GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 19, 2014, Pages

  He, Shuangba ^a,b   Chen, Chun Hao ^a   Chernichenko, Natalya ^a   He, Shizhi ^a   Bakst, Richard L ^c   Barajas, Fernando ^a   Deborde, Sylvie ^a   Allen, Peter J ^a   Vakiani, Efsevia ^a   Yu, Zhenkun ^d   Wong, Richard J ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b ANHUI MEDICAL UNIVERSITY   (China)

^c MOUNT SINAI HOSPITAL   (United States)

^d SOUTHEAST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR RECEPTOR ALPHA1; MESSENGER RNA; PROTEIN RET; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MECHANICS; MOUSE; NERVE FUNCTION; NONHUMAN; PANCREAS ADENOCARCINOMA; PERINEURAL INVASION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPINAL GANGLION; TISSUE MICROARRAY; TUMOR INVASION;

3T3 CELLS; ADENOCARCINOMA; ANIMALS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; CELL MOVEMENT; COCULTURE TECHNIQUES; GANGLIA, SPINAL; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; NEOPLASM INVASIVENESS; NERVE TISSUE; PANCREATIC NEOPLASMS; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; PROTO-ONCOGENE PROTEINS C-RET; RNA, SMALL INTERFERING; SCIATIC NEUROPATHY; SOLUBILITY;

EID: 84900514239     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402944111     Document Type: Article

References (21)

1. Batsakis JG (1985) Nerves and neurotropic carcinomas. Ann Otol Rhinol Laryngol 94(4 Pt 1):426-427.
2. Liebig C, Ayala G, Wilks JA, Berger DH, Albo D (2009) Perineural invasion in cancer: A review of the literature. Cancer 115(15):3379-3391.
3. Bapat AA, Hostetter G, Von Hoff DD, Han H (2011) Perineural invasion and associated pain in pancreatic cancer. Nat Rev Cancer 11(10):695-707.
4. Fagan JJ, et al. (1998) Perineural invasion in squamous cell carcinoma of the head and neck. Arch Otolaryngol Head Neck Surg 124(6):637-640.
5. Beard CJ, et al. (2004) Perineural invasion is associated with increased relapse after external beam radiotherapy for men with low-risk prostate cancer and may be a marker for occult, high-grade cancer. Int J Radiat Oncol Biol Phys 58(1):19-24.
6. Law WL, Chu KW (2004) Anterior resection for rectal cancer with mesorectal excision: A prospective evaluation of 622 patients. Ann Surg 240(2):260-268.
7. Veit C, et al. (2004) Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells. Cancer Res 64(15):5291-5300.
8. Gil Z, et al. (2010) Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J Natl Cancer Inst 102(2):107-118.
9. Jing S, et al. (1996) GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell 85(7):1113-1124.
10. Treanor JJ, et al. (1996) Characterization of a multicomponent receptor for GDNF. Nature 382(6586):80-83.
11. Paratcha G, Ledda F, Ibáñez CF (2003) The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell 113(7):867-879.
12. Barnett MW, Fisher CE, Perona-Wright G, Davies JA (2002) Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan. J Cell Sci 115(Pt 23):4495-4503.
13. Bespalov MM, et al. (2011) Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin. J Cell Biol 192(1):153-169.
14. Paratcha G, et al. (2001) Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron 29(1):171-184.
15. Ledda F, Paratcha G, Ibáñez CF (2002) Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5. Neuron 36(3):387-401.
16. Bakst RL, et al. (2012) Radiation impairs perineural invasion by modulating the nerve microenvironment. PLoS ONE 7(6):e39925.
17. Ayala GE, et al. (2001) In vitro dorsal root ganglia and human prostate cell line interaction: Redefining perineural invasion in prostate cancer. Prostate 49(3):213-223.
18. Enomoto H, et al. (1998) GFR α1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron 21(2):317-324.
19. Takahashi T, et al. (1997) Perineural invasion by ductal adenocarcinoma of the pancreas. J Surg Oncol 65(3):164-170.
20. Noto M, et al. (2005) Pancreas head carcinoma: Frequency of invasion to soft tissue adherent to the superior mesenteric artery. Am J Surg Pathol 29(8):1056-1061.
21. Tonge DA, et al. (1997) Effects of extracellular matrix components on axonal outgrowth from peripheral nerves of adult animals in vitro. Exp Neurol 146(1):81-90.