Early goal-directed therapy in pediatric septic shock: Comparison of outcomes "with" and "without" intermittent superior venacaval oxygen saturation monitoring: A prospective cohort study

Pediatric Critical Care Medicine

Volumn 15, Issue 4, 2014, Pages

  Sankar, Jhuma ^a   Sankar, M Jeeva ^b   Suresh, C P ^a   Dubey, Nandkishore K ^a   Singh, Archana ^a  

^a DR RAM MANOHAR LOHIA HOSPITAL   (India)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Early goal directed therapy; Pediatric Logistic Organ Dysfunction Scores; Septic shock; Therapeutic goals

Indexed keywords

ADOLESCENT; ARTICLE; CATHETER; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HOSPITALIZATION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; ORGAN DYSFUNCTION SCORE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESUSCITATION; RISK FACTOR; SCHOOL CHILD; SCORING SYSTEM; SEPTIC SHOCK; SUPERIOR CAVA VEIN; TREATMENT OUTCOME; VENOUS OXYGEN TENSION; ARTERIAL PRESSURE; ARTIFICIAL VENTILATION; BLOOD; CENTRAL VENOUS CATHETERIZATION; CENTRAL VENOUS PRESSURE; COMPARATIVE STUDY; FLUID THERAPY; HEART RATE; PHYSIOLOGIC MONITORING; SHOCK, SEPTIC; TIME;

CARDIOTONIC AGENT; DOBUTAMINE; DOPAMINE; OXYGEN;

ARTERIAL PRESSURE; CARDIOTONIC AGENTS; CATHETERIZATION, CENTRAL VENOUS; CENTRAL VENOUS PRESSURE; CHILD; CHILD, PRESCHOOL; DOBUTAMINE; DOPAMINE; FEMALE; FLUID THERAPY; HEART RATE; HOSPITAL MORTALITY; HUMANS; INFANT; MALE; MONITORING, PHYSIOLOGIC; OXYGEN; PROSPECTIVE STUDIES; RESPIRATION, ARTIFICIAL; SHOCK, SEPTIC; TIME FACTORS; TREATMENT OUTCOME; VENA CAVA, SUPERIOR;

EID: 84900525676     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0000000000000073     Document Type: Article

References (34)

