Renal NMDA receptors independently stimulate proximal reabