Does expiratory muscle activity influence dynamic hyperinflation and exertional dyspnea in COPD?

Respiratory Physiology and Neurobiology

Volumn 199, Issue , 2014, Pages 24-33

  Laveneziana, Pierantonio ^a,b,c,d   Webb, Katherine A ^a   Wadell, Karin ^a   Neder, J Alberto ^a   O'Donnell, Denis E ^a  

^a KINGSTON GENERAL HOSPITAL   (Canada)

^b SORBONNE UNIVERSITÉ   (France)

^c INSERM   (France)

^d PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

COPD; Dyspnea; Exercise; Expiratory muscles; Respiratory mechanics

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CORTICOSTEROID; LONG ACTING DRUG; SHORT ACTING DRUG;

ADULT; ARTICLE; BREATHING MECHANICS; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DIAPHRAGM; DYSPNEA; END EXPIRATORY LUNG VOLUME; ESOPHAGUS PRESSURE; EXERCISE TOLERANCE; EXERTIONAL DYSPNEA; EXPIRATORY FLOW; FEMALE; HUMAN; HYPERINFLATION; INSPIRATORY CAPACITY; LUNG FUNCTION; LUNG VOLUME; MALE; MUSCLE FUNCTION; PRIORITY JOURNAL; STOMACH PRESSURE; AGED; BREATHING MUSCLE; ERGOMETRY; ESOPHAGUS; EXERCISE; EXHALATION; INHALATION; LUNG FUNCTION TEST; MIDDLE AGED; MUSCLE STRENGTH; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSURE; SEVERITY OF ILLNESS INDEX; STOMACH;

AGED; DIAPHRAGM; DYSPNEA; ERGOMETRY; ESOPHAGUS; EXERCISE; EXHALATION; FEMALE; HUMANS; INHALATION; MALE; MIDDLE AGED; MUSCLE STRENGTH; PHYSICAL EXERTION; PRESSURE; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RESPIRATORY FUNCTION TESTS; RESPIRATORY MUSCLES; SEVERITY OF ILLNESS INDEX; STOMACH;

EID: 84900827646     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2014.04.005     Document Type: Article

References (53)

