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Volumn 20, Issue 8, 2010, Pages 2533-2537

Heterocyclic fused pyridone carboxylic acid M1 positive allosteric modulators

Author keywords

Allosteric; Alzheimer's; M1; Muscarinic; Quinolone

Indexed keywords

CARBOXYLIC ACID DERIVATIVE; PYRIDONE DERIVATIVE; QUINOLONE DERIVATIVE;

EID: 77950119053     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.096     Document Type: Article
Times cited : (23)

References (20)
  • 16
    • 77950111582 scopus 로고    scopus 로고
    • note
    • 4 receptors.
  • 18
    • 77950128128 scopus 로고    scopus 로고
    • note
    • 1/2 3.7 h, Cl 6.8 ml/min/kg. Mouse PK was not measured.
  • 19
    • 77950119494 scopus 로고    scopus 로고
    • note
    • Total brain levels were also ∼3-fold higher in the P-gp knock-out mice compared to the wild-type animals.
  • 20
    • 34547184042 scopus 로고    scopus 로고
    • Alternatively, the rat CSF levels may not reflect the actual brain interstitial fluid levels. There is literature that suggests P-gp substrates may have higher CSF levels due to efflux.
    • Alternatively, the rat CSF levels may not reflect the actual brain interstitial fluid levels. There is literature that suggests P-gp substrates may have higher CSF levels due to efflux. Venkatakrishnan K., Tseng E., Nelson F.R., Rollema H., French J.L., Kaplan I.V., Horner W.E., and Gibbs M.A. Drug Metab. Dispos. 35 (2007) 1341
    • (2007) Drug Metab. Dispos. , vol.35 , pp. 1341
    • Venkatakrishnan, K.1    Tseng, E.2    Nelson, F.R.3    Rollema, H.4    French, J.L.5    Kaplan, I.V.6    Horner, W.E.7    Gibbs, M.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.