1. Watson RS, Carcillo JA, Linde-Zwirble WT, et al: The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003; 167:695-701 (Pubitemid 36801744)
2. Wong HR, Cvijanovich N, Wheeler DS, et al: Interleukin-8 as a stratification tool for interventional trials involving pediatric septic shock. Am J Respir Crit Care Med 2008; 178:276-282
3. Jaramillo-Bustamante JC, Marín-Agudelo A, Fernández-Laverde M, et al: Epidemiology of sepsis in pediatric intensive care units: First Colombian multicenter study. Pediatr Crit Care Med 2012; 13:501-508
4. Khan MR, Maheshwari PK, Masood K, et al: Epidemiology and outcome of sepsis in a tertiary care PICU of Pakistan. Indian J Pediatr 2012; 79:1454-1458
5. Thukral A, Lodha R, Irshad M, et al: Performance of Pediatric Risk of Mortality (PRISM), Pediatric Index of Mortality (PIM), and PIM2 in a pediatric intensive care unit in a developing country. Pediatr Crit Care Med 2006; 7:356-361 (Pubitemid 44048280)
6. Sankar J, Chandel A, Dubey NK, et al: Do interventions in an ICU affect the predictive ability of Pediatric Index of Mortality and Pediatric Index of Mortality-2 scores in a tertiary care hospital? Pediatr Crit Care Med 2013; 14:e70-e76
7. Cruz AT, Perry AM, Williams EA, et al: Implementation of goal-directed therapy for children with suspected sepsis in the emergency department. Pediatrics 2011; 127:e758-e766
8. Inwald DP, Tasker RC, Peters MJ, et al; Paediatric Intensive Care Society Study Group (PICS-SG): Emergency management of children with severe sepsis in the United Kingdom: The results of the paediatric intensive care society sepsis audit. Arch Dis Child 2009; 94:348-353
9. Rivers E, Nguyen B, Havstad S, et al; Early Goal-Directed Therapy Collaborative Group: Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345:1368-1377
10. Castellanos-Ortega A, Suberviola B, García-Astudillo LA, et al: Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: Results of a three-year follow- up quasi-experimental study. Crit Care Med 2010; 38:1036-1043
11. Focht A, Jones AE, Lowe TJ: Early goal-directed therapy: Improving mortality and morbidity of sepsis in the emergency department. Jt Comm J Qual Patient Saf 2009; 35:186-191
12. Puskarich MA, Marchick MR, Kline JA, et al: One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: A before and after study. Crit Care 2009; 13:R167
13. Levinson AT, Casserly BP, Levy MM: Reducing mortality in severe sepsis and septic shock. Semin Respir Crit Care Med 2011; 32:195-205
14. Rivers EP, Katranji M, Jaehne KA, et al: Early interventions in severe sepsis and septic shock: A review of the evidence one decade later. Minerva Anestesiol 2012; 78:712-724
15. Dellinger RP, Levy MM, Rhodes A, et al; Surviving Sepsis Campaign Guidelines Committee including The Pediatric Subgroup: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med 2013; 39:165-228
16. Irazuzta J, Sullivan KJ, Garcia PC, et al: Pharmacologic support of infants and children in septic shock. J Pediatr (Rio J) 2007; 83:S36-S45 (Pubitemid 46920391)
17. Carcillo JA, Fields AI; American College of Critical Care Medicine Task Force Committee Members: Clinical practice parameters for hemodynamic support of pediatric and neonatal patients in septic shock. Crit Care Med 2002; 30:1365-1378 (Pubitemid 34620986)
18. Khilnani P, Singhi S, Lodha R, et al: Pediatric sepsis guidelines: Summary for resource-limited countries. Indian J Crit Care Med 2010; 14:41-52
19. de Oliveira CF, de Oliveira DS, Gottschald AF, et al: ACCM/PALS haemodynamic support guidelines for paediatric septic shock: An outcomes comparison with and without monitoring central venous oxygen saturation. Intensive Care Med 2008; 34:1065-1075 (Pubitemid 351903800)
20. Carcillo JA, Davis AL, Zaritsky A: Role of early fluid resuscitation in pediatric septic shock. JAMA 1991; 266:1242-1245
21. Han YY, Carcillo JA, Dragotta MA, et al: Early reversal of pediatric- neonatal septic shock by community physicians is associated with improved outcome. Pediatrics 2003; 112:793-799 (Pubitemid 37248685)
22. Ceneviva G, Paschall JA, Maffei F, et al: Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics 1998; 102:e19
23. Goldstein B, Giroir B, Randolph A; International Consensus Conference on Pediatric Sepsis: International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2-8
24. Mehta RL, Kellum JA, Shah SV, et al; Acute Kidney Injury Network: Acute Kidney Injury Network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007; 11:R31
25. Tripathi MS, Sharma V: Assessment of nutritional status of pre- schoolers in slum areas of Udaipur City. Indian J Public Health 2006; 50:33-34
26. Leteurtre S, Martinot A, Duhamel A, et al: Validation of the Paediatric Logistic Organ Dysfunction (PELOD) score: Prospective, observational, multicentre study. Lancet 2003; 362:192-197 (Pubitemid 36859934)
27. Shann F, Pearson G, Slater A, et al: Paediatric index of mortality (PIM): A mortality prediction model for children in intensive care. Intensive Care Med 1997; 23:201-207 (Pubitemid 27110398)
28. Proulx F, Proulx BB, Lacroix J: Pediatric multiple organ dysfunction syndrome. Intensive Care World 1997; 14:78-82
29. Donnino MW, Nguyen B, Jacobsen G, et al: Cryptic septic shock: A sub-analysis of early, goal-directed therapy. Chest 2003; 124:90S-90b
30. Bateman RM, Walley KR: Microvascular resuscitation as a therapeutic goal in severe sepsis. Crit Care 2005; 9(Suppl 4):S27-32
31. Gunn SR, Fink MP, Wallace B: Equipment review: The success of early goal-directed therapy for septic shock prompts evaluation of current approaches for monitoring the adequacy of resuscitation. Crit Care 2005; 9:349-359 (Pubitemid 41136278)
32. Boulos M, Astiz ME, Barua RS, et al: Impaired mitochondrial function induced by serum from septic shock patients is attenuated by inhibition of nitric oxide synthase and poly(ADP-ribose) synthase. Crit Care Med 2003; 31:353-358 (Pubitemid 36232925)
33. Kern JW, Shoemaker WC: Meta-analysis of hemodynamic optimization in high-risk patients. Crit Care Med 2002; 30:1686-1692 (Pubitemid 34879575)
34. 2 monitoring on sepsis bundle compliance and mortality [abstract]. Chest 2009; 136:21S