Molecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA) results in upstaging of a quarter of patients in a prospective, European, multicentre study

British Journal of Cancer

Volumn 110, Issue 10, 2014, Pages 2544-2550

  Croner, R S ^a   Geppert, C I ^a   Bader, F G ^b   Nitsche, U ^b   Spath C ^b   Rosenberg, R ^c   Zettl, A ^d   Matias Guiu, X ^e   Tarragona, J ^e   Guller U ^f,g   Sturzl M ^a   Zuber, M ^f  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Cantonal Hospital Baden   (Switzerland)

^d Viollier AG   (Switzerland)

^e HOSPITAL UNIVERSITARI ARNAU DE VILANOVA   (Spain)

^f Hospital Universitari Arnau de Vilanova University of Lleida IRBLLEIDA ^*  (Switzerland)

^g UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; COLON CARCINOMA; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NUCLEIC ACID AMPLIFICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; SAMPLING BIAS;

ADENOCARCINOMA; ADULT; AGED; CHEMOTHERAPY, ADJUVANT; COLECTOMY; COLONIC NEOPLASMS; EUROPE; FALSE NEGATIVE REACTIONS; FEMALE; HUMANS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASM STAGING; NUCLEIC ACID AMPLIFICATION TECHNIQUES; PATIENT SELECTION; PROSPECTIVE STUDIES; RNA, MESSENGER; RNA, NEOPLASM; STAINING AND LABELING; YOUNG ADULT;

EID: 84900561809     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/bjc.2014.170     Document Type: Article

References (28)

