메뉴 건너뛰기




Volumn 4 APR, Issue , 2014, Pages

Metronomics as maintenance treatment in oncology: Time for chemo-switch

Author keywords

Chemo switch; Global perspective; Low dose chemotherapy; Maintenance; Metronomic chemotherapy

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; CELECOXIB; CYCLOPHOSPHAMIDE; DOCETAXEL; ETOPOSIDE; GEMCITABINE; ISOTRETINOIN; METHOTREXATE; PACLITAXEL; PAZOPANIB; TEMOZOLOMIDE;

EID: 84901001797     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2014.00076     Document Type: Note
Times cited : (36)

References (58)
  • 1
    • 66449133323 scopus 로고    scopus 로고
    • A change of strategy in the war on cancer
    • doi:10.1038/459508a
    • Gatenby RA. A change of strategy in the war on cancer. Nature (2009) 28(7246):508-9. doi:10.1038/459508a.
    • (2009) Nature , vol.28 , Issue.7246 , pp. 508-509
    • Gatenby, R.A.1
  • 2
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • doi:10.1172/JCI9872
    • Hanahan D, Bergers G, Bergsland E. Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest (2000) 105(8):1045-7. doi:10.1172/JCI9872.
    • (2000) J Clin Invest , vol.105 , Issue.8 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 3
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • doi:10.1172/JCI8829
    • Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest (2000) 105(8):R15-24. doi:10.1172/JCI8829.
    • (2000) J Clin Invest , vol.105 , Issue.8
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6
  • 4
    • 0034032882 scopus 로고    scopus 로고
    • Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer
    • Browder T, Butterfield CE, Kräling BM, Shi B, Marshall B, O'Reilly MS, et al. Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer. Cancer Res (2000) 60(7):1878-86.
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 1878-1886
    • Browder, T.1    Butterfield, C.E.2    Kräling, B.M.3    Shi, B.4    Marshall, B.5    O'Reilly, M.S.6
  • 5
    • 77955172181 scopus 로고    scopus 로고
    • Metronomic chemotherapy: new rationale for new directions
    • doi:10.1038/nrclinonc.2010.82
    • Pasquier E, Kavallaris M, André N. Metronomic chemotherapy: new rationale for new directions. Nat Rev Clin Oncol (2010) 7(8):455-65. doi:10.1038/nrclinonc.2010.82.
    • (2010) Nat Rev Clin Oncol , vol.7 , Issue.8 , pp. 455-465
    • Pasquier, E.1    Kavallaris, M.2    André, N.3
  • 6
    • 33847368549 scopus 로고    scopus 로고
    • Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
    • doi:10.1007/s00262-006-0225-8
    • Ghiringhelli F, Menard C, Puig PE, Ladoire S, Roux S, Martin F, et al. Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol Immunother (2007) 56(5):641-8. doi:10.1007/s00262-006-0225-8.
    • (2007) Cancer Immunol Immunother , vol.56 , Issue.5 , pp. 641-648
    • Ghiringhelli, F.1    Menard, C.2    Puig, P.E.3    Ladoire, S.4    Roux, S.5    Martin, F.6
  • 8
    • 84885179445 scopus 로고    scopus 로고
    • Low-dose metronomic chemotherapy: a systematic literature analysis
    • doi:10.1016/j.ejca.2013.06.038
    • Lien K, Georgsdottir S, Sivanathan L, Chan K, Emmenegger U. Low-dose metronomic chemotherapy: a systematic literature analysis. Eur J Cancer (2013) 49(16):3387-95. doi:10.1016/j.ejca.2013.06.038.
    • (2013) Eur J Cancer , vol.49 , Issue.16 , pp. 3387-3395
    • Lien, K.1    Georgsdottir, S.2    Sivanathan, L.3    Chan, K.4    Emmenegger, U.5
  • 9
    • 84871600705 scopus 로고    scopus 로고
    • Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea
    • doi:10.1200/JCO.2012.43.7459
    • Gerber DE, Schiller JH. Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea. J Clin Oncol (2013) 31(8):1009-20. doi:10.1200/JCO.2012.43.7459.
    • (2013) J Clin Oncol , vol.31 , Issue.8 , pp. 1009-1020
    • Gerber, D.E.1    Schiller, J.H.2
  • 10
    • 0030825783 scopus 로고    scopus 로고
    • Continuing (maintenance) therapy in lymphoblastic leukaemia: lessons from MRC UKALL X. Medical Research Council Working Party in Childhood Leukaemia
    • doi:10.1046/j.1365-2141.1997.3113127.x
    • Chessells JM, Harrison G, Lilleyman JS, Bailey CC, Richards SM. Continuing (maintenance) therapy in lymphoblastic leukaemia: lessons from MRC UKALL X. Medical Research Council Working Party in Childhood Leukaemia. Br J Haematol (1997) 98(4):945-51. doi:10.1046/j.1365-2141.1997.3113127.x.
