메뉴 건너뛰기




Volumn 4, Issue 1, 2013, Pages 6-13

Fixed dose combination therapy of antioxidants in treatment of idiopathic oligoasthenozoospermia: Results of a randomized, double-blind, placebo-controlled clinical trial

Author keywords

Asthenozoospermia; L carnitine; Lycopene; Oligospermia; Ubiquinone (coenzyme Q10); Zinc

Indexed keywords

CARNITINE; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; LYCOPENE; PLACEBO; PROLACTIN; SPERM ANTIBODY; TESTOSTERONE; UBIDECARENONE; ZINC;

EID: 84901003504     PISSN: 22293817     EISSN: 22293833     Source Type: Journal    
DOI: 10.5005/jp-journals-10016-1053     Document Type: Article
Times cited : (13)

References (51)
  • 1
    • 68449084730 scopus 로고    scopus 로고
    • Advances in development reverse fertility declines
    • Myrskylä M, Kohler HP, Billari FC. Advances in development reverse fertility declines. Nature 2009;460:741-43.
    • (2009) Nature , vol.460 , pp. 741-743
    • Myrskylä, M.1    Kohler, H.P.2    Billari, F.C.3
  • 2
    • 33645229830 scopus 로고    scopus 로고
    • Fertility rates and future population trends: Will Europe's birth rate recover or continue to decline?
    • Lutz W. Fertility rates and future population trends: Will Europe's birth rate recover or continue to decline? Int J Androl 2006;29:25-33.
    • (2006) Int J Androl , vol.29 , pp. 25-33
    • Lutz, W.1
  • 4
    • 0025766021 scopus 로고
    • Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989)
    • Thonneau P, Marchand S, Tallec A, Ferial ML, Ducot B, Lansac J, et al. Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988-1989). Hum Reprod 1991;6:811-16.
    • (1991) Hum Reprod , vol.6 , pp. 811-816
    • Thonneau, P.1    Marchand, S.2    Tallec, A.3    Ferial, M.L.4    Ducot, B.5    Lansac, J.6
  • 5
    • 0001570848 scopus 로고
    • Clinical use of frozen semen; report of four cases
    • Bunge RG, Keettel WC, Sherman JK. Clinical use of frozen semen; report of four cases. Fertil Steril 1954;5(6):520-29.
    • (1954) Fertil Steril , vol.5 , Issue.6 , pp. 520-529
    • Bunge, R.G.1    Keettel, W.C.2    Sherman, J.K.3
  • 7
    • 0024427034 scopus 로고
    • Generation of reactive oxygen species, lipid peroxidation and human sperm function
    • Aitken RJ, Clarkson JS, Fishel S. Generation of reactive oxygen species, lipid peroxidation and human sperm function. Biol Reprod 1989;40:183-97.
    • (1989) Biol Reprod , vol.40 , pp. 183-197
    • Aitken, R.J.1    Clarkson, J.S.2    Fishel, S.3
  • 8
    • 0024420213 scopus 로고
    • Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility
    • Rao B, Soufir JC, Martin M, David G. Lipid peroxidation in human spermatozoa as related to midpiece abnormalities and motility. Gamete Res 1989;24:127-34.
    • (1989) Gamete Res , vol.24 , pp. 127-134
    • Rao, B.1    Soufir, J.C.2    Martin, M.3    David, G.4
  • 9
    • 0345064028 scopus 로고
    • Heart and skeletal muscle ubiquinone or CoQ10 as protective agent against radical formation in man
    • Karlsson J. Heart and skeletal muscle ubiquinone or CoQ10 as protective agent against radical formation in man. Adv Myochem 1987;1:305-08.
    • (1987) Adv Myochem , vol.1 , pp. 305-308
    • Karlsson, J.1
  • 10
    • 0027234508 scopus 로고
    • Ubiquinol: An endogenous antioxidant in aerobic organisms
    • Ernster L, Forsmark-Andree P. Ubiquinol: An endogenous antioxidant in aerobic organisms. Clin Invest 1993;71:60-65.