1. Aliverti A., Stevenson N., Dellaca R.L., Lo Mauro A., Pedotti A., Calverley P.M. Regional chest wall volumes during exercise in chronic obstructive pulmonary disease. Thorax 2004, 59:210-216.
2. Aliverti A., Macklem P.T., Debigare R., Maltais F., O'Donnell D.E., Webb K.A. Point: counterpoint - the major limitations to exercise performance in COPD. J. Appl. Physiol. 2008, 105:749-757.
3. American Thoracic Society/European Respiratory Society ATS/ERS Statement on respiratory muscle testing. Am. J. Respir. Crit. Care Med. 2002, 166:518-624.
4. Bachasson D., Wuyam B., Pepin J-L., Tamisier R., Levy P., Verges S. Quadriceps and respiratory muscle fatigue following high-intensity cycling in COPD patients. PLoS ONE 2013, 8(12):e83432.
5. Black L.F., Hyatt R.E. Maximal respiratory pressures: normal values and relationship to age and sex. Am. Rev. Respir. Dis. 1969, 99:696-702.
6. Borg G.A. Psychophysical bases of perceived exertion. Med. Sci. Sports Exerc. 1982, 14:377-381.
7. Briscoe W.A., Dubois A.B. The relationship between airway resistance, airway conductance and lung volume in subjects of different age and body size. J. Clin. Invest. 1958, 37:1279-1285.
8. Burrows B., Kasik J.E., Niden A.H., Barclay W.R. Clinical usefulness of the single-breath pulmonucy diffusing capacity test. Am. Rev. Respir. Dis. 1961, 84:789-806.
9. Crapo R.O., Morris A.H., Clayton P.D., Nixon C.R. Lung volumes in healthy nonsmoking adults. Bull. Eur. Physiopathol. Respir. 1982, 18:419-425.
10. Dodd D.S., Brancatisano T., Engel L.A. Chest wall mechanics during exercise in patients with severe chronic air-flow obstruction. Am. Rev. Respir. Dis. 1984, 129:33-38.
11. Fletcher C.M., Elmes P.C., Fairbairn A.S., Wood C.H. The significance of respiratory symptoms and the diagnosis of chronic bronchitis in a working population. Br. Med. J. 1959, 2:257-266.
12. Grimby G., Bunn J., Mead J. Relative contribution of rib cage and abdomen to ventilation during exercise. J. Appl. Physiol. 1968, 24:159-166.
13. Guenette J.A., Webb K.A., O'Donnell D.E. Does dynamic hyperinflation contribute to dyspnoea during exercise in patients with COPD?. Eur. Respir. J. 2012, 40:322-329.
14. Hamilton A.L., Killian K.J., Summers E., Jones N.L. Muscle strength, symptom intensity, and exercise capacity in patients with cardiorespiratory disorders. Am. J. Respir. Crit. Care Med. 1995, 152:2021-2031.
15. Hey E.N., Lloyd B.B., Cunningham D.J., Jukes M.G., Bolton D.P. Effects of various respiratory stimuli on the depth and frequency of breathing in man. Respir. Physiol. 1966, 1:193-205.
16. Hopkinson N.S., Dayer M.J., Moxham J., Polkey M.I. Abdominal muscle fatigue following exercise in chronic obstructive pulmonary disease. Respir. Res. 2010, 11:15.
17. Hyatt R.E. Forced expiration. Handbook of Physiology: The Respiratory System. Mechanics of Breathing 1986, 295-314. American Physiological Society/Oxford University Press, Bethesda, MD/Oxford. A.P. Fishman (Ed.).
18. Jones N.L. Clinical Exercise Testing 1988, WB Saunders, Philadelphia. 3rd ed.
19. Kyroussis D., Polkey M.I., Hamnegard C.H., Mills G.H., Green M., Moxham J. Respiratory muscle activity in patients with COPD walking to exhaustion with and without pressure support. Eur. Respir. J. 2000, 15:649-655.
20. Laveneziana P., Webb K.A., Ora J., Wadell K., O'Donnell D.E. Evolution of dyspnea during exercise in chronic obstructive pulmonary disease: impact of critical volume constraints. Am. J. Respir. Crit. Care Med. 2011, 184:1367-1373.
21. Leaver D.G., Pride N.B. Flow-volume curves and expiratory pressures during exercise in patients with chronic airways obstruction. Scandinavian journal of respiratory diseases. Supplementum 1971, 77:23-27.
22. Leblanc P., Bowie D.M., Summers E., Jones N.L., Killian K.J. Breathlessness and exercise in patients with cardiorespiratory disease. Am. Rev. Respir. Dis. 1986, 133:21-25.
23. Levine S., Kaiser L., Leferovich J., Tikunov B. Cellular adaptations in the diaphragm in chronic obstructive pulmonary disease. N. Engl. J. Med. 1997, 337:1799-1806.
24. MacIntyre N., Crapo R.O., Viegi G., Johnson D.C., van der Grinten C.P., Brusasco V., Burgos F., Casaburi R., Coates A., Enright P., Gustafsson P., Hankinson J., Jensen R., McKay R., Miller M.R., Navajas D., Pedersen O.F., Pellegrino R., Wanger J. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. Eur. Respir. J. 2005, 26:720-735.
25. Mador M.J., Kufel T.J., Pineda L.A., Sharma G.K. Diaphragmatic fatigue and high-intensity exercise in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000, 161:118-123.
26. Mahler D.A., Weinberg D.H., Wells C.K., Feinstein A.R. The measurement of dyspnea. Contents, interobserver agreement, and physiologic correlates of two new clinical indexes. Chest 1984, 85:751-758.
27. Marin J.M., Montes de Oca M., Rassulo J., Celli B.R. Ventilatory drive at rest and perception of exertional dyspnea in severe COPD. Chest 1999, 115:1293-1300.
28. Martinez F.J., Couser J.I., Celli B.R. Factors influencing ventilatory muscle recruitment in patients with chronic airflow obstruction. Am. Rev. Respir. Dis. 1990, 142:276-282.
