Development of an analytical strategy based on LC-MS/MS for the measurement of different classes of pesticides and theirs metabolites in meconium: Application and characterisation of foetal exposure in France

Environmental Research

Volumn 132, Issue , 2014, Pages 311-320

  Berton, Thierry ^a,b   Mayhoub, Flora ^a   Chardon, Karen ^a   Duca, Radu Corneliu ^a,b   Lestremau, Francois ^b   Bach, Véronique ^a   Tack, Karine ^b  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

Author keywords

Foetal exposure; LC MS MS; Mass spectrometry; Meconium; Pesticides

Indexed keywords

ACETONITRILE; AMMONIUM ACETATE; AMMONIUM FORMATE; CARBAMIC ACID DERIVATIVE; CARBANILAMIDE; CHLORPYRIFOS; CYPERMETHRIN; DELTAMETHRIN; DIMPYLATE; DRUG METABOLITE; FORMIC ACID; HERBICIDE; MALATHION; ORGANOPHOSPHATE; ORGANOPHOSPHATE PESTICIDE; PESTICIDE; PHENOXY HERBICIDE; PHOSPHOROTHIOIC ACID; PHTHALIC ACID DIMETHYL ESTER; PROPOXUR; PYRETHROID; UNCLASSIFIED DRUG;

ANALYTICAL METHOD; FECES; HEALTH IMPACT; HEALTH RISK; METABOLITE; PESTICIDE; POLYMER; SORPTION;

ARTICLE; EXTRACTION; FRANCE; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID SOLID EXTRACTION; MAJOR CLINICAL STUDY; MECONIUM; NEWBORN; PREVALENCE; PRIORITY JOURNAL; PURIFICATION; QUADRUPOLE MASS SPECTROMETRY; SOLID PHASE EXTRACTION;

FRANCE; PICARDIE;

FOETAL EXPOSURE; LC-MS/MS; MASS SPECTROMETRY; MECONIUM; PESTICIDES;

CHROMATOGRAPHY, LIQUID; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; FRANCE; HUMANS; INFANT, NEWBORN; MASS SPECTROMETRY; MATERNAL EXPOSURE; MECONIUM; PESTICIDES;

EID: 84900444166     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2014.03.034     Document Type: Article

References (62)

