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Volumn 31, Issue 5, 2014, Pages 395-404

Intravitreal aflibercept (Eylea®): A review of its use in patients with macular oedema secondary to central retinal vein occlusion

Author keywords

[No Author keywords available]

Indexed keywords

AFLIBERCEPT; HYBRID PROTEIN; VASCULOTROPIN RECEPTOR;

EID: 84900531920     PISSN: 1170229X     EISSN: 11791969     Source Type: Journal    
DOI: 10.1007/s40266-014-0176-2     Document Type: Review
Times cited : (20)

References (27)
  • 1
    • 84855655264 scopus 로고    scopus 로고
    • The expanding role of vascular endothelial growth factor inhibitors in ophthalmology
    • Stewart MW. The expanding role of vascular endothelial growth factor inhibitors in ophthalmology. Mayo Clin Proc. 2012;87(1):77-88.
    • (2012) Mayo Clin Proc , vol.87 , Issue.1 , pp. 77-88
    • Stewart, M.W.1
  • 2
    • 84867697322 scopus 로고    scopus 로고
    • Potential anti-vascular endothelial growth factor therapies for central retinal vein occlusion
    • Figueroa MS, Contreras I. Potential anti-vascular endothelial growth factor therapies for central retinal vein occlusion. Drugs. 2012;72(16):2063-71.
    • (2012) Drugs , vol.72 , Issue.16 , pp. 2063-2071
    • Figueroa, M.S.1    Contreras, I.2
  • 3
    • 75149172639 scopus 로고    scopus 로고
    • The prevalence of retinal vein occlusion: Pooled data from population studies from the United States, Europe, Asia, and Australia
    • Rogers S, McIntosh RL, Cheung N, et al. The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia. Ophthalmology. 2010;117(2):313-9.
    • (2010) Ophthalmology , vol.117 , Issue.2 , pp. 313-319
    • Rogers, S.1    McIntosh, R.L.2    Cheung, N.3
  • 4
    • 84878498006 scopus 로고    scopus 로고
    • Aflibercept: Newly approved for the treatment of macular edema following central retinal vein occlusion
    • Evoy KE, Abel SR. Aflibercept: newly approved for the treatment of macular edema following central retinal vein occlusion. Ann Pharmacother. 2013;47(6):819-27.
    • (2013) Ann Pharmacother , vol.47 , Issue.6 , pp. 819-827
    • Evoy, K.E.1    Abel, S.R.2
  • 7
    • 84874614309 scopus 로고    scopus 로고
    • Aflibercept for intravitreal injection: In neovascular age-related macular degeneration
    • Frampton JE. Aflibercept for intravitreal injection: in neovascular age-related macular degeneration. Drugs Aging. 2012;29(10):839-46.
    • (2012) Drugs Aging , vol.29 , Issue.10 , pp. 839-846
    • Frampton, J.E.1
  • 8
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: A VEGF blocker with potent antitumor effects
    • Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA. 2002;99(17):11393-8.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.17 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 9
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • Papadopoulos N, Martin J, Ruan Q, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15(2):171-85.
    • (2012) Angiogenesis , vol.15 , Issue.2 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 10
    • 43649083100 scopus 로고    scopus 로고
    • Predicted biological activity of intravitreal VEGF Trap
    • Stewart MW, Rosenfeld PJ. Predicted biological activity of intravitreal VEGF Trap. Br J Ophthalmol. 2008;92(5):667-8.
    • (2008) Br J Ophthalmol , vol.92 , Issue.5 , pp. 667-668
    • Stewart, M.W.1    Rosenfeld, P.J.2
  • 11
    • 84876968687 scopus 로고    scopus 로고
    • The effects of aflibercept on the viability and metabolism of ocular cells in vitro
