메뉴 건너뛰기




Volumn 306, Issue 10, 2014, Pages

Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin

Author keywords

Blood flow restriction exercise; Fractional synthetic rate; Mammalian target of rapamycin; Mammalian target of rapamycin complex 1; Rapamycin

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MUSCLE PROTEIN; RAPAMYCIN; SERINE; THREONINE;

EID: 84900561233     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00600.2013     Document Type: Article
Times cited : (92)

References (40)
  • 1
    • 33646425305 scopus 로고    scopus 로고
    • Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training
    • Abe T, Kearns CF, Sato Y. Muscle size and strength are increased following walk training with restricted venous blood flow from the leg muscle, Kaatsu-walk training. J Appl Physiol 100: 1460-1466, 2006.
    • (2006) J Appl Physiol , vol.100 , pp. 1460-1466
    • Abe, T.1    Kearns, C.F.2    Sato, Y.3
  • 2
    • 84862163587 scopus 로고    scopus 로고
    • Exercise intensity and muscle hypertrophy in blood flow-restricted limbs and non-restricted muscles: A brief review
    • Abe T, Loenneke JP, Fahs CA, Rossow LM, Thiebaud RS, Bemben MG. Exercise intensity and muscle hypertrophy in blood flow-restricted limbs and non-restricted muscles: a brief review. Clin Physiol Funct Imaging 32: 247-252, 2012.
    • (2012) Clin Physiol Funct Imaging , vol.32 , pp. 247-252
    • Abe, T.1    Loenneke, J.P.2    Fahs, C.A.3    Rossow, L.M.4    Thiebaud, R.S.5    Bemben, M.G.6
  • 3
    • 77952694516 scopus 로고    scopus 로고
    • Effects of low-intensity walk training with restricted leg blood flow on muscle strength and aerobic capacity in older adults
    • Abe T, Sakamaki M, Fujita S, Ozaki H, Sugaya M, Sato Y, Nakajima T. Effects of low-intensity walk training with restricted leg blood flow on muscle strength and aerobic capacity in older adults. J Geriatr Phys Ther 33: 34-40, 2010.
    • (2010) J Geriatr Phys Ther , vol.33 , pp. 34-40
    • Abe, T.1    Sakamaki, M.2    Fujita, S.3    Ozaki, H.4    Sugaya, M.5    Sato, Y.6    Nakajima, T.7
  • 6
    • 0026892585 scopus 로고
    • The determination of low d5-phenylalanine enrichment (0.002-0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spectrometry
    • Calder AG, Anderson SE, Grant I, McNurlan MA, Garlick PJ. The determination of low d5-phenylalanine enrichment (0.002-0.09 atom percent excess), after conversion to phenylethylamine, in relation to protein turnover studies by gas chromatography/electron ionization mass spectrometry. Rapid Commun Mass Spectrom 6: 421-424, 1992.
    • (1992) Rapid Commun Mass Spectrom , vol.6 , pp. 421-424
    • Calder, A.G.1    Anderson, S.E.2    Grant, I.3    McNurlan, M.A.4    Garlick, P.J.5
  • 9
    • 33749351995 scopus 로고    scopus 로고
    • Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle
    • Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E, Rasmussen BB. Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576: 613-624, 2006.
    • (2006) J Physiol , vol.576 , pp. 613-624
    • Dreyer, H.C.1    Fujita, S.2    Cadenas, J.G.3    Chinkes, D.L.4    Volpi, E.5    Rasmussen, B.B.6
  • 10
    • 66149097065 scopus 로고    scopus 로고
    • Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling
    • Drummond MJ, Dreyer HC, Fry CS, Glynn EL, Rasmussen BB. Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol 106: 1374-1384, 2009.
    • (2009) J Appl Physiol , vol.106 , pp. 1374-1384
    • Drummond, M.J.1    Dreyer, H.C.2    Fry, C.S.3    Glynn, E.L.4    Rasmussen, B.B.5
  • 13
    • 77954219956 scopus 로고    scopus 로고
    • Short-term resistance training with blood flow restriction enhances microvascular filtration capacity of human calf muscles
    • Evans C, Vance S, Brown M. Short-term resistance training with blood flow restriction enhances microvascular filtration capacity of human calf muscles. J Sports Sci 28: 999-1007, 2010.
