Recent evidence on the management of bronchiolitis

Current Opinion in Pediatrics

Volumn 26, Issue 3, 2014, Pages 328-333

  Schroeder, Alan R ^a   Mansbach, Jonathan M ^b  

^a SANTA CLARA VALLEY MEDICAL CENTER   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Bronchiolitis; hypertonic saline; overutilization; pulse oximetry; respiratory syncytial virus; rhinovirus

Indexed keywords

BRONCHODILATING AGENT; CORTICOSTEROID DERIVATIVE; OXYGEN; PALIVIZUMAB; SODIUM CHLORIDE; ADRENALIN; GLUCOCORTICOID;

BRONCHIOLITIS; COST BENEFIT ANALYSIS; FEVER; HUMAN; IMMUNOPROPHYLAXIS; META ANALYSIS (TOPIC); OXYGEN THERAPY; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; SUCTION; THORAX RADIOGRAPHY; VIROLOGY; CHILD; HOSPITALIZATION; HUMAN RESPIRATORY SYNCYTIAL VIRUS; INFANT; ISOLATION AND PURIFICATION; LENGTH OF STAY; NEWBORN; PATHOPHYSIOLOGY; PRESCHOOL CHILD; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

BRONCHIOLITIS; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; EPINEPHRINE; GLUCOCORTICOIDS; HOSPITALIZATION; HUMANS; INFANT; INFANT, NEWBORN; LENGTH OF STAY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; RESPIRATORY SYNCYTIAL VIRUSES; SALINE SOLUTION, HYPERTONIC; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 84900417299     PISSN: 10408703     EISSN: 1531698X     Source Type: Journal    
DOI: 10.1097/MOP.0000000000000090     Document Type: Review

References (73)