    • (1997) Br J Haematol , vol.98 , Issue.4 , pp. 945-951
    • Chessells, J.M.1    Harrison, G.2    Lilleyman, J.S.3    Bailey, C.C.4    Richards, S.M.5
  • 11
    • 0018835194 scopus 로고
    • Therapy of acute lymphoblastic leukemia in childhood
    • Mauer AM. Therapy of acute lymphoblastic leukemia in childhood. Blood (1980) 56(1):1-10.
    • (1980) Blood , vol.56 , Issue.1 , pp. 1-10
    • Mauer, A.M.1
  • 12
    • 63749097149 scopus 로고    scopus 로고
    • Maintenance rituximab after cyclophosphamide, vincristine, and prednisone prolongs progression-free survival in advanced indolent lymphoma: results of the randomized phase III ECOG1496 Study
    • doi:10.1200/JCO.2008.17.1561
    • Hochster H, Weller E, Gascoyne RD, Habermann TM, Gordon LI, Ryan T, et al. Maintenance rituximab after cyclophosphamide, vincristine, and prednisone prolongs progression-free survival in advanced indolent lymphoma: results of the randomized phase III ECOG1496 Study. J Clin Oncol (2009) 27(10):1607-14. doi:10.1200/JCO.2008.17.1561.
    • (2009) J Clin Oncol , vol.27 , Issue.10 , pp. 1607-1614
    • Hochster, H.1    Weller, E.2    Gascoyne, R.D.3    Habermann, T.M.4    Gordon, L.I.5    Ryan, T.6
  • 13
    • 78650823247 scopus 로고    scopus 로고
    • Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial
    • doi:10.1016/S0140-6736(10)62175-7
    • Salles G, Seymour JF, Offner F, López-Guillermo A, Belada D, Xerri L, et al. Rituximab maintenance for 2 years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial. Lancet (2011) 377(9759):42-51. doi:10.1016/S0140-6736(10)62175-7.
    • (2011) Lancet , vol.377 , Issue.9759 , pp. 42-51
    • Salles, G.1    Seymour, J.F.2    Offner, F.3    López-Guillermo, A.4    Belada, D.5    Xerri, L.6
  • 14
    • 79960414995 scopus 로고    scopus 로고
    • Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: a systematic review and meta-analysis
    • doi:10.1378/chest.10-2745
    • Zhang X, Zang J, Xu J, Bai C, Qin Y, Liu K, et al. Maintenance therapy with continuous or switch strategy in advanced non-small cell lung cancer: a systematic review and meta-analysis. Chest (2011) 140(1):117-26. doi:10.1378/chest.10-2745.
    • (2011) Chest , vol.140 , Issue.1 , pp. 117-126
    • Zhang, X.1    Zang, J.2    Xu, J.3    Bai, C.4    Qin, Y.5    Liu, K.6
  • 15
    • 79957936823 scopus 로고    scopus 로고
    • Duration of chemotherapy for metastatic breast cancer: a systematic review and meta-analysis of randomized clinical trials
    • doi:10.1200/JCO.2010.31.5374
    • Gennari A, Stockler M, Puntoni M, Sormani M, Nanni O, Amadori D, et al. Duration of chemotherapy for metastatic breast cancer: a systematic review and meta-analysis of randomized clinical trials. J Clin Oncol (2011) 29(16):2144-9. doi:10.1200/JCO.2010.31.5374.
    • (2011) J Clin Oncol , vol.29 , Issue.16 , pp. 2144-2149
    • Gennari, A.1    Stockler, M.2    Puntoni, M.3    Sormani, M.4    Nanni, O.5    Amadori, D.6
  • 16
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-a GERCOR study
    • doi:10.1200/JCO.2005.03.0106
    • Tournigand C, Cervantes A, Figer A, Lledo G, Flesch M, Buyse M, et al. OPTIMOX1: a randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-Go fashion in advanced colorectal cancer-a GERCOR study. J Clin Oncol (2006) 24(3):394-400. doi:10.1200/JCO.2005.03.0106.
    • (2006) J Clin Oncol , vol.24 , Issue.3 , pp. 394-400
    • Tournigand, C.1    Cervantes, A.2    Figer, A.3    Lledo, G.4    Flesch, M.5    Buyse, M.6
  • 17
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200
    • doi:10.1200/JCO.2006.09.6305
    • Giantonio BJ, Catalano PJ, Meropol NJ, O'Dwyer PJ, Mitchell EP, Alberts SR, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol (2007) 25(12):1539-44. doi:10.1200/JCO.2006.09.6305.
