Inotodiol inhabits proliferation and induces apoptosis through modulating expression of cyclinE, p27, bcl-2, and bax in human cervical cancer HeLa cells

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 7, 2014, Pages 3195-3199

  Zhao, Li Wei ^a   Zhong, Xiu Hong ^a   Yang, Shu Yan ^a   Zhang, Yi Zhong ^a   Yang, Ning Jiang ^b  

^a JILIN MEDICAL COLLEGE   (China)

^b Affiliated Hospital of Jilin Medical College   (China)

Author keywords

Bax; Bcl 2; Cell cycle; Cervical cancer; CyclinE; Inotodiol; P27

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; INOTODIOL; LANOSTEROL; PROTEIN BAX; PROTEIN BCL 2;

AGARICALES; ANALOGS AND DERIVATIVES; APOPTOSIS; BIOSYNTHESIS; CELL CYCLE; CELL PROLIFERATION; DRUG EFFECTS; FEMALE; HELA CELL LINE; HUMAN; METABOLISM; TUMOR CELL LINE; UTERINE CERVICAL NEOPLASMS;

AGARICALES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HELA CELLS; HUMANS; LANOSTEROL; PROTO-ONCOGENE PROTEINS C-BCL-2; UTERINE CERVICAL NEOPLASMS;

EID: 84900857963     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.7.3195     Document Type: Article

References (28)

1. Chung MJ, Chung C-K, Jeong Y, et al (2010). Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. Nutr Res Pract, 4, 177-82.
2. 2 -induced cytotoxicity. Toxicol Appl Pharmacol, 205, 225-36.
3. Darzynkiewicz Z, Bedner E, Smolewski P (2001). Flow cytometry in analysis of cell cycle and apoptosis. Semin Hematol, 38, 179-93.
4. Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.
5. Ham SS, Kim SH, Moon SY, et al (2009). Antimutagenic effects of subfractions of Chaga Mushroom (Inonotus obliquus) extract. Mutat Res, 672, 55-9.
6. KahlosK (1987). Antitumor activity of some compounds and fractions from an n-hexane extract of Inonotus obliquus. Acta Pharm Fenn, 96, 33-40.
7. Kanthan R, Senger JL, Diudea D (2010). Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins. World J Surg Oncol, 19, 8, 60.
8. Koehn FE, Carter GT (2005). The evolving role of natural products in drug discovery. Nat Rev Drug Discov, 4, 206-20.
9. Krajewski S, Krajewska M, Shabaik A, et al (1994). Immunohistochemical determination of in vivo distribution of Bax, adominant inhibitor of Bcl-2. Am J Pathol, 145, 1323-36.
10. Lim S, Kaldis P (2013). Cdks, cyclins and CKIs: roles beyond cell cycle regulation. Development, 140, 3079-93.
11. Ma L, Chen H, Dong P, Lu X (2013). Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus. Food Chem, 139, 503-8.
12. Mishra BB, Tiwari VK (2011). Natural products: An evolving role in future drug discovery. Eur J Med Chem, 46, 4769-807.
13. Nakajima Y, Nishida H, Matsugo S, et al (2009). Cancer cell cytotoxicity of cxtracts and small phenolic compounds from chaga [Inonotus obliquus (persoon) Pilat], J Med Food, 12, 501-7.
14. Nakata T, Yamada T, Taji S, et al (2007). Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem, 15, 257-64.
15. Nomura M, Takahashi T, Uesugi A, et al (2008). Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res, 28, 2691-6.
16. Pachon G, Rasoanaivo H, Azqueta A, et al (2007). Anticancer effect of a new benzophenanthridine isolated from Zanthoxylum madagascariense (Rutaceline). In Vivo, 21, 417-22.
17. Ramachandran S, Kwon KY, Shin SJ, et al (2008). Cyclindependent kinase inhibitor p27Kip1 controls growth and cell cycle progression in human uterine leiomyoma. J Korean Med Sci, 23, 667-73.
18. Slingerland J, Pagano M (2000). Regulation of the CDK inhibitor p27 and its deregulation in cancer. J Cell Physiol, 183, 10-7.
19. Song FQ, Liu Y, Kong XS, et al (2013). Progress on understanding the anticancer mechanisms of medicinal mushroom: Inonotus obliquus. Asian Pac J Cancer Prev, 14, 1571-8.
20. Suryadinata R, Sadowski M, Steel R, et al (2011). Cyclindependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30 mSin3 HDAC transcriptional repressor complex. J Biol Chem, 286, 5108-18.
21. van Meir H, Kenter GG, Burggraaf J, et al (2014). The need for improvement of the treatment of advanced and metastatic cervical cancer, the rationale for combined Chemoimmunotherapy. Anticancer Agents Med Chem, 14, 190-203.
22. Vermeulen K, Van Bockstaele DR, Berneman ZN (2003). The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer. Cell Prolif, 36, 131-49.
23. 1 arrest and apoptosis in human hepatoma HepG2 cells. World J Gastroenterol, 14, 511-7.
24. Youn MJ, Kim JK, Park SY, et al (2009). Potential anticancer properties of the water extract of Inonotus obliquus by induction of apoptosis in melanoma B16-F10 cells. J Ethnopharmacol, 21, 221-8.
25. Zhao FQ, Piao HS (2006). Studies of anti-mutation active constituents from Inonotus obliquus. Chinese Traditional and Herbal Drugs, 37, 1777-80.
26. Zhao FQ, Yan L, Cui XH, et al (2012). Triterpenoids from Inonotus obliquus protect mice against oxidative damage induced by CCl4. Yao Xue Xue Bao, 47, 680-84.
27. Zhong XH, Ren K, Lu SJ, et al (2009). Progress of research on Inonotus obliquus. Chin J Integr Med, 15, 156-60.
28. Zhong XH, Wang LB, Sun DZ (2011). Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549. Chin J Integr, 17, 218-23.