    • (1993) Clin Invest , vol.71 , pp. 60-65
    • Ernster, L.1    Forsmark-Andree, P.2
  • 11
    • 0025017435 scopus 로고
    • Nonaprenyl-4-hydroxibenzoate transferase, an enzyme involved in ubiquinone biosynthesis in endoplasmic reticulum-Golgi system
    • Kalen A, Appelkvist EL, Chojnaki T, Dallner G. Nonaprenyl-4-hydroxibenzoate transferase, an enzyme involved in ubiquinone biosynthesis in endoplasmic reticulum-Golgi system. J Biol Chem 1990;25:1158-64.
    • (1990) J Biol Chem , vol.25 , pp. 1158-1164
    • Kalen, A.1    Appelkvist, E.L.2    Chojnaki, T.3    Dallner, G.4
  • 12
  • 14
    • 0031947852 scopus 로고    scopus 로고
    • Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele
    • Mancini A, Conte G, Milardi D, De Marinis L, Littarru G. Relationship between sperm cell ubiquinone and seminal parameters in subjects with and without varicocele. Andrologia 1998;30:1-4.
    • (1998) Andrologia , vol.30 , pp. 1-4
    • Mancini, A.1    Conte, G.2    Milardi, D.3    De Marinis, L.4    Littarru, G.5
  • 15
  • 16
    • 0037217281 scopus 로고    scopus 로고
    • Oxyradical scavenging capacity toward different reactive species in seminal plasma and sperm cells. A possible influence on kinetic parameters
    • Balercia G, Mantero F, Armeni T, Principato G, Regoli F. Oxyradical scavenging capacity toward different reactive species in seminal plasma and sperm cells. A possible influence on kinetic parameters. Clin Chem Lab Med 2003;41:13-19.
    • (2003) Clin Chem Lab Med , vol.41 , pp. 13-19
    • Balercia, G.1    Mantero, F.2    Armeni, T.3    Principato, G.4    Regoli, F.5
  • 17
    • 33746059387 scopus 로고    scopus 로고
    • An update of coenzyme Q10 implications in male infertility: Biochemical and therapeutic aspects
    • Mancini A, De Marinis L, Littarru GP, Balercia G. An update of coenzyme Q10 implications in male infertility: Biochemical and therapeutic aspects. Biofactors 2005;25:165-74.
    • (2005) Biofactors , vol.25 , pp. 165-174
    • Mancini, A.1    De Marinis, L.2    Littarru, G.P.3    Balercia, G.4
  • 18
    • 78649757817 scopus 로고    scopus 로고
    • Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility
    • Moradi M, Moradi A, Alemi M, Ahmadnia H, Abdi H, Ahmadi A, et al. Safety and efficacy of clomiphene citrate and L-carnitine in idiopathic male infertility. Urol J 2010;7:188-93.
    • (2010) Urol J , vol.7 , pp. 188-193
    • Moradi, M.1    Moradi, A.2    Alemi, M.3    Ahmadnia, H.4    Abdi, H.5    Ahmadi, A.6
  • 19
    • 77953376585 scopus 로고    scopus 로고
    • Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine
    • Adel RA, Abd-Allah ARA, Helal GK, Al-Yahya AA, Aleisa AM, Al-Rejaie SS, et al. Pro-inflammatory and oxidative stress pathways which compromise sperm motility and survival may be altered by L-carnitine. Oxid Med Cell Long 2009;2:73-81.
    • (2009) Oxid Med Cell Long , vol.2 , pp. 73-81
    • Adel, R.A.1    Abd-Allah, A.R.A.2    Helal, G.K.3    Al-Yahya, A.A.4    Aleisa, A.M.5    Al-Rejaie, S.S.6
  • 20
    • 79960766859 scopus 로고    scopus 로고
    • Role of L-carnitine in male infertility
    • Ahmed SD, Karira KA, Jagdesh, Ahsan S. Role of L-carnitine in male infertility. J Pak Med Assoc 2011;61(8):732-36.
    • (2011) J Pak Med Assoc , vol.61 , Issue.8 , pp. 732-736
    • Ahmed, S.D.1    Karira, K.A.2    Jagdesh, A.S.3
  • 21
    • 0343051747 scopus 로고    scopus 로고
    • Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility
    • Wang Y, Aggrawal A, et al. Importance of reactive oxygen species in the peritoneal fluid of women with endometriosis or idiopathic infertility. Fertil Steril 1997;68:826-30.