    • (2007) J Clin Oncol , vol.25 , Issue.12 , pp. 1539-1544
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3    O'Dwyer, P.J.4    Mitchell, E.P.5    Alberts, S.R.6
  • 18
    • 42949149159 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study
    • doi:10.1200/JCO.2007.14.9930
    • Saltz LB, Clarke S, Díaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol (2008) 26(12):2013-9. doi:10.1200/JCO.2007.14.9930.
    • (2008) J Clin Oncol , vol.26 , Issue.12 , pp. 2013-2019
    • Saltz, L.B.1    Clarke, S.2    Díaz-Rubio, E.3    Scheithauer, W.4    Figer, A.5    Wong, R.6
  • 19
    • 0038690538 scopus 로고    scopus 로고
    • Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial
    • doi:10.1200/JCO.2003.07.013
    • Markman M, Liu PY, Wilczynski S, Monk B, Copeland LJ, Alvarez RD, et al. Phase III randomized trial of 12 versus 3 months of maintenance paclitaxel in patients with advanced ovarian cancer after complete response to platinum and paclitaxel-based chemotherapy: a Southwest Oncology Group and Gynecologic Oncology Group trial. J Clin Oncol (2003) 21(13):2460-5. doi:10.1200/JCO.2003.07.013.
    • (2003) J Clin Oncol , vol.21 , Issue.13 , pp. 2460-2465
    • Markman, M.1    Liu, P.Y.2    Wilczynski, S.3    Monk, B.4    Copeland, L.J.5    Alvarez, R.D.6
  • 20
    • 70350442636 scopus 로고    scopus 로고
    • Phase III trial of observation versus six courses of paclitaxel in patients with advanced epithelial ovarian cancer in complete response after six courses of paclitaxel/platinum-based chemotherapy: final results of the After-6 protocol 1
    • doi:10.1200/JCO.2009.21.9691
    • Pecorelli S, Favalli G, Gadducci A, Katsaros D, Panici PB, Carpi A, et al. Phase III trial of observation versus six courses of paclitaxel in patients with advanced epithelial ovarian cancer in complete response after six courses of paclitaxel/platinum-based chemotherapy: final results of the After-6 protocol 1. J Clin Oncol (2009) 27(28):4642-8. doi:10.1200/JCO.2009.21.9691.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4642-4648
    • Pecorelli, S.1    Favalli, G.2    Gadducci, A.3    Katsaros, D.4    Panici, P.B.5    Carpi, A.6
  • 22
    • 84861736119 scopus 로고    scopus 로고
    • OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
    • doi:10.1200/JCO.2012.42.0505
    • Aghajanian C, Blank SV, Goff BA, Judson PL, Teneriello MG, Husain A, et al. OCEANS: a randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol (2012) 30(17):2039-45. doi:10.1200/JCO.2012.42.0505.
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2039-2045
    • Aghajanian, C.1    Blank, S.V.2    Goff, B.A.3    Judson, P.L.4    Teneriello, M.G.5    Husain, A.6
  • 23
    • 84859523588 scopus 로고    scopus 로고
    • Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer
    • doi:10.1056/NEJMoa1105535
    • Ledermann J, Harter P, Gourley C, Friedlander M, Vergote I, Rustin G, et al. Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer. N Engl J Med (2012) 366(15):1382-92. doi:10.1056/NEJMoa1105535.
    • (2012) N Engl J Med , vol.366 , Issue.15 , pp. 1382-1392
    • Ledermann, J.1    Harter, P.2    Gourley, C.3    Friedlander, M.4    Vergote, I.5    Rustin, G.6
  • 24
    • 84885594084 scopus 로고    scopus 로고
    • Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): results of an international Intergroup trial (AGO-OVAR16)
    • LBA5503
    • Du Bois A, Floquet A, Kim JW, Rau J, Campo JMD, Friedlander M, et al. Randomized, double-blind, phase III trial of pazopanib versus placebo in women who have not progressed after first-line chemotherapy for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (AEOC): results of an international Intergroup trial (AGO-OVAR16). J Clin Oncol (2013) 31(Suppl 18):LBA5503.
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL. 18
    • Du Bois, A.1    Floquet, A.2    Kim, J.W.3    Rau, J.4    Campo, J.M.D.5    Friedlander, M.6
  • 25
    • 77955097091 scopus 로고    scopus 로고
    • Cost-effectiveness of pemetrexed as first-line maintenance therapy for advanced nonsquamous non-small cell lung cancer
    • doi:10.1097/JTO.0b013e3181e15d16
    • Klein R, Wielage R, Muehlenbein C, Liepa AM, Babineaux S, Lawson A, et al. Cost-effectiveness of pemetrexed as first-line maintenance therapy for advanced nonsquamous non-small cell lung cancer. J Thorac Oncol (2010) 5(8):1263-72. doi:10.1097/JTO.0b013e3181e15d16.
