A microfluidic chip capable of switching W/O droplets to vertical laminar flow for electrochemical detection of droplet contents

Analytica Chimica Acta

Volumn 828, Issue , 2014, Pages 70-79

  Lin, Xingyu ^a   Hu, Xianqiao ^a   Bai, Zeqing ^a   He, Qiaohong ^a   Chen, Hengwu ^a   Yan, Yangzhi ^b   Ding, Zhihua ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

Droplets; Electrochemical detection; Enzyme kinetics; Glucose; Microfluidic chip; Vertical laminar flow

Indexed keywords

ENZYME KINETICS; FLUIDIC DEVICES; GLUCOSE; LAMINAR FLOW; MICROPROCESSOR CHIPS; RIVERS; SILICONES;

AMPEROMETRIC DETECTION; CAPACITIVE CURRENTS; DROPLET-BASED MICROFLUIDICS; ELECTROCHEMICAL DETECTION; LIMIT OF DETECTION; MICROFLUIDIC CHIP; SENSING ELECTRODE; STEADY-STATE CURRENTS;

DROPS;

CHEMICAL COMPOUND; DIMETICONE; FAT DROPLET; GLASS; OCTADECYLTRICHLOROSILANE; OIL; UNCLASSIFIED DRUG; WATER;

AMPEROMETRY; ANALYTICAL EQUIPMENT; AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; ELECTROCHEMICAL DETECTION; ELECTRODE; HYDROPHOBICITY; LAMINAR FLOW; LIMIT OF DETECTION; LIPID TRANSPORT; MICROCHIP ANALYSIS; MICROFLUIDICS; POLYDIMETHYLSILOXANE GLASS CHIP; PRIORITY JOURNAL; SURFACE PROPERTY; WATER FLOW; WATER TRANSPORT; WETTABILITY;

EID: 84900546248     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2014.04.023     Document Type: Article

References (37)