    • Ammar DA, Mandava N, Kahook MY. The effects of aflibercept on the viability and metabolism of ocular cells in vitro. Retina. 2013;33(5):1056-61.
    • (2013) Retina , vol.33 , Issue.5 , pp. 1056-1061
    • Ammar, D.A.1    Mandava, N.2    Kahook, M.Y.3
  • 12
    • 84879417461 scopus 로고    scopus 로고
    • Comparative toxicity and proliferation testing of aflibercept, bevacizumab and ranibizumab on different ocular cells
    • Schnichels S, Hagemann U, Januschowski K, et al. Comparative toxicity and proliferation testing of aflibercept, bevacizumab and ranibizumab on different ocular cells. Br J Ophthalmol. 2013;97(7):917-23.
    • (2013) Br J Ophthalmol , vol.97 , Issue.7 , pp. 917-923
    • Schnichels, S.1    Hagemann, U.2    Januschowski, K.3
  • 13
    • 0037401890 scopus 로고    scopus 로고
    • VEGF-TRAP(R1R2) suppresses choroidal vascularization and VEGF-induced breakdown of the blood-retinal barrier
    • Saishin Y, Saishin Y, Takahashi K, et al. VEGF-TRAP(R1R2) suppresses choroidal vascularization and VEGF-induced breakdown of the blood-retinal barrier. J Cell Physiol. 2003;195:241-8.
    • (2003) J Cell Physiol , vol.195 , pp. 241-248
    • Saishin, Y.1    Saishin, Y.2    Takahashi, K.3
  • 14
    • 79957986348 scopus 로고    scopus 로고
    • Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration
    • Brown DM, Heier JS, Ciulla T, et al. Primary endpoint results of a phase II study of vascular endothelial growth factor trap-eye in wet age-related macular degeneration. Ophthalmology. 2011;118(6):1089-97.
    • (2011) Ophthalmology , vol.118 , Issue.6 , pp. 1089-1097
    • Brown, D.M.1    Heier, J.S.2    Ciulla, T.3
  • 15
    • 84870256403 scopus 로고    scopus 로고
    • Pharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET/CT
    • Christoforidis JB, Williams MM, Kothandaraman S, et al. Pharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET/CT. Curr Eye Res. 2012;37(12):1171-4.
    • (2012) Curr Eye Res , vol.37 , Issue.12 , pp. 1171-1174
    • Christoforidis, J.B.1    Williams, M.M.2    Kothandaraman, S.3
  • 16
    • 84874647026 scopus 로고    scopus 로고
    • VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6-month results of the phase III GALILEO study
    • Holz FG, Roider J, Ogura Y, et al. VEGF Trap-Eye for macular oedema secondary to central retinal vein occlusion: 6-month results of the phase III GALILEO study. Br J Ophthalmol. 2013;97(3):278-84.
    • (2013) Br J Ophthalmol , vol.97 , Issue.3 , pp. 278-284
    • Holz, F.G.1    Roider, J.2    Ogura, Y.3
  • 17
    • 84891626905 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for macular edema resulting from central retinal vein occlusion: One-year results of the phase 3 GALILEO study
    • Korobelnik JF, Holz FG, Roider J, et al. Intravitreal aflibercept injection for macular edema resulting from central retinal vein occlusion: one-year results of the phase 3 GALILEO study. Ophthalmology. 2014;121:202-8.
    • (2014) Ophthalmology , vol.121 , pp. 202-208
    • Korobelnik, J.F.1    Holz, F.G.2    Roider, J.3
  • 18
    • 84900524690 scopus 로고    scopus 로고
    • Eighteen-month results of the GALILEO study evaluating intravitreal aflibercept injection (IAI) for macular edema secondary to central retinal vein occlusion (CRVO)
    • abstract no. 4516 May Seattle, WA
    • Ogura Y, Korobelnik JF, Roider J, et al. Eighteen-month results of the GALILEO study evaluating intravitreal aflibercept injection (IAI) for macular edema secondary to central retinal vein occlusion (CRVO) [abstract no. 4516]. 2013 Annual Meeting of the Association for Research and Vision in Ophthalmology; 5-9 May 2013; Seattle, WA.