1. Mansbach JM, Pelletier AJ, Camargo CA Jr. US outpatient office visits for bronchiolitis. Ambul Pediatr 2007; 7:304-307
2. Quinonez RA, Garber MD, Schroeder AR, et al. Choosing wisely in pediatric hospital medicine: five opportunities for improved healthcare value. J Hosp Med 2013; 8:479-485. The first 'Top 5'list put out by a pediatric subspecialty group for the Choosing Wisely Campaign. Four of the five recommendations involve limiting unnecessary care in bronchiolitis
3. Ralston S, Garber M, Narang S, et al. Decreasing unnecessary utilization in acute bronchiolitis care: results from the value in inpatient pediatrics network. J Hosp Med 2013; 8:25-30. A successful collaborative quality improvement effort in 17 centers to standardize care in bronchiolitis. Albuterol usage decreased significantly
4. Akenroye AT, Baskin MN, Samnaliev M, Stack AM. Impact of a bronchiolitis guideline on ED resource use and cost: a segment ed time-series analysis. Pediatrics 2013; 131:e227-e234
5. McCulloh RJ, Smitherman SE, Koehn KL, Alverson BK. Assessing the impact of national guidelines on the management of children hospitali zed for acute bronchiolitis. Pediatr Pulmonol 2013. [Epub ahead of print]
6. Parikh K, Hall M, Teach SJ. Bronchiolitis management before and after the AAP guidelines. Pediatrics 2014; 133:e1-e7
7. Mallory MD, Shay DK, Garrett J, Bordley WC. Bronchiolitis management preferences and the influence of pulse oximetry and respiratory rate on the decision to admit. Pediatrics 2003; 111: e45-e51
8. Shay DK, Holman RC, Newman RD, et al. Bronchiolitis-associated hospitalizations among US children, 1980-1996. JAMA 1999; 282:1440-1446
9. Shay DK, Holman RC, Roosevelt GE, et al. Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997. J Infect Dis 2001; 183:16-22
10. Hasegawa K, Tsugawa Y, Brown DF, et al. Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics 2013; 132: 28-36
11. Ma nsbach JM, Piedra PA, Teach SJ, et al. Prospective multicenter study of viral etiology and hospital length of stay in children with severe bronchiolitis. Arch Pediatr Adolesc Med 2012; 166:700-706. The first publicat ion from the MARC-30 bronchiolitis study, which demonstrated that a wide variety of viruses cause bronchiolitis and that 30% of children are infected with at least two viruses
12. Jartti T, Lehtinen P, Vanto T, et al . Evaluation of the efficacy of prednisolone in early wheezing induced by rhinovirus or respiratory syncytial virus. Pediatr Infect Dis J 2006; 25:482-488
13. Schroeder AR, Mansbach JM, Stevenson M, et al. Apnea in children hospitalized with bronchiolitis. Pediatrics 2013; 132:e1194-e1201
14. Ricart S, Marcos MA, Sarda M, et al. Clinical risk factors are more relevant than respir atory viruses in predicting bronchiolitis severity. Pediatr Pulmonol 2013; 48:456-463
15. Diagnosis and management of bronchiolitis. Pediatrics 2006; 118:1774-1793
16. Knapp JF, Simon SD, Sharma V. Variation and trends in ED use of radiographs for asthma, bronchiolitis, and croup in children. Pediatrics 2013; 132:245-252
17. Johnson LW, Robles J, Hudg ins A, et al. Management of bronchiolitis in the emergency department: impact of evidence-based guidelines Pediatrics 2013; 131 (Suppl 1):S103-S109
18. Schuh S Lalani A Allen U et al. Evaluation of the utility of radiography in acute bronchiolitis. J Pediatr 2007 150 429-433
19. Aslanzadeh J, Zheng X, Li H, et al. Prospective evaluation of rapid antigen tests for diagnosis of respiratory syncytial virus and human metapneumovirus infections. J Clin Microbiol 2008; 46:1682-1685
20. Henrickson KJ, Hall CB. Diagnostic assays for respiratory syncytial virus disease. Pediatr Infect Dis J 2007; 26 (11 Suppl):S36-40
21. Meerhoff TJ, Houben ML, Coenjaerts FE, et al. Detection of multiple respiratory pathogens during primary respiratory infection: nasal swab versus nasopharyngeal aspirate using real-time polymerase chain reaction. Eur J Clin Microbiol Infect Dis 2010; 29:365-371
22. Levine DA, Platt SL, Dayan PS, et al. Risk of serious bacterial infection in young febrile infants with respiratory syncytial virus infections. Pediatrics 2004; 113:1728-1734
23. Ralston S, Hill V, Waters A. Occult serious bacterial infection in infants younger than 60 to 90 days with bronchiolitis: a systematic review. Arch Pediatr Adolesc Med 2011; 165:951-956
24. Ti tus MO, Wright SW. Prevalence of serious bacterial infections in febrile infants with respiratory syncytial virus infection. Pediatrics 2003; 112:282-284
25. Roberts KB. Urinary tract infection: cl inical practice guideline for the diagnosis and management of the initial UTI in febrile infants and children 2 to 24 months. Pediatrics 2011; 128:595-610
26. Wettergren B, Hellstrom M, Stokland E, Jodal U. Six year follow up of infants with bacteriuria on screening. BMJ 1990; 301:845-848
27. Wettergren B, Jodal U. Spontaneous clearance of asymptomatic bacteriuria in infants. Acta Paediatr Scand 1990; 79:300-304
28. Wright FH, Beem MO. Diagnosis and treatment: management of acute viral bronchiolitis in infancy. Pediatrics 1965; 35:334-337
29. Gad omski AM, Brower M. Bronchodilators for bronchiolitis. Cochrane Database Syst Rev 2010; (12):CD001266
30. Zorc JJ, Hall CB. Bronchiolitis: recent evidence on diagnosis and management. Pediatrics 2010; 125:342-349
31. Hartling L, Bialy LM, Vandermeer B, et al. Epinephrine for bronchiolitis. Cochrane Database Syst Rev 2011; CD003123
32. Skjerven HO, Hunderi JO, Brugmann-Pieper SK, et al. Racemic adrenaline and inhalation strategies in acute bronchiolitis. N Engl J Med 2013; 368: 2286-2293
33. Toaimah FH, Al-Ansari K. Life-threatening cardiac arrhythmia after a single dose of nebulized epinephrine in pediatric emergency department. J Trop Pediatr 2011; 57:497-499
34. Mandelberg A, Amirav I. Hypert onic saline or high volume normal saline for viral bronchiolitis: mechanisms and rationale. Pediatr Pulmonol 2010; 45:36-40
35. Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP. Nebulised hypertonic saline solu tion for acute bronchiolitis in infants. Cochrane Database Syst Rev 2013; 7:CD006458. Latest meta-analysis on hypertonic saline, demonstrating a reduction in LOS. However, two subsequent trials [36,37] found no benefit
