Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: Early detection of renal dysfunction using the ratio of serine enantiomers

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Sasabe, Jumpei ^a   Suzuki, Masataka ^a   Miyoshi, Yurika ^b   Tojo, Yosuke ^c   Okamura, Chieko ^c   Ito, Sonomi ^a   Konno, Ryuichi ^d   Mita, Masashi ^c   Hamase, Kenji ^b   Aiso, Sadakazu ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c SHISEIDO RESEARCH CENTER   (Japan)

^d INTERNATIONAL UNIVERSITY OF HEALTH AND WELFARE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; CYSTATIN C; DEXTRO AMINO ACID OXIDASE; KIDNEY INJURY MOLECULE 1; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; RACEMASE; SERINE;

ACUTE KIDNEY FAILURE; AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BODY FLUID; CONTROLLED STUDY; ENANTIOMER; ENZYME ACTIVITY; ENZYME INACTIVATION; EXCRETION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; HOMEOSTASIS; HUMAN; KIDNEY DYSFUNCTION; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MONITORING; MOUSE; NONHUMAN; URINALYSIS;

ACUTE KIDNEY INJURY; ACUTE-PHASE PROTEINS; ANIMALS; CREATININE; CYSTATIN C; D-AMINO-ACID OXIDASE; HUMANS; KIDNEY FUNCTION TESTS; LIPOCALINS; MALE; MICE; ONCOGENE PROTEINS; REPERFUSION INJURY; SERINE; STEREOISOMERISM;

EID: 84900397811     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0086504     Document Type: Article

References (35)

