Improved light collection and wavelet de-noising enable quantification of cerebral blood flow and oxygen metabolism by a low-cost, off-the-shelf spectrometer

Journal of Biomedical Optics

Volumn 19, Issue 5, 2014, Pages

  Diop, Mamadou ^a,b   Wright, Eric ^a,b   Toronov, Vladislav ^c   Lee, Ting Yim ^a,b,d   St Lawrence, Keith ^a,b  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c RYERSON UNIVERSITY   (Canada)

^d ROBARTS RESEARCH INSTITUTE   (Canada)

Author keywords

broadband near infrared spectroscopy; CCD noise; cerebral oxygenation; spectrometer; wavelet de noising

Indexed keywords

METABOLISM; OPTICAL FIBERS; OXYGEN; PHYSIOLOGY; SPECTRAL RESOLUTION;

CEREBRAL BLOOD FLOW; CEREBRAL HEMODYNAMICS; CEREBRAL OXYGENATION; FREQUENCY DOMAIN TECHNIQUES; MEASUREMENT NOISE; OXYGEN METABOLISMS; TISSUE SPECTROSCOPY; WAVELET DENOISING;

SPECTROMETERS;

INDOCYANINE GREEN; OXYGEN;

ALGORITHM; ANIMAL; ARTICLE; BLOOD; BRAIN CIRCULATION; CHEMISTRY; HEMODYNAMICS; METHODOLOGY; NEAR INFRARED SPECTROSCOPY; PHYSIOLOGY; SWINE; WAVELET ANALYSIS;

ALGORITHMS; ANIMALS; CEREBROVASCULAR CIRCULATION; HEMODYNAMICS; INDOCYANINE GREEN; OXYGEN; SPECTROSCOPY, NEAR-INFRARED; SWINE; WAVELET ANALYSIS;

EID: 84901008821     PISSN: 10833668     EISSN: 15602281     Source Type: Journal    
DOI: 10.1117/1.JBO.19.5.057007     Document Type: Article

References (46)