    • (2010) J Thorac Oncol , vol.5 , Issue.8 , pp. 1263-1272
    • Klein, R.1    Wielage, R.2    Muehlenbein, C.3    Liepa, A.M.4    Babineaux, S.5    Lawson, A.6
  • 26
    • 80051552827 scopus 로고    scopus 로고
    • Consolidation paclitaxel is more cost-effective than bevacizumab following upfront treatment of advanced epithelial ovarian cancer
    • doi:10.1016/j.ygyno.2011.05.014
    • Lesnock JL, Farris C, Krivak TC, Smith KJ, Markman M. Consolidation paclitaxel is more cost-effective than bevacizumab following upfront treatment of advanced epithelial ovarian cancer. Gynecol Oncol (2011) 122(3):473-8. doi:10.1016/j.ygyno.2011.05.014.
    • (2011) Gynecol Oncol , vol.122 , Issue.3 , pp. 473-478
    • Lesnock, J.L.1    Farris, C.2    Krivak, T.C.3    Smith, K.J.4    Markman, M.5
  • 27
    • 84891634642 scopus 로고    scopus 로고
    • A systematic review of cost-effectiveness of monoclonal antibodies for metastatic colorectal cancer
    • doi:10.1016/j.ejca.2013.08.008
    • Lange A, Prenzler A, Frank M, Kirstein M, Vogel A, von der Schulenburg JM. A systematic review of cost-effectiveness of monoclonal antibodies for metastatic colorectal cancer. Eur J Cancer (2014) 50(1):40-9. doi:10.1016/j.ejca.2013.08.008.
    • (2014) Eur J Cancer , vol.50 , Issue.1 , pp. 40-49
    • Lange, A.1    Prenzler, A.2    Frank, M.3    Kirstein, M.4    Vogel, A.5    von der Schulenburg, J.M.6
  • 28
    • 84875706413 scopus 로고    scopus 로고
    • Effects of erlotinib first-line maintenance therapy versus placebo on the health-related quality of life of patients with metastatic non-small-cell lung cancer
    • doi:10.1016/j.ejca.2012.11.006
    • Juhász E, Kim J-H, Klingelschmitt G, Walzer S. Effects of erlotinib first-line maintenance therapy versus placebo on the health-related quality of life of patients with metastatic non-small-cell lung cancer. Eur J Cancer (2013) 49(6):1205-15. doi:10.1016/j.ejca.2012.11.006.
    • (2013) Eur J Cancer , vol.49 , Issue.6 , pp. 1205-1215
    • Juhász, E.1    Kim, J.-H.2    Klingelschmitt, G.3    Walzer, S.4
  • 29
    • 84862781680 scopus 로고    scopus 로고
    • Quality of life in patients with advanced non-small-cell lung cancer given maintenance treatment with pemetrexed versus placebo (H3E-MC-JMEN): results from a randomised, double-blind, phase 3 study
    • doi:10.1016/S1470-2045(11)70339-4
    • Belani CP, Brodowicz T, Ciuleanu TE, Krzakowski M, Yang SH, Franke F, et al. Quality of life in patients with advanced non-small-cell lung cancer given maintenance treatment with pemetrexed versus placebo (H3E-MC-JMEN): results from a randomised, double-blind, phase 3 study. Lancet Oncol (2012) 13(3):292-9. doi:10.1016/S1470-2045(11)70339-4.
    • (2012) Lancet Oncol , vol.13 , Issue.3 , pp. 292-299
    • Belani, C.P.1    Brodowicz, T.2    Ciuleanu, T.E.3    Krzakowski, M.4    Yang, S.H.5    Franke, F.6
  • 30
    • 84863853923 scopus 로고    scopus 로고
    • Maintenance therapy for advanced non-small-cell lung cancer: a pilot study on patients' perceptions
    • doi:10.1097/JTO.0b013e31825879ea
    • Peeters L, Sibille A, Anrys B, Oyen C, Dooms C, Nackaerts K, et al. Maintenance therapy for advanced non-small-cell lung cancer: a pilot study on patients' perceptions. J Thorac Oncol (2012) 7(8):1291-5. doi:10.1097/JTO.0b013e31825879ea.
    • (2012) J Thorac Oncol , vol.7 , Issue.8 , pp. 1291-1295
    • Peeters, L.1    Sibille, A.2    Anrys, B.3    Oyen, C.4    Dooms, C.5    Nackaerts, K.6
  • 31
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • doi:10.1200/JCO.2005.07.093
    • Pietras K, Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol (2005) 23(5):939-52. doi:10.1200/JCO.2005.07.093.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 32
    • 84883804389 scopus 로고    scopus 로고
    • Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells
    • doi:10.1002/ijc.28259
    • Vives M, Ginestà MM, Gracova K, Graupera M, Casanovas O, Capellà G, et al. Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells. Int J Cancer (2013) 133(10):2464-72. doi:10.1002/ijc.28259.
