-
1
-
-
84890461947
-
Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society
-
Nordestgaard BG, Chapman MJ, Humphri es SE, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus Statement of the European Atherosclerosis Society. Eur Heart J 2013; 34:3478-3490.
-
(2013)
Eur Heart J
, vol.34
, pp. 3478-3490
-
-
Nordestgaard, B.G.1
Chapman, M.J.2
Humphries, S.E.3
-
2
-
-
84868628467
-
Familial hypercholesterolemia in the Danish general population: Prevalence, coronary artery disease, and cholesterol-lowering medication
-
Benn M, Watts GF, Tybjaerg-Hansen A, Nordestgaard BG. Familial hypercholesterolemia in the Danish general population: Prevalence, coronary artery disease, and cholesterol-lowering medication. J Clin Endocrinol Metab 2012; 97:3956-3964.
-
(2012)
J Clin Endocrinol Metab
, vol.97
, pp. 3956-3964
-
-
Benn, M.1
Watts, G.F.2
Tybjaerg-Hansen, A.3
Nordestgaard, B.G.4
-
3
-
-
79959332777
-
Efficacy of statins in familial hypercholesterolaemia: A long term cohort study
-
Versmissen J, Oosterveer DM, Yazdanpanah M, et al. Efficacy of statins in familial hypercholesterolaemia: A long term cohort study. BMJ 2008; 337: A2423.
-
(2008)
BMJ
, vol.337
-
-
Versmissen, J.1
Oosterveer, D.M.2
Yazdanpanah, M.3
-
4
-
-
33750597734
-
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
-
Lagace TA, Curtis DE, Garuti R, et al. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 2006; 116:2995-3005.
-
(2006)
J Clin Invest
, vol.116
, pp. 2995-3005
-
-
Lagace, T.A.1
Curtis, D.E.2
Garuti, R.3
-
5
-
-
84879315149
-
Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therapy
-
Raal F, Panz V, Immelman A, Pilcher G. Elevated PCSK9 levels in untreated patients with heterozygous or homozygous familial hypercholesterolemia and the response to high-dose statin therap y. J Am Heart Assoc 2013; 2:e000028.
-
(2013)
J Am Heart Assoc
, vol.2
-
-
Raal, F.1
Panz, V.2
Immelman, A.3
Pilcher, G.4
-
6
-
-
84887030875
-
Hepatic cholesterol homeostasis: Is the lowdensity lipoprotein pathway a regulatory or a shunt pathway
-
Sniderman AD, Qi Y, Ma CI, et al. Hepatic cholesterol homeostasis: Is the lowdensity lipoprotein pathway a regulatory or a shunt pathway Arterioscler Thr omb Vasc Biol 2013; 33:2481-2490.
-
(2013)
Arterioscler Thromb Vasc Biol
, vol.33
, pp. 2481-2490
-
-
Sniderman, A.D.1
Qi, Y.2
Ma, C.I.3
-
7
-
-
2942518215
-
Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina unde rgoing secondary prevention treatment: A long-term follow-up study
-
Sposito AC, Lemos PA, Santos RD, et al. Impaired intravascular triglyceride lipolysis constitutes a marker of clinical outcome in patients with stable angina unde rgoing secondary prevention treatment: A long-term follow-up study. J Am Coll Cardiol 2004; 43:2225-2232.
-
(2004)
J Am Coll Cardiol
, vol.43
, pp. 2225-2232
-
-
Sposito, A.C.1
Lemos, P.A.2
Santos, R.D.3
-
8
-
-
84857029783
-
The removal from plasma of chylomicrons and remnants is reduced in heterozygous familial hypercholesterolemia subjects with identified LDL receptor mutations: Study with artificial emulsions
-
Carneiro MM, Miname MH, Gagliardi AC, et al. The removal from plasma of chylomicrons a nd remnants is reduced in heterozygous familial hypercholesterolemia subjects with identified LDL receptor mutations: Study with artificial emulsions. Atherosclerosis 2012; 221:268-274.
-
(2012)
Atherosclerosis
, vol.221
, pp. 268-274
-
-
Carneiro, M.M.1
Miname, M.H.2
Gagliardi, A.C.3
-
9
-
-
84863987783
-
Reverse cholesterol transport in familial hypercholesterolemia
-
Guerin M. Reverse cholesterol transport in familial hypercholesterolemia. Curr Opin Lipidol 2012; 23:377-385.
-
(2012)
Curr Opin Lipidol
, vol.23
, pp. 377-385
-
-
Guerin, M.1
-
10
-
-
84886603461
-
Cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia: A systematic review and meta-analysis
-
Li C, Zhang W, Zhou F, et al. Cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia: A systematic review and meta-analysis. PLoS One 2013; 8:e77049.