1. Alano M.A., Ngougmna E., Ostrea E.M., Konduri G.G. Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn. Pediatrics 2001, 107:519-523.
2. Baranowski J., Pochopien G., Baranowska I. Determination of nicotine, cotinine and caffeine in meconium using high-performance liquid chromatography. J. Chromatogr. B 1998, 707:317-321.
3. Barr D.B., Ananth C.V., Yan X., Lashley S., Smulian J.C., Ledoux T.A., Hore P., Robson M.G. Pesticide concentrations in maternal and umbilical cord sera and their relation to birth outcomes in a population of pregnant women and newborns in New Jersey. Sci. Total Environ. 2010, 408:790-795.
4. Bearer C.F., Lee S., Salvator A.E., Minnes S., Swick A., Yamashita T., Singer L.T. Ethyl linoleate in meconium: a biomarker for prenatal ethanol exposure. Alcohol.: Clin. Exp. Res. 1999, 23:487-493.
5. Berman T., Hochner-Celnikier D., Barr D.B., Needham L.L., Amitai Y., Wormser U., Richter E. Pesticide exposure among pregnant women in Jerusalem, Israel: results of a pilot study. Environ. Int. 2011, 37:198-203.
6. Bielawski D., Ostrea E., Posecion N., Corrion M., Seagraves J. Detection of several classes of pesticides and metabolites in meconium by gas chromatography-mass spectrometry. Chromatographia 2005, 62:623-629.
7. Bradman A., Eskenazi B., Barr D.B., Bravo R., Castorina R., Chevrier J., Kogut K., Harnly M.E., McKone T.E. Organophosphate urinary metabolite levels during pregnancy and after delivery in women living in an agricultural community. Environ. Health Perspect. 2005, 113:1802-1807.
8. Buckley J.D., Robison L.L., Swotinsky R., Garabrant D.H., Lebeau M., Manchester P., Nesbit M.E., Odom L., Peters J.M., Woods W.G., Hammond G.D. Occupational exposures of parents of children with acute nonlymphocytic leukemia: a report from the childrens cancer study group. Cancer Res. 1989, 49:4030-4037.
9. Callahan C.M., Grant T.M., Phipps P., Clark G., Novack A.H., Streissguth A.P., Raisys V.A. Measurement of gestational cocaine exposure: sensitivity of infants hair, meconium and urine. J. Pediatr. 1992, 120:763-768.
10. Chanda S.M., Harp P., Liu J., Pope C.N. Comparative developmental and maternal neurotoxicity following acute gestational exposure to chlorpyrifos in rats. J. Toxicol. Environ. Health 1995, 44:189-202.
11. Chanda S.M., Pope C.N. Neurochemical and neurobehavioral effects of repeated gestational exposure to chlorpyrifos in maternal and developing rats. Pharmacol. Biochem. Behav. 1996, 53:771-776.
12. Cohn B.A., Wolff M.S., Cirillo P.M., Sholtz R.I. DDT and breast cancer in young women: new date on the significance of age at exposure. Environ. Health Perspect. 2007, 115:1406-1414.
13. De Brito Sa Stoppelli I.M., Crestana S. Pesticide exposure and cancer among rural workers from Bariri, Sao Paulo State, Brazil. Environ. Int. 2005, 31:731-738.
14. Eskenazi B., Bradman A., Castorina R. Exposures of children to organophosphate pesticides and their potential adverse health effects. Environ. Health Perspect. 1999, 107:409-419.
15. Eskenazi B., Harley K., Bradman A., Weltzien E., Jewell N.A., Barr D.B., Furlong C.E., Holland N.T. Association of in utero organophosphate pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ. Health Perspect. 2004, 112:1116-1124.
16. Eskenazi B., Marks A.R., Bradman A., Harley K., Barr D.B., Johnson C., Morga N., Jewell N.A. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ. Health Perspect. 2007, 115:792-798.
17. Fenster L., Eskenazi B., Anderson M., Bradman A., Harley K., Hernandez H., Hubbard A., Barr D.B. Association of in utero organochlorine pesticide exposure and fetal growth and length of gestation in an agricultural population. Environ. Health Perspect. 2006, 114:597-602.
18. Fujii Y., Haraguchi K., Harada K.H., Hitomi T., Inoue K., Itoh Y., Watanabe T., Takenaka K., Uehara S., Yang H.-R., Kim M.-Y., Moon C.-S., Kim H.-S., Wang P., Liu A., Nguyen Ngoc H., Koizumi A. Detection of dicofol and related pesticides in human breast milk from China, Korea and Japan. Chemosphere 2011, 82:25-31.
19. Garabrant D.H., Held J., Langholz B., Peters J.M., Mack T.M. DDT and related compounds and risk of pancreatic cancer. J. Natl. Cancer Inst. 1992, 84:764-771.
20. Garcia-Jares C., Regueiro J., Barro R., Dagnac T., Llompart M. Analysis of industrial contaminants in indoor air. Part 2. Emergent contaminants and pesticides. J. Chromatogr. A 2009, 1216:567-597.
21. Gray T.R., Eiden R.D., Leonard K.E., Connors G., Shisler S., Huestis M.A. Nicotine and metabolites in meconium as evidence of maternal cigarette smoking during pregnancy and predictors of neonatal growth deficits. Nicotine Tob. Res. 2010, 12:658-664.