    • (2013) Int J Cancer , vol.133 , Issue.10 , pp. 2464-2472
    • Vives, M.1    Ginestà, M.M.2    Gracova, K.3    Graupera, M.4    Casanovas, O.5    Capellà, G.6
  • 33
    • 34248550985 scopus 로고    scopus 로고
    • Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors
    • doi:10.1158/0008-5472.CAN-06-4238
    • Folkins C, Man S, Xu P, Shaked Y, Hicklin DJ, Kerbel RS. Anticancer therapies combining antiangiogenic and tumor cell cytotoxic effects reduce the tumor stem-like cell fraction in glioma xenograft tumors. Cancer Res (2007) 67(8):3560-4. doi:10.1158/0008-5472.CAN-06-4238.
    • (2007) Cancer Res , vol.67 , Issue.8 , pp. 3560-3564
    • Folkins, C.1    Man, S.2    Xu, P.3    Shaked, Y.4    Hicklin, D.J.5    Kerbel, R.S.6
  • 34
    • 84885366390 scopus 로고    scopus 로고
    • Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC): the phase III CAIRO3 study of the Dutch Colorectal Cancer Group (DCCG). oral abstract session, gastrointestinal (colorectal) cancer
    • Koopman M, Simkens LH, Tije AJT, Creemers G-J, Loosveld OJ, de Jongh FE, et al. Maintenance treatment with capecitabine and bevacizumab versus observation after induction treatment with chemotherapy and bevacizumab in metastatic colorectal cancer (mCRC): the phase III CAIRO3 study of the Dutch Colorectal Cancer Group (DCCG). oral abstract session, gastrointestinal (colorectal) cancer. J Clin Oncol (2013) (suppl; abstr 3502).
    • (2013) J Clin Oncol , Issue.SUPPL.ABSTR 3502
    • Koopman, M.1    Simkens, L.H.2    Tije, A.J.T.3    Creemers, G.-J.4    Loosveld, O.J.5    de Jongh, F.E.6
  • 35
    • 0041885404 scopus 로고    scopus 로고
    • Multicenter, randomized trial for stage IIIB or IV non-small-cell lung cancer using weekly paclitaxel and carboplatin followed by maintenance weekly paclitaxel or observation
    • doi:10.1200/JCO.2003.02.563
    • Belani CP, Barstis J, Perry MC, La Rocca RV, Nattam SR, Rinaldi D, et al. Multicenter, randomized trial for stage IIIB or IV non-small-cell lung cancer using weekly paclitaxel and carboplatin followed by maintenance weekly paclitaxel or observation. J Clin Oncol (2003) 21(15):2933-9. doi:10.1200/JCO.2003.02.563.
    • (2003) J Clin Oncol , vol.21 , Issue.15 , pp. 2933-2939
    • Belani, C.P.1    Barstis, J.2    Perry, M.C.3    La Rocca, R.V.4    Nattam, S.R.5    Rinaldi, D.6
  • 36
    • 38649124303 scopus 로고    scopus 로고
    • Randomized, phase III study of weekly paclitaxel in combination with carboplatin versus standard every-3-weeks administration of carboplatin and paclitaxel for patients with previously untreated advanced non-small-cell lung cancer
    • doi:10.1200/JCO.2007.13.1912
    • Belani CP, Ramalingam S, Perry MC, LaRocca RV, Rinaldi D, Gable PS, et al. Randomized, phase III study of weekly paclitaxel in combination with carboplatin versus standard every-3-weeks administration of carboplatin and paclitaxel for patients with previously untreated advanced non-small-cell lung cancer. J Clin Oncol (2008) 26(3):468-73. doi:10.1200/JCO.2007.13.1912.
    • (2008) J Clin Oncol , vol.26 , Issue.3 , pp. 468-473
    • Belani, C.P.1    Ramalingam, S.2    Perry, M.C.3    LaRocca, R.V.4    Rinaldi, D.5    Gable, P.S.6
  • 37
    • 77958099612 scopus 로고    scopus 로고
    • Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers
    • Sun JF, Wu RR, Norris C, Noone A-M, Amankwa-Sakyi M, Slack R, et al. Safety of chronic low-dose capecitabine as maintenance therapy in gastrointestinal cancers. Gastrointest Cancer Res (2009) 3(4):134-40.