    • (1997) Fertil Steril , vol.68 , pp. 826-830
    • Wang, Y.1    Aggrawal, A.2
  • 22
    • 0024464691 scopus 로고
    • Lycopene as the most efficient biological cartenoid singlet oxygen quencher
    • Di Mascio P, Kaiser S. Sies H. Lycopene as the most efficient biological cartenoid singlet oxygen quencher. Arch Biochem Biophys 1989;274:532-38.
    • (1989) Arch Biochem Biophys , vol.274 , pp. 532-538
    • Di Mascio, P.1    Kaiser, S.2    Sies, H.3
  • 23
    • 61749083635 scopus 로고    scopus 로고
    • Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men
    • Colagar AH, Marzony ET, Chaichi MJ. Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res 2009;29(2):82-88.
    • (2009) Nutr Res , vol.29 , Issue.2 , pp. 82-88
    • Colagar, A.H.1    Marzony, E.T.2    Chaichi, M.J.3
  • 24
    • 65649121866 scopus 로고    scopus 로고
    • Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: A placebo-controlled, double-blind randomized trial
    • Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S, et al. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: A placebo-controlled, double-blind randomized trial. Fertil Steril 2009;91(5):1785-92.
    • (2009) Fertil Steril , vol.91 , Issue.5 , pp. 1785-1792
    • Balercia, G.1    Buldreghini, E.2    Vignini, A.3    Tiano, L.4    Paggi, F.5    Amoroso, S.6
  • 25
    • 67349116634 scopus 로고    scopus 로고
    • Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men
    • Safarinejad MR. Efficacy of coenzyme Q10 on semen parameters, sperm function and reproductive hormones in infertile men. J Urol 2009;182(1):237-48.
    • (2009) J Urol , vol.182 , Issue.1 , pp. 237-248
    • Safarinejad, M.R.1
  • 27
    • 84855507529 scopus 로고    scopus 로고
    • Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenozoospermia: A randomized double-blind, placebo controlled trial
    • Nadjarzadeh A, Sadeghi MR, Amirjannati N, Vafa MR, Motevalian SA, Gohari MR, et al. Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenozoospermia: A randomized double-blind, placebo controlled trial. J Endocrinol Invest 2011;34(8):e224-28.
    • (2011) J Endocrinol Invest , vol.34 , Issue.8
    • Nadjarzadeh, A.1    Sadeghi, M.R.2    Amirjannati, N.3    Vafa, M.R.4    Motevalian, S.A.5    Gohari, M.R.6
  • 28
    • 0028224982 scopus 로고
    • L-carnitine in idiopathic asthenozoospermia: A multicenter study. Italian Study Group on Carnitine and Male Infertility
    • Costa M, Canale D, Filicori M, D'lddio S, Lenzi A. L-carnitine in idiopathic asthenozoospermia: A multicenter study. Italian Study Group on Carnitine and Male Infertility. Andrologia 1994; 26(3):155-59.
    • (1994) Andrologia , vol.26 , Issue.3 , pp. 155-159
    • Costa, M.1    Canale, D.2    Filicori, M.3    D'lddio, S.4    Lenzi, A.5
  • 29
    • 0037309210 scopus 로고    scopus 로고
    • Use of carnitine therapy in selected cases of male factor infertility: A double-blind crossover trial
    • Lenzi A, Lombardo F, Sgrò P, Salacone P, Caponecchia L, Dondero F, et al. Use of carnitine therapy in selected cases of male factor infertility: A double-blind crossover trial. Fertil Steril 2003;79(2):292-300.
    • (2003) Fertil Steril , vol.79 , Issue.2 , pp. 292-300
    • Lenzi, A.1    Lombardo, F.2    Sgrò, P.3    Salacone, P.4    Caponecchia, L.5    Dondero, F.6
  • 30
    • 33646093473 scopus 로고    scopus 로고
    • Carnitine for the treatment of idiopathic asthenospermia: A randomized, doubleblind, placebo-controlled trial
    • Sigman M, Glass S, Campagnone J, Pryor JL. Carnitine for the treatment of idiopathic asthenospermia: A randomized, doubleblind, placebo-controlled trial. Fertil Steril 2006;85(5):1409-14.
