoS ONE 7 2012 e32135