Suppressive effects of iron overloading on vascular calcification in uremic rats

Journal of Nephrology

Volumn 27, Issue 2, 2014, Pages 135-142

  Seto, Takuya ^a   Hamada, Chieko ^a   Tomino, Yasuhiko ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Iron dextran; M nckeberg medial calcification; Osteoblastic transdifferentiation; Pit 1; Runx2

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CALCIFEDIOL; CALCITRIOL; CALCIUM; CREATININE; FERRITIN; FIBROBLAST GROWTH FACTOR 23; IRON; IRON DEXTRAN; PARATHYROID HORMONE; PHOSPHORUS; SINGLE STRANDED DNA BINDING PROTEIN; TRANSCRIPTION FACTOR PIT 1; TRANSCRIPTION FACTOR RUNX2; TRANSFERRIN; ADENINE; MESSENGER RNA; PHOSPHATE; RUNX2 PROTEIN, RAT; SINGLE STRANDED DNA; SLC20A1 PROTEIN, RAT; SODIUM PHOSPHATE COTRANSPORTER 3;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL CALCIFICATION; BODY WEIGHT; CONTROLLED STUDY; HEMATOCRIT; IMMUNOHISTOCHEMISTRY; IRON BINDING CAPACITY; IRON OVERLOAD; LEUKOCYTE ADHERENCE; MALE; MONCKEBERG MEDIAL CALCIFIC SCLEROSIS; MRNA EXPRESSION ASSAY; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA; UREMIA; ANIMAL; BLOOD; CHEMICALLY INDUCED; CHEMISTRY; COMPLICATION; GENETICS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT; TUNICA MEDIA; VASCULAR CALCIFICATION;

ADENINE; ANIMALS; AORTA, THORACIC; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CREATININE; DNA, SINGLE-STRANDED; FERRITINS; IRON; IRON-DEXTRAN COMPLEX; MALE; PHOSPHATES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SODIUM-PHOSPHATE COTRANSPORTER PROTEINS, TYPE III; TRANSFERRIN; TUNICA MEDIA; UREMIA; VASCULAR CALCIFICATION;

EID: 84901027416     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.1007/s40620-014-0046-3     Document Type: Article

References (15)

1. Collins AJ, Li S, Gilbertson DT et al (2003) Chronic kidney disease and cardiovascular disease in medicare population. Kidney Int 87:24-31
2. London GM, Guerin AP, Marchais SJ et al (2003) Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality. Nephrol Dial Transpl 18:1731-1740
3. Reynolds JL, Joannides AJ, Skepper JN et al (2004) Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 15:2857-2867
4. Steitz SA, Speer MY, Curinga G et al (2001) Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa-1 and downregulation of smooth muscle lineage markers. Circ Res 89:1147-1154
5. Masahide M, Dwight T, Eduardo S (2009) Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol 20:1453-1464
6. Balla G, Jacob HS, Balla J et al (1992) Ferritin: a cytoprotective antioxidant stratagem of endothelium. J Biol Chem 267: 18148-18153
7. Katsumata K, Kusano K, Hirata M et al (2003) Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats. Kidney Int 64:441-450
8. Kamanna VS, Ganji SH, Shelkovnikov S et al (2012) Iron sucrose promotes endothelial injury and dysfunction and monocyte adhesion/infiltration. Am J Nephrol 35(2):114-119
9. Giachelli CM (2004) Vascular calcification mechanisms. J Am Soc Nephrol 15:2959-2964
10. Shanahan CM, Crouthamel MH, Kapustin A, Giachelli CM (2011) Arterial calcification in chronic kidney disease: key roles for calcium and phosphate. Circ Res 109:697-711
11. Hryska KA, Mathew S, Saab G (2005) Bone morphogenetic proteins in vascular calcification. Circ Res 97:105-114
12. Zarjou A, Jeney V, Arosio P et al (2010) Ferritin ferroxidase activity: a potent inhibitor of osteogenesis. J Bone Miner Res 25:164-172
13. Messer JG, Kilbarger AK, Erikson KM, Kipp DE (2009) Iron overload alters iron-regulatory genes and proteins, down-regulates osteoblastic phenotype, and is associated with apoptosis in fetal rat calvaria cultures. Bone 45:972-979
14. Guggenbuhl P, Filmon R, Mabilleau G, Baslé MF, Chappard D (2008) Iron inhibits hydroxyapatite crystal growth in vitro. Metabolism 57:903-910
15. Block GA, Brillhart SL, Paersky MS, Amer A, Slade AJ (2010) Efficacy and safety of SBR759, a new iron-based phosphate binder. Kidney Int 77:897-903