Immunological responses following experimental endobronchial infection of badgers (Meles meles) with different doses of Mycobacterium bovis

Veterinary Immunology and Immunopathology

Volumn 127, Issue 1-2, 2009, Pages 174-180

  Lesellier, Sandrine ^a,e   Corner, Leigh ^a   Costello, Eamon ^b   Sleeman, Paddy ^c   Lyashchenko, Konstantin P ^d   Greenwald, Rena ^d   Esfandiari, Javan ^d   Glyn Hewinson, R ^e   Chambers, Mark ^e   Gormley, Eamonn ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b CENTRAL VETERINARY RESEARCH LABORATORY   (Ireland)

^c UNIVERSITY COLLEGE CORK   (Ireland)

^d CHEMBIO DIAGNOSTIC SYSTEMS INC   (United States)

^e VETERINARY LABORATORIES AGENCY   (United Kingdom)

Author keywords

Badgers; Brock test; MAPIA; PPD B; Tuberculosis

Indexed keywords

TUBERCULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; LYMPHOCYTE TRANSFORMATION; MALE; MELES MELES; MUSTELIDAE; MYCOBACTERIUM BOVIS; NONHUMAN; TUBERCULOSIS;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNITY, CELLULAR; IMMUNOASSAY; MALE; MUSTELIDAE; MYCOBACTERIUM BOVIS; TIME FACTORS; TUBERCULOSIS;

ANIMALIA; BOS; BOVINAE; MELES MELES; MYCOBACTERIUM BOVIS; TAXIDIINAE;

EID: 57849113104     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.09.012     Document Type: Article

References (17)

1. Buddle B.M., Aldwell F.E., Pfeffer A., and de Lisle G.W. Experimental Mycobacterium bovis infection in the brushtail possum (Trichosurus vulpecula): pathology, haematology and lymphocyte stimulation responses. Vet. Microbiol. 38 (1994) 241-254
2. Buddle B.M., Aldwell F.E., Pfeffer A., De Lisle G.W., and Corner L.A. Experimental Mycobacterium bovis infection of cattle: effect of dose of M. bovis and pregnancy on immune responses and distribution of lesions. N. Z. Vet. J. 42 (1994) 167-172
3. Clifton-Hadley R.S., Wilesmith J.W., and Stuart F.A. Mycobacterium bovis in the European badger (Meles meles): epidemiological findings in tuberculous badgers from a naturally infected population. Epidemiol. Infect. 111 (1993) 9-19
4. Corner L.A., Costello E., Lesellier S., O'Meara D., Sleeman D.P., and Gormley E. Experimental tuberculosis in the European badger (Meles meles) after endobronchial inoculation of Mycobacterium bovis. I. Pathology and bacteriology. Res. Vet. Sci. 83 (2007) 53-62
5. Costello E., O'Grady D., Flynn O., O'Brien R., Rogers M., Quigley F., Egan J., and Griffin J. Study of restriction fragment length polymorphism analysis and spoligotyping for epidemiological investigation of Mycobacterium bovis infection. J. Clin. Microbiol. 37 (1999) 3217-3222
6. Dalley D., Chambers M.A., Cockle P., Pressling W., Gavier-Widen D., and Hewinson R.G. A lymphocyte transformation assay for the detection of Mycobacterium bovis infection in the Eurasian badger (Meles meles). Vet. Immunol. Immunopathol. 70 (1999) 85-94
7. Dalley D., Dave D., Lesellier S., Palmer S., Crawshaw T.R., Hewinson R.G., and Chambers M.A. Development and evaluation of a gamma-interferon assay for tuberculosis in badgers (Meles meles). Tuberculosis (Edinb) 88 (2008) 235-243
8. Davison K.E., Hughes J.M., Gormley E., Lesellier S., Costello E., and Corner L.A. Evaluation of the anaesthetic effects of combinations of ketamine, medetomidine, romifidine and butorphanol in European badgers (Meles meles). Vet. Anaesth. Analg. 34 (2007) 394-402
9. Dean G.S., Rhodes S.G., Coad M., Whelan A.O., Cockle P.J., Clifford D.J., Hewinson R.G., and Vordermeier H.M. Minimum infective dose of Mycobacterium bovis in cattle. Infect. Immun. 73 (2005) 6467-6471
10. Gallagher J., and Clifton-Hadley R.S. Tuberculosis in badgers; a review of the disease and its significance for other animals. Res. Vet. Sci. 69 (2000) 203-217
11. Goodger J., Nolan A., Russell W.P., Dalley D.J., Thorns C.J., Stuart F.A., Croston P., and Newell D.G. Serodiagnosis of Mycobacterium bovis infection in badgers: development of an indirect ELISA using a 25 kDa antigen. Vet. Rec. 135 (1994) 82-85
12. Gormley E., and Collins J.D. The development of wildlife control strategies for eradication of tuberculosis in cattle in Ireland. Tuberc. Lung Dis. 80 (2000) 229-236
13. Greenwald R., Esfandiari J., Lesellier S., Houghton R., Pollock J., Aagaard C., Andersen P., Hewinson R.G., Chambers M., and Lyashchenko K. Improved serodetection of Mycobacterium bovis infection in badgers (Meles meles) using multiantigen test formats. Diagn. Microbiol. Infect. Dis. 46 (2003) 197-203
14. Lesellier S., Corner L., Costello E., Sleeman P., Lyashchenko K., Greenwald R., Esfandiari J., Singh M., Hewinson R.G., Chambers M., and Gormley E. Antigen specific immunological responses of badgers (Meles meles) experimentally infected with Mycobacterium bovis. Vet. Immunol. Immunopathol. 122 (2008) 35-44
15. Newell D.G., Clifton-Hadley R.S., and Cheeseman C.L. The kinetics of serum antibody responses to natural infections with Mycobacterium bovis in one badger social group. Epidemiol. Infect. 118 (1997) 173-180
16. Sawyer J., Mealing D., Dalley D., Dave D., Lesellier S., Palmer S., Bowen-Davies J., Crawshaw T.R., and Chambers M.A. Development and evaluation of a test for tuberculosis in live European badgers (Meles meles) based on measurement of IFN{gamma} mRNA by real-time PCR. J. Clin. Microbiol. 45 (2007) 2398-2403
17. Southey A., Costello E., and Gormley E. Detection of Mycobacterium bovis infection and production of interleukin-2 by in vitro stimulation of badger lymphocytes. Vet. Immunol. Immunopathol. 87 (2002) 73-78