29. Mercadier J.J., Schwartz K., Schiaffino S., Wisnewsky C., Ausoni S., Heimburger M., Marrash R., Pariente R., Aubier M. Myosin heavy chain gene expression changes in the diaphragm of patients with chronic lung hyperinflation. Am. J. Physiol. 1998, 274:L527-L534.
30. Miller M.R., Hankinson J., Brusasco V., Burgos F., Casaburi R., Coates A., Crapo R., Enright P., van der Grinten C.P., Gustafsson P., Jensen R., Johnson D.C., MacIntyre N., McKay R., Navajas D., Pedersen O.F., Pellegrino R., Viegi G., Wanger J. Standardisation of spirometry. Eur. Respir. J. 2005, 26:319-338.
31. Montes de Oca M., Celli B.R. Respiratory muscle recruitment and exercise performance in eucapnic and hypercapnic severe chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000, 161:880-885.
32. Morris J.F., Koski A., Temple W.P., Claremont A., Thomas D.R. Fifteen-year interval spirometric evaluation of the Oregon predictive equations. Chest 1988, 93:123-127.
33. O'Donnell D.E., Sanii R., Anthonisen N.R., Younes M. Effect of dynamic airway compression on breathing pattern and respiratory sensation in severe chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1987, 135:912-918.
34. O'Donnell D.E., Bertley J.C., Chau L.K., Webb K.A. Qualitative aspects of exertional breathlessness in chronic airflow limitation: pathophysiologic mechanisms. Am. J. Respir. Crit. Care Med. 1997, 155:109-115.
35. O'Donnell D.E., Revill S.M., Webb K.A. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001, 164:770-777.
36. O'Donnell D.E., Hamilton A.L., Webb K.A. Sensory-mechanical relationships during high-intensity, constant-work-rate exercise in COPD. J. Appl. Physiol. 2006, 101:1025-1035.
37. O'Donnell D.E., Guenette J.A., Maltais F., Webb K.A. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise. Chest 2012, 141:753-762.
38. Ora J., Laveneziana P., Wadell K., Preston M., Webb K.A., O'Donnell D.E. Effect of obesity on respiratory mechanics during rest and exercise in COPD. J. Appl. Physiol. 2011, 111:10-19.
39. Orozco-Levi M., Gea J., Lloreta J.L., Felez M., Minguella J., Serrano S., Broquetas J.M. Subcellular adaptation of the human diaphragm in chronic obstructive pulmonary disease. Eur. Respir. J. 1999, 13:371-378.
40. Parshall M.B., Schwartzstein R.M., Adams L., Banzett R.B., Manning H.L., Bourbeau J., Calverley P.M., Gift A.G., Harver A., Lareau S.C., Mahler D.A., Meek P.M., O'Donnell D.E. An official American thoracic society statement: update on the mechanisms, assessment, and management of dyspnea. Am. J. Respir. Crit. Care Med. 2012, 185:435-452.
41. Potter W.A., Olafsson S., Hyatt R.E. Ventilatory mechanics and expiratory flow limitation during exercise in patients with obstructive lung disease. J. Clin. Invest. 1971, 50:910-919.
42. Puente-Maestu L., Garcia de Pedro J., Martinez-Abad Y., Ruiz de Ona J.M., Llorente D., Cubillo J.M. Dyspnea, ventilatory pattern, and changes in dynamic hyperinflation related to the intensity of constant work rate exercise in COPD. Chest 2005, 128:651-656.
43. Rabe K.F., Hurd S., Anzueto A., Barnes P.J., Buist S.A., Calverley P., Fukuchi Y., Jenkins C., Rodriguez-Roisin R., van Weel C., Zielinski J. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 2007, 176:532-555.
44. Similowski T., Yan S., Gauthier A.P., Macklem P.T., Bellemare F. Contractile properties of the human diaphragm during chronic hyperinflation. N. Engl. J. Med. 1991, 325:917-923.
45. Simon P.M., Schwartzstein R.M., Weiss J.W., Fencl V., Teghtsoonian M., Weinberger S.E. Distinguishable types of dyspnea in patients with shortness of breath. Am. Rev. Respir. Dis. 1990, 142:1009-1014.
46. Sinderby C., Spahija J., Beck J., Kaminski D., Yan S., Comtois N., Sliwinski P. Diaphragm activation during exercise in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2001, 163:1637-1641.
47. Stubbing D.G., Pengelly L.D., Morse J.L., Jones N.L. Pulmonary mechanics during exercise in subjects with chronic airflow obstruction. J. Appl. Physiol. 1980, 49:511-515.
48. Supinski G.S., Kelsen S.G. Effect of elastase-induced emphysema on the force-generating ability of the diaphragm. J. Clin. Invest. 1982, 70:978-988.
49. Taylor B.J., How S.C., Romer L.M. Expiratory muscle fatigue does not regulate operating lung volumes during high-intensity exercise in healthy humans. J. Appl. Physiol. 2013, 114:1569-1576.
50. Tobin M.J. Monitoring respiratory mechanics in spontaneously breathing patients. Principles and Practice of Intensive Care Monitoring 1997, 617-654. McGraw-Hill, New York. M.J. Tobin (Ed.).
51. Wanger J., Clausen J.L., Coates A., Pedersen O.F., Brusasco V., Burgos F., Casaburi R., Crapo R., Enright P., van der Grinten C.P., Gustafsson P., Hankinson J., Jensen R., Johnson D., Macintyre N., McKay R., Miller M.R., Navajas D., Pellegrino R., Viegi G. Standardisation of the measurement of lung volumes. Eur. Respir. J. 2005, 26:511-522.
52. Yan S., Sinderby C., Bielen P., Beck J., Comtois N., Sliwinski P. Expiratory muscle pressure and breathing mechanics in chronic obstructive pulmonary disease. Eur. Respir. J. 2000, 16:684-690.
53. Younes M. Determinants of thoracic excursions during exercise. Exercise, Pulmonary Physiology and Pathophysiology 1991, 1-65. Dekker, New York. B.J. Whipp, K. Wasserman (Eds.).