    • (2010) J Sports Sci , vol.28 , pp. 999-1007
    • Evans, C.1    Vance, S.2    Brown, M.3
  • 14
    • 68949118382 scopus 로고    scopus 로고
    • Evidence that mechanosensors with distinct biomechanical properties allow for specificity in mechanotransduction
    • Frey JW, Farley EE, O'Neil TK, Burkholder TJ, Hornberger TA. Evidence that mechanosensors with distinct biomechanical properties allow for specificity in mechanotransduction. Biophys J 97: 347-356, 2009.
    • (2009) Biophys J , vol.97 , pp. 347-356
    • Frey, J.W.1    Farley, E.E.2    O'Neil, T.K.3    Burkholder, T.J.4    Hornberger, T.A.5
  • 18
    • 34548463369 scopus 로고    scopus 로고
    • Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis
    • Fujita S, Abe T, Drummond MJ, Cadenas JG, Dreyer HC, Sato Y, Volpi E, Rasmussen BB. Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol 103: 903-910, 2007.
    • (2007) J Appl Physiol , vol.103 , pp. 903-910
    • Fujita, S.1    Abe, T.2    Drummond, M.J.3    Cadenas, J.G.4    Dreyer, H.C.5    Sato, Y.6    Volpi, E.7    Rasmussen, B.B.8
  • 21
    • 2942754280 scopus 로고    scopus 로고
    • Mechanotransduction and the regulation of protein synthesis in skeletal muscle
    • Hornberger TA, Esser KA. Mechanotransduction and the regulation of protein synthesis in skeletal muscle. Proc Nutr Soc 63: 331-335, 2004.
    • (2004) Proc Nutr Soc , vol.63 , pp. 331-335
    • Hornberger, T.A.1    Esser, K.A.2
  • 23
    • 14844302667 scopus 로고    scopus 로고
    • Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner
    • Kubica N, Bolster DR, Farrell PA, Kimball SR, Jefferson LS. Resistance exercise increases muscle protein synthesis and translation of eukaryotic initiation factor 2Bepsilon mRNA in a mammalian target of rapamycin-dependent manner. J Biol Chem 280: 7570-7580, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 7570-7580
    • Kubica, N.1    Bolster, D.R.2    Farrell, P.A.3    Kimball, S.R.4    Jefferson, L.S.5
  • 24
    • 84896692038 scopus 로고    scopus 로고
    • Rapamycin: One Drug, Many Effects
    • Li J, Kim SG, Blenis J. Rapamycin: One Drug, Many Effects. Cell Metab 19: 373-379, 2014.
    • (2014) Cell Metab , vol.19 , pp. 373-379
    • Li, J.1    Kim, S.G.2    Blenis, J.3
  • 27
    • 84865581170 scopus 로고    scopus 로고
    • Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction
    • Nielsen JL, Aagaard P, Bech RD, Nygaard T, Hvid LG, Wernbom M, Suetta C, Frandsen U. Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood flow restriction. J Physiol 590: 4351-4361, 2012.
    • (2012) J Physiol , vol.590 , pp. 4351-4361
    • Nielsen, J.L.1    Aagaard, P.2    Bech, R.D.3    Nygaard, T.4    Hvid, L.G.5    Wernbom, M.6    Suetta, C.7    Frandsen, U.8
  • 28
    • 76749106445 scopus 로고    scopus 로고
    • Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women
    • Patterson SD, Ferguson RA. Increase in calf post-occlusive blood flow and strength following short-term resistance exercise training with blood flow restriction in young women. Eur J Appl Physiol 108: 1025-1033, 2010.
    • (2010) Eur J Appl Physiol , vol.108 , pp. 1025-1033
    • Patterson, S.D.1    Ferguson, R.A.2
  • 29
    • 84878538610 scopus 로고    scopus 로고
    • Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men
    • Patterson SD, Leggate M, Nimmo MA, Ferguson RA. Circulating hormone and cytokine response to low-load resistance training with blood flow restriction in older men. Eur J Appl Physiol 113: 713-719, 2013.
    • (2013) Eur J Appl Physiol , vol.113 , pp. 713-719
    • Patterson, S.D.1    Leggate, M.2    Nimmo, M.A.3    Ferguson, R.A.4
  • 31
    • 0033923607 scopus 로고    scopus 로고
    • Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans
    • Takarada Y, Takazawa H, Sato Y, Takebayashi S, Tanaka Y, Ishii N. Effects of resistance exercise combined with moderate vascular occlusion on muscular function in humans. J Appl Physiol 88: 2097-2106, 2000.