    • (2013) 2013 Annual Meeting of the Association for Research and Vision in Ophthalmology , pp. 5-9
    • Ogura, Y.1    Korobelnik, J.F.2    Roider, J.3
  • 19
    • 84862779327 scopus 로고    scopus 로고
    • Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: Six-month results of the phase 3 COPERNICUS study
    • Boyer D, Heier J, Brown DM, et al. Vascular endothelial growth factor Trap-Eye for macular edema secondary to central retinal vein occlusion: six-month results of the phase 3 COPERNICUS study. Ophthalmology. 2012;119(5):1024-32.
    • (2012) Ophthalmology , vol.119 , Issue.5 , pp. 1024-1032
    • Boyer, D.1    Heier, J.2    Brown, D.M.3
  • 20
    • 84873738185 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study
    • Brown DM, Heier JS, Clark WL, et al. Intravitreal aflibercept injection for macular edema secondary to central retinal vein occlusion: 1-year results from the phase 3 COPERNICUS study. Am J Ophthalmol. 2013;155(3):429-37.
    • (2013) Am J Ophthalmol , vol.155 , Issue.3 , pp. 429-437
    • Brown, D.M.1    Heier, J.S.2    Clark, W.L.3
  • 21
    • 84903819352 scopus 로고    scopus 로고
    • Intravitreal aflibercept injection for macular edema due to central retinal vein occlusion: Two-year results from the COPERNICUS study
    • Mar. doi:10.1016/j.ophtha.2014.01.027
    • Heier JS, Clark WL, Boyer DS, et al. Intravitreal aflibercept injection for macular edema due to central retinal vein occlusion: two-year results from the COPERNICUS study. Ophthalmology. 2014 Mar. doi:10.1016/j.ophtha.2014.01.027.
    • (2014) Ophthalmology
    • Heier, J.S.1    Clark, W.L.2    Boyer, D.S.3
  • 22
    • 84866091781 scopus 로고    scopus 로고
    • Aflibercept (VEGF trap-eye): The newest anti-VEGF drug
    • Stewart MW. Aflibercept (VEGF trap-eye): the newest anti-VEGF drug. Br J Ophthalmol. 2012;96(9):1157-8.
    • (2012) Br J Ophthalmol , vol.96 , Issue.9 , pp. 1157-1158
    • Stewart, M.W.1
  • 23
    • 84860156429 scopus 로고    scopus 로고
    • Biological, preclinical and clinical characteristics of inhibitors of vascular endothelial growth factors
    • Chong V. Biological, preclinical and clinical characteristics of inhibitors of vascular endothelial growth factors. Ophthalmologica. 2012;227(Suppl 1):2-10.
    • (2012) Ophthalmologica , vol.227 , Issue.SUPPL. 1 , pp. 2-10
    • Chong, V.1
  • 25
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • Heier JS, Brown DM, Chong V, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012;119(12):2537-48.
    • (2012) Ophthalmology , vol.119 , Issue.12 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 26
    • 84862817252 scopus 로고    scopus 로고
    • Ranibizumab for macular edema due to retinal vein occlusions: Long-term follow-up in the HORIZON trial
    • Heier JS, Campochiaro PA, Yau L, et al. Ranibizumab for macular edema due to retinal vein occlusions: long-term follow-up in the HORIZON trial. Ophtholmology. 2012;119:802-9.
    • (2012) Ophtholmology , vol.119 , pp. 802-809
    • Heier, J.S.1    Campochiaro, P.A.2    Yau, L.3
  • 27
    • 85081807693 scopus 로고    scopus 로고
    • US National Institutes of Health. ClinicalTrials.gov. Accessed 6 Jan 2014
    • US National Institutes of Health. ClinicalTrials.gov. 2014. http://clinicaltrials.gov/. Accessed 6 Jan 2014.
    • (2014)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.