Serum carboxymethyl-lysine, disability, and frailty in older persons: The cardiovascular health study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 69, Issue 6, 2014, Pages 710-716

  Whitson, Heather E ^a,b   Arnold, Alice M ^c   Yee, Laura M ^c   Mukamal, Kenneth J ^d   Kizer, Jorge R ^e   Djousse, Luc ^d   Ix, Joachim H ^f,g   Siscovick, David ^c   Tracy, Russell P ^h   Thielke, Stephen M ^c,i   Hirsch, Calvin ^j   Newman, Anne B ^k   Zieman, Susan ^l  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

^h UNIVERSITY OF VERMONT   (United States)

ⁱ VETERANS AFFAIRS MEDICAL CENTER   (United States)

^j UNIVERSITY OF CALIFORNIA   (United States)

^k UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^l NATIONAL INSTITUTE ON AGING   (United States)

more..

Author keywords

Biomarkers; Disablement process; Epidemiology; Frailty Metabolism

Indexed keywords

BIOLOGICAL MARKER; DRUG DERIVATIVE; LYSINE; N(6) CARBOXYMETHYLLYSINE; N(6)-CARBOXYMETHYLLYSINE;

AGED; AGING; ARTICLE; BLOOD; CARDIOVASCULAR DISEASE; DAILY LIFE ACTIVITY; DISABLED PERSON; DISABLEMENT PROCESS; EPIDEMIOLOGY; FEMALE; FOLLOW UP; FRAIL ELDERLY; FRAILTY; HEALTH STATUS; HUMAN; INCIDENCE; MALE; METABOLISM.; MULTICENTER STUDY; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDY; UNITED STATES; VERY ELDERLY;

BIOMARKERS; DISABLEMENT PROCESS; EPIDEMIOLOGY; FRAILTY; METABOLISM.;

ACTIVITIES OF DAILY LIVING; AGED; AGED, 80 AND OVER; AGING; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; DISABLED PERSONS; FEMALE; FOLLOW-UP STUDIES; FRAIL ELDERLY; HEALTH STATUS; HUMANS; INCIDENCE; LYSINE; MALE; PREVALENCE; PROGNOSIS; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 84901024965     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/glt155     Document Type: Article

References (33)