-
(2013)
PLoS One
, vol.8
-
-
Li, C.1
Zhang, W.2
Zhou, F.3
-
11
-
-
84880570559
-
Transfer of lipids to high-density lipoprotein (HDL) is altered in patients with familial hypercholesterolemia
-
Martinez LR, Sa ntos RD, Miname MH, et al. Transfer of lipids to high-density lipoprotein (HDL) is altered in patients with familial hypercholesterolemia. Metabolism 2013; 62:1061-1064.
-
(2013)
Metabolism
, vol.62
, pp. 1061-1064
-
-
Martinez, L.R.1
Santos, R.D.2
Miname, M.H.3
-
12
-
-
84893647246
-
Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation
-
Watts GF,Gidding S,Wierzbicki AS,et al. Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation. Int J Cardiol, 2014, 171, 309-325.
-
(2014)
Int J Cardiol
, vol.171
, pp. 309-325
-
-
Watts, G.F.1
Gidding, S.2
Wierzbicki, A.S.3
-
13
-
-
79955017150
-
Familial hypercholesterolemia: The lipids or the genes
-
Fahed A, Nemer GM. Famili al hypercholesterolemia: The lipids or the genes Nutr Metab (Lond) 2011; 8:23.
-
(2011)
Nutr Metab (Lond)
, vol.8
, pp. 23
-
-
Fahed, A.1
Nemer, G.M.2
-
14
-
-
84890050247
-
The use of next-generation sequencing in clinical diagnosis of familial hypercholesterolemia
-
Vandrovcova J, Thomas ER, Atanur SS, et al. The use of next-generation sequencing in clinical diagnosis of familial hypercholesterolemia. Genet Med 2013; 15:948-957.
-
(2013)
Genet Med
, vol.15
, pp. 948-957
-
-
Vandrovcova, J.1
Thomas, E.R.2
Atanur, S.S.3
-
15
-
-
77953949143
-
Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade project
-
Taylor A, Wang D, Patel K, et al. Mutation detection rate and spectrum in familial hypercholesterolaemia patients in the UK pilot cascade p roject. Clin Genet 2010; 77:572-580.
-
(2010)
Clin Genet
, vol.77
, pp. 572-580
-
-
Taylor, A.1
Wang, D.2
Patel, K.3
-
16
-
-
84876167878
-
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: A case-control study
-
Talmud PJ, Shah S, Whittall R, et al. Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: A case-control study. Lancet 2013; 381:1293-1301.
-
(2013)
Lancet
, vol.381
, pp. 1293-1301
-
-
Talmud, P.J.1
Shah, S.2
Whittall, R.3
-
17
-
-
77955505564
-
Biological, clinical and population relevance of 95 loci for blood lipids
-
Teslovich TM, Musunuru K, Smith AV, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature 2010; 466:707-713.
-
(2010)
Nature
, vol.466
, pp. 707-713
-
-
Teslovich, T.M.1
Musunuru, K.2
Smith, A.V.3
-
18
-
-
58149505978
-
Family tracing to identify patients with familial hypercholesterolaemia: The second audit of the department of health familial hypercholesterolaemia cascade testing project
-
Hadfield SG, Horara S, Starr BJ, et al. Family tracing to identify patients with familial hypercholesterolaemia: The second audit of the Department of Health familial hypercholesterolaemia cascade testing project. Ann Clin Biochem 2009; 46:24-32.
-
(2009)
Ann Clin Biochem
, vol.46
, pp. 24-32
-
-
Hadfield, S.G.1
Horara, S.2
Starr, B.J.3
-
19
-
-
84902576469
-
ACC/AHA guideline on the treatment of blood choles terol to reduce atherosclerotic cardiovascular risk in adults: A report of the american college of cardiology/american heart association task force on practice guidelines
-
doi: 10.1016/j.jacc.2013.11.002. Epub ahead of print
-
Stone NJ, Robinson J, Lichtenstein AH, et al. 2013 ACC/AHA Guideline on the Treatment of Blood Choles terol to Reduce Atherosclerotic Cardiovascular Risk in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013. doi: 10.1016/j.jacc.2013.11.002. [Epub ahead of print]
-
(2013)
J Am Coll Cardiol 2013
-
-
Stone, N.J.1
Robinson, J.2
Lichtenstein, A.H.3
-
20
-
-
0033539313
-
Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC ) study
-
Napoli C, Glass CK, Witztum JL, et al. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC ) study. Lancet 1999; 354:1234-1241.
-
(1999)
Lancet
, vol.354
, pp. 1234-1241
-
-
Napoli, C.1
Glass, C.K.2
Witztum, J.L.3
-
22
-
-
84883204563
-
Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk
-
Kusters DM, Avis HJ, Braamskamp MJ, et al. Inheritance pattern of familial hypercholesterolemia and markers of cardiovascular risk. J Lipid Res 2013; 54:2543-2549.