    • (2006) Fertil Steril , vol.85 , Issue.5 , pp. 1409-1414
    • Sigman, M.1    Glass, S.2    Campagnone, J.3    Pryor, J.L.4
  • 31
    • 0042815077 scopus 로고    scopus 로고
    • Lycopene therapy in idiopathic male infertility-a preliminary report
    • Gupta NP, Kumar R. Lycopene therapy in idiopathic male infertility-a preliminary report. Int Urol Nephrol 2002;34(3): 369-72.
    • (2002) Int Urol Nephrol , vol.34 , Issue.3 , pp. 369-372
    • Gupta, N.P.1    Kumar, R.2
  • 32
    • 34447338896 scopus 로고    scopus 로고
    • The effects of dietary lycopene supplementation on human seminal plasma
    • Goyal A, Chopra M, Lwaleed BA, Birch B, Cooper AJ. The effects of dietary lycopene supplementation on human seminal plasma. BJU Int 2007;99(6):1456-60.
    • (2007) BJU Int , vol.99 , Issue.6 , pp. 1456-1460
    • Goyal, A.1    Chopra, M.2    Lwaleed, B.A.3    Birch, B.4    Cooper, A.J.5
  • 33
    • 0036180440 scopus 로고    scopus 로고
    • Effects of folic acid and zinc sulfate on male factor subfertility: A double-blind, randomized, placebo-controlled trial
    • Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: A double-blind, randomized, placebo-controlled trial. Fertil Steril 2002;77(3):491-98.
    • (2002) Fertil Steril , vol.77 , Issue.3 , pp. 491-498
    • Wong, W.Y.1    Merkus, H.M.2    Thomas, C.M.3    Menkveld, R.4    Zielhuis, G.A.5    Steegers-Theunissen, R.P.6
  • 34
    • 33644898570 scopus 로고    scopus 로고
    • Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men?
    • Ebisch IM, Pierik FH, DE Jong FH, Thomas CM, Steegers-Theunissen RP. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men? Int J Androl 2006;29(2):339-45.
    • (2006) Int J Androl , vol.29 , Issue.2 , pp. 339-345
    • Ebisch, I.M.1    Pierik, F.H.2    De Jong, F.H.3    Thomas, C.M.4    Steegers-Theunissen, R.P.5
  • 36
    • 76349094334 scopus 로고    scopus 로고
    • (5th ed) (page no. 238-41) (Appendix I). WHO Library Cataloguing 0020
    • WHO laboratory manual for the examination and processing of human semen (5th ed) (page no. 238-41) (Appendix I). WHO Library Cataloguing 0020. http://whqlibdoc.who.int/ publications/2010/9789241547789_eng.pdf
    • WHO laboratory manual for the examination and processing of human semen
  • 37
    • 0023617012 scopus 로고
    • Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa
    • Aitken RJ, Clarkson JS. Cellular basis of defective sperm function and its association with the genesis of reactive oxygen species by human spermatozoa. J Reprod Fertil 1987;81:459-69.
    • (1987) J Reprod Fertil , vol.81 , pp. 459-469
    • Aitken, R.J.1    Clarkson, J.S.2
  • 38
    • 10544244585 scopus 로고    scopus 로고
    • Lipid peroxidation and human sperm motility: Protective role of vitamin E
    • Suleiman SA, Ali ME, Zaki ZM, El-Malik EM, Nasr MA. Lipid peroxidation and human sperm motility: Protective role of vitamin E. J Androl 1996;17:530-37.
    • (1996) J Androl , vol.17 , pp. 530-537
    • Suleiman, S.A.1    Ali, M.E.2    Zaki, Z.M.3    El-Malik, E.M.4    Nasr, M.A.5
  • 39
    • 0034758449 scopus 로고    scopus 로고
    • Oxidative stress, DNA damage and the Y chromosome
    • Aitken RJ, Krausz C. Oxidative stress, DNA damage and the Y chromosome. Reproduction 2001;122:497-506.
    • (2001) Reproduction , vol.122 , pp. 497-506
    • Aitken, R.J.1    Krausz, C.2
  • 40
    • 0035996498 scopus 로고    scopus 로고
    • Reactive oxygen species generation by human spermatozoa: A continuing enigma
    • Aitken RJ, Baker MA. Reactive oxygen species generation by human spermatozoa: A continuing enigma. Int J Androl 2002;25: 191-94.