1. Goldin A, Beckman JA, Schmidt AM, Creager MA. Advanced glycationend products: sparking the development of diabetic vascularinjury. Circulation. 2006114(6):597-605.
2. Uribarri J, Woodruff S, Goodman S, et al. Advanced glycation endproducts in foods and a practical guide to their reduction in the diet. JAm Diet Assoc. 2010110(6):911-916.
3. Goh SY, Cooper ME. Clinical review: the role of advanced glycationend products in progression and complications of diabetes. J ClinEndocrinol Metab. 200893(4):1143-1152.
4. Singh R, Barden A, Mori T, Beilin L. Advanced glycation end-products:a review. Diabetologia. 200144(2):129-146.
5. Huebschmann AG, Regensteiner JG, Vlassara H, Reusch JE.Diabetes and advanced glycoxidation end products. Diabetes Care200629(6):1420-1432.
6. Srikanth V, Maczurek A, Phan T, et al. Advanced glycation endproductsand their receptor RAGE in Alzheimer's disease. NeurobiolAging. 201132(5):763-777.
7. Fuentealba D, Friguet B, Silva E. Advanced glycation endproductsinduce photocrosslinking and oxidation of bovine lens proteins throughtype-I mechanism. Photochem Photobiol. 200985(1):185-194.
8. Odetti P, Rossi S, Monacelli F, et al. Advanced glycation end productsand bone loss during aging. Ann N Y Acad Sci. 20051043:710-717.
9. Haus JM, Carrithers JA, Trappe SW, Trappe TA. Collagen, crosslinking,and advanced glycation end products in aging human skeletalmuscle. J Appl Physiol. 2007103(6):2068-2076.
10. Semba RD, Nicklett EJ, Ferrucci L. Does accumulation of advancedglycation end products contribute to the aging phenotype? J GerontolA Biol Sci Med Sci. 201065(9):963-975.
11. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications:a new perspective on an old paradigm. Diabetes.199948(1):1-9.
12. Anderson MM, Heinecke JW. Production of N(epsilon)-(carboxymethyl)lysine is impaired in mice deficient in NADPHoxidase: a role for phagocyte-derived oxidants in the formation ofadvanced glycation end products during inflammation. Diabetes.200352(8):2137-2143.
13. Fu MX, Requena JR, Jenkins AJ, Lyons TJ, Baynes JW, Thorpe SR.The advanced glycation end product, Nepsilon-(carboxymethyl)lysine, is a product of both lipid peroxidation and glycoxidation reactions.J Biol Chem. 1996271(17):9982-9986.
14. Semba RD, Bandinelli S, Sun K, Guralnik JM, Ferrucci L. Plasma carboxymethyl-lysine, an advanced glycation end product, and all-causeand cardiovascular disease mortality in older community-dwellingadults. J Am Geriatr Soc. 200957(10):1874-1880.
15. Kilhovd BK, Juutilainen A, Lehto S, et al. High serum levels ofadvanced glycation end products predict increased coronary heart diseasemortality in nondiabetic women but not in nondiabetic men: apopulation-based 18-year follow-up study. Arterioscler Thromb VascBiol. 200525(4):815-820.
16. Semba RD, Ferrucci L, Sun K, et al. Advanced glycation end productsand their circulating receptors predict cardiovascular diseasemortality in older community-dwelling women. Aging Clin Exp Res.200921(2):182-190.
17. Kilhovd BK, Juutilainen A, Lehto S, et al. Increased serum levelsof advanced glycation endproducts predict total, cardiovascular andcoronary mortality in women with type 2 diabetes: a population-based18 year follow-up study. Diabetologia. 200750(7):1409-1417.
18. Semba RD, Bandinelli S, Sun K, Guralnik JM, Ferrucci L. Relationshipof an advanced glycation end product, plasma carboxymethyl-lysine,with slow walking speed in older adults: the InCHIANTI study. Eur JAppl Physiol. 2010108(1):191-195.
19. Semba RD, Arab L, Sun K, Nicklett EJ, Ferrucci L. Fat massis inversely associated with serum carboxymethyl-lysine, anadvanced glycation end product, in adults. J Nutr. 2011141(9):1726-1730.
20. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults:evidence for a phenotype. J Gerontol A Biol Sci Med Sci.200156(3):M146-M156.
21. Fried LP, Borhani NO, Enright P, et al. The CardiovascularHealth Study: design and rationale. Ann Epidemiol. 19911(3):263-276.
22. Psaty BM, Lee M, Savage PJ, Rutan GH, German PS, Lyles M.Assessing the use of medications in the elderly: methods and initialexperience in the Cardiovascular Health Study. The CardiovascularHealth Study Collaborative Research Group. J Clin Epidemiol.199245(6):683-692.
23. Arnold AM, Newman AB, Cushman M, Ding J, Kritchevsky S. Bodyweight dynamics and their association with physical function andmortality in older adults: the Cardiovascular Health Study. J GerontolA Biol Sci Med Sci. 201065(1):63-70.
24. Ives DG, Fitzpatrick AL, Bild DE, et al. Surveillance and ascertainmentof cardiovascular events. The Cardiovascular Health Study. AnnEpidemiol. 19955(4):278-285.
25. Psaty BM, Kuller LH, Bild D, et al. Methods of assessing prevalentcardiovascular disease in the Cardiovascular Health Study. AnnEpidemiol. 19955(4):270-277.
26. Teng EL, Chui HC. The Modified Mini-Mental State (3MS) examination.J Clin Psychiatry. 198748(8):314-318.
27. Cushman M, Cornell ES, Howard PR, Bovill EG, Tracy RP. Laboratorymethods and quality assurance in the Cardiovascular Health Study.Clin Chem. 199541(2):264-270.
28. Stevens LA, Coresh J, Schmid CH, et al. Estimating GFR usingserum cystatin C alone and in combination with serum creatinine: apooled analysis of 3,418 individuals with CKD. Am J Kidney Dis.200851(3):395-406.
29. Cuzick J. A Wilcoxon-type test for trend. Stat Med. 19854(1):87-90.
30. Sun K, Semba RD, Fried LP, Schaumberg DA, Ferrucci L,Varadhan R. Elevated serum carboxymethyl-lysine, an advancedglycation end product, predicts severe walking disability in olderwomen: The Women's Health and Aging Study I. J Aging Res.20122012:586385.
31. Henle T. AGEs in foods: do they play a role in uremia? Kidney IntSuppl. 200363(84):S145-S147.
32. Uribarri J, Cai W, Peppa M, et al. Circulating glycotoxins and dietaryadvanced glycation endproducts: two links to inflammatoryresponse, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci.200762(4):427-433.
33. Semba RD, Ang A, Talegawkar S, et al. Dietary intake associated withserum versus urinary carboxymethyl-lysine, a major advanced glycationend product, in adults: the Energetics Study. Eur J Clin Nutr.201266(1):3-9.