17β-oestradiol enhances global DNA hypomethylation in CD4-positive T cells from female patients with lupus, through overexpression of oestrogen receptor-α-mediated downregulation of DNMT1

Clinical and Experimental Dermatology

Volumn 39, Issue 4, 2014, Pages 525-532

  Wu, Z ^a   Sun, Y ^a   Mei, X ^a   Zhang, C ^b   Pan, W ^c   Shi, W ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Songjiang District Central Hospital   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; DNA METHYLTRANSFERASE 1; DOUBLE STRANDED DNA ANTIBODY; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; CD4 ANTIGEN; ESTROGEN RECEPTOR ANTAGONIST; FULVESTRANT; DNA (CYTOSINE 5) METHYLTRANSFERASE; DNA (CYTOSINE-5-)-METHYLTRANSFERASE 1; ESTROGEN RECEPTOR ALPHA, HUMAN;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; DRUG EXPOSURE; ENZYME LINKED IMMUNOSORBENT ASSAY; ERYTHROCYTE COUNT; ESTROGEN BLOOD LEVEL; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE COUNT; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RASH; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SLEDAI; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTE COUNT; UPREGULATION; WESTERN BLOTTING; ENZYME INHIBITION; ESTRADIOL BLOOD LEVEL; ESTROGEN ACTIVITY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; PATHOGENESIS; ANALYSIS OF VARIANCE; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; LUPUS ERYTHEMATOSUS, SYSTEMIC; METABOLISM;

ADULT; ANALYSIS OF VARIANCE; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; RNA, MESSENGER;

EID: 84900416859     PISSN: 03076938     EISSN: 13652230     Source Type: Journal    
DOI: 10.1111/ced.12346     Document Type: Article

References (21)

1. Hewagama A, Richardson B,. The genetics and epigenetics of autoimmune diseases. J Autoimmun 2009; 33: 3-11.
2. Richardson BC, Liebling MR, Hudson JL,. CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation. Clin Immunol Immunopathol 1990; 55: 368-81.
3. Wu Z, Li X, Qin H, et al,. Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity. J Dermatol Sci 2013; 71: 167-73.
4. Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK,. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med 1978; 147: 1568-83.
5. Khorasanizadeh S, Rastinejad F,. Nuclear-receptor interactions on DNA-response elements. Trends Biochem Sci 2001; 26: 384-90.
6. O'Malley BW,. Coregulators: from whence came these "master genes". Mol Endocrinol 2007; 21: 1009-13.
7. Rider V, Jones S, Evans M, et al,. Estrogen increases CD40 ligand expression in T cells from women with systemic lupus erythematosus. J Rheumatol 2001; 28: 2644-9.
8. Katz U, Zandman-Goddard G,. Drug-induced lupus: an update. Autoimmun Rev 2010; 10: 46-50.
9. Scheinbart LS, Johnson MA, et al,. Procainamide inhibits DNA methyltransferase in a human T cell line. J Rheumatol 1991; 18: 530-4.
10. Passas CM, Wong RL, Peterson M, et al,. A comparison of the specificity of the 1971 and 1982 American Rheumatism Association criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1985; 28: 620-3.
11. Patel MV, Ghosh M, Fahey JV, Wira CR,. Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol. PLoS ONE 2012; 7: e35654.
12. Qin H, Zhu X, Liang J, et al,. MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1. J Dermatol Sci 2013; 69: 61-7.
13. Yakimchuk K, Jondal M, Okret S,. Estrogen receptor alpha and beta in the normal immune system and in lymphoid malignancies. Mol Cell Endocrinol 2013; 375: 121-9.
14. Zhang Y, Zhao M, Sawalha AH, et al,. Impaired DNA methylation and its mechanisms in CD4(+)T cells of systemic lupus erythematosus. J Autoimmun 2013; 41: 92-9.
15. Yamagata Y, Asada H, Tamura I, et al,. DNA methyltransferase expression in the human endometrium: down-regulation by progesterone and estrogen. Hum Reprod 2009; 24: 1126-32.
16. Treas JN, Tyagi T, Singh KP,. Effects of chronic exposure to arsenic and estrogen on epigenetic regulatory genes expression and epigenetic code in human prostate epithelial cells. PLoS ONE 2012; 7: e43880.
17. Ward JM, Rider V, Abdou NI, Kimler B,. Estradiol differentially regulates calreticulin: a potential link with abnormal T cell function in systemic lupus erythematosus? Lupus 2013; 22: 583-96.
18. Rider V, Abdou NI,. Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus. Int Immunopharmacol 2001; 1: 1009-24.
19. Lin HL, Yen JH, Chiou SS, et al,. Estradiol upregulates calcineurin expression via overexpression of estrogen receptor alpha gene in systemic lupus erythematosus. Kaohsiung J Med Sci 2011; 27: 125-31.
20. Walters E, Rider V, Abdou NI, et al,. Estradiol targets T cell signaling pathways in human systemic lupus. Clin Immunol 2009; 133: 428-36.
21. Higuchi T, Aiba Y, Nomura T, et al,. Cutting edge: ectopic expression of CD40 ligand on B cells induces lupus-like autoimmune disease. J Immunol 2002; 168: 9-12.