Oral vaccination of badgers (Meles meles) against tuberculosis: Comparison of the protection generated by BCG vaccine strains Pasteur and Danish

Veterinary Journal

Volumn 200, Issue 3, 2014, Pages 362-367

  Murphy, Denise ^a   Costello, Eamon ^b   Aldwell, Frank E ^c   Lesellier, Sandrine ^d   Chambers, Mark A ^d   Fitzsimons, Tara ^a   Corner, Leigh A L ^a   Gormley, Eamonn ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b CENTRAL VETERINARY RESEARCH LABORATORY   (Ireland)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

Badgers; Mycobacterium bovis; Oral BCG; Tuberculosis; Vaccine

Indexed keywords

BCG DANISH 1331 VACCINE; BCG PASTEUR 1173P2 VACCINE; BCG VACCINE; GAMMA INTERFERON; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL LOAD; BACTERIAL STRAIN; BCG VACCINATION; BOVINE TUBERCULOSIS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; ENZYME LINKED IMMUNOSPOT ASSAY; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOPROPHYLAXIS; INFECTION PREVENTION; LUNG; LYMPH NODE; MAMMALIAN DISEASE; MELES MELES; MYCOBACTERIUM BOVIS; NONHUMAN; OUTCOME ASSESSMENT; THORACIC LYMPH NODE; ANIMAL; COMPARATIVE STUDY; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; MUSTELIDAE; ORAL DRUG ADMINISTRATION; STANDARDS; TUBERCULOSIS; VACCINATION; VETERINARY;

ANIMALIA; BACTERIA (MICROORGANISMS); MELES MELES; MYCOBACTERIUM BOVIS; TAXIDIINAE;

ADMINISTRATION, ORAL; ANIMALS; BCG VACCINE; INTERFERON-GAMMA; LUNG; LYMPH NODES; MUSTELIDAE; MYCOBACTERIUM BOVIS; TUBERCULOSIS; VACCINATION;

EID: 84901026412     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2014.02.031     Document Type: Article

References (32)

