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Volumn 5, Issue 5, 2014, Pages 604-608

Discovery of naphthyl-fused 5-membered lactams as a new class of M 1 positive allosteric modulators

Author keywords

acetylcholine; Alzheimer's disease; muscarinic; positive allosteric modulators

Indexed keywords

ACETYLCHOLINE; LACTAM DERIVATIVE; MULTIDRUG RESISTANCE PROTEIN; MUSCARINIC AGENT; MUSCARINIC M1 RECEPTOR; NAPHTHYL GROUP; SCOPOLAMINE;

EID: 84900448647     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml500055h     Document Type: Article
Times cited : (19)

References (20)
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  • 2
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    • The molecular basis of muscarinic acetylcholine receptor diversity
    • Bonner, T. I. The molecular basis of muscarinic acetylcholine receptor diversity Trends Neurosci. 1989, 12, 148-151
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    • Bonner, T.I.1
  • 3
    • 0024472059 scopus 로고
    • Subtypes of muscarinic acetylcholine receptors
    • Bonner, T. I. Subtypes of muscarinic acetylcholine receptors Trends Pharmacol. Sci. 1989, 11-15
    • (1989) Trends Pharmacol. Sci. , pp. 11-15
    • Bonner, T.I.1
  • 4
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    • Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease
    • Levey, A. I. Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease Proc. Natl. Acad. Sci. 1996, 93, 13451-13546
    • (1996) Proc. Natl. Acad. Sci. , vol.93 , pp. 13451-13546
    • Levey, A.I.1
  • 5
    • 58149193205 scopus 로고    scopus 로고
    • Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders
    • Conn, P. J.; Christopulos, A.; Lindsley, C. W. Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders Nat. Rev. Drug Discovery 2009, 8, 41-54
    • (2009) Nat. Rev. Drug Discovery , vol.8 , pp. 41-54
    • Conn, P.J.1    Christopulos, A.2    Lindsley, C.W.3
  • 8
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    • 1 mAChR allosteric and bitopic ligands: Therapeutics for the treatment of cognitive deficits
    • 1 mAChR allosteric and bitopic ligands: therapeutics for the treatment of cognitive deficits ACS Chem. Neurosci. 2013, 4, 1026-1048
    • (2013) ACS Chem. Neurosci. , vol.4 , pp. 1026-1048
    • Davie, B.J.1    Christopoulos, A.2    Scammells, P.J.3
  • 20
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    • Structural modifications that alter the P-glycopprotein efflux properties of compounds
    • Hitchcock, S. A. Structural modifications that alter the P-glycopprotein efflux properties of compounds J. Med. Chem. 2012, 55, 4877-4895
    • (2012) J. Med. Chem. , vol.55 , pp. 4877-4895
    • Hitchcock, S.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.