Seronegative hepatitis C virus infection in patients with lymphoproliferative disorders

Journal of Viral Hepatitis

Volumn 21, Issue 6, 2014, Pages 424-429

  Kisiel, E ^a   Radkowski, M ^b   Pawelczyk, A ^b   Horban, A ^c   Stanczak, J ^c   Bukowska Osko I ^b   Caraballo Cortes, K ^b   Kazmierczak J ^b   Popiel, M ^b   Laskus, T ^b  

^a INSTITUTE OF HEMATOLOGY AND TRANSFUSION MEDICINE   (Poland)

^b MEDICAL UNIVERSITY OF WARSAW   (Poland)

^c SP ZOZ Wojewodzki Szpital Zakazny Centrum Diagnostyki i Terapii AIDS Warszawa   (Poland)

Author keywords

hepatitis C virus; immunostaining; lymphoproliferative; nonstructural protein 3; seronegative

Indexed keywords

NONSTRUCTURAL PROTEIN 3; VIRUS RNA; HEPATITIS C ANTIBODY; NS3 PROTEIN, HEPATITIS C VIRUS; VIRUS PROTEIN;

ADULT; AGED; ARTICLE; BONE MARROW; CHEMILUMINESCENCE IMMUNOASSAY; CONTROLLED STUDY; ENZYME IMMUNOASSAY; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HODGKIN DISEASE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LARGE CELL LYMPHOMA; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LIVER BIOPSY; LYMPHATIC LEUKEMIA; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MALE; MANTLE CELL LYMPHOMA; MULTIPLE MYELOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS LOAD; BLOOD; COMPLICATION; IMMUNOLOGY; ISOLATION AND PURIFICATION; MIDDLE AGED; MONONUCLEAR CELL; VERY ELDERLY; VIROLOGY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; BLOOD; BONE MARROW; FEMALE; HEPATITIS C; HEPATITIS C ANTIBODIES; HUMANS; IMMUNOHISTOCHEMISTRY; LEUKOCYTES, MONONUCLEAR; LYMPHOPROLIFERATIVE DISORDERS; MALE; MIDDLE AGED; RNA, VIRAL; VIRAL LOAD; VIRAL NONSTRUCTURAL PROTEINS; YOUNG ADULT;

EID: 84901000929     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/jvh.12181     Document Type: Article

References (40)

