A Web-based nomogram predicting para-aortic nodal metastasis in incompletely staged patients with endometrial cancer: A Korean multicenter study

International Journal of Gynecological Cancer

Volumn 24, Issue 3, 2014, Pages 513-519

  Kang, Sokbom ^a   Lee, Jong Min ^b   Lee, Jae Kwan ^c   Kim, Jae Weon ^d   Cho, Chi Heum ^e   Kim, Seok Mo ^f   Park, Sang Yoon ^a   Park, Chan Yong ^g   Kim, Ki Tae ^h  

^a National Cancer Center   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

^c Korea University College of Medicine   (South Korea)

^d Seoul National University   (South Korea)

^e Dongsan Medical Center   (South Korea)

^f Chonnam National University   (South Korea)

^g Gachon University   (South Korea)

^h Inje University College of Medicine   (South Korea)

Author keywords

Endometrial cancer; Lymph node; Lymphadenectomy; Metastasis; Para aortic; Staging

Indexed keywords

CA 125 ANTIGEN;

ADULT; ARTICLE; BOOTSTRAPPING; CA 125 ANTIGEN BLOOD LEVEL; CALIBRATION; CANCER STAGING; ENDOMETRIUM CANCER; ENDOMETRIUM CARCINOMA; ENDOMETRIUM SARCOMA; FEMALE; HUMAN; INTERMEDIATE RISK POPULATION; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; NOMOGRAM; PARAAORTIC NODAL METASTASIS; PREDICTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PUBLICATION; RETROSPECTIVE STUDY; WEB BASED NOMOGRAM; ABDOMINAL AORTA; AGED; CLINICAL TRIAL; ENDOMETRIUM TUMOR; LYMPH NODE; MIDDLE AGED; MULTICENTER STUDY; PATHOLOGY; RISK ASSESSMENT; SOUTH KOREA; STATISTICAL MODEL; VALIDATION STUDY; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; AORTA, ABDOMINAL; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; LOGISTIC MODELS; LYMPH NODES; LYMPHATIC METASTASIS; MIDDLE AGED; NOMOGRAMS; REPUBLIC OF KOREA; RETROSPECTIVE STUDIES; RISK ASSESSMENT; YOUNG ADULT;

EID: 84900404333     PISSN: 1048891X     EISSN: 15251438     Source Type: Journal    
DOI: 10.1097/IGC.0000000000000090     Document Type: Article

References (22)

1. Benedetti Panici P, Basile S, Maneschi F, et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stageendometrial carcinoma: randomized clinical trial. J Natl Cancer Inst. 2008;100:1707-1716.
2. ASTEC study group, Kitchener H, Swart AM, Qian Q, et al. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): a randomised study. Lancet. 2009;373:125-136.
3. Greer BE, Koh WJ, Abu-Rustum N, et al. Uterine neoplasms. Clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2009;7:498-531.
4. American College of Obstetricians and Gynecologists. ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer. Obstet Gynecol. 2005; 106:413-425.
5. Todo Y, Kato H, Kaneuchi M, et al. Survival effect of para-aortic lymphadenectomy in endometrial cancer (SEPAL study): a retrospective cohort analysis. Lancet. 2010;375:1165-1172.
6. Sakuragi N. Emerging concept of tailored lymphadenectomy in endometrial cancer. J Gynecol Oncol. 2012;23:210-212.
7. Chan JK, Wu H, Cheung MK, et al. The outcomes of 27,063 women with unstaged endometrioid uterine cancer. Gynecol Oncol. 2007;106:282-288.
8. Mariani A,Webb MJ, Keeney GL, et al. Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary? Am J Obstet Gynecol. 2000;182:1506-1519.
9. Milam MR, Java J, Walker JL, et al. Nodal metastasis risk in endometrioid endometrial cancer. Obstet Gynecol. 2012; 119:286-292.
10. Creasman WT, Morrow CP, Bundy BN, et al. Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer. 1987;60:2035-2041.
11. Turan T, Hizli D, Sarici S, et al. Is it possible to predict para-aortic lymph node metastasis in endometrial cancer? Eur J Obstet Gynecol Reprod Biol. 2011;158:274-279.
12. Chang SJ, Kong TW, Kim WY, et al. Lymph-vascular space invasion as a significant risk factor for isolated para-aortic lymph node metastasis in endometrial cancer: a study of 203 consecutive patients. Ann Surg Oncol. 2011;18:58-64.
13. Todo Y, Sakuragi N, Nishida R, et al. Combined use of magnetic resonance imaging, CA 125 assay, histologic type, and histologic grade in the prediction of lymph node metastasis in endometrial carcinoma. Am J Obstet Gynecol. 2003;188: 1265-1272.
14. Ebina Y, Sakuragi N, Hareyama H, et al. Para-aortic lymph node metastasis in relation to serum CA 125 levels and nuclear grade in endometrial carcinoma. Acta Obstet Gynecol Scand. 2002;81:458-465.
15. Nomura H, Aoki D, Suzuki N, et al. Analysis of clinicopathologic factors predicting para-aortic lymph node metastasis in endometrial cancer. Int J Gynecol Cancer. 2006;16:799-804.
16. Karube Y, Fujimoto T, Takahashi O, et al. Histopathological prognostic factors predicting para-aortic lymph node metastasis in patients with endometrioid uterine cancer. Gynecol Oncol. 2010;118:151-154.
17. Kang S, Lee JM, Lee JK, et al. How low is low enough? Evaluation of various risk-assessment models for lymph node metastasis in endometrial cancer: a Korean multicenter study. J Gynecol Oncol. 2012;23:251-256.
18. Lemeshow S, Hosmer DW Jr. A review of goodness of fit statistics for use in the development of logistic regression models. Am J Epidemiol. 1982;115:92-106
19. Deeks JJ, Altman DG. Diagnostic tests 4: likelihood ratios. BMJ. 2004;329:168-169.
20. Todo Y, Okamoto K, Hayashi M, et al. A validation study of a scoring system to estimate the risk of lymph node metastasis for patients with endometrial cancer for tailoring the indication of lymphadenectomy. Gynecol Oncol. 2007; 104:623-628.
21. Kumar S, Mariani A, Bakkum-Gamez JN, et al. Risk factors that mitigate the role of paraaortic lymphadenectomy in uterine endometrioid cancer. Gynecol Oncol. 2013;130:441-445.
22. Takeshima N, Umayahara K, Fujiwara K, et al. Effectiveness of postoperative chemotherapy for para-aortic lymph node metastasis of endometrial cancer. Gynecol Oncol. 2006; 102:214-217.