22. Gray T.R., Shakleya D.M., Huestis M.A. Quantification of nicotine, cotinine, trans-3[U+05F3]-hydroxycotinine, nornicotine and norcotinine in human meconium by liquid chromatography/tandem mass spectrometry. J. Chromatogr. B 2008, 863:107-114.
23. Hong Z.Y., Gunter M., Randow F.F.E. Meconium: a matrix reflecting potential fetal exposure to organochlorine pesticides and its metabolites. Ecotoxicol. Environ. Saf. 2002, 51:60-64.
24. Hutson J.R., Rao C., Fulga N., Aleksa K., Koren G. An improved method for rapidly quantifying fatty acid ethyl esters in meconium suitable for prenatal alcohol screening. Alcohol 2011, 45:193-199.
25. Jaraczewska K., Lulek J., Covaci A., Voorspoels S., Kaluba-Skotarczak A., Drews K., Schepens P. Distribution of polychlorinated biphenyls, organochlorine pesticides and polybrominated diphenyl ethers in human umbilical cord serum, maternal serum and milk from Wielkopolska region, Poland. Sci. Total Environ. 2006, 372:20-31.
26. Jimenez Torres M., Campoy Folgoso C., Canabate Reche F., Rivas Velasco A., Cerrillo Garcia I., Mariscal Arcas M., Olea-Serrano F. Organochlorine pesticides in serum and adipose tissue of pregnant women in Southern Spain giving birth by cesarean section. Sci. Total Environ. 2006, 372:32-38.
27. Klein J., Karaskov T., Koren G. Fatty acid ethyl esters: a novel biologic marker for heavy in utero ethanol exposure: a case report. Ther. Drug Monit. 1999, 21:644-646.
28. Lopez Carrillo L., Torres Arreola L., Torres Sanchez L., Espinosa Torres F., Jimenez C., Cebrian M., Waliszewski S., Saldate O. Is DDT use a public health problem in Mexico?. Environ. Health Perspect. 1996, 104:584-588.
29. Madej K.A. Analysis of meconium, nails and tears for determination of medicines and drugs of abuse. Trac-Trends Anal. Chem. 2010, 29:246-259.
30. Mirochnick M., Frank D.A., Cabral H., Turner A., Zuckerman B. Relation between meconium concentration of the cocaine metabolite benzoylecgonine and fetal growth. J. Pediatr. 1995, 126:636-638.
31. Moore C., Negrusz A., Lewis D. Determination of drugs of abuse in meconium. J. Chromatogr. B 1998, 713:137-146.
32. Morini L., Marchei E., Vagnarelli F., Garcia Algar O., Groppi A., Mastrobattista L., Pichini S. Ethyl glucuronide and ethyl sulfate in meconium and hair-potential biomarkers of intrauterine exposure to ethanol. Forensic Sci. Int. 2010, 196:74-77.
33. Mukerjee S., Ellenson W.D., Lewis R.G., Stevens R.K., Somerville M.C., Shadwick D.S., Willis R.D. An environmental scoping study in the lower Rio Grande Valley of Texas.3. Residential microenvironmental monitoring for air, house dust, and soil. Environ. Int. 1997, 23:657-673.
34. Muto M.A., Lobelle F., Bidanset J.H., Wurpel J.N.D. Embryotoxicity and neurotoxicity in rats associated with prenatal exposure to Dursban. Vet. Hum. Toxicol. 1992, 34:498-501.
35. Nguyen Minh T., Sudaryanto A., Tu Binh M., Bui Hong N., Isobe T., Takahashi S., Pham Hung V., Tanabe S. Kinetic differences of legacy organochlorine pesticides and polychlorinated biphenyls in Vietnamese human breast milk. Chemosphere 2010, 81:1006-1011.
36. O'Leary E.S., Vena J.E., Freudenheim J.L., Brasure J. Pesticide exposure and risk of breast cancer: a nested case-control study of residentially stable women living on Long Island. Environ. Res. 2004, 94:134-144.
37. Ostrea E.M., Bielawski D.M., Posecion N.C., Corrion M., Villanueva-Uy E., Bernardo R.C., Jin Y., Janisse J.J., Ager J.W. Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood and meconium) matrices to detect fetal exposure to environmental pesticides. Environ. Res. 2009, 109:116-122.
38. Ostrea E.M., Bielawski D.M., Posecion N.C., Corrion M., Villanueva-Uy E., Jin Y., Janisse J.J., Ager J.W. A comparison of infant hair, cord blood and meconium analysis to detect fetal exposure to environmental pesticides. Environ. Res. 2008, 106:277-283.
39. Ostrea E.M., Brady M., Gause S., Raymundo A.L., Stevens M. Drug screening of newborns by meconium analysis: a large-scale, prospective, epidemiologic study. Pediatrics 1992, 89:107-113.
40. Ostrea E.M., Knapp D.K., Romero A., Montes M., Ostrea A.R. Meconium analysis to assess fetal exposure to nicotine by active and passive maternal smoking. J. Pediatr. 1994, 124:471-476.
41. Ostrea E.M., Matias O., Keane C., Mac E., Utarnachitt R., Ostrea A., Mazhar M. Spectrum of gestational exposure to illicit drugs and other xenobiotic agents in newborn infants by meconium analysis. J. Pediatr. 1998, 133:513-515.
42. Ostrea E.M., Morales V., Ngoumgna E., Prescilla R., Tan E., Hernandez E., Ramirez G.B., Cifra H.L., Manlapaz M.L. Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology 2002, 23:329-339.
43. Ostrea E.M., Romero A., Yee H. Adaptation of the meconium drug test for mass screening. J. Pediatr. 1993, 122:152-154.