1. Chamie G, Bonacini M, Bangsberg DR, et al,. Factors associated with seronegative chronic hepatitis C virus infection in HIV infection. Clin Infect Dis 2007; 44: 577-583. (Pubitemid 46233263)
2. Hanuka N, Sikuler E, Tovbin D, et al,. Hepatitis C virus infection in renal failure patients in the absence of anti-hepatitis C virus antibodies. J Viral Hepat 2002; 9: 141-145. (Pubitemid 36002478)
3. Thomson EC, Nastouli E, Main J, et al,. Delayed anti-HCV antibody response in HIV-positive men acutely infected with HCV. Aids 2009; 23: 89-93.
4. Castillo I, Pardo M, Bartolome J, et al,. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis 2004; 189: 7-14. (Pubitemid 38122323)
5. De Marco L, Gillio-Tos A, Fiano V, et al,. Occult HCV infection: an unexpected finding in a population unselected for hepatic disease. PLoS One 2009; 4: e8128.
6. Di Liberto G, Roque-Afonso AM, Kara R, et al,. Clinical and therapeutic implications of hepatitis C virus compartmentalization. Gastroenterology 2006; 131: 76-84. (Pubitemid 44015750)
7. Laskus T, Radkowski M, Wang LF, Jang SJ, Vargas H, Rakela J,. Hepatitis C virus quasispecies in patients infected with HIV-1: correlation with extrahepatic viral replication. Virology 1998; 248: 164-171. (Pubitemid 28393940)
8. Navas S, Martin J, Quiroga JA, Castillo I, Carreno V,. Genetic diversity and tissue compartmentalization of the hepatitis C virus genome in blood mononuclear cells, liver, and serum from chronic hepatitis C patients. J Virol 1998; 72: 1640-1646. (Pubitemid 28116955)
9. Roque-Afonso AM, Ducoulombier D, Di Liberto G, et al,. Compartmentalization of hepatitis C virus genotypes between plasma and peripheral blood mononuclear cells. J Virol 2005; 79: 6349-6357. (Pubitemid 40617238)
10. Radkowski M, Wilkinson J, Nowicki M, et al,. Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. J Virol 2002; 76: 600-608. (Pubitemid 34033359)
11. Wilkinson J, Radkowski M, Laskus T,. Hepatitis C virus neuroinvasion: identification of infected cells. J Virol 2009; 83: 1312-1319.
12. Shimizu YK, Igarashi H, Kanematu T, et al,. Sequence analysis of the hepatitis C virus genome recovered from serum, liver, and peripheral blood mononuclear cells of infected chimpanzees. J Virol 1997; 71: 5769-5773. (Pubitemid 27304911)
13. Laskus T, Radkowski M, Jablonska J, et al,. Human immunodeficiency virus facilitates infection/replication of hepatitis C virus in native human macrophages. Blood 2004; 103: 3854-3859. (Pubitemid 38596305)
14. Sung VM, Shimodaira S, Doughty AL, et al,. Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection. J Virol 2003; 77: 2134-2146. (Pubitemid 36110026)
15. Radkowski M, Kubicka J, Kisiel E, et al,. Detection of active hepatitis C virus and hepatitis G virus/GB virus C replication in bone marrow in human subjects. Blood 2000; 95: 3986-3989. (Pubitemid 30412878)
16. Radkowski M, Gallegos-Orozco JF, Jablonska J, et al,. Persistence of hepatitis C virus in patients successfully treated for chronic hepatitis C. Hepatology 2005; 41: 106-114. (Pubitemid 40066388)
17. Jonas G, Pelzer C, Beckert C, Hausmann M, Kapprell HP,. Performance characteristics of the ARCHITECT anti-HCV assay. J Clin Virol 2005; 34: 97-103. (Pubitemid 41282797)
18. Alter MJ, Kuhnert WL, Finelli L,. Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. Centers for Disease Control and Prevention. MMWR Recomm Rep 2003; 52: 1-13, 15; quiz CE11-14.
19. Petruzziello A, Coppola N, Fraulo M, et al,. Ortho VITROS enhanced chemiluminescence assay for detection of hepatitis C virus (HCV) antibodies: determination of a "borderline" range. AJMR 2013; 7: 2359-2364.
20. Colucci G, Ferguson J, Harkleroad C, et al,. Improved COBAS TaqMan hepatitis C virus test (Version 2.0) for use with the High Pure system: enhanced genotype inclusivity and performance characteristics in a multisite study. J Clin Microbiol 2007; 45: 3595-3600. (Pubitemid 350156854)