1. Aldwell F.E., Keen D.L., Stent V.C., Thomson A., Yates G.F., de Lisle G.W., Buddle B.M. Route of BCG administration in possums affects protection against bovine tuberculosis. New Zealand Veterinary Journal 1995, 43:356-359.
2. Aldwell F.E., Pfeffer A., DeLisle G.W., Jowett G., Heslop J., Keen D., Thomson A., Buddle B.M. Effectiveness of BCG vaccination in protecting possums against bovine tuberculosis. Research in Veterinary Science 1995, 58:90-95.
3. Aldwell F.E., Keen D.L., Parlane N.A., Skinner M.A., de Lisle G.W., Buddle B.M. Oral vaccination with Mycobacterium bovis BCG in a lipid formulation induces resistance to pulmonary tuberculosis in brushtail possums. Vaccine 2003, 22:70-76.
4. Aldwell F.E., Brandt L., Fitzpatrick C., Orme I.M. Mice fed lipid-encapsulated Mycobacterium bovis BCG are protected against aerosol challenge with Mycobacterium tuberculosis. Infection and Immunity 2005, 73:1903-1905.
5. Ancelet L.R., Aldwell F.E., Rich F.J., Kirman J.R. Oral vaccination with lipid-formulated BCG induces a long-lived, multifunctional CD4(+) T cell memory immune response. PLoS ONE 2012, 7:e45888.
6. Behr M.A., Small P.M. A historical and molecular phylogeny of BCG strains. Vaccine 1999, 17:915-922.
7. Buddle B.M., Keen D., Thomson A., Jowett G., McCarthy A.R., Heslop J., De Lisle G.W., Stanford J.L., Aldwell F.E. Protection of cattle from bovine tuberculosis by vaccination with BCG by the respiratory or subcutaneous route, but not by vaccination with killed Mycobacterium vaccae. Research in Veterinary Science 1995, 59:10-16.
8. Buddle B.M., Aldwell F.E., Skinner M.A., de Lisle G.W., Denis M., Vordermeier H.M., Hewinson R.G., Wedlock D.N. Effect of oral vaccination of cattle with lipid-formulated BCG on immune responses and protection against bovine tuberculosis. Vaccine 2005, 23:3581-3589.
9. Buddle B.M., Aldwell F.E., Keen D.L., Parlane N.A., Hamel K.L., de Lisle G.W. Oral vaccination of brushtail possums with BCG: Investigation into factors that may influence vaccine efficacy and determination of duration of protection. New Zealand Veterinary Journal 2006, 54:224-230.
10. Castillo-Rodal A.I., Castanon-Arreola M., Hernandez-Pando R., Calva J.J., Sada-Diaz E., Lopez-Vidal Y. Mycobacterium bovis BCG substrains confer different levels of protection against Mycobacterium tuberculosis infection in a BALB/c model of progressive pulmonary tuberculosis. Infection and Immunity 2006, 74:1718-1724.
11. Chambers M.A., Rogers F., Delahay R.J., Lesellier S., Ashford R., Dalley D., Gowtage S., Dave D., Palmer S., Brewer J., et al. Bacillus Calmette-Guerin vaccination reduces the severity and progression of tuberculosis in badgers. Proceedings of the Royal Society of London Series B - Biological Sciences 2011, 278:1913-1920.
12. Corner L.A. The role of wild animal populations in the epidemiology of tuberculosis in domestic animals: How to assess the risk. Veterinary Microbiology 2006, 112:303-312.
13. Corner L.A., Norton S., Buddle B.M., Morris R.S. The efficacy of bacille Calmette-Guerin vaccine in wild brushtail possums (Trichosurus vulpecula). Research in Veterinary Science 2002, 73:145-152.
14. Corner L.A., Costello E., Lesellier S., O'Meara D., Sleeman D.P., Gormley E. Experimental tuberculosis in the European badger (Meles meles) after endobronchial inoculation of Mycobacterium bovis: I. Pathology and bacteriology. Research in Veterinary Science 2007, 83:53-62.
15. Corner L.A., Costello E., Lesellier S., O'Meara D., Gormley E. Vaccination of European badgers (Meles meles) with BCG by the subcutaneous and mucosal routes induces protective immunity against endobronchial challenge with Mycobacterium bovis. Tuberculosis (Edinburgh, Scotland) 2008, 88:601-609.
16. Corner L.A., Costello E., O'Meara D., Lesellier S., Aldwell F.E., Singh M., Hewinson R.G., Chambers M.A., Gormley E. Oral vaccination of badgers (Meles meles) with BCG and protective immunity against endobronchial challenge with Mycobacterium bovis. Vaccine 2010, 28:6265-6272.
17. Donnelly C.A., Wei G., Johnston W.T., Cox D.R., Woodroffe R., Bourne F.J., Cheeseman C.L., Clifton-Hadley R.S., Gettinby G., Gilks P., et al. Impacts of widespread badger culling on cattle tuberculosis: Concluding analyses from a large-scale field trial. International Journal of Infectious Diseases 2007, 11:300-308.
18. Gavier-Widen D., Chambers M.A., Palmer N., Newell D.G., Hewinson R.G. Pathology of natural Mycobacterium bovis infection in European badgers (Meles meles) and its relationship with bacterial excretion. The Veterinary Record 2001, 148:299-304.
19. Gormley E., Costello E. Tuberculosis and badgers: New approaches to diagnosis and control. Journal of Applied Microbiology 2003, 94(Suppl. 1):80-86.
20. Griffin J.F.T., Mackintosh C.G., Slobbe L., Thomson A.J., Buchan G.S. Vaccine protocols to optimise the protective efficacy of BCG. Tubercle and Lung Disease 1999, 79:135-143.
21. Griffin J.M., Williams D.H., Kelly G.E., Clegg T.A., O'Boyle I., Collins J.D., More S.J. The impact of badger removal on the control of tuberculosis in cattle herds in Ireland. Preventive Veterinary Medicine 2005, 67:237-266.
22. Kamerbeek J., Schouls L., Kolk A., van Agterveld M., van Soolingen D., Kuijper S., Bunschoten A., Molhuizen H., Shaw R., Goyal M., et al. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. Journal of Clinical Microbiology 1997, 35:907-914.
23. Lagranderie M.R., Balazuc A.M., Deriaud E., Leclerc C.D., Gheorghiu M. Comparison of immune responses of mice immunized with five different Mycobacterium bovis BCG vaccine strains. Infection and Immunity 1996, 64:1-9.
24. Lesellier S., Palmer S., Dalley D.J., Dave D., Johnson L., Hewinson R.G., Chambers M.A. The safety and immunogenicity of Bacillus Calmette-Guerin (BCG) vaccine in European badgers (Meles meles). Veterinary Immunology and Immunopathology 2006, 112:24-37.
25. Lesellier S., Corner L., Costello E., Sleeman P., Lyashchenko K.P., Greenwald R., Esfandiari J., Glyn Hewinson R., Chambers M., Gormley E. Immunological responses following experimental endobronchial infection of badgers (Meles meles) with different doses of Mycobacterium bovis. Veterinary Immunology and Immunopathology 2009, 127:174-180.
26. Oettinger T., Jorgensen M., Ladefoged A., Haslov K., Andersen P. Development of the Mycobacterium bovis BCG vaccine: Review of the historical and biochemical evidence for a genealogical tree. Tubercle and Lung Disease 1999, 79:243-250.
27. Palmer M.V., Thacker T.C., Waters W.R. Vaccination of white-tailed deer (Odocoileus virginianus) with Mycobacterium bovis bacillus Calmette Guerin. Vaccine 2007, 25:6589-6597.
28. Qureshi T., Labes R.E., Cross M.L., Griffin J.F., Mackintosh C.G. Partial protection against oral challenge with Mycobacterium bovis in ferrets (Mustela furo) following oral vaccination with BCG. The International Journal of Tuberculosis and Lung Disease 1999, 3:1025-1033.
29. Tompkins D.M., Ramsey D.S., Cross M.L., Aldwell F.E., de Lisle G.W., Buddle B.M. Oral vaccination reduces the incidence of tuberculosis in free-living brushtail possums. Proceedings of the Royal Society of London Series B - Biological Sciences 2009, 276:2987-2995.
30. Wedlock D.N., Aldwell F.E., Keen D., Skinner M.A., Buddle B.M. Oral vaccination of brushtail possums (Trichosurus vulpecula) with BCG: Immune responses, persistence of BCG in lymphoid organs and excretion in faeces. New Zealand Veterinary Journal 2005, 53:301-306.
31. Wedlock D.N., Denis M., Vordermeier H.M., Hewinson R.G., Buddle B.M. Vaccination of cattle with Danish and Pasteur strains of Mycobacterium bovis BCG induce different levels of IFN gamma post-vaccination, but induce similar levels of protection against bovine tuberculosis. Veterinary Immunology and Immunopathology 2007, 118:50-58.
32. WHO, World Health Organization Report of WHO/FAO/OIE consultation on animal tuberculosis. Vol. WHO/CDS/VPH/94 1994, Geneva: World Health Organization Veterinary Pubic Health Unit.