Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Gao, Bo ^a,b   Russell, Amanda ^c   Beesley, Jonathan ^d   Chen, Xiao Qing ^d   Healey, Sue ^d   Henderson, Michelle ^c   Wong, Mark ^a   Emmanuel, Catherine ^a,b   Galletta, Laura ^e   Johnatty, Sharon E ^d   Bowtell, David ^e,f,g   Haber, Michelle ^c   Norris, Murray ^c   Harnett, Paul ^a,b   Chenevix Trench, Georgia ^d   Balleine, Rosemary L ^a,b,h   Defazio, Anna ^a,b   Gertig, Dorota ⁱ   Green, Adèle ^d   Webb, Penelope ^d   Hung, Jillian ^b   Moore, Sue ^d   Traficante, Nadia ^e   Fereday, Sian ^e   Harrap, Karen ^d   Sadkowsky, Troy ^d   Pandeya, Nirmala ^d   Stuart Harris, Robin ^j   Kirsten, Fred ^k   Rutovitz, Josie ^l   Clingan, Peter ^m   Glasgow, Amanda ^m   Proietto, Anthony ⁿ   Braye, Stephen ⁿ   Otton, Greg ⁿ   Shannon, Jennifer ^o   Bonaventura, Tony ^p   Stewart, James ^p   Begbie, Stephen ^q   Friedlander, Michael ^r   Bell, David ^s   Baron Hay, Sally ^s   Ferrier, Alan ^s   Gard, Greg ^s   Nevell, David ^s   Pavlakis, Nick ^s   Valmadre, Sue ^s   Young, Barbara ^s   Camaris, Catherine ^t   Crouch, Roger ^t   Edwards, Lyndal ^t   Hacker, Neville ^t   Marsden, Donald ^t   Robertson, Greg ^t   Beale, Phillip ^u   Beith, Jane ^u   Carter, Jonothan ^u   Dalrymple, Chris ^u   Hamilton, Anne ^u   Houghton, Roger ^u   Russell, Peter ^u   Links, Matthew ^v   Grygiel, John ^w   Hill, Jane ^x   Brand, Alison ^a   Byth, Karen ^a   Jaworski, Richard ^a   Sharma, Raghwa ^a   Achen, Anita ^a   Wain, Gerard ^a   Ward, Bruce ^y   Papadimos, David ^y   Crandon, Alex ^z   Cummings, Margaret ^z   Horwood, Ken ^z   Obermair, Andreas ^z   Perrin, Lew ^z   Wyld, David ^z   Nicklin, Jim ^z,aa   Davy, Margaret ^ab   Oehler, Martin K ^ab   Hall, Chris ^ab   Dodd, Tom ^ab   Healy, Tabitha ^ab   Pittman, Ken ^ab   Henderson, Doug ^ac   Miller, John ^ad   Pierdes, John ^ad   Blomfield, Penny ^ae   Challis, David ^ae   McIntosh, Robert ^ae   Parker, Andrew ^ae   Brown, Bob ^af   Rome, Robert ^af   Allen, David ^ag   Grant, Peter ^ag   Hyde, Simon ^ag   Laurie, Rohan ^ag   Robbie, Melissa ^ag   Healy, David ^ah   Jobling, Tom ^ah   Manolitsas, Tom ^ah   McNealage, Jane ^ah   Rogers, Peter ^ah   Susil, Beatrice ^ah   Sumithran, Eric ^ah   Simpson, Ian ^ah   Phillips, Kelly ^e   Rischin, Danny ^e   Fox, Stephen ^e   Johnson, Daryl ^e   Waring, Paul ^e   Lade, Stephen ^e   Loughrey, Maurice ^e   O'Callaghan, Neil ^e   Murray, William ^e   Billson, Virginia ^ai   Pyman, Jan ^ai   Neesham, Debra ^ai   Quinn, Michael ^ai   Underhill, Craig ^aj   Bell, Richard ^ak   Ng, Leong Fook ^al   Blum, Robert ^am   Ganju, Vinod ^an   Hammond, Ian ^ao   Leung, Yee ^ao   McCartney, Anthony ^ap   Buck, Martin ^aq   Haviv, Izak ^e   Purdie, David ^d   Whiteman, David ^d   Zeps, Nikolajs ^ar,as   Malt, Mary Rose ^d   Mellon, Anne ⁿ   Robertson, Randall ⁿ   Vanden Bergh, Trish ^t   Jones, Marian ^t   Mackenzie, Patricia ^t   Maidens, Jane ^s   Nattress, Kath ^u   Chiew, Yoke Eng ^a,b   Stenlake, Annie ^a   Sullivan, Helen ^a   Alexander, Barbara ^d   Ashover, Pat ^d   Brown, Sue ^d   Corrish, Tracy ^d   Green, Lyn ^d   Jackman, Leah ^d   Ferguson, Kaltin ^d   Martin, Karen ^d   Martyn, Adam ^d   Ranieri, Barbara ^d   White, Jo ^ab,ac,ad   Jayde, Victoria ^ae   Bowes, Leanne ^e   Mamers, Pamela ^ah   Giles, Debra ^e   Hendley, Joy ^e   Alsop, Katherine ^e   Schmidt, Trudy ^ar   Shirley, Helen ^ar   Ball, Colleen ^ar   Young, Cherry ^ar   Viduka, Suzanna ^ar   Tran, Hoa ^ar   Bilic, Sanela ^ar   Glavinas, Lydia ^ar   Brooks, Julia ^as   more..