21. Laskus T, Radkowski M, Wang LF, Vargas H, Rakela J,. Lack of evidence for hepatitis G virus replication in the livers of patients coinfected with hepatitis C and G viruses. J Virol 1997; 71: 7804-7806. (Pubitemid 27391727)
22. Horner SM, Park HS, Gale M Jr,. Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix alpha0. J Virol 2012; 86: 3112-3120.
23. Wilkinson J, Radkowski M, Eschbacher JM, Laskus T,. Activation of brain macrophages/microglia cells in hepatitis C infection. Gut 2010; 59: 1394-1400.
24. Pham TN, MacParland SA, Mulrooney PM, Cooksley H, Naoumov NV, Michalak TI,. Hepatitis C virus persistence after spontaneous or treatment-induced resolution of hepatitis C. J Virol 2004; 78: 5867-5874. (Pubitemid 38661674)
25. Puro V, Petrosillo N, Ippolito G,. Risk of hepatitis C seroconversion after occupational exposures in health care workers. Italian Study Group on Occupational Risk of HIV and Other Bloodborne Infections. Am J Infect Control 1995; 23: 273-277.
26. Santantonio T, Medda E, Ferrari C, et al,. Risk factors and outcome among a large patient cohort with community-acquired acute hepatitis C in Italy. Clin Infect Dis 2006; 43: 1154-1159. (Pubitemid 44632798)
27. Quer J, Esteban JI, Cos J, et al,. Effect of bottlenecking on evolution of the nonstructural protein 3 gene of hepatitis C virus during sexually transmitted acute resolving infection. J Virol 2005; 79: 15131-15141. (Pubitemid 43032296)
28. Muller HJ,. The Relation of Recombination to Mutational Advance. Mutat Res 1964; 106: 2-9.
29. Bronowicki JP, Vetter D, Uhl G, et al,. Lymphocyte reactivity to hepatitis C virus (HCV) antigens shows evidence for exposure to HCV in HCV-seronegative spouses of HCV-infected patients. J Infect Dis 1997; 176: 518-522. (Pubitemid 27328779)
30. Kamal SM, Amin A, Madwar M, et al,. Cellular immune responses in seronegative sexual contacts of acute hepatitis C patients. J Virol 2004; 78: 12252-12258. (Pubitemid 39458745)
31. Post JJ, Pan Y, Freeman AJ, et al,. Clearance of hepatitis C viremia associated with cellular immunity in the absence of seroconversion in the hepatitis C incidence and transmission in prisons study cohort. J Infect Dis 2004; 189: 1846-1855. (Pubitemid 38657221)
32. Hashem M, El-Karaksy H, Shata MT, et al,. Strong hepatitis C virus (HCV)-specific cell-mediated immune responses in the absence of viremia or antibodies among uninfected siblings of HCV chronically infected children. J Infect Dis 2011; 203: 854-861.
33. Shata MT, Tricoche N, Perkus M, et al,. Exposure to low infective doses of HCV induces cellular immune responses without consistently detectable viremia or seroconversion in chimpanzees. Virology 2003; 314: 601-616. (Pubitemid 37209981)
34. Michalak TI, Mulrooney PM, Coffin CS,. Low doses of hepadnavirus induce infection of the lymphatic system that does not engage the liver. J Virol 2004; 78: 1730-1738. (Pubitemid 38176705)
35. Coffin CS, Michalak TI,. Persistence of infectious hepadnavirus in the offspring of woodchuck mothers recovered from viral hepatitis. J Clin Invest 1999; 104: 203-212.
36. Blackard JT, Smeaton L, Hiasa Y, et al,. Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons. J Infect Dis 2005; 192: 258-265. (Pubitemid 40993395)
37. Daar ES, Lynn H, Donfield S, et al,. Relation between HIV-1 and hepatitis C viral load in patients with hemophilia. J Acquir Immune Defic Syndr 2001; 26: 466-472. (Pubitemid 32489026)
38. Laskus T, Radkowski M, Wang LF, Vargas H, Rakela J,. The presence of active hepatitis C virus replication in lymphoid tissue in patients coinfected with human immunodeficiency virus type 1. J Infect Dis 1998; 178: 1189-1192. (Pubitemid 28452222)
39. Sherman KE, O'Brien J, Gutierrez AG, et al,. Quantitative evaluation of hepatitis C virus RNA in patients with concurrent human immunodeficiency virus infections. J Clin Microbiol 1993; 31: 2679-2682. (Pubitemid 23284901)
40. Li Y, Wang X, Douglas SD, et al,. CD8+ T cell depletion amplifies hepatitis C virus replication in peripheral blood mononuclear cells. J Infect Dis 2005; 192: 1093-1101. (Pubitemid 41266809)