-
(2013)
J Lipid Res
, vol.54
, pp. 2543-2549
-
-
Kusters, D.M.1
Avis, H.J.2
Braamskamp, M.J.3
-
23
-
-
78649720717
-
Evaluation of subclinical atherosclerosis by computed tomography coronary angiography and its association with risk factors in familial hypercholesterolemia
-
Miname MH, Ribeiro MS 2nd, Parga Filho, et al. Evaluation of subclinical atherosclerosis by computed tomography coronary angiography and its association with risk factors in familial hypercholesterolemia. Atherosclerosis 201 0; 213:486-491.
-
(2010)
Atherosclerosis
, vol.213
, pp. 486-491
-
-
Miname, M.H.1
Ribeiro Iind, M.S.2
Filho, P.3
-
24
-
-
0025597137
-
The LDL receptor locus in familial hyperchole sterolemia: Mutational analysis of a membrane protein
-
Hobbs HH, Russell DW, Brown MS, Goldstein JL. The LDL receptor locus in familial hyperchole sterolemia: Mutational analysis of a membrane protein. Annu Rev Genet 1990; 24:133-170.
-
(1990)
Annu Rev Genet
, vol.24
, pp. 133-170
-
-
Hobbs, H.H.1
Russell, D.W.2
Brown, M.S.3
Goldstein, J.L.4
-
25
-
-
84875055351
-
The effect of LDLR-negative genotype on CT coronary atheroscle rosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia
-
Ten Kate GJ, Neefjes LA, Dedic A, et al. The effect of LDLR-negative genotype on CT coronary atheroscle rosis in asymptomatic statin treated patients with heterozygous familial hypercholesterolemia. Atherosclerosis 2013; 227: 334-341.
-
(2013)
Atherosclerosis
, vol.227
, pp. 334-341
-
-
Ten Kate, G.J.1
Neefjes, L.A.2
Dedic, A.3
-
26
-
-
77949485460
-
Mipomersen, an apolipop rotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial
-
Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipop rotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: A randomised, double-blind, placebo-controlled trial. Lancet 2010; 375:998-1006.
-
(2010)
Lancet
, vol.375
, pp. 998-1006
-
-
Raal, F.J.1
Santos, R.D.2
Blom, D.J.3
-
27
-
-
84868518061
-
Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: Results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease
-
Stein EA, Dufour R, Gagne C, et al. Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: Results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safe ty as add-on therapy in patients with coronary artery disease. Circulation 2012; 126:2283-2292.
-
(2012)
Circulation
, vol.126
, pp. 2283-2292
-
-
Stein, E.A.1
Dufour, R.2
Gagne, C.3
-
29
-
-
84871945617
-
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in pati ents with homozygous familial hypercholesterolaemia: A single-arm, open-label, phase 3 study
-
Cuchel M, Meagher EA, du Toit Theron H, et al. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in pati ents with homozygous familial hypercholesterolaemia: A single-arm, open-label, phase 3 study. Lancet 2013; 381:40-46.
-
(2013)
Lancet
, vol.381
, pp. 40-46
-
-
Cuchel, M.1
Meagher, E.A.2
Toit, D.3
Theron, H.4
-
30
-
-
84863494422
-
Effect of a monoclonal antibody to PCSK9 , REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
-
Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9 , REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial. Lancet 2012; 380 :29-36.
-
(2012)
Lancet
, vol.380
, pp. 29-36
-
-
Stein, E.A.1
Gipe, D.2
Bergeron, J.3
-
31
-
-
84869220345
-
Low-density lipoprotein cholesterollowering effects ofAMG145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial
-
Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterollowering effects ofAMG145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation 2012; 126:2408-2417.
-
(2012)
Circulation
, vol.126
, pp. 2408-2417
-
-
Raal, F.1
Scott, R.2
Somaratne, R.3
-
32
-
-
84888294490
-
Low-density lipoprotein cholesterol reduction by inhibition of PCSK9
-
. Stein EA. Low-density lipoprotein cholesterol reduction by inhibition of PCSK9. Curr Opin Lipidol 2013; 24:510-517.
-
(2013)
Curr Opin Lipidol
, vol.24
, pp. 510-517
-
-
Stein, E.A.1
-
33
-
-
84892679366
-
Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial
-
Koren MJ,Giugliano RP,Raal FJ,et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial. Circulation, 2014, 129, 234-243.
-
(2014)
Circulation
, vol.129
, pp. 234-243
-
-
Koren, M.J.1
Giugliano, R.P.2
Raal, F.J.3
-
34
-
-
84887164358
-
Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia
-
Stein EA, Honarpour N, Wasserman SM, et al. Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation 2013; 128:21 13-2120.
-
(2013)
Circulation
, vol.128
, pp. 2113-2120
-
-
Stein, E.A.1
Honarpour, N.2
Wasserman, S.M.3
|