1. Song H., Chen D.L., Ismagilov R.F. Reactions in droplets in microfluidic channels. Angewandte Chemie International Edition 2006, 45:7336-7356.
2. Teh S.Y., Lin R., Hung L.H., Lee A.P. Droplet microfluidics. Lab on a Chip 2008, 8:198-220.
3. Pompano R.R., Liu W.S., Du W.B., Ismagilov R.F. Microfluidics using spatially defined arrays of droplets in one, two, and three dimensions. Annual Reviews of Analytical Chemistry 2011, 4:59-81.
4. Theberge A.B., Courtois F., Yolanda S., Fischlechner M., Abell C., Hollfelder F., Huck W.T.S. Microdroplets in microfluidics: an evolving platform for discoveries in chemistry and biology. Angewandte Chemie International Edition 2010, 49:5846-5868.
5. Huebner A., Sharma S., Srisa-Art M., Hollfelder F., Edel J.B., deMello A.J. Microdroplets: a sea of applications. Lab on a Chip 2008, 8:1244-1254.
6. I Solvas X.C., deMello A. Droplet microfluidics: recent developments and future applications. Chemical Communications 2011, 47:1936-1942.
7. Guo M.T., Rotem A., Heyman J.A., Weitz D.A. Droplet microfluidics for high-throughput biological assays. Lab on a Chip 2012, 12:2146-2155.
8. Schneider T., Kreutz J., Chiu D.T. The potential impact of droplet microfluidics in biology. Analytical Chemistry 2013, 85:3476-3482.
9. Shui L.L., Eijkel J.C.T., Van den Berg A. Multiphase flow in microfluidic systems - control and applications of droplets and interfaces. Advances in Colloid and Interface Science 2007, 133:35-49.
10. Zhu Y., Fang Q. Analytical detection techniques for droplet microfluidics - a review. Analytica Chimica Acta 2013, 787:24-35.
11. Woolley A.T., Lao K., Glazer A.N., Mathies R.A. Capillary electrophoresis chips with integrated electrochemical detection. Analytical Chemistry 1998, 70:684-688.
12. Vandaveer W.R., Pasas-Farmer S.A., Fischer D.J., Frankenfeld C.N., Lunte S.M. Recent developments in electrochemical detection for microchip capillary electrophoresis. Electrophoresis 2004, 25:3528-3549.
13. Xu J.J., Wang A.J., Chen H.Y. Electrochemical detection modes for microchip capillary electrophoresis. Trends in Analytical Chemistry 2007, 26:125-132.
14. Johnson A.S., Selimovic A., Martin R.S. Microchip-based electrochemical detection for monitoring cellular systems. Analytical and Bioanalytical Chemistry 2013, 405:3013-3020.
15. Dungchai W., Chailapakul O., Henry C.S. Electrochemical detection for paper-based microfluidics. Analytical Chemistry 2009, 81:5821-5826.
16. Liu S.J., Gu Y.F., Le Roux R.B., Matthews R.M., Bratton D., Yunus K., Fisher A.C., Huck W.T.S. The electrochemical detection of droplets in microfluidic devices. Lab on a Chip 2008, 8:1937-1942.
17. Han Z.Y., Li W.T., Huang Y.Y., Zheng B. Measuring rapid enzymatic kinetics by electrochemical method in droplet-based microfluidic devices with pneumatic valves. Analytical Chemistry 2009, 81:5840-5845.
18. Gu S.Q., Lu Y.L., Ding Y.P., Li L., Zhang F.F., Wu Q.S. Droplet-based microfluidics for dose-response assay of enzyme inhibitors by electrochemical method. Analytica Chimica Acta 2013, 796:68-74.
19. Hu X.Q. Doctoral Thesis 2013, Zhejiang University.
20. Liu H., Crooks R.M. Highly reproducible chronoamperometric analysis in microdroplets. Lab on a Chip 2013, 13:1364-1370.
21. Han Z.Y., Chang Y.Y., Au S.W.N., Zheng B. Measuring rapid kinetics by a potentiometric method in droplet-based microfluidic devices. Chemical Communications 2012, 48:1601-1603.
22. Filla L.A., Kirkpatrick D.C., Martin R.S. Use of a corona discharge to selectively pattern a hydrophilic/hydrophobic interface for integrating segmented flow with microchip electrophoresis and electrochemical detection. Analytical Chemistry 2011, 83:5996-6003.
23. Sassa F., Laghzali H., Fukuda J., Suzuki H. Coulometric detection of components in liquid plugs by microfabricated flow channel and electrode structures. Analytical Chemistry 2010, 82:8725-8732.
24. Itoh D., Sassa F., Nishi T., Kani Y., Murata M., Suzuki H. Droplet-based microfluidic sensing system for rapid fish freshness determination. Sensors and Actuator B: Chemical 2012, 171-172:619-626.
25. Aota A., Mawatari K., Kitamori T. Parallel multiphase microflows: fundamental physics, stabilization methods and applications. Lab on a Chip 2009, 9:2470-2476.
26. Bai Z.Q., He Q.H., Huang S.S., Hu X.Q., Chen H.W. Preparation of hybrid soda-lime/quartz glass chips with wettability-patterned channels for manipulation of flow profiles in droplet-based analytical systems. Analytica Chimica Acta 2013, 767:97-103.
27. Logtenberg H., Lopez-Martinez M.J., Feringa B.L., Browne W.R., Verpoorte E. Multiple flow profiles for two-phase flow in single microfluidic channels through site-selective channel coating. Lab on a Chip 2011, 11:2030-2034.
28. Kuban P., Berg J., Dasgupta P.K. Vertically stratified flows in microchannels. Computational simulations and applications to solvent extraction and ion exchange. Analytical Chemistry 2003, 75:3549-3556.
29. Aota A., Nonaka M., Hibara A., Kitamori T. Countercurrent laminar microflow for highly efficient solvent extraction. Angewandte Chemie International Edition 2007, 46:878-880.
30. Kim J.H., Kang C.J., Jeon D., Kim Y.S. A disposable capillary electrophoresis microchip with an indium tin oxide decoupler/amperometric detector. Microelectronic Engineering 2005, 78-79:563-570.
31. Wang Y., He Q.H., Dong Y.Y., Chen H.W. In-channel modification of biosensor electrodes integrated on a polycarbonate microfluidic chip for micro flow-injection amperometric determination of glucose. Sensors and Actuator B: Chemical 2010, 145.
32. He P., Greenway G., Haswell S.J. Development of enzyme immobilized monolith micro-reactors integrated with microfluidic electrochemical cell for the evaluation of enzyme kinetics. Microfluidics and Nanofluidics 2010, 8:565-573.
33. Hao Z.X., Chen H.W., Zhu X.Y., Li J.M., Liu C. Modification of amorphous poly (ethylene terephthalate) surface by UV light and plasma for fabrication of an electrophoresis chip with an integrated gold microelectrode. Journal of Chromatography A 2008, 1209:246-252.
34. Kaneda S., Ono K., Fukuba T., Nojima T., Yamamoto T. Modification of the glass surface property in PDMS-glass hybrid microfluidic devices. Analytical Sciences 2012, 28:39-44.
35. Illa X., Ordeig O., Snakenborg D., Romano-Rodriguez A., Compton R.G., Kutter J.P. A cyclo olefin polymer microfluidic chip with integrated gold microelectrodes for aqueous and non-aqueous electrochemistry. Lab on a Chip 2010, 10:1254-1261.
36. Nord L., Karlberg B. Extraction based on the flow-injection principle part 6. Film formation and dispersion in liquid-liquid segmented flow extraction systems. Analytica Chimica Acta 1984, 164:233-249.
37. Wang C., Ye D.K., Wang Y.Y., Lu T., Xia X.H. Insights into the "free state'' enzyme reaction kinetics in nanoconfinement. Lab on a Chip 2013, 13:1546-1553.