Platelets for neonatal transfusion - Study 2: A randomised controlled trial to compare two different platelet count thresholds for prophylactic platelet transfusion to preterm neonates

Neonatology

Volumn 106, Issue 2, 2014, Pages 102-106

  Curley, Anna ^a   Venkatesh, Vidheya ^a   Stanworth, Simon ^c   Clarke, Paul ^d   Watts, Timothy ^e   New, Helen ^f   Willoughby, Karen ^a   Khan, Rizwan ^a   Muthukumar, Priya ^d   Deary, Alison ^b  

^a CAMBRIDGE UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^b NHS BLOOD AND TRANSPLANT   (United Kingdom)

^c OXFORD UNIVERSITY HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^d NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

^e GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^f IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

Author keywords

Newborn; Platelets; Thrombocytopenia; Transfusion

Indexed keywords

ARTICLE; BLEEDING; CONTROLLED STUDY; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; NEWBORN; OUTCOME ASSESSMENT; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; APHERESIS; BACTERIAL INFECTION; BACTERIUM CONTAMINATION; BLOOD COMPONENT; BLOOD SAFETY; BLOOD TRANSFUSION REACTION; CREUTZFELDT JAKOB DISEASE; GESTATIONAL AGE; LIVER DYSFUNCTION; MEDICAL ERROR; NECROTIZING ENTEROCOLITIS; NEONATAL THROMBOCYTOPENIA; PROPHYLACTIC PLATELET TRANSFUSION; RANDOMIZED CONTROLLED TRIAL (TOPIC); TRANSFUSION ERROR; ADVERSE EFFECTS; BLOOD; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPARATIVE STUDY; HEMORRHAGE; INFANT; INFANT MORTALITY; METHODOLOGY; MORTALITY; MULTICENTER STUDY; PREDICTIVE VALUE; PROCEDURES; THROMBOCYTOPENIA, NEONATAL ALLOIMMUNE; TIME; TREATMENT OUTCOME; UNITED KINGDOM;

THROMBOCYTE CONCENTRATE;

CLINICAL PROTOCOLS; GREAT BRITAIN; HEMORRHAGE; HUMANS; INFANT; INFANT MORTALITY; INFANT, NEWBORN; INFANT, PREMATURE; PLATELET COUNT; PLATELET TRANSFUSION; PREDICTIVE VALUE OF TESTS; RESEARCH DESIGN; THROMBOCYTOPENIA, NEONATAL ALLOIMMUNE; TIME FACTORS; TREATMENT OUTCOME;

EID: 84900890764     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000358481     Document Type: Article

References (14)

1. Del Vecchio A Sola MC Theriaque DW et a l: Platelet transfusions in the neonatal intensive care unit: factors predicting which patients will require multiple transfusions. Transfusion 2001; 41: 803-808.
2. Roberts IA Murray NA: Thrombocyt openia in the newborn. Curr Opin Pediatr 2003; 15: 17-23.
3. Baer VL Lambert DK Henry E et al: Do platelet transfusions in the NICU adversely affect survival? Analysis of 1,600 thrombocytopenic neonates in a multihospital healthcare system. J Perinatol 2007; 27: 790-796.
4. Chaudhary R Clarke P: Current transfusion practices for platelets and fresh frozen plasma in UK tertiary level neonatal units. Acta Paediatr 2008; 97: 135.
5. Gibson BE Todd A Roberts I et al: Transfusion guidelines for neonates and older children. Br J Haematol 2004; 124: 433-453.
6. Saxonhouse M Slayton W Sola MC (eds): Platelet Transfusions in the Infant and Child. San Diego Elsevier 2004.
7. Josephson CD Su LL Christensen RD et al: Platelet transfusion prac tices among neonatologists in the United States and Canada: results of a survey. Pediatrics 2009; 123: 278-285.
8. Andrew M Vegh P Caco C et al: A randomized controlled trial of platelet transfusions in thrombocytopenic premature infants. J Pediatr 1993; 123: 285-291.
9. Stainsby D Jones H Wells AW et al: Adverse outcomes of blood transfusion in children: analysis of UK reports to the serious hazards of transfusion scheme 1996 -2005. Br J Haematol 2008; 141: 73-79.
10. Bolton-Maggs P Cohen H et al: The 2011 Annual SHOT Report. Manchester SHOT 2012.
11. Kenton AB O'Donovan D Cass DL et al: Severe thrombocytopenia predicts outcome in neonates with necrotizing enterocolitis. J Perinatol 2005; 25: 14-20.
12. Stanworth SJ C larke P Watts T et al: Prospective observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics 2009; 124:e826-e834.
13. Muthukumar P Venkatesh V Curley A et al: Severe thrombocytopenia and patterns of bleeding in neonates: results from a prospective observational study and implications for use of platelet transfusions. Transfus Me d 2012; 22: 338-343.
14. Venkatesh V Curley A Khan R et al: A novel approach to standardised recording of bleeding in a high risk neonatal population. Arch Dis Child Fetal Neonatal Ed 201 3; 98:F260-F263.