^a WESTMEAD HOSPITAL   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c CHILDREN S CANCER INSTITUTE AUSTRALIA FOR MEDICAL RESEARCH   (Australia)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^e PETER MACCALLUM CANCER CENTRE   (Australia)

^f Molecular Imaging and Therapeutic Nuclear Medicine at Peter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology at University of Melbourne   (Australia)

^g UNIVERSITY OF MELBOURNE   (Australia)

^h Pathology West ICPMR Westmead   (Australia)

ⁱ Victorian Cervical Cytology Registry Melbourne   (Australia)

^j CANBERRA HOSPITAL   (Australia)

^k BANKSTOWN LIDCOMBE HOSPITAL   (Australia)

^l Hornsby Hospital   (Australia)

^m South Eastern Sydney Illawarra Area Health Service   (Australia)

ⁿ JOHN HUNTER HOSPITAL   (Australia)

^o NEPEAN HOSPITAL   (Australia)

^p NEWCASTLE MATER HOSPITAL   (Australia)

^q PORT MACQUARIE BASE HOSPITAL   (Australia)

^r PRINCE OF WALES HOSPITAL   (Australia)

^s ROYAL NORTH SHORE HOSPITAL   (Australia)

^t ROYAL HOSPITAL FOR WOMEN   (Australia)

^u ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^v ST GEORGE HOSPITAL   (Australia)

^w ST VINCENT S HOSPITAL   (Australia)

^x Wagga Wagga Base Hospital   (Australia)

^y MATER HOSPITAL   (Australia)

^z ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^aa WESLEY HOSPITAL   (Australia)

^ab ROYAL ADELAIDE HOSPITAL   (Australia)

^ac FLINDERS MEDICAL CENTRE   (Australia)

^ad QUEEN ELIZABETH HOSPITAL   (Australia)

^ae ROYAL HOBART HOSPITAL   (Australia)

^af Epworth Freemasons Hospital   (Australia)

^ag MERCY HOSPITAL FOR WOMEN   (Australia)

^ah MONASH MEDICAL CENTRE   (Australia)

^ai ROYAL WOMEN'S HOSPITAL   (Australia)

^aj Border Medical Oncology Australia   (Australia)

^ak Andrew Love Cancer Centre   (Australia)

^al BALLARAT HEALTH SERVICES   (Australia)

^am Australia   (Australia)

^an PENINSULA HEALTH   (Australia)

^ao UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^ap KING EDWARD MEMORIAL HOSPITAL   (Australia)

^aq Mount Hospital   (Australia)

^ar Western Australia Research Tissue Network WARTN   (Australia)

^as ST JOHN OF GOD HOSPITAL   (Australia)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL;

FEMALE; GENETICS; GENOTYPE; HUMAN; OVARIAN NEOPLASMS; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; FEMALE; GENOTYPE; HUMANS; OVARIAN NEOPLASMS; P-GLYCOPROTEINS; PACLITAXEL; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84901049508     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04669     Document Type: Article

References (31)

