Personalized prostate specific antigen testing using genetic variants may reduce unnecessary prostate biopsies

Journal of Urology

Volumn 189, Issue 5, 2013, Pages 1697-1701

  Helfand, Brian T ^a   Loeb, Stacy ^c   Hu, Qiaoyan ^b   Cooper, Phillip R ^b   Roehl, Kimberly A ^b   McGuire, Barry B ^b   Baumann, Nikola A ^d   Catalona, William J ^b  

^a NORTHSHORE UNIVERSITY HEALTHSYSTEM   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d MAYO CLINIC   (United States)

Author keywords

biopsy; polymorphism, single nucleotide; prostate; prostate specific antigen; prostatic neoplasms

Indexed keywords

PROSTATE SPECIFIC ANTIGEN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; MALE; NORMAL HUMAN; PERSONALIZED MEDICINE; PRIORITY JOURNAL; PROSTATE BIOPSY; PROSTATE CANCER; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BIOPSY; GENETIC VARIATION; HUMANS; INDIVIDUALIZED MEDICINE; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; UNNECESSARY PROCEDURES;

EID: 84876295479     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2012.12.023     Document Type: Article

References (26)

1. A. Jemal, R. Siegel, J. Xu Cancer statistics, 2010 CA Cancer J Clin 60 2010 277
2. G. Bartsch, W. Horninger, H. Klocker Tyrol Prostate Cancer Demonstration Project: early detection, treatment, outcome, incidence and mortality BJU Int 101 2008 809
3. F.H. Schröder, J. Hugosson, M.J. Roobol Screening and prostate-cancer mortality in a randomized European study N Engl J Med 360 2009 1320
4. R.B. Nadler, P.A. Humphrey, D.S. Smith Effect of inflammation and benign prostatic hyperplasia on elevated serum prostate specific antigen levels J Urol 154 1995 407
5. G. Aus, J.E. Damber, A. Khatami Individualized screening interval for prostate cancer based on prostate-specific antigen level: results of a prospective, randomized, population-based study Arch Intern Med 165 2005 1857
6. B.B. McGuire, B.T. Helfand, S. Loeb Outcomes in patients with Gleason score 8-10 prostate cancer: relation to preoperative PSA level BJU Int 109 2012 1764
7. K.L. Greene, P.C. Albertsen, R.J. Babaian Prostate specific antigen best practice statement: 2009 update J Urol 182 2009 2232
8. M.B. Ishak, V.N. Giri A systematic review of replication studies of prostate cancer susceptibility genetic variants in high-risk men originally identified from genome-wide association studies Cancer Epidemiol Biomarkers Prev 20 2011 1599
9. B.T. Helfand, A.J. Fought, S. Loeb Genetic prostate cancer risk assessment: common variants in 9 genomic regions are associated with cumulative risk J Urol 184 2010 501
10. J. Sun, B.L. Chang, S.D. Isaacs Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations Prostate 68 2008 1257
11. S.L. Zheng, J. Sun, F. Wiklund Cumulative association of five genetic variants with prostate cancer N Engl J Med 358 2008 910
12. A. Bansal, D.K. Murray, J.T. Wu Heritability of prostate-specific antigen and relationship with zonal prostate volumes in aging twins J Clin Endocrinol Metab 85 2000 1272
13. G. Pilia, W.M. Chen, A. Scuteri Heritability of cardiovascular and personality traits in 6,148 Sardinians PLoS Genet 2 2006 e132
14. Z. Kote-Jarai, A. Amin Al Olama, D. Leongamornlert Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript Hum Genet 129 2011 687
15. K.L. Penney, F.R. Schumacher, P. Kraft Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels Carcinogenesis 32 2011 853
16. R.A. Eeles, Z. Kote-Jarai, G.G. Giles Multiple newly identified loci associated with prostate cancer susceptibility Nat Genet 40 2008 316
17. J. Gudmundsson, S. Besenbacher, P. Sulem Genetic correction of PSA values using sequence variants associated with PSA levels Sci Transl Med 2 2010 62ra92
18. S. Loeb, H.B. Carter, P.C. Walsh Single nucleotide polymorphisms and the likelihood of prostate cancer at a given prostate specific antigen level J Urol 182 2009 101
19. B.V. Le, C.R. Griffin, S. Loeb [-2] Proenzyme prostate specific antigen is more accurate than total and free prostate specific antigen in differentiating prostate cancer from benign disease in a prospective prostate cancer screening study J Urol 183 2010 1355
20. F.H. Schröder, J. Hugosson, M.J. Roobol Prostate-cancer mortality at 11 years of follow-up N Engl J Med 366 2012 981
21. C. Savblom, A. Giwercman, J. Malm Association between polymorphisms in the prostate-specific antigen (PSA) promoter and release of PSA Int J Androl 32 2009 479
22. P. Pal, H. Xi, G. Sun Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin Hum Genet 122 2007 251
23. C.H. Chiang, K.K. Chen, L.S. Chang The impact of polymorphism on prostate specific antigen gene on the risk, tumor volume and pathological stage of prostate cancer J Urol 171 2004 1529
24. S.D. Cramer, B.L. Chang, A. Rao Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels J Natl Cancer Inst 95 2003 1044
25. D.G. Bostwick, I. Meiers Prostate biopsy and optimization of cancer yield Eur Urol 49 2006 415
26. S. Loeb, S. van den Heuvel, X. Zhu Infectious complications and hospital admissions after prostate biopsy in a European randomized trial Eur Urol 61 2012 1110