    • (2009) Gastrointest Cancer Res , vol.3 , Issue.4 , pp. 134-140
    • Sun, J.F.1    Wu, R.R.2    Norris, C.3    Noone, A.-M.4    Amankwa-Sakyi, M.5    Slack, R.6
  • 38
    • 41849122758 scopus 로고    scopus 로고
    • Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors
    • doi:10.1002/pbc.21381
    • Choi LMR, Rood B, Kamani N, La Fond D, Packer RJ, Santi MR, et al. Feasibility of metronomic maintenance chemotherapy following high-dose chemotherapy for malignant central nervous system tumors. Pediatr Blood Cancer (2008) 50(5):970-5. doi:10.1002/pbc.21381.
    • (2008) Pediatr Blood Cancer , vol.50 , Issue.5 , pp. 970-975
    • Choi, L.M.R.1    Rood, B.2    Kamani, N.3    La Fond, D.4    Packer, R.J.5    Santi, M.R.6
  • 39
    • 67651027346 scopus 로고    scopus 로고
    • Weekly low-dose paclitaxel as maintenance treatment in patients with advanced ovarian cancer who had microscopic residual disease at second- look surgery after 6 cycles of paclitaxel/platinum-based chemotherapy: results of an open noncomparative phase 2 multicenter Italian study (After-6 Protocol 2)
    • doi:10.1111/IGC.0b013e3181a4476b
    • Gadducci A, Katsaros D, Zola P, Scambia G, Ballardini M, Pasquini E, et al. Weekly low-dose paclitaxel as maintenance treatment in patients with advanced ovarian cancer who had microscopic residual disease at second- look surgery after 6 cycles of paclitaxel/platinum-based chemotherapy: results of an open noncomparative phase 2 multicenter Italian study (After-6 Protocol 2). Int J Gynecol Cancer (2009) 19(4):615-9. doi:10.1111/IGC.0b013e3181a4476b.
    • (2009) Int J Gynecol Cancer , vol.19 , Issue.4 , pp. 615-619
    • Gadducci, A.1    Katsaros, D.2    Zola, P.3    Scambia, G.4    Ballardini, M.5    Pasquini, E.6
  • 40
    • 84901041337 scopus 로고    scopus 로고
    • First-line therapy with metronomic capecitabine (mC) plus docetaxel (D) followed by mC as maintenance for patients with HER2-negative metastatic breast cancer (MBC): preliminary analysis of a monocentric phase II trial
    • Aurilio G, Sciandivasci E, Munzone E, Riva DF, Radice D, Bertolini F, et al. First-line therapy with metronomic capecitabine (mC) plus docetaxel (D) followed by mC as maintenance for patients with HER2-negative metastatic breast cancer (MBC): preliminary analysis of a monocentric phase II trial. J Clin Oncol (2011) 29(15 suppl): e11547.
    • (2011) J Clin Oncol , vol.29 , Issue.15 SUPPL.
    • Aurilio, G.1    Sciandivasci, E.2    Munzone, E.3    Riva, D.F.4    Radice, D.5    Bertolini, F.6
  • 41
    • 33846441659 scopus 로고    scopus 로고
    • Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer
    • doi:10.1158/0008-5472.CAN-06-3282
    • Kamat AA, Kim TJ, Landen CN Jr., Lu C, Han LY, Lin YG, et al. Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer. Cancer Res (2007) 67(1):281-8. doi:10.1158/0008-5472.CAN-06-3282.
    • (2007) Cancer Res , vol.67 , Issue.1 , pp. 281-288
    • Kamat, A.A.1    Kim, T.J.2    Landen Jr., C.N.3    Lu, C.4    Han, L.Y.5    Lin, Y.G.6
  • 42
    • 84877746890 scopus 로고    scopus 로고
    • A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs
    • doi:10.1158/0008-5472.CAN-12-4183
    • Guerin E, Man S, Xu P, Kerbel RS. A model of postsurgical advanced metastatic breast cancer more accurately replicates the clinical efficacy of antiangiogenic drugs. Cancer Res (2013) 73(9):2743-8. doi:10.1158/0008-5472.CAN-12-4183.
    • (2013) Cancer Res , vol.73 , Issue.9 , pp. 2743-2748
    • Guerin, E.1    Man, S.2    Xu, P.3    Kerbel, R.S.4
  • 43
    • 84880741126 scopus 로고    scopus 로고
    • The combination of intravenous bevacizumab and metronomic oral cyclophosphamide is an effective regimen for platinum-resistant recurrent ovarian cancer
    • doi:10.3802/jgo.2013.24.3.258
    • Barber EL, Zsiros E, Lurain JR, Rademaker A, Schink JC, Neubauer NL. The combination of intravenous bevacizumab and metronomic oral cyclophosphamide is an effective regimen for platinum-resistant recurrent ovarian cancer. J Gynecol Oncol (2013) 24(3):258-64. doi:10.3802/jgo.2013.24.3.258.
