Activation and inhibition of TMEM16A calcium-activated chloride channels

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Ni, Yu Li ^a   Kuan, Ai Seon ^a   Chen, Tsung Yu ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BARIUM; CALCIUM; CALCIUM ACTIVATED CHLORIDE CHANNEL; MAGNESIUM; NIFLUMIC ACID; STRONTIUM; TRANSMEMBRANE PROTEINS OF UNKNOWN FUNCTION 16; UNCLASSIFIED DRUG;

ANION TRANSPORT; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CALCIUM CURRENT; CHANNEL GATING; COMPETITIVE INHIBITION;

ANIMALS; BARIUM; BINDING, COMPETITIVE; CALCIUM; CATIONS, DIVALENT; CHLORIDE CHANNELS; CHLORIDES; GENE EXPRESSION; HEK293 CELLS; HUMANS; ION CHANNEL GATING; ION TRANSPORT; MAGNESIUM; MEMBRANE POTENTIALS; MICE; NIFLUMIC ACID; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS;

EID: 84900460157     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086734     Document Type: Article

References (43)

1. Hartzell C, Putzier I, Arreola J (2005) Calcium-activated chloride channels. Annu Rev Physiol 67: 719-758. (Pubitemid 40404508)
2. Huang F, Wong X, Jan LY (2012) International Union of Basic and Clinical Pharmacology. LXXXV: calcium-activated chloride channels. Pharmacol Rev 64: 1-15.
3. Scudieri P, Sondo E, Ferrera L, Galietta LJ (2011) The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Exp Physiol 97: 177-183.
4. Schroeder BC, Cheng T, Jan YN, Jan LY (2008) Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell 134: 1019-1029.
5. Caputo A, Caci E, Ferrera L, Pedemonte N, Barsanti C, et al. (2008) TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science 322: 590-594.
6. Yang YD, Cho H, Koo JY, Tak MH, Cho Y, et al. (2008) TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature 455: 1210-1215.
7. Yang H, Kim A, David T, Palmer D, Jin T, et al. (2013) TMEM16F forms a Ca2+-activated cation channel required for lipid scrambling in platelets during blood coagulation. Cell 151: 111-122.
8. Kunzelmann K, Nilius B, Owsianik G, Schreiber R, Ousingsawat J, et al. (2013) Molecular functions of anoctamin 6 (TMEM16F): a chloride channel, cation channel, or phospholipid scramblase? Pflugers Arch [Epub ahead of print].
9. Fallah G, Romer T, Detro-Dassen S, Braam U, Markwardt F, et al. (2010) TMEM16A(a)/anoctamin-1 shares a homodimeric architecture with CLC chloride channels. Mol Cell Proteomics 10: M110 004697.
10. Tien J, Lee HY, Minor DL, Jr., Jan YN, Jan LY (2013) Identification of a dimerization domain in the TMEM16A calcium-activated chloride channel (CaCC). Proc Natl Acad Sci U S A 110: 6352-6357.
11. Huang WC, Xiao S, Huang F, Harfe BD, Jan YN, et al. (2012) Calcium-activated chloride channels (CaCCs) regulate action potential and synaptic response in hippocampal neurons. Neuron 74: 179-192.
12. Billig GM, Pal B, Fidzinski P, Jentsch TJ (2011) Ca2+-activated Cl- currents are dispensable for olfaction. Nat Neurosci 14: 763-769.
13. Hengl T, Kaneko H, Dauner K, Vocke K, Frings S, et al. (2010) Molecular components of signal amplification in olfactory sensory cilia. Proc Natl Acad Sci U S A 107: 6052-6057.
14. Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, et al. (2009) ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A 106: 11776-11781.
15. Kurahashi T, Yau KW (1993) Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. Nature 363: 71-74. (Pubitemid 23144963)
16. Reisert J, Bauer PJ, Yau KW, Frings S (2003) The Ca-activated Cl channel and its control in rat olfactory receptor neurons. J Gen Physiol 122: 349-363. (Pubitemid 37163282)
17. Reisert J, Lai J, Yau KW, Bradley J (2005) Mechanism of the excitatory Cl- response in mouse olfactory receptor neurons. Neuron 45: 553-561. (Pubitemid 40249867)
18. Qu Z, Hartzell HC (2000) Anion permeation in Ca(2+)-activated Cl(-) channels. J Gen Physiol 116: 825-844.
19. Qu Z, Hartzell HC (2001) Functional geometry of the permeation pathway of Ca2+-activated Cl-channels inferred from analysis of voltage-dependent block. J Biol Chem 276: 18423-18429.
20. Kleene SJ, Gesteland RC (1991) Calcium-activated chloride conductance in frog olfactory cilia. J Neurosci 11: 3624-3629.
21. Smith SS, Steinle ED, Meyerhoff ME, Dawson DC (1999) Cystic fibrosis transmembrane conductance regulator. Physical basis for lyotropic anion selectivity patterns. J Gen Physiol 114: 799-818.
22. Machaca K, Qu Z, Kuruma A, Hartzell C, McCarty NA (2002) The endogenous calcium-activated Cl channel in Xenopus oocytes: A physiologically and biophysically rich model system. In: Fuller CM, editor. Calcium-Activated Chloride Channels: Academic Press. 3-39. (Pubitemid 36010633)
23. Dibattista M, Amjad A, Maurya DK, Sagheddu C, Montani G, et al. (2012) Calcium-activated chloride channels in the apical region of mouse vomeronasal sensory neurons. J Gen Physiol 140: 3-15.
24. Ferrera L, Caputo A, Galietta LJ (2010) TMEM16A protein: a new identity for Ca(2+)-dependent Cl(-) channels. Physiology (Bethesda) 25: 357-363.
25. Hartzell HC (2008) Physiology. CaCl-ing channels get the last laugh. Science 322: 534-535.
26. Ferrera L, Caputo A, Ubby I, Bussani E, Zegarra-Moran O, et al. (2009) Regulation of TMEM16A chloride channel properties by alternative splicing. J Biol Chem 284: 33360-33368.
27. Chen Y, An H, Li T, Liu Y, Gao C, et al. (2011) Direct or indirect regulation of calcium-activated chloride channel by calcium. J Membr Biol 240: 121-129.
28. Xiao Q, Yu K, Perez-Cornejo P, Cui Y, Arreola J, et al. (2011) Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop. Proc Natl Acad Sci U S A 108: 8891-8896.
29. Adomaviciene A, Smith KJ, Garnett H, Tammaro P (2013) Putative pore-loops of TMEM16/anoctamin channels affect channel density in cell membranes. J Physiol 591: 3487-3505.
30. Kuruma A, Hartzell HC (2000) Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals. J Gen Physiol 115: 59-80. (Pubitemid 30043668)
31. Colquhoun D (1998) Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br J Pharmacol 125: 924-947.
32. Yu K, Duran C, Qu Z, Cui YY, Hartzell HC (2012) Explaining calcium-dependent gating of anoctamin-1 chloride channels requires a revised topology. Circ Res 110: 990-999.
33. Pallotta BS, Magleby KL, Barrett JN (1981) Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture. Nature 293: 471-474. (Pubitemid 12193176)
34. Marty A (1981) Ca-dependent K channels with large unitary conductance in chromaffin cell membranes. Nature 291: 497-500.
35. Zhou Y, Zeng XH, Lingle CJ (2012) Barium ions selectively activate BK channels via the Ca2+-bowl site. Proc Natl Acad Sci U S A 109: 11413-11418.
36. Shi J, Krishnamoorthy G, Yang Y, Hu L, Chaturvedi N, et al. (2002) Mechanism of magnesium activation of calcium-activated potassium channels. Nature 418: 876-880. (Pubitemid 34966306)
37. Xia XM, Zeng X, Lingle CJ (2002) Multiple regulatory sites in large-conductance calcium-activated potassium channels. Nature 418: 880-884. (Pubitemid 34966307)
38. Zhang X, Solaro CR, Lingle CJ (2001) Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site. J Gen Physiol 118: 607-636.
39. Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R (2010) Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science 329: 182-186.
40. Arreola J, Melvin JE, Begenisich T (1996) Activation of calcium-dependent chloride channels in rat parotid acinar cells. J Gen Physiol 108: 35-47. (Pubitemid 26238811)
41. Zhang XD, Tseng PY, Yu WP, Chen TY (2009) Blocking pore-open mutants of CLC-0 by amphiphilic blockers. J Gen Physiol 133: 43-58.
42. Richman DP, Yu Y, Lee TT, Tseng PY, Yu WP, et al. (2012) Dominantly inherited myotonia congenita resulting from a mutation that increases open probability of the muscle chloride channel CLC-1. Neuromolecular Med 14: 328-337.
43. Lee TT, Zhang XD, Chuang CC, Chen JJ, Chen YA, et al. (2013) Myotonia congenita mutation enhances the degradation of human CLC-1 chloride channels. PLoS One 8: e55930.