Glatiramer acetate (Copaxone) modulates platelet activation and inhibits thrombin-induced calcium influx: Possible role of copaxone in targeting platelets during autoimmune neuroinflammation

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Starossom, Sarah C ^a,b   Veremeyko, Tatyana ^c   Dukhinova, Marina ^c   Yung, Amanda W Y ^c   Ponomarev, Eugene D ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CALCIUM ION; GLATIRAMER; PADGEM PROTEIN; THROMBIN; CALCIUM; CD31 ANTIGEN; CD86 ANTIGEN; FIBRINOGEN RECEPTOR; HLA ANTIGEN CLASS 2; IMMUNOLOGICAL ADJUVANT; PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLEEDING TIME; CALCIUM TRANSPORT; CELL INTERACTION; COCULTURE; CONTROLLED STUDY; DRUG MECHANISM; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE ACTIVATION; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PROTEIN EXPRESSION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; UPREGULATION; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ION TRANSPORT; METABOLISM; PERITONEUM MACROPHAGE; THROMBOCYTE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS, CD31; ANTIGENS, CD86; BLEEDING TIME; BLOOD PLATELETS; CALCIUM; CELLS, CULTURED; COCULTURE TECHNIQUES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; ION TRANSPORT; MACROPHAGES, PERITONEAL; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; P-SELECTIN; PEPTIDES; PLATELET ACTIVATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; THROMBIN;

EID: 84900423968     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0096256     Document Type: Article

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