    • (2013) J Gynecol Oncol , vol.24 , Issue.3 , pp. 258-264
    • Barber, E.L.1    Zsiros, E.2    Lurain, J.R.3    Rademaker, A.4    Schink, J.C.5    Neubauer, N.L.6
  • 44
    • 79956334386 scopus 로고    scopus 로고
    • Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma
    • doi:10.1200/JCO.2010.29.4496
    • Hecht JR, Trarbach T, Hainsworth JD, Major P, Jäger E, Wolff RA, et al. Randomized, placebo-controlled, phase III study of first-line oxaliplatin-based chemotherapy plus PTK787/ZK 222584, an oral vascular endothelial growth factor receptor inhibitor, in patients with metastatic colorectal adenocarcinoma. J Clin Oncol (2011) 29(15):1997-2003. doi:10.1200/JCO.2010.29.4496.
    • (2011) J Clin Oncol , vol.29 , Issue.15 , pp. 1997-2003
    • Hecht, J.R.1    Trarbach, T.2    Hainsworth, J.D.3    Major, P.4    Jäger, E.5    Wolff, R.A.6
  • 45
    • 84865721505 scopus 로고    scopus 로고
    • Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer
    • doi:10.1200/JCO.2011.39.7646
    • Paz-Ares LG, Biesma B, Heigener D, von Pawel J, Eisen T, Bennouna J, et al. Phase III, randomized, double-blind, placebo-controlled trial of gemcitabine/cisplatin alone or with sorafenib for the first-line treatment of advanced, nonsquamous non-small-cell lung cancer. J Clin Oncol (2012) 30(25):3084-92. doi:10.1200/JCO.2011.39.7646.
    • (2012) J Clin Oncol , vol.30 , Issue.25 , pp. 3084-3092
    • Paz-Ares, L.G.1    Biesma, B.2    Heigener, D.3    von Pawel, J.4    Eisen, T.5    Bennouna, J.6
  • 46
    • 80051713290 scopus 로고    scopus 로고
    • Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial
    • doi:10.1016/j.clbc.2011.03.005
    • Robert NJ, Saleh MN, Paul D, Generali D, Gressot L, Copur MS, et al. Sunitinib plus paclitaxel versus bevacizumab plus paclitaxel for first-line treatment of patients with advanced breast cancer: a phase III, randomized, open-label trial. Clin Breast Cancer (2011) 11(2):82-92. doi:10.1016/j.clbc.2011.03.005.
    • (2011) Clin Breast Cancer , vol.11 , Issue.2 , pp. 82-92
    • Robert, N.J.1    Saleh, M.N.2    Paul, D.3    Generali, D.4    Gressot, L.5    Copur, M.S.6
  • 47
    • 84860625265 scopus 로고    scopus 로고
    • First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phase III study
    • doi:10.1200/JCO.2011.35.7376
    • Bergh J, Bondarenko IM, Lichinitser MR, Liljegren A, Greil R, Voytko NL, et al. First-line treatment of advanced breast cancer with sunitinib in combination with docetaxel versus docetaxel alone: results of a prospective, randomized phase III study. J Clin Oncol (2012) 30(9):921-9. doi:10.1200/JCO.2011.35.7376.
    • (2012) J Clin Oncol , vol.30 , Issue.9 , pp. 921-929
    • Bergh, J.1    Bondarenko, I.M.2    Lichinitser, M.R.3    Liljegren, A.4    Greil, R.5    Voytko, N.L.6
  • 48
    • 77950811722 scopus 로고    scopus 로고
    • Bridging the gap between cytotoxic and biologic therapy with metronomic topotecan and pazopanib in ovarian cancer
    • doi:10.1158/1535-7163.MCT-09-0967
    • Merritt WM, Nick AM, Carroll AR, Lu C, Matsuo K, Dumble M, et al. Bridging the gap between cytotoxic and biologic therapy with metronomic topotecan and pazopanib in ovarian cancer. Mol Cancer Ther (2010) 9(4):985-95. doi:10.1158/1535-7163.MCT-09-0967.
    • (2010) Mol Cancer Ther , vol.9 , Issue.4 , pp. 985-995
    • Merritt, W.M.1    Nick, A.M.2    Carroll, A.R.3    Lu, C.4    Matsuo, K.5    Dumble, M.6
  • 49
    • 34247179157 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 and its inhibition in cancer: is there a role?
    • doi:10.2165/00003495-200767060-00001
    • Liao Z, Mason KA, Milas L. Cyclo-oxygenase-2 and its inhibition in cancer: is there a role? Drugs (2007) 67(6):821-45. doi:10.2165/00003495-200767060-00001.
    • (2007) Drugs , vol.67 , Issue.6 , pp. 821-845
    • Liao, Z.1    Mason, K.A.2    Milas, L.3
  • 50
    • 33644534205 scopus 로고    scopus 로고
    • Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice
    • doi:10.1016/S0753-3322(05)80052-6
    • Olsen SR. Taxanes and COX-2 inhibitors: from molecular pathways to clinical practice. Biomed Pharmacother (2005) 59(Suppl 2):S306-10. doi:10.1016/S0753-3322(05)80052-6.