44. Pichini S., Pacifici R., Pellegrini M., Marchei E., Perez-Alarcon E., Puig C., Vall O., Garcia-Algar O. Development and validation of a liquid chromatography mass spectrometry assay for the determination of opiates and cocaine in meconium. J. Chromatogr. B 2003, 794:281-292.
45. Pichini S., Puig C., Zuccaro P., Marchei E., Pellegrini M., Murillo J., Vall O., Pacifici R., Garcia-Algar S. Assessment of exposure to opiates and cocaine during pregnancy in a Mediterranean city: preliminary results of the "Meconium Project". Forensic Sci. Int. 2005, 153:59-65.
46. Pichini S., Pellegrini M., Gareri J., Koren G., Garcia-Algar O., Vall O., Vagnarelli F., Zuccaro P., Marchei E. Liquid chromatography-tandem mass spectrometry for fatty acid ethyl esters in meconium: assessment of prenatal exposure to alcohol in two European cohorts. J. Pharm. Biomed. Anal. 2008, 48:927-933.
47. Polder A., Gabrielsen G.W., Odland J.O., Savinova T.N., Tkachev A., Loken K.B., Skaare J.U. Spatial and temporal changes of chlorinated pesticides, PCBs, dioxins (PCDDs/PCDFs) and brominated flame retardants in human breast milk from Northern Russia. Sci. Total Environ. 2008, 391:41-54.
48. Polder A., Skaare J.U., Skjerve E., Loken K.B., Eggesbo M. Levels of chlorinated pesticides and polychlorinated biphenyls in Norwegian breast milk (2002-2006), and factors that may predict the level of contamination. Sci. Total Environ. 2009, 407:4584-4590.
49. Shim Y.K., Mlynarek S.P., van Wijngaarden E. Parental exposure to pesticides and childhood brain cancer: US Atlantic coast childhood brain cancer study. Environ. Health Perspect. 2009, 117:1002-1006.
50. Szyrwinska K., Lulek J. Exposure to specific polychlorinated biphenyls and some chlorinated pesticides via breast milk in Poland. Chemosphere 2007, 66:1895-1903.
51. Torres-Sanchez L., Rothenberg S.J., Schnaas L., Cebrian M.E., Osorio E., Hernandez M.D., Garcia-Hernandez R.M., del Rio-Garcia C., Wolff M.S., Lopez-Carrillo L. In utero p,p[U+05F3]-DDE exposure and infant neurodevelopment: a perinatal cohort in Mexico. Environ. Health Perspect. 2007, 115:435-439.
52. Tsatsakis A.M., Tzatzarakis M.N., Koutroulakis D., Toutoudaki M., Sifakis S. Dialkyl phosphates in meconium as a biomarker of prenatal exposure to organophosphate pesticides: a study on pregnant women of rural areas in Crete, Greece. Xenobiotica 2009, 39:364-373.
53. Wallace J.C., Brzuzy L.P., Simonich S.L., Visscher S.M., Hites R.A. Case study of organochlorine pesticides in the indoor air of a home. Environ. Sci. Technol. 1996, 30:2715-2718.
54. Whyatt R.M., Barr D.B. Measurement of organophosphate metabolites in postpartum meconium as a potential biomarker of prenatal exposure: a validation study. Environ. Health Perspect. 2001, 109:417-420.
55. Whyatt R.M., Camann D., Perera F.P., Rauh V.A., Tang D., Kinney P.L., Garfinkel R., Andrews H., Hoepner L., Barr D.B. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol. Appl. Pharm. 2005, 206:246-254.
56. Whyatt R.M., Rauh V., Barr D.B., Camann D.E., Andrews H.F., Garfinkel R., Hoepner L.A., Diaz D., Dietrich J., Reyes A., Tang D.L., Kinney P.L., Perera F.P. Prenatal insecticide exposures and birth weight and length among an urban minority cohort. Environ. Health Perspect. 2004, 112:1125-1132.
57. Xia Y., Xu M., Alexander R.R., Bernert J.T. Measurement of nicotine, cotinine and trans-3[U+05F3]-hydroxycotinine in meconium by liquid chromatography-tandem mass spectrometry. J. Chromatogr. B 2011, 879:2142-2148.
58. Ye X., Pierik F.H., Angerer J., Meltzer H.M., Jaddoe V.W.V., Tiemeier H., Hoppin J.A., Longnecker M.P. Levels of metabolites of organophosphate pesticides, phthalates, and bisphenol A in pooled urine specimens from pregnant women participating in the Norwegian Mother and Child Cohort Study (MoBa). Int. J. Hyg. Environ. Health 2009, 212:481-491.
59. Ye X., Pierik F.H., Hauser R., Duty S., Angerer J., Park M.M., Burdorf A., Hofman A., Jaddoe V.W.V., Mackenbach J.P., Steegers E.A.P., Tiemeier H., Longnecker M.P. Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study. Environ. Res. 2008, 108:260-267.
60. Young J.G., Eskenazi B., Gladstone E.A., Bradman A., Pedersen L., Johnson C., Barr D.B., Furlong C.E., Holland N.T. Association between in utero organophosphate pesticide exposure and abnormal reflexes in neonates. Neurotoxicology 2005, 26:199-209.
61. Zhao G., Xu Y., Li W., Han G., Ling B. Prenatal exposures to persistent organic pollutants as measured in cord blood and meconium from three localities of Zhejiang, China. Sci. Total Environ. 2007, 377:179-191.
62. Zhou P., Wu Y., Yin S., Li J., Zhao Y., Zhang L., Chen H., Liu Y., Yang X., Li X. National survey of the levels of persistent organochlorine pesticides in the breast milk of mothers in China. Environ. Pollut. 2011, 159:524-531.