Prevalence and characterization of uropathogenic Escherichia coli harboring plasmid-mediated quinolone resistance in a Tunisian university hospital

Diagnostic Microbiology and Infectious Disease

Volumn 79, Issue 2, 2014, Pages 247-251

  Sana, Ferjani ^a   Mabrouka, Saidani ^a,b   Claudine, Quentin ^c   Faouzi, Slim Amine ^b   Ilhem, Boutiba Ben Boubaker ^a,b   Véronique, Dubois ^c  

^a UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^b CHARLES NICOLLE HOSPITAL   (Tunisia)

^c University Victor Segalen   (France)

Author keywords

Escherichia coli; Phylogenetic groups; Plasmid mediated quinolone resistance; ST131 clone; Uropathogenic strains; Virulence factors

Indexed keywords

AMIKACIN; AMPICILLIN; BETA LACTAMASE CTX M; CEFOTAXIME; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; NALIDIXIC ACID; NETILMICIN; NORFLOXACIN; PROTEIN PARC; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT; QUINOLONE DERIVATIVE; VIRULENCE FACTOR;

AAC(6') IB CR GENE; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL VIRULENCE; BACTERIUM EXAMINATION; BACTERIUM ISOLATE; BLACTX M 15 GENE; CONTROLLED STUDY; GENE IDENTIFICATION; GENETIC VARIABILITY; GYRA GENE; HETEROZYGOTE; HORIZONTAL GENE TRANSFER; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR CLONING; NONHUMAN; PARC GENE; PLASMID; PRIORITY JOURNAL; QNRA6 GENE; QNRB1 GENE; QNRS1 GENE; TUNISIA; UNIVERSITY HOSPITAL; UROPATHOGENIC ESCHERICHIA COLI; ADOLESCENT; ADULT; AGED; ANALYSIS; CHILD; CLASSIFICATION; CLUSTER ANALYSIS; DRUG EFFECTS; EPIDEMIOLOGY; ESCHERICHIA COLI INFECTIONS; FEMALE; GENETICS; HUMAN; INFANT; ISOLATION AND PURIFICATION; MALE; MICROBIOLOGY; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; PRESCHOOL CHILD; PREVALENCE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CLUSTER ANALYSIS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI INFECTIONS; FEMALE; GENES, BACTERIAL; HOSPITALS, UNIVERSITY; HUMANS; INFANT; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MOLECULAR TYPING; PLASMIDS; PREVALENCE; QUINOLONES; TUNISIA; UROPATHOGENIC ESCHERICHIA COLI; VIRULENCE FACTORS; YOUNG ADULT;

EID: 84900518509     PISSN: 07328893     EISSN: 18790070     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2014.03.011     Document Type: Article

References (25)