    • (2000) J Appl Physiol , vol.88 , pp. 2097-2106
    • Takarada, Y.1    Takazawa, H.2    Sato, Y.3    Takebayashi, S.4    Tanaka, Y.5    Ishii, N.6
  • 32
    • 56049083751 scopus 로고    scopus 로고
    • Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics
    • Volpi E, Chinkes DL, Rasmussen BB. Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics. Am J Physiol Endocrinol Metab 295: E959-E963, 2008.
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Volpi, E.1    Chinkes, D.L.2    Rasmussen, B.B.3
  • 33
    • 0032080924 scopus 로고    scopus 로고
    • Exogenous amino acids stimulate net muscle protein synthesis in the elderly
    • Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest 101: 2000-2007, 1998.
    • (1998) J Clin Invest , vol.101 , pp. 2000-2007
    • Volpi, E.1    Ferrando, A.A.2    Yeckel, C.W.3    Tipton, K.D.4    Wolfe, R.R.5
  • 34
    • 0042068305 scopus 로고    scopus 로고
    • Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
    • Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr 78: 250-258, 2003.
    • (2003) Am J Clin Nutr , vol.78 , pp. 250-258
    • Volpi, E.1    Kobayashi, H.2    Sheffield-Moore, M.3    Mittendorfer, B.4    Wolfe, R.R.5
  • 35
    • 84890265315 scopus 로고    scopus 로고
    • Acute low-load resistance exercise with and without blood flow restriction increased protein signalling and number of satellite cells in human skeletal muscle
    • Wernbom M, Apro W, Paulsen G, Nilsen TS, Blomstrand E, Raastad T. Acute low-load resistance exercise with and without blood flow restriction increased protein signalling and number of satellite cells in human skeletal muscle. Eur J Appl Physiol 113: 2953-2965, 2013.
    • (2013) Eur J Appl Physiol , vol.113 , pp. 2953-2965
    • Wernbom, M.1    Apro, W.2    Paulsen, G.3    Nilsen, T.S.4    Blomstrand, E.5    Raastad, T.6
  • 36
    • 70449334446 scopus 로고    scopus 로고
    • Acute effects of blood flow restriction on muscle activity and endurance during fatiguing dynamic knee extensions at low load
    • Wernbom M, Jarrebring R, Andreasson MA, Augustsson J. Acute effects of blood flow restriction on muscle activity and endurance during fatiguing dynamic knee extensions at low load. J Strength Cond Res 23: 2389-2395, 2009.
    • (2009) J Strength Cond Res , vol.23 , pp. 2389-2395
    • Wernbom, M.1    Jarrebring, R.2    Andreasson, M.A.3    Augustsson, J.4
  • 38
    • 77955783936 scopus 로고    scopus 로고
    • Effects of lowintensity bench press training with restricted arm muscle blood flow on chest muscle hypertrophy: A pilot study
    • Yasuda T, Fujita S, Ogasawara R, Sato Y, Abe T. Effects of lowintensity bench press training with restricted arm muscle blood flow on chest muscle hypertrophy: a pilot study. Clin Physiol Funct Imaging 30: 338-343, 2010.
    • (2010) Clin Physiol Funct Imaging , vol.30 , pp. 338-343
    • Yasuda, T.1    Fujita, S.2    Ogasawara, R.3    Sato, Y.4    Abe, T.5
  • 39
    • 77952305988 scopus 로고    scopus 로고
    • Effects of low-intensity resistance exercise with vascular occlusion on physical function in healthy elderly people
    • Yokokawa Y, Hongo M, Urayama H, Nishimura T, Kai I. Effects of low-intensity resistance exercise with vascular occlusion on physical function in healthy elderly people. Biosci Trends 2: 117-123, 2008.
    • (2008) Biosci Trends , vol.2 , pp. 117-123
    • Yokokawa, Y.1    Hongo, M.2    Urayama, H.3    Nishimura, T.4    Kai, I.5
  • 40
    • 33745337968 scopus 로고    scopus 로고
    • An isotopic method for measurement of muscle protein fractional breakdown rate in vivo
    • Zhang XJ, Chinkes DL, Sakurai Y, Wolfe RR. An isotopic method for measurement of muscle protein fractional breakdown rate in vivo. Am J Physiol Endocrinol Metab 270: E759-E767, 1996.
    • (1996) Am J Physiol Endocrinol Metab , vol.270
    • Zhang, X.J.1    Chinkes, D.L.2    Sakurai, Y.3    Wolfe, R.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.