1. Armitage P (1955) Trends for linear trends in proportions and frequencies. Biometrics 11: 375-386.
2. Baloch ZW, Abraham S, Roberts S, LiVolsi VA (1999) Differential expression of cytokeratins in follicular variant of papillary carcinoma: An immunohistochemical study and its diagnostic u tility. Hum Pathol 30: 1166-1171.
3. Croner RS, Fortsch T, Bruckl WM, Rodel F, Rodel C, Papadopoulos T, Brabletz T, Kirchner T, Sachs M, Behrens J, Klein-Hitpass L, Sturzl M, Hoh enberger W, Lausen B (2008) Molecular signature for lymphatic metastasis in colorectal carcinomas. Ann Surg 247: 803-810.
4. Croner RS, Merkel S, Papadopoulos T, Schellerer V, Hohenberger W, Goehl J (2009) Multivisceral resection for colon carcinoma. Dis Colon Rectum 52: 1381-1386.
5. Croner RS, Schellerer V, Demund H, Schildberg C, Papadopulos T, Naschberger E, Sturzl M, Matzel KE, Hohenberger W, Schlabrakowski A (2010) One step nucleic acid amplification (OSNA)-A new method for lymph n ode staging in colorectal carcinomas. J Transl Med 8: 83.
6. Cserni G (2012) Intraoperative analysis of sentinel lymph nodes in breast cancer by one-step nucleic acid amplification. J Clin Pathol 65: 193-199.
7. Davies M, Arumugam PJ, Shah VI, Watkins A, Roger Morgan A, Carr ND, Beynon J (2008) The clinical significance of lymph node micrometastasis in stage I and stage II colorectal cancer. Clin Transl Oncol 1 0: 175-179.
8. Gray RG, Quirke P, Handley K, Lopatin M, Magill L, Baehner FL, Beaumont C, Clark-Langone KM, Yoshizawa CN, Lee M, Watson D, Shak S, Kerr DJ (2011) Validation study of a quantitative multigene reverse transcriptasepolymerase chai n reaction assay for assessment of recurrence risk in patients with stage II colon cancer. J Clin Oncol 29: 4611-4619.
9. Guller U, Zettl A, Worni M, Langer I, Cabalzar-Wondberg D, Viehl CT, Demartines N, Zuber M (2012) Molecular investigation of lymph nodes in colon cancer patients using one-step nucleic acid amplification (OSNA): A new road to better staging Cancer 118(24): 6039-6045.
10. Iddings D, Ahmad A, Elashoff D, Bilchik A (2006) The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: A meta-analysis. Ann Surg Oncol 13: 1386-1392.
11. Kennedy RD, Bylesj o M, Kerr P, Davison T, Black JM, Kay EW, Holt RJ, Proutski V, Ahdesmaki M, Farztdinov V, Goffard N, Hey P, McDyer F, Mulligan K, Mussen J, O?Brien E, Oliver G, Walker SM, Mulligan JM, Wilson C, Winter A, O?Donoghue D, Mulcahy H, O?Sullivan J, Sheahan K, Hyland J, Dhir R, Bathe OF, Winqvist O, Manne U, Shanmugam C, Ramaswamy S, Leon EJ, Smith Jr. WI, McDermott U, Wilson RH, Longley D, Marshall J, Cummins R, Sargent DJ, Johnston PG, Harkin DP (2011) Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue. J Clin Onc ol 29: 4620-4626.
12. Langheinrich MC, Schellerer V, Perrakis A, Lohmuller C, Schildberg C, Naschberger E, Sturzl M, Hohenberger W, Croner RS (2012) Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract. Int J Clin Exp Pathol 5: 614-623.
13. Lee JK, Delaney CP, Lipman JM (2012) Current state of the art in laparoscopic colorectal surgery for cancer: Update on the multi-centric international trials. Ann Surg Innov Res 6: 5.
14. Maak M, Simon I, Nitsche U, Roepman P, Snel M, Glas AM, Schuster T, Keller G, Zeestraten E, Goossens I, Janssen KP, Friess H, Rosenberg R (2013) Independent validation of a prognostic genomic signature (ColoPrint) for patients with Stage II colon cancer. Ann Surg 257: 1053-1058.
15. Merkel S, Mansmann U, Papadopoulos T, Wittekind C, Hohenberger W, Hermanek P (2001a ) The prognostic inhomogeneity of colorectal carcinomas Stage III: A proposal for subdivision of Stage III. Cancer 92: 2754-2759.
16. Merkel S Mansmann U Siassi M Papadopoulos T Hohenberger W Hermanek P 2001b The prognostic inhomogeneity in pT3 rectal carcinomas Int J Colorectal Dis 16 298-304
17. Meyer A, Merkel S, Bruckl W, Schellerer V, Schil dberg C, Campean V, Hohenberger W, Croner RS (2009) Cdc2 as prognostic marker in stage UICC II colon carcinomas. Eur J Cancer 45: 1466-1473.
18. Nitsche U, Rosenberg R, Balmert A, Schuster T, Slotta-Huspenina J, Herrmann P, Bader FG, Friess H, Schlag PM, Stein U, Janssen KP (2012) Integrative marker analysis allows risk assessment for metastasis in stage II colon cancer. Ann Surg 256: 763-771.
19. Rosenberg R, Hoos A, Mueller J, Baier P, Stricker D, Werner M, Nekarda H, Siewert JR (2002) Prognostic significance of cytokeratin-20 reverse transcriptase polymerase chain reaction in lymph nodes of node-negat ive colorectal cancer patients. J Clin Oncol 20: 1049-1055.
20. Salazar R, Roepman P, Capella G, Moreno V, Simon I, Dreezen C, Lopez-Doriga A, Santos C, Marijnen C, Westerga J, Bruin S, Kerr D, Kuppen P, Van De Velde C, Morreau H, Van Velthuysen L, Glas AM, Van?t Veer LJ, Tollenaar R (2011) Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol 29: 17-24.
21. Sargent D, Sobrero A, Grothey A, O?Connell MJ, Buyse M, Andre T, Zheng Y, Green E, Labianca R, O?Callaghan C, Seitz JF, Francini G, Haller D, Yothers G, Goldberg R, De Gramont A (2009) Evidence for cure by adjuvant therapy in colon cancer: Observations based on individual patient data from 20,898 patients on 18 randomized trials. J Clin Oncol 27: 872-877.
22. SAS Institute Inc. (2010a) SAS/STAT 922 User?s Guide. SAS Proprietary Software 9.2. Cary, NC, USA.
23. SAS Institute Inc. (2010b) SAS/STAT 9.2 User?s Guide: Introduction to Statistical Modeling with SAS/STAT Software. SAS Proprietary Software 9.2. Cary, NC, USA.
24. Tsujimoto M, Nakabayashi K, Yoshidome K, Kaneko T, Iwase T, Akiyama F, Kato Y, Tsuda H, Ueda S, Sato K, Tamaki Y, Noguchi S, Kataoka TR, Nakajima H, Komoike Y, Inaji H, Tsugawa K, Suzuki K, Nakamura S, Daitoh M, Otomo Y, Matsuura N (2007) One-step nucleic acid amplification for intraoperative detection of lymph node metastasis in breast cancer patients. Clin Cancer Res 13: 4807-4816.
25. Uen YH, Lin SR, Wu DC, Su YC, Wu JY, Cheng TL, Chi CW, Wang JY (2007) Prognostic significance of multiple molecular markers for patients with stage II colorectal cancer undergoing curative resection. Ann Surg 246: 1040-1046.
26. West NP, Hohenberger W, Weber K, Perrakis A, Finan PJ, Quirke P (2010) Complete mesocolic excision with central vascular ligation produces an oncologically superior specimen compared with standard surgery for carcinoma of the colon. J Clin Oncol 28: 272-278.
27. Yamamoto H, Sekimoto M, Oya M, Yamamoto N, Konishi F, Sasaki J, Yamada S, Taniyama K, Tominaga H, Tsujimoto M, Akamatsu H, Yanagisawa A, Sakakura C, Kat o Y, Matsuura N (2011) OSNA-based novel molecular testing for lymph node metastases in colorectal cancer patients: Results from a multicenter clinical performance study in Japan. Ann Surg Oncol 18: 1891-1898.
28. Yamamoto N, Daito M, Hiyama K, Ding J, Nakabayashi K, Otomo Y, Tsujimoto M, Matsuura N, Kato Y (2013) An optimal mRNA marker for OSNA (One-step Nucleic Acid Amplification) based lymph node metastasis detection in colorectal cancer patients. Jpn J Clin Oncol 43: 264-270.