    • (2005) Biomed Pharmacother , vol.59 , Issue.SUPPL. 2
    • Olsen, S.R.1
  • 51
    • 84883165443 scopus 로고    scopus 로고
    • Repositioning metformin for cancer prevention and treatment
    • doi:10.1016/j.tem.2013.05.004
    • Quinn BJ, Kitagawa H, Memmott RM, Gills JJ, Dennis PA. Repositioning metformin for cancer prevention and treatment. Trends Endocrinol Metab (2013) 24(9):469-80. doi:10.1016/j.tem.2013.05.004.
    • (2013) Trends Endocrinol Metab , vol.24 , Issue.9 , pp. 469-480
    • Quinn, B.J.1    Kitagawa, H.2    Memmott, R.M.3    Gills, J.J.4    Dennis, P.A.5
  • 52
    • 84892678284 scopus 로고    scopus 로고
    • New perspective for an old antidiabetic drug: metformin as anticancer agent
    • doi:10.1007/978-3-642-38007-5_21
    • Leone A, Di Gennaro E, Bruzzese F, Avallone A, Budillon A. New perspective for an old antidiabetic drug: metformin as anticancer agent. Cancer Treat Res (2014) 159:355-76. doi:10.1007/978-3-642-38007-5_21.
    • (2014) Cancer Treat Res , vol.159 , pp. 355-376
    • Leone, A.1    Di Gennaro, E.2    Bruzzese, F.3    Avallone, A.4    Budillon, A.5
  • 53
    • 84879685044 scopus 로고    scopus 로고
    • β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma
    • doi:10.1038/bjc.2013.205
    • Pasquier E, Street J, Pouchy C, Carre M, Gifford AJ, Murray J, et al. β-blockers increase response to chemotherapy via direct antitumour and anti-angiogenic mechanisms in neuroblastoma. Br J Cancer (2013) 108(12):2485-94. doi:10.1038/bjc.2013.205.
    • (2013) Br J Cancer , vol.108 , Issue.12 , pp. 2485-2494
    • Pasquier, E.1    Street, J.2    Pouchy, C.3    Carre, M.4    Gifford, A.J.5    Murray, J.6
  • 54
    • 84858428443 scopus 로고    scopus 로고
    • Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment
    • Pasquier E, Ciccolini J, Carre M, Giacometti S, Fanciullino R, Pouchy C, et al. Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment. Oncotarget (2011) 2(10):797-809.
    • (2011) Oncotarget , vol.2 , Issue.10 , pp. 797-809
    • Pasquier, E.1    Ciccolini, J.2    Carre, M.3    Giacometti, S.4    Fanciullino, R.5    Pouchy, C.6
  • 56
    • 84866519738 scopus 로고    scopus 로고
    • The molecular mechanism of the anticancer effect of atorvastatin: DNA microarray and bioinformatic analyses
    • doi:10.3892/ijmm.2012.1054
    • Gao Y, Lu X-C, Yang H-Y, Liu X-F, Cao J, Fan L. The molecular mechanism of the anticancer effect of atorvastatin: DNA microarray and bioinformatic analyses. Int J Mol Med (2012) 30(4):765-74. doi:10.3892/ijmm.2012.1054.
    • (2012) Int J Mol Med , vol.30 , Issue.4 , pp. 765-774
    • Gao, Y.1    Lu, X.-C.2    Yang, H.-Y.3    Liu, X.-F.4    Cao, J.5    Fan, L.6
  • 57
    • 80054888464 scopus 로고    scopus 로고
    • Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer
    • doi:10.1158/0008-5472.CAN-11-0691
    • Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Itraconazole inhibits angiogenesis and tumor growth in non-small cell lung cancer. Cancer Res (2011) 71(21):6764-72. doi:10.1158/0008-5472.CAN-11-0691.
    • (2011) Cancer Res , vol.71 , Issue.21 , pp. 6764-6772
    • Aftab, B.T.1    Dobromilskaya, I.2    Liu, J.O.3    Rudin, C.M.4
  • 58
    • 84876954809 scopus 로고    scopus 로고
    • Has the time come for metronomics in low-income and middle-income countries?
    • doi:10.1016/S1470-2045(13)70056-1
    • André N, Banavali S, Snihur Y, Pasquier E. Has the time come for metronomics in low-income and middle-income countries? Lancet Oncol (2013) 14(6):e239-48. doi:10.1016/S1470-2045(13)70056-1.
    • (2013) Lancet Oncol , vol.14 , Issue.6
    • André, N.1    Banavali, S.2    Snihur, Y.3    Pasquier, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.