1. Wolosker H, Sheth KN, Takahashi M, Mothet JP, Brady RO Jr, et al. (1999) Purification of serine racemase: biosynthesis of the neuromodulator D-serine. Proc Natl Acad Sci U S A 96: 721-725. (Pubitemid 29061275)
2. Basu AC, Tsai GE, Ma CL, Ehmsen JT, Mustafa AK, et al. (2009) Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry 14: 719-727.
3. Silbernagl S, Volker K, Dantzler WH (1999) D-Serine is reabsorbed in rat renal pars recta. Am J Physiol 276: F857-863. (Pubitemid 29323559)
4. Nagata Y, Akino T, Ohno K, Kataoka Y, Ueda T, et al. (1987) Free D-amino acids in human plasma in relation to senescence and renal diseases. Clin Sci (Lond) 73: 105-108. (Pubitemid 17079485)
5. Brückner H, Hausch M (1993) Gas chromatographic characterization of free Damino acids in the blood serum of patients with renal disorders and of healthy volunteers. J Chromatogr 614: 7-17. (Pubitemid 23122475)
6. Fukushima T, Santa T, Homma H, Nagatomo R, Imai K (1995) Determination of D-amino acids in serum from patients with renal dysfunction. Biol Pharm Bull 18: 1130-1132.
7. Kawasaka K, Tatsumi N (1998) D-Amino acid oxidase activity in urine obtained from patients with renal disorders. Clin Nephrol 49: 214-220. (Pubitemid 28181561)
8. Zhang H, Qi L, Lin Y, Mao L, Chen Y (2012) Study on the decrease of renal Damino acid oxidase activity in the rat after renal ischemia by chiral ligand exchange capillary electrophoresis. Amino Acids 42: 337-345.
9. Ganote CE, Peterson DR, Carone FA (1974) The nature of D-serine-induced nephrotoxicity. Am J Pathol 77: 269-282.
10. Kaltenbach JP, Carone FA, Ganote CE (1982) Compounds protective against renal tubular necrosis induced by D-serine and D-2,3-diaminopropionic acid in the rat. Exp Mol Pathol 37: 225-234. (Pubitemid 13201258)
11. Sasabe J, Miyoshi Y, Suzuki M, Mita M, Konno R, et al. (2012) D-Amino acid oxidase controls motoneuron degeneration through D-serine. Proc Natl Acad Sci U S A 109: 627-632.
12. Miyoshi Y, Konno R, Sasabe J, Ueno K, Tojo Y, et al. (2012) Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase. Amino Acids 43: 1919-1931.
13. Miyoshi Y, Hamase K, Okamura T, Konno R, Kasai N, et al. (2011) Simultaneous two-dimensional HPLC determination of free D-serine and Dalanine in the brain and periphery of mutant rats lacking D-amino-acid oxidase. J Chromatogr B 879: 3184-3189.
14. Watanabe T, Motomura Y, Suga T (1978) A new colorimetric determination of D-amino acid oxidase and urate oxidase activity. Anal Biochem 86: 310-315. (Pubitemid 9050400)
15. Xia M, Liu Y, Figueroa DJ, Chiu CS, Wei N, et al. (2004) Characterization and localization of a human serine racemase. Brain Res Mol Brain Res 125: 96-104. (Pubitemid 38757395)
16. Horiike K, Tojo H, Arai R, Nozaki M, Maeda T (1994) D-Amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res 652: 297-303.
17. Han W, Bailly V, Abichandani R, Thadhani R, Bonventre J (2002) Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Kidney Int 62: 237-44. (Pubitemid 34754067)
18. Mishra J, Ma Q, Prada A, Mitsnefes M, Zahedi K, et al. (2003) Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol 14: 2534-43. (Pubitemid 37169339)
19. Hashimoto K, Fukushima T, Shimizu E, Komatsu N, Watanabe H, et al. (2003) Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry 60: 572-576. (Pubitemid 36682314)
20. Grant SL, Shulman Y, Tibbo P, Hampson DR, Baker GB (2006) Determination of D-serine and related neuroactive amino acids in human plasma by highperformance liquid chromatography with fluorimetric detection. J Chromatogr B 844: 278-282. (Pubitemid 44792012)
21. Miyoshi Y, Hamase K, Tojo Y, Mita M, Konno R, et al. (2009) Determination of D-serine and D-alanine in the tissues and physiological fluids of mice with various D-amino-acid oxidase activities using two-dimensional high-performance liquid chromatography with fluorescence detection. J Chromatogr B 877: 2506-2512.
22. Maekawa M, Okamura T, Kasai N, Hori Y, Summer KH, et al. (2005) D-Amino-acid oxidase is involved in D-serine-induced nephrotoxicity. Chem Res Toxicol 18: 1678-1682. (Pubitemid 43257749)
23. Krug AW, Volker K, Dantzler WH, Silbernagl S (2007) Why is D-serine nephrotoxic and alpha-aminoisobutyric acid protective? Am J Physiol Renal Physiol 293: F382-390. (Pubitemid 47345039)
24. Mothet JP, Parent AT, Wolosker H, Brady RO Jr, Linden DJ, et al. (2000) D-Serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A 97: 4926-4931. (Pubitemid 30238659)
25. Anderson M, Suh JM, Kim EY, Dryer SE (2011) Functional NMDA receptors with atypical properties are expressed in podocytes. Am J Physiol Cell Physiol 300: C22-32.
26. Gonzalez-Cadavid NF, Ryndin I, Vernet D, Magee TR, Rajfer J (2000) Presence of NMDA receptor subunits in the male lower urogenital tract. J Androl 21: 566-578. (Pubitemid 30437703)
27. Kottgen M, Benzing T (2011) Strangers on a train: atypical glutamate receptors in the kidney glomerulus. Focus on "Functional NMDA receptors with atypical properties are expressed in podocytes". Am J Physiol Cell Physiol 300: C9-10.
28. Leung JC, Travis BR, Verlander JW, Sandhu SK, Yang SG, et al. (2002) Expression and developmental regulation of the NMDA receptor subunits in the kidney and cardiovascular system. Am J Physiol Regul Integr Comp Physiol 283: R964-971.
29. Sproul A, Steele SL, Thai TL, Yu S, Klein JD, et al. (2011) N-methyl-Daspartate receptor subunit NR3a expression and function in principal cells of the collecting duct. Am J Physiol Renal Physiol 301: F44-54.
30. Deng A, Thomson SC (2009) Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration. Am J Physiol Renal Physiol 296: F976-982.
31. Yang CC, Chien CT, Wu MH, Ma MC, Chen CF (2008) NMDA receptor blocker ameliorates ischemia-reperfusion-induced renal dysfunction in rat kidneys. Am J Physiol Renal Physiol 294: F1433-1440.
32. Pundir M, Arora S, Kaur T, Singh R, Singh AP (2013) Effect of modulating the allosteric sites of N-methyl-D-aspartate receptors in ischemia-reperfusion induced acute kidney injury. J Surg Res: 183: 668-677.
33. Obermuller N, Geiger H, Weipert C, Urbschat A (2013) Current developments in early diagnosis of acute kidney injury. Int Urol Nephrol, in press.
34. Furst P (1989) Amino acid metabolism in uremia. J Am Coll Nutr 8: 310-323.
35. Tizianello A, Deferrari G, Garibotto G, Robaudo C, Saffioti S, et al. (1989) Amino acid imbalance in patients with chronic renal failure. Contrib Nephrol 75: 185-193.