    • (2002) Int J Androl , vol.25 , pp. 191-194
    • Aitken, R.J.1    Baker, M.A.2
  • 42
    • 33746069330 scopus 로고    scopus 로고
    • Estimation of plasma and saliva levels of coenzyme Q10 and influence of oral supplementation
    • Sekine K, Ota N, Nishii M, Uetake T, Shimadzu M. Estimation of plasma and saliva levels of coenzyme Q10 and influence of oral supplementation. Biofactors 2005;25:205-11.
    • (2005) Biofactors , vol.25 , pp. 205-211
    • Sekine, K.1    Ota, N.2    Nishii, M.3    Uetake, T.4    Shimadzu, M.5
  • 43
    • 0029116225 scopus 로고
    • Total antioxidant capacity of seminal plasma is different in fertile and infertile men
    • Lewis S, Boyle P, McKinney MB, Young I, Thompson W. Total antioxidant capacity of seminal plasma is different in fertile and infertile men. Fertil Steril 1995;64:868-70.
    • (1995) Fertil Steril , vol.64 , pp. 868-870
    • Lewis, S.1    Boyle, P.2    McKinney, M.B.3    Young, I.4    Thompson, W.5
  • 44
    • 0033753955 scopus 로고    scopus 로고
    • Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contribution of various seminal compounds
    • Rhemrev JP, Van Overveld FW, Haenen GR, Teerlink T, Bast A, Vermeiden JP. Quantification of the nonenzymatic fast and slow TRAP in a postaddition assay in human seminal plasma and the antioxidant contribution of various seminal compounds. J Androl 2000;21:913-20.
    • (2000) J Androl , vol.21 , pp. 913-920
    • Rhemrev, J.P.1    Van Overveld, F.W.2    Haenen, G.R.3    Teerlink, T.4    Bast, A.5    Vermeiden, J.P.6
  • 46
    • 0029562799 scopus 로고
    • Role of oxidative stress and antioxidant in male infertility
    • Sikka SC, Rajasekaran M, Hellstrom WJG. Role of oxidative stress and antioxidant in male infertility. J Androl 1995;16:464-68.
    • (1995) J Androl , vol.16 , pp. 464-468
    • Sikka, S.C.1    Rajasekaran, M.2    Hellstrom, W.J.G.3
  • 47
    • 0029148377 scopus 로고
    • Carnitine supplementation in human idiopathic asthenozoospermia: Clinical results
    • Vitali G, Parente R, Melotti C. Carnitine supplementation in human idiopathic asthenozoospermia: Clinical results. Drugs Exp Clin Res 1995;21:157-59.
    • (1995) Drugs Exp Clin Res , vol.21 , pp. 157-159
    • Vitali, G.1    Parente, R.2    Melotti, C.3
  • 48
    • 0031860242 scopus 로고    scopus 로고
    • Antioxidant treatment for male subfertility: A promise that remains unfulfilled
    • Ford WCL, Whittington K. Antioxidant treatment for male subfertility: A promise that remains unfulfilled. Hum Reprod 1998;13:1416-19.
    • (1998) Hum Reprod , vol.13 , pp. 1416-1419
    • Ford, W.C.L.1    Whittington, K.2
  • 49
    • 2642620237 scopus 로고    scopus 로고
    • Free radicals, antioxidants and human spermatozoa: Clinical implications
    • Geva E, Lessing JB, Lerner-Geva L, Amit A. Free radicals, antioxidants and human spermatozoa: Clinical implications. Hum Reprod 1998;13:1415-24.
    • (1998) Hum Reprod , vol.13 , pp. 1415-1424
    • Geva, E.1    Lessing, J.B.2    Lerner-Geva, L.3    Amit, A.4
  • 50
    • 0032086213 scopus 로고    scopus 로고
    • Antioxidants may protect against infertility
    • Tarin JJ, Brines J, Cano A. Antioxidants may protect against infertility. Hum Reprod 1998;13:1415-16.
    • (1998) Hum Reprod , vol.13 , pp. 1415-1416
    • Tarin, J.J.1    Brines, J.2    Cano, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.