Sustained in vivo depletion of splenic langerin+ CD8α+ dendritic cells is well-tolerated by lang-DTREGFP mice

Journal of Immunological Methods

Volumn 406, Issue , 2014, Pages 104-109

  Prendergast, Kelly A ^a,b   Osmond, Taryn L ^a,b   Ochiai, Sotaro ^a,c   Hermans, Ian F ^a,b   Kirman, Joanna R ^c  

^a MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^b VICTORIA UNIVERSITY OF WELLINGTON   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Dendritic cells; Depletion; Diphtheria toxin; Langerin

Indexed keywords

CD8ALPHA ANTIGEN; DIPHTHERIA TOXIN; ENHANCED GREEN FLUORESCENT PROTEIN; LANGERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CLINICAL PROTOCOL; CONTROLLED STUDY; DENDRITIC CELL; IMMUNE RESPONSE; IN VIVO STUDY; LYMPHOCYTE DEPLETION; MOUSE; MOUSE MODEL; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; SPLEEN; TURNOVER TIME; WEIGHT REDUCTION;

MURINAE; MUS;

DENDRITIC CELLS; DEPLETION; DIPHTHERIA TOXIN; LANGERIN;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD8; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DIPHTHERIA TOXIN; LECTINS, C-TYPE; LYMPHOCYTE ACTIVATION; LYMPHOCYTE DEPLETION; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SPLEEN;

EID: 84900862091     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2014.02.005     Document Type: Article

References (11)

1. Brewig N., Kissenpfennig A., Malissen B., Veit A., Bickert T., Fleischer B., Mostböck S., Ritter U. Priming of CD8+ and CD4+ T cells in experimental leishmaniasis is initiated by different dendritic cell subtypes. J. Immunol. 2009, 182:774.
2. Farrand K.J., Dickgreber N., Stoitzner P., Ronchese F., Petersen T.R., Hermans I.F. Langerin(+)CD8 alpha(+) dendritic cells are critical for cross-priming and IL-12 production in response to systemic antigens. J. Immunol. 2009, 183:7732.
3. Hochweller K., Striegler J., Hämmerling G.J., Garbi N. A novel CD11c.DTR transgenic mouse for depletion of dendritic cells reveals their requirement for homeostatic proliferation of natural killer cells. Eur. J. Immunol. 2008, 38:2776.
4. Jung S., Unutmaz D., Wong P., Sano G.-I., De los Santos K., Sparwasser T., Wu S., Vuthoori S., Ko K., Zavala F., Pamer E.G., Littman D.R., Lang R.A. In vivo depletion of CD11c+dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 2002, 17:211.
5. Kissenpfennig A., Henri S., Dubois B., Laplace-Builhé C., Perrin P., Romani N., Tripp C.H., Douillard P., Leserman L., Kaiserlian D., Saeland S., Davoust J., Malissen B. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 2005, 22:643.
6. Loukoushkina E.F., Bobko P.V., Kolbasova E.V., Kazakova L.V., Krasnov V.V., Shipova L.G., Lazareva T.S., Vlasova I.N., Schmaltz A.A. The clinical picture and diagnosis of diphtheritic carditis in children. Eur. J. Pediatr. 1998, 157:528.
7. Pooley J.L., Heath W.R., Shortman K. Cutting edge: intravenous soluble antigen is presented to CD4 T cells by CD8- dendritic cells, but cross-presented to CD8 T cells by CD8+ dendritic cells. J. Immunol. 2001, 166:5327.
8. Qiu C.-H., Miyake Y., Kaise H., Kitamura H., Ohara O., Tanaka M. Novel subset of CD8{alpha}+dendritic cells localized in the marginal zone is responsible for tolerance to cell-associated antigens. J. Immunol. 2009, 182:4127.
9. Stoecklinger A., Eticha T.D., Mesdaghi M., Kissenpfennig A., Malissen B., Thalhamer J., Hammerl P. Langerin+dermal dendritic cells are critical for CD8+ T cell activation and IgH γ-1 class switching in response to gene gun vaccines. J. Immunol. 2011, 186:1377.
10. Tittel A.P., Heuser C., Ohliger C., Llanto C., Yona S., Hämmerling G.J., Engel D.R., Garbi N., Kurts C. Functionally relevant neutrophilia in CD11c diphtheria toxin receptor transgenic mice. Nat. Methods 2012, 9:385.
11. Zaft T., Sapoznikov A., Krauthgamer R., Littman D.R., Jung S. CD11chigh dendritic cell ablation impairs lymphopenia-driven proliferation of naive and memory CD8+ T cells. J. Immunol. 2005, 175:6428.