Prostate cancer risk alleles are associated with prostate cancer volume and prostate size

Journal of Urology

Volumn 191, Issue 6, 2014, Pages 1733-1736

  Reinhardt, Daniel ^a   Helfand, Brian T ^b   Cooper, Phillip R ^a   Roehl, Kimberly A ^a   Catalona, William J ^a   Loeb, Stacy ^c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

organ size; polymorphism; prostate; prostatic neoplasms; risk; single nucleotide

Indexed keywords

PROSTATE SPECIFIC ANTIGEN; DNA;

ADULT; ALLELE; ARTICLE; CANCER RISK; CANCER SIZE; CHROMOSOME 8Q; CHROMOSOME 8Q24; COHORT ANALYSIS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GLEASON SCORE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE SIZE; PROSTATE VOLUME; PROSTATECTOMY; SINGLE NUCLEOTIDE POLYMORPHISM; BIOPSY; CANCER STAGING; CHROMOSOME 8; COMPARATIVE STUDY; FOLLOW UP; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENETICS; MIDDLE AGED; ORGAN SIZE; PATHOLOGY; PROSTATE; PROSTATIC NEOPLASMS; RETROSPECTIVE STUDY; CANCER SUSCEPTIBILITY; CHROMOSOME 10Q; CHROMOSOME 19; GENETIC MARKER;

ALLELES; BIOPSY; CHROMOSOMES, HUMAN, PAIR 8; DNA, NEOPLASM; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; ORGAN SIZE; POLYMORPHISM, GENETIC; PROSTATE; PROSTATECTOMY; PROSTATIC NEOPLASMS; RETROSPECTIVE STUDIES;

EID: 84900411720     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2013.12.030     Document Type: Article

References (29)

1. M.B. Ishak, and V.N. Giri A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genome-wide association studies Cancer Epidemiol Biomarkers Prev 20 2011 1599
2. B.T. Helfand, A.J. Fought, and S. Loeb et al. Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk J Urol 184 2010 501
3. J. Sun, B.L. Chang, and S.D. Isaacs et al. Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations Prostate 68 2008 1257
4. S.L. Zheng, J. Sun, and F. Wiklund et al. Cumulative association of five genetic variants with prostate cancer N Engl J Med 358 2008 910
5. R.A. Eeles, A.A. Olama, and S. Benlloch et al. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array Nat Genet 45 2013 385
6. L.T. Amundadottir, P. Sulem, and J. Gudmundsson et al. A common variant associated with prostate cancer in European and African populations Nat Genet 38 2006 652
7. J. Gudmundsson, P. Sulem, and D.F. Gudbjartsson et al. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility Nat Genet 41 2009 1122
8. J. Gudmundsson, P. Sulem, and D.F. Gudbjartsson et al. A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer Nat Genet 44 2012 1326
9. J. Gudmundsson, P. Sulem, and T. Rafnar et al. Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer Nat Genet 40 2008 281
10. J. Gudmundsson, P. Sulem, and V. Steinthorsdottir et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes Nat Genet 39 2007 977
11. A.K. Kader, J. Sun, and B.H. Reck et al. Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial Eur Urol 62 2012 953
12. K.H. Kim, S.K. Lim, and T.Y. Shin et al. Tumor volume adds prognostic value in patients with organ-confined prostate cancer Ann Surg Oncol 20 2013 3133
13. B.I. Chung, T.V. Tarin, and M. Ferrari et al. Comparison of prostate cancer tumor volume and percent cancer in prediction of biochemical recurrence and cancer specific survival Urol Oncol 29 2011 314
14. F.K. Chun, A. Briganti, and C. Jeldres et al. Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy Eur J Cancer 43 2007 536
15. B.A. Nelson, S.B. Shappell, and S.S. Chang et al. Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer BJU Int 97 2006 1169
16. J. Gudmundsson, S. Besenbacher, and P. Sulem et al. Genetic correction of PSA values using sequence variants associated with PSA levels Science Transl Med 2 2010 62ra92
17. B.T. Helfand, S. Loeb, and Q.Y. Hu et al. Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies J Urol 189 2013 1697
18. B.T. Helfand, Q. Hu, and S. Loeb et al. Genetic sequence variants are associated with severity of lower urinary tract symptoms and prostate cancer susceptibility J Urol 189 2013 845
19. J. Gudmundsson, P. Sulem, and A. Manolescu et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 Nat Genet 39 2007 631
20. P.A. Humphrey, and R.T. Vollmer Percentage carcinoma as a measure of prostatic tumor size in radical prostatectomy tissues Mod Pathol 10 1997 326
21. B.T. Larson, C. Magi-Galluzzi, and G. Casey et al. Pathological aggressiveness of prostatic carcinomas related to RNASEL R462Q allelic variants J Urol 179 2008 1344
22. E.R. Ortner, R.B. Hayes, and J. Weissfeld et al. Effect of homeodomain protein NKX3.1 R52C polymorphism on prostate gland size Urology 67 2006 311
23. C.H. Chiang, K.K. Chen, and L.S. Chang et al. The impact of polymorphism on prostate specific antigen gene on the risk, tumor volume and pathological stage of prostate cancer J Urol 171 2004 1529
24. L. Jia, G. Landan, and M. Pomerantz et al. Functional enhancers at the gene-poor 8q24 cancer-linked locus PLoS Genet 5 2009 e1000597
25. N. Ahmadiyeh, M.M. Pomerantz, and C. Grisanzio et al. 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC Proc Natl Acad Sci U S A 107 2010 9742
26. M.M. Pomerantz, C.A. Beckwith, and M.M. Regan et al. Evaluation of the 8q24 prostate cancer risk locus and MYC expression Cancer Res 69 2009 5568
27. S. Tuupanen, M. Turunen, and R. Lehtonen et al. The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling Nat Genet 41 2009 885
28. K.B. Meyer, A.T. Maia, and M. O'Reilly et al. A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression PLoS Genet 7 2011 e1002165
29. Z. Kote-Jarai, A. Amin Al Olama, and D. Leongamornlert et al. Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript Hum Genet 129 2011 687