1. Cannistra, S. A. Cancer of the ovary. The N Engl J Med 351, 2519-2529 (2004).
2. Bosch, T. M. Pharmacogenomics of drug-metabolizing enzymes and drug transporters in chemotherapy. Methods Mol Bio 448, 63-76 (2008).
3. Goldstein, L. J. et al. Expression of a multidrug resistance gene in human cancers. J Natl Cancer Inst 81, 116-124 (1989). (Pubitemid 19031328)
4. Cascorbi, I. Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs. Pharmacol Ther 112, 457-473 (2006). (Pubitemid 44486412)
5. Green, H., Soderkvist, P., Rosenberg, P., Horvath, G. & Peterson, C. mdr-1 single nucleotide polymorphisms in ovarian cancer tissue: G2677T/A correlates with response to paclitaxel chemotherapy. Clin Cancer Res 12, 854-859 (2006). (Pubitemid 43259868)
6. Tian, C. et al. Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: a Gynecologic Oncology Group study. Gynecol Oncol 124, 575-581 (2012).
7. Bergmann, T. K. et al. Impact of CYP2C83 on paclitaxel clearance: a population pharmacokinetic and pharmacogenomic study in 93 patients with ovarian cancer. Pharmacogenomics J 11, 113-120 (2011).
8. Johnatty, S. E. et al. ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy. Clin Cancer Res 14, 5594-5601 (2008).
9. Panczyk, M. et al. ABCB1 gene polymorphisms and haplotype analysis in colorectal cancer. Int J Colorectal Dis 24, 895-905 (2009).
10. Yang, J. J. et al. Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Blood 120, 4197-4204 (2012).
11. Levy, P. et al. Influence of ABCB1 polymorphisms and docetaxel pharmacokinetics on pathological response to neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Res Treat 139, 421-428 (2013).
12. Obata, H., Yahata, T., Quan, J., Sekine, M. & Tanaka, K. Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer. Anticancer Res 26, 2227-2232 (2006). (Pubitemid 43980177)
13. Drach, D. et al. Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood 80, 2729-2734 (1992).
14. Skipper, H. E., Schabel, F. M., Jr. & Wilcox, W. S. Experimental Evaluation of Potential Anticancer Agents. Xiii. On the Criteria and Kinetics Associated with ''Curability'' of Experimental Leukemia. Cancer Chemother Rep 35, 1-111 (1964).
15. Hitzl, M. et al. The C3435T mutation in the human MDR1 gene is associated with altered efflux of the P-glycoprotein substrate rhodamine 123 from CD561natural killer cells. Pharmacogenetics 11, 293-298 (2001). (Pubitemid 32537402)
16. Wong, M. et al. Hepatic technetium Tc 99m-labeled sestamibi elimination rate and ABCB1 (MDR1) genotype as indicators of ABCB1 (P-glycoprotein) activity in patients with cancer. Clin Pharmacol Ther 77, 33-42 (2005). (Pubitemid 40075387)
17. Fojo, A. T. et al. Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A 84, 265-269 (1987). (Pubitemid 17013615)
18. Park, J. G. et al. MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines. J Natl Cancer Inst 86, 700-705 (1994).
19. Efferth, T., Lohrke, H. & Volm, M. Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines. Urol Res 18, 309-312 (1990). (Pubitemid 20344032)
20. Guichard, S. M., Macpherson, J. S., Thurston, D. E. & Jodrell, D. I. Influence of Pglycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136. Eur J Cancer 41, 1811-1818 (2005). (Pubitemid 41132645)
21. Johnatty, S. E. et al. ABCB1 (MDR1) polymorphisms and ovarian cancer progression and survival: a comprehensive analysis from the Ovarian Cancer Association Consortium and The Cancer Genome Atlas. Gynecol Oncol 131, 8-14 (2013).
22. Domcke, S., Sinha, R., Levine, D. A., Sander, C. & Schultz, N. Evaluating cell lines as tumour models by comparison of genomic profiles. Nat Commun 4, 2126 (2013).
23. Slamon, D. J. et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science 244, 707-712 (1989). (Pubitemid 19147683)
24. Orr, G. A., Verdier-Pinard, P., McDaid, H. & Horwitz, S. B. Mechanisms of Taxol resistance related to microtubules. Oncogene 22, 7280-7295 (2003). (Pubitemid 37487160)
25. Smoter, M. et al. The role of Tau protein in resistance to paclitaxel. Cancer Chemother Pharmacol 68, 553-557 (2011).
26. Ertel, A., Verghese, A., Byers, S. W., Ochs, M. & Tozeren, A. Pathway-specific differences between tumor cell lines and normal and tumor tissue cells. Mol Cancer 5, 55 (2006).
27. Stein, W. D., Litman, T., Fojo, T. & Bates, S. E. A Serial Analysis of Gene Expression (SAGE) database analysis of chemosensitivity: comparing solid tumors with cell lines and comparing solid tumors from different tissue origins. Cancer Research 64, 2805-2816 (2004). (Pubitemid 38500619)
28. Green, H. et al. Pharmacogenetic studies of Paclitaxel in the treatment of ovarian cancer. Basic Clin Pharmacol Toxicol 104, 130-137 (2009).
29. Yamaguchi, H. et al. Genetic variation in ABCB1 influences paclitaxel pharmacokinetics in Japanese patients with ovarian cancer. Int J Gynecol Cancer 16, 979-985 (2006). (Pubitemid 43886713)
30. Tothill, R. W. et al. Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome. Clin Cancer Res 14, 5198-5208 (2008).
31. Haber, M. et al. Association of high-level MRP1 expression with poor clinical outcome in a large prospective study of primary neuroblastoma. J Clin Oncol 24, 1546-1553 (2006). (Pubitemid 46638777)