36. Jacobs JD, Foster M, Wan J, Pershad J. 7% Hypertonic saline in acute bronchiolitis: a randomized controlled trial. Pediatrics 2014; 133:e8-e13
37. Sharma BS, Gupta MK, Rafik SP. Hypertonic (3%) saline vs 0.93% saline nebulization for acute viral bronchiolitis: a randomized controlled trial. Indian Pediatr 2013; 50:743-747
38. Cornfield DN. Bronchiolitis: doing less and still getting better. Pediatrics 2014; 133:e213-e214
39. Garrison MM, Christakis DA, Harvey E, et al. Systemic corticosteroids in infant bronchiolitis: a meta-analysis. Pediatrics 2000; 105:E44
40. Fernandes RM Bialy LM Vandermeer B et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev 2013 6 CD004878
41. Van Cleve WC, Christakis DA. Unnecessary care for bronchiolitis decreases with increasing inpatient prevalence of bronchiolitis. Pediatrics 2011; 128:e1106-e1112
42. Plint AC, Johnson DW, Patel H, et al. Epinephrine and dexamethasone in children with bronchiolitis. N Engl J Med 2009; 360:2079-2089
43. Alverson BK, Ralston S, Garber M. A cost analysis is premature. Pediatrics 2011; 127:e513-e514; author reply e515-e516
44. Alansari K, Sakran M, Davidson BL, et al. Oral dexamethasone for bronchiolitis: a randomized trial. Pediatrics 2013; 132:e810-e816
45. Corneli HM, Zorc JJ, Mahajan P, et al. A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med 2007; 357:331-339
46. Panickar J, Lakhanpaul M, Lambert PC, et al. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med 2009; 360:329-338
47. Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD. A clinical index to define risk of asthma in young children with recurrent wheezing. Am J Respir Crit Care Med 2000; 162 (4 Pt 1):1403-1406
48. Lukkarinen M, Lukkarinen H, Lehtinen P, et al. Prednisolone reduces recurrent wheezing after first rhinovirus wheeze: a 7-year follow-up. Pediatr Allergy Immunol 2013; 24:237-243
49. Palivizumab, a huma nized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. The IMpact-RSV Study Group. Pediatrics 1998; 102 (3 Pt 1):531-537
50. Feltes TF, Cabalka AK, Meissner HC, et al. Palivizumab prophylaxis reduces hospitalization due to respiratory syncytial virus in young children with hemodynamically significant congenital heart disease. J Pediatr 2003; 143: 532-540
51. Meissner HC, Kimberlin DW. RSV immunoprophylaxis: does the benefit justify the cost Pediatrics 2013; 132:915-918
52. Blanken MO, Rovers MM, Molenaar JM, et al. Respiratory syncytial virus and recurrent wheeze in healthy preterm infants. N Engl J Med 2013; 368:1791-1799
53. Yoshihara S, Kusuda S, Mochizuki H, et al. Effect of palivizumab prophylaxis on subsequent recurrent wheezing in preterm infants. Pediatrics 2013; 132:811-818
54. Mansbach JM, Piedra PA, Stevenson MD, et al. Prospective multicenter study of children with bronchiolitis requiring mechanical ventilation. Pediatrics 2012; 130:e492-500
55. Mussman GM, Parker MW, Statile A, et al. Suctioning and length of stay in infants hospitalized with bronchiolitis. JAMA Pediatr 2013; 167:414-421
56. Schroeder AR, Marmor AK, Pantell RH, Newman TB. Impact of pulse oximetry and oxygen therapy on length of stay in bronchiolitis hospitalization s. Arch Pediatr Adolesc Med 2004; 158:527-530
57. Unger S, Cunningham S. Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis. Pediatrics 2008; 121: 470-475
58. Bass JL, Gozal D. Oxygen therapy for bronchiolitis. Pediatrics 2007; 119:611
59. Cunningham S, McMurray A. Observational study of two oxygen saturation targets for discharge in bronchiolitis. Arch Dis Child 2012; 97:361-363
60. Bass JL, Corwin M, Gozal D, et al. The effect of chronic or intermittent hypoxia on cognition in childhood: a review of the evidence. Pediatrics 2004; 114: 805-816
61. Hunt CE Corwin MJ Lister G et al. Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months of age. Collaborative Home Infant Monitoring Evaluation (CHIME) Study Group. J Pediatr 1999 135 580-586
62. Hunt CE, Corwin MJ, Weese-Mayer DE, et al. Longitudinal assessment of hemoglobin oxygen satu ration in preterm and term infants in the first six months of life. J Pediatr 2011; 159:377-383; e1
63. Bajaj L, Turner CG, Bothner J. A randomized trial of home oxygen therapy from the emergency department for acute bronchiolitis. Pediatrics 2006; 117: 633-640
64. Halstead S, Roosevelt G, Deakyne S, Bajaj L. Discharged on supplemental oxygen from an emergency department in patients with bronchiolitis. Pediatrics 2012; 129:e605-e610
65. Sandweiss DR, Mundorff MB, Hill T, et al. Decreasing hospital length of stay for bronchiolitis by using an observation unit and home oxygen therapy. JAMA Pediatr 2013; 167:422-428
66. Sandweiss DR, Kadish HA, Campbell KA. Outpatient management of patients with bronchiolitis discharged home on oxygen: a survey of general pediatricians. Clin Pediatr (Phila) 2012; 51:442-446
67. McKiernan C, Chua LC, Visintainer PF, Allen H. High flow nasal cannulae therapy in infants with bronchiolitis. J Pediatr 2010; 156:634-638
68. Schibler A, Pham TM, Dunster KR, et al. Reduced intubation rates for infants after introduction of high-flow nasal prong oxygen delivery. Intensive Care Med 2011; 37:847-852
69. Wing R, James C, Maranda LS, Armsby CC. Use of high-flow nasal cannula support in the emergency department reduces the need for intubation in pediatric acute respiratory insufficiency . Pediatr Emerg Care 2012; 28: 1117-1123
70. Hegde S, Prodhan P. Serious air leak syndrome complicating high-flow nasal cannula therapy: a report of 3 cases. Pediatrics 2013; 131:e939-e944
71. Ioannidis JP. Contradicted and initially stronger effects in highly cited clinical research. JAMA 2005; 294:218-228
72. Lehtinen P, Ruohola A, Vanto T, et a l. Prednisolone reduces recurrent wheezing after a first wheezing episode associated with rhinovirus infection or eczema. J Allergy Clin Immunol 2007; 119:570-575
73. Berwick DM, Hackbarth AD. Elim inating waste in US healthcare. JAMA 2012; 307:1513-1516.