1. A. Sola et al., "Potential for protection and repair following injury to the developing brain: a role for erythropoietin?," Pediatr. Res. 57(5), 110R-117R (2005). (Pubitemid 40593255)
2. G. Greisen, T. Leung, and M. Wolf, "Has the time come to use nearinfrared spectroscopy as a routine clinical tool in preterm infants undergoing intensive care?," Philos. Trans. R. Soc., A 369(1955), 4440-4451 (2011).
3. F. Gora et al., "Noninvasive measurement of cerebral blood flow in adults using near-infrared spectroscopy and indocyanine green: a pilot study," J. Neurosurg. Anesthesiol. 14(3), 218-222 (2002). (Pubitemid 34756058)
4. H. Owen-Reece et al., "Use of near infrared spectroscopy to estimate cerebral blood flow in conscious and anaesthetized adult subjects," Br. J. Anaesth. 76(1), 43-48 (1996). (Pubitemid 26030215)
5. J. T. Elliott et al., "Quantitative measurement of cerebral blood flow in a juvenile porcine model by depth-resolved near-infrared spectroscopy," J. Biomed. Opt. 15(3), 037014 (2010).
6. F. Bevilacqua et al., "Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods," Appl. Opt. 39(34), 6498-6507 (2000).
7. M. Diop et al., "Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets," J. Biomed. Opt. 15(5), 057004 (2010).
8. S. J. Matcher and C. E. Cooper, "Absolute quantification of deoxyhaemoglobin concentration in tissue near infrared spectroscopy," Phys. Med. Biol. 39(8), 1295-1312 (1994). (Pubitemid 24246751)
9. S. J. Matcher, M. Cope, and D. T. Delpy, "Use of the water absorption spectrum to quantify tissue chromophore concentration changes in near-infrared spectroscopy," Phys. Med. Biol. 38, 177-196 (1993). (Pubitemid 24063707)
10. H. Z. Yeganeh et al., "Broadband continuous-wave technique to measure baseline values and changes in the tissue chromophore concentrations," Biomed. Opt. Express 3(11), 2761-2770 (2012).
11. D. W. Brown et al., "Quantitative near infrared spectroscopy measurement of cerebral hemodynamics in newborn piglets," Pediatr. Res. 51(5), 564-570 (2002). (Pubitemid 34453571)
12. K. M. Tichauer et al., "Measurement of cerebral oxidative metabolism with near-infrared spectroscopy: a validation study," J. Cereb. Blood Flow. Metab. 26(5), 722-730 (2005).
13. M. Diop et al., "A broadband continuous-wave multichannel nearinfrared system for measuring regional cerebral blood flow and oxygen consumption in newborn piglets," Rev. Sci. Instrum. 80(5), 054302 (2009).
14. R. Arora et al., "Preservation of the metabolic rate of oxygen in preterm infants during indomethacin therapy for closure of the ductus arteriosus," Pediatr. Res. 73(6), 713-718 (2013).
15. R. Yang et al., "Monitoring angiogenesis using a human compatible calibration for broadband near-infrared spectroscopy," J. Biomed. Opt. 18(1), 016011 (2013).
16. H. Xu et al., "Magnetic-resonance-imaging-coupled broadband nearinfrared tomography system for small animal brain studies," Appl. Opt. 44(11), 2177-2188 (2005). (Pubitemid 40567090)
17. E. Wright, K. St. Lawrence, and M. Diop, "Conversion of a low cost off-the-shelf spectrometer into a suitable instrument for deep tissue spectroscopy," Proc. SPIE 8573, 85730V (2013).
18. Ocean Optics, "QE65000 Scientific-grade Spectrometer," http://www .oceanoptics.com/products/qe65000.asp (2010).
19. G. Zonios, "Noise and stray light characterization of a compact CCD spectrophotometer used in biomedical applications," Appl. Opt. 49(2), 163-169 (2010).
20. M. Diop and K. St Lawrence, "Deconvolution method for recovering the photon time-of-flight distribution from time-resolved measurements," Opt. Lett. 37(12), 2358-2360 (2012).
21. M. Diop and K. St Lawrence, "Improving the depth sensitivity of timeresolved measurements by extracting the distribution of times-of-flight, " Biomed. Opt. Express 4(3), 447-459 (2013).
22. M. Mäkitalo and A. Foi, "Optimal inversion of the Anscombe transformation in low-count Poisson image denoising," IEEE Trans. Image Process. 20(1), 99-109 (2011).
23. F. Martelli et al., Light Propagation through Biological Tissue and Other Diffusive Media: Theory, Solutions, and Software SPIE Press, Bellingham, WA (2010).
24. S. Fantini, M. Franceschini, and E. Gratton, "Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation," J. Opt. Soc. Am. B 11(10), 2128-2138 (1994).
25. R. C. Haskell et al., "Boundary conditions for the diffusion equation in radiative transfer," J. Opt. Soc. Am. A 11(10), 2727-2741 (1994).
26. H. Zabihi-Yeganeh, "Non-invasive measurement of tissue chromophore concentrations and cerebral blood flow using broad-band continuous wave near infrared spectroscopy," Masters Thesis, Paper 1693 (2012).
27. J. D'Errico, http://www.mathworks.com/matlabcentral/fileexchange/ 8277-fminsearchbnd-fminsearchcon (6 February 2012).
28. S. L. Jacques, "Optical properties of biological tissues: a review," Phys. Med. Biol. 58, R37-R61 (2013).
29. E. Okada and D. T. Delpy, "Near-infrared light propagation in an adult head model. II. Effect of superficial tissue thickness on the sensitivity of the near-infrared spectroscopy signal," Appl. Opt. 42(16), 2915-2922 (2003).
30. K. Verdecchia et al., "Quantifying the cerebral metabolic rate of oxygen by combining diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy," J. Biomed. Opt. 18(2), 027007 (2013).
31. K. M. Tichauer et al., "Assessing the severity of perinatal hypoxiaischemia in piglets using near-infrared spectroscopy to measure the cerebral metabolic rate of oxygen," Pediatr. Res. 65(3), 301-306 (2009).
32. D. A. Boas and M. A. Franceschini, "Haemoglobin oxygen saturation as a biomarker: the problem and a solution," Philos. Trans. R. Soc., A 369(1955), 4407-4424 (2011).
33. K. M. Tichauer et al., "Near-infrared spectroscopy measurements of cerebral blood flow and oxygen consumption following hypoxia-ischemia in newborn piglets," J. Appl. Physiol. 100(3), 850-857 (2006). (Pubitemid 43671540)
34. T. S. Leung et al., "Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus indocyanine green injection and near-infrared spectroscopy," Appl. Opt. 46(10), 1604-1614 (2007). (Pubitemid 46659526)
35. C. E. Cooper et al., "The noninvasive measurement of absolute cerebral deoxyhemoglobin concentration and mean optical path length in the neonatal brain by second derivative near infrared spectroscopy," Pediatr. Res. 39, 32-38 (1996). (Pubitemid 26003519)
36. S. Prahl and S. L. Jacques, "Optical properties spectra," http://omlc.ogi .edu/spectra/ (2001).
37. Z. Cai et al., "Quantification and elimination of the CCD dark current in weak spectrum measurement by modulation and correlation method," Proc. SPIE 7850, 785005 (2010).
38. J. J. Davenport et al., "Noise analysis of a CCD based ultra-violet spectrometry system," Proc. SPIE 8439, 84391P (2012).
39. R. Springett, Y. Sakata, and D. T. Delpy, "Precise measurement of cerebral blood flow in newborn piglets from the bolus passage of indocyanine green," Phys. Med. Biol. 46(8), 2209-2225 (2001). (Pubitemid 32747072)
40. D. E. Myers et al., "Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy," J. Biomed. Opt. 10(3), 034017 (2005).
41. R. Nachabé et al., "Estimation of lipid and water concentrations in scattering media with diffuse optical spectroscopy from 900 to 1,600 nm," J. Biomed. Opt. 15(3), 037015 (2010).
42. O. Pucci, V. Toronov, and K. St Lawrence, "Measurement of the optical properties of a two-layer model of the human head using broadband near-infrared spectroscopy," Appl. Opt. 49(32), 6324-6332 (2010).
43. S. Ijichi et al., "Quantification of cerebral hemoglobin as a function of oxygenation using near-infrared time-resolved spectroscopy in a piglet model of hypoxia," J. Biomed. Opt. 10(2), 024026 (2005).
44. S. H. Chung et al., "In vivo water state measurements in breast cancer using broadband diffuse optical spectroscopy," Phys. Med. Biol. 53(23), 6713-6727 (2008).
45. S. H. Chung et al., "Non-invasive tissue temperature measurements based on quantitative diffuse optical spectroscopy (DOS) of water," Phys. Med. Biol. 55(13), 3753-3765 (2010).
46. S. H. Chung et al., "Non-invasive measurement of deep tissue temperature changes caused by apoptosis during breast cancer neoadjuvant chemotherapy: a case study," J. Innovative Opt. Health Sci. 4(4), 361-372 (2011).