1. Branger C., Zamfir O., Geoffroy S., Laurans G., Arlet G., Thien H.V., et al. Genetic background of Escherichia coli and extended-spectrum beta-lactamase type. Emerg Infect Dis 2005, 11:54-61.
2. Boyd D.A., Tyler S., Christianson S., Mcgeer A., Muller M.P., Willey B.M., et al. Canadian Nosocomial Infection Surveillance Program, Health Canada. Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum b-lactamase involved in an outbreak in long-term care facilities in Toronto, Canada. Antimicrob Agents Chemother 2004, 48:3758-3764.
3. Carattoli A., Bertini A., Villa L., Falbo V., Hopkins K.L., Threlfall E.J. Identification of plasmids by PCR-based replicon typing. J Microbiol Methods 2005, 63:219-228.
4. Cattoir V., Poirel L., Rotimi V., Soussy C.J., Nordmann P. Multiplex PCR for detection of plasmid-mediated quinolone resistance qnr genes in ESBL-producing enterobacterial isolates. J Antimicrob Chemother 2007, 60:394-397.
5. Cattoir V., Nordmann P. Plasmid-mediated quinolone resistance in gram-negative bacterial species: an update. Curr Med Chem 2009, 19:1028-1046.
6. Cavaco L.M., Hasman H., Xia S., Aarestrup F.M. qnrD, a novel gene conferring transferable quinolone resistance in Salmonella enterica serovar Kentucky and Bovismorbificans strains of human origin. Antimicrob Agents Chemother 2009, 53:603-608.
7. Clermont O., Bonacorsi S., Bingen E. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl Environ Microbiol 2000, 66:4555-4558.
8. Clermont O., Dhanji H., Upton M., Gibreel T., Fox A., Boyd D., et al. Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15-producing strains. J Antimicrob Chemother 2009, 64:274-277.
9. Dahmen S., Poirel L., Mansour W., Bouallègue O., Nordmann P. Prevalence of plasmid mediated quinolone resistance determinants in Enterobacteriaceae from Tunisia. Clin Microbiol Infect 2010, 16:1019-1023.
10. Everett M.J., Jin Y.F., Ricci V., Piddock L.J. Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. Antimicrob Agents Chemother 1996, 40:2380-2386.
11. Hopkins K.L., Wootton L., Day M.R., Threlfall E.J. Plasmid-mediated quinolone resistance determinant qnrS1 found in Salmonella enterica strains isolated in the UK. J Antimicrob Chemother 2007, 59:1071-1075.
12. Johnson J.R., Stell A. Extended virulence genotypes of Escherichia coli strains from patients with urosepsis in relation to phylogeny and host compromise. J Infect Dis 2000, 181:261-272.
13. Johnson J.R., Russo T.A. Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli. IJMM 2005, 295:383-404.
14. Jones G.L., Warren R.E., Skdmore S.J., Davies V.A., Gilbreel T., Upton M. Prevalence and distribution of plasmid-mediated quinolone resistance genes in clinical isolates of Escherichia coli lacking extended-spectrum β-lactamases. J Antimicrob Chemother 2008, 62:1245-1251.
15. Jouini A., Ben Slama K., Vinué L., Ruiz E., Saenz Y., Somalo S., et al. Detection of unrelated Escherichia coli strains harboring genes of CTX-M-15, OXA-1, and AAC(6')-Ib-cr enzymes in a Tunisian hospital and characterization of their integrons and virulence factors. J Chemother 2010, 22:318-323.
16. Karah N., Poirel L., Bengtsson S., Sundqvist M., Kahlmeter G., Nordmann P., et al. Plasmid mediated quinolone resistance determinants qnr and aac(6')-Ib-cr in Escherichia coli and Klebsiella spp. from Norway and Sweden. Diagn Microbiol Infect Dis 2010, 66:425-431.
17. Kim H.B., Wang M., Park C.H., Kim E.C., Jacoby G.A., Hooper D.C. oqxAB encoding a multidrug efflux pump in human clinical isolates of Enterobacteriaceae. Antimicrob Agents Chemother 2009, 53:3582-3584.
18. Mahenthiralingam E., Campbell M.E., Foster J., Lam J.S., Speert D.P. Random amplified polymorphic DNA typing of Pseudomonas aeruginosa isolates recovered from patients with cystic fibrosis. J Clin Microbiol 1996, 34:1129-1135.
19. Musumeci R., Rausa M., Giovannoni R., Cialdella A., Bramati S., Sibra B., et al. Prevalence of plasmid-mediated quinolone resistance genes in uropathogenic Escherichia coli isolated in a teaching hospital of Northern Italy. Microb Drug Resist 2011, 8:33-41.
20. Peirano G., Costello M., Pitout J.D. Molecular characteristics of extended-spectrum beta lactamase-producing Escherichia coli from the Chicago area: high prevalence of ST131 producing CTX-M-15 in community hospitals. Int J Antimicrob Agents 2010, 36:19-23.
21. Pérez-Pérez F.J., Hanson N.D. Detection of plasmid-mediated AmpC beta-lactamase genes in clinical isolates by using multiplex PCR. J Clin Microbiol 2002, 40:2153-2162.
22. Robicsek A., Strahilevitz J., Jacoby G.A., Macielag M., Abbanat D., Park C.H., et al. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nat Med 2006, 12:83-88.
23. Strahilevitz J., Jacoby George A., Hooper D.C., Robicsek A. Plasmid-mediated quinolone resistance: a multifaceted threat. Clin Microbiol Rev 2009, 22:664-689.
24. Wang M., Guo Q., Xu X., Wang X., Ye X., Wu S., et al. New plasmid-mediated quinolone resistance gene, qnrC, found in a clinical isolate of Proteus mirabilis. Antimicrob Agents Chemother 2009, 53:1892-1897.
25. Yamane K., Wachino J., Suzuki S., Kimura K., Shibata N., Kato H., et al. New plasmid mediated fluoroquinolone efflux pump, QepA, found in an Escherichia coli clinical isolate. Antimicrob Agents Chemother 2007, 51:3354-3360.