Molecular basis of DEL phenotype in the Chinese population

BMC Medical Genetics

Volumn 15, Issue 1, 2014, Pages

  Gu, Juan ^a,b   Wang, Xue Dong ^a,b   Shao, Chao Peng ^a,b,c   Wang, Jun ^a,b   Sun, An Yuan ^a,b,d   Huang, Li Hua ^a,b   Pan, Zhao Lin ^a,b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b JIANGNAN UNIVERSITY   (China)

^c SECOND PEOPLE S HOSPITAL OF SHENZHEN   (China)

^d ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Chinese population; DEL phenotype; Rh blood type; RHD allele

Indexed keywords

ALLELE; ARTICLE; CHINESE; DEL GENE; EXON; GENE; GENE SEQUENCE; GENETIC ANALYSIS; GENOTYPE; HUMAN; HYBRID GENE; INTRON; MAJOR CLINICAL STUDY; MISSENSE MUTATION; NUCLEOTIDE SEQUENCE; PHENOTYPE; POPULATION RESEARCH; RHD GENE;

ALLELES; EXONS; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INTRONS; MUTATION; PHENOTYPE; POLYMORPHISM, GENETIC; RH-HR BLOOD-GROUP SYSTEM; SEQUENCE ANALYSIS, DNA;

EID: 84900854608     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-15-54     Document Type: Article

References (22)

1. Wagner FF, Flegel WA. RHD gene deletion occurred in the Rhesus box. Blood 2000, 95:3662-3668.
2. Pham BN, Roussel M, Peyrard T, Beolet M, Jan-Lasserre V, Gien D, Ripaux M, Bourgouin S, Kappler-Gratias S, Rouger P, Le Pennec PY. Anti-D investigations in individuals expressing weak D Type 1 or weak D Type 2: allo- or autoantibodies?. Transfusion 2011, 51:2679-2685. 10.1111/j.1537-2995.2011.03207.x, 21658048.
3. Lin IL, Shih MC, Hsieh MH, Liu TC, Chang SE, Lin CL, Chang JG. Molecular basis of weak D in Taiwanese. Ann Hematol 2003, 82:617-620. 10.1007/s00277-003-0711-4, 12898187.
4. Silvy M, Chapel-Fernandes S, Callebaut I, Beley S, Durousseau C, Simon S, Lauroua P, Dubosc-Marchenay N, Babault C, Mouchet C, Ferrera V, Chiaroni J, Bailly P. Characterization of novel RHD alleles: relationship between phenotype, genotype, and trimeric architecture. Transfusion 2012, 52:2020-2029. 10.1111/j.1537-2995.2011.03544.x, 22320258.
5. Brajovich ME, Boggione CT, Biondi CS, Racca AL, Tarragó M, Nogués N, Muñiz-Díaz E, Cotorruelo CM. Comprehensive analysis of RHD alleles in Argentineans with variant D phenotypes. Transfusion 2012, 52:389-396. 10.1111/j.1537-2995.2011.03297.x, 21883261.
6. Singleton BK, Green CA, Avent ND, Martin PG, Smart E, Daka A, Narter-Olaga EG, Hawthorne LM, Daniels G. The presence of an RHD pseudogene containing a 37 bp duplication and a nonsense mutation in Africans with the Rh D-negative blood group phenotype. Blood 2000, 95:12-18.
7. Peng CT, Shih MC, Liu TC, Lin IL, Jaung SJ, Chang JG. Molecular basis for the RhD negative phenotype in Chinese. Int J Mol Med 2003, 11:515-521.
8. Wagner FF, Frohmajer A, Flegel WA. RHD positive haplotypes in D negative Europeans. BMC Genet 2001, 2:10. 37267, 11495631.
9. Shao CP, Maas JH, Su YQ, Köhler M, Legler TJ. Molecular background of Rh D- positive, D-negative, D (el) and weak D phenotypes in Chinese. Vox Sang 2002, 83:156-161. 10.1046/j.1423-0410.2002.00192.x, 12201845.
10. Gassner C, Doesher A, Drnovsek D, Rozman P, Eicher NI, Legler TJ, Lukin S, Garritsen H, Kleinrath T, Egger B, Ehling R, Körmöczi GF, Kilga-Nogler S, Schoenitzer D, Petershofen EK. Presence of RHD in serologically D-, C/E + individuals: a European multicenter study. Transfusion 2005, 45:527-538. 10.1111/j.0041-1132.2004.04211.x, 15819673.
11. Richard M, Perreault J, Constanzo-Yanez J, Khalifé S, St-Louis M. A new DEL variant caused by exon 8 deletion. Transfusion 2007, 47:852-857. 10.1111/j.1537-2995.2007.01199.x, 17465950.
12. Luettringhaus TA, Cho D, Ryang DW, Flegel WA. An easy RHD genotyping strategy for D- East Asian persons applied to Korean blood donors. Transfusion 2006, 46:2128-2137. 10.1111/j.1537-2995.2006.01042.x, 17176325.
13. Xu Q, Grootkerk-Tax MG, Maaskant-van Wijk PA, van der Schoot CE. Systemic analysis and zygosity determination of the RHD gene in a D-negative Chinese Han population reveals a novel D-negative RHD gene. Vox Sanguinis 2005, 88:35-40. 10.1111/j.1423-0410.2005.00584.x, 15663721.
14. Brecher M. Red cell typing methods. Technical Manual 2002, 677-679. American Association of Blood Banks: Bethesda, MD, Brecher M, 14.
15. Gardener GJ, Legler TJ, Hyett JA, Liew YW, Flower RL, Hyland CA. Anti-D in pregnant women with the RHD (IVS3 + 1G > A)-associated DEL phenotype. Transfusion 2012, 52:2016-2019. 10.1111/j.1537-2995.2011.03538.x, 22313164.
16. Körmöczi GF, Gassner C, Shao CP, Uchikawa M, Legler TJ. A comprehensive analysis of DEL types: partial DEL individuals are prone to anti-D alloimmunization. Transfusion 2005, 45:1561-1567. 10.1111/j.1537-2995.2005.00584.x, 16181205.
17. Li Q, Hou L, Guo ZH, Ye LY, Yue DQ, Zhu ZY. Molecular basis of the RHD gene in blood donors with DEL phenotypes in Shanghai. Vox Sanguinis 2009, 97:139-146. 10.1111/j.1423-0410.2009.01181.x, 19490579.
18. Hasekura H, Ota M, Ito S, Hasegawa Y, Ichinose A, Fukushima H, Ogata H. Flow cytometric studies of the D antigen of various Rh phenotypes with particular reference to Du and Del. Transfusion 1990, 30:236-238. 10.1046/j.1537-2995.1990.30390194344.x, 2107610.
19. Wagner T, Körmöczi GF, Buchta C, Vadon M, Lanzer G, Mayr WR, Legler TJ. Anti-D immunization by DEL red blood cells. Transfusion 2005, 45:520-526. 10.1111/j.0041-1132.2005.04256.x, 15819672.
20. Yasuda H, Ohto H, Sakuma S, Ishikawa Y. Secondary anti-D immunization by Del red blood cells. Transfusion 2005, 45:1581-1584. 10.1111/j.1537-2995.2005.00579.x, 16181208.
21. Shao CP. Transfusion of RhD-Positive Blood in ''Asia Type'' DEL Recipients. N Engl J Med 2010, 362:472-473. 10.1056/NEJMc0909552, 20130261.
22. Wang QP, Dong GT, Wang XD, Gu J, Li Z, Sun AY, Shao CP, Pan ZL, Huang LH, Xie WX, Sun GM, Chen JJ, Pei H, Yang XJ, Shan PN. An investigation of secondary anti-D immunisation among phenotypically RhD-negative individuals in the Chinese population. Blood Transfus 2013, 1-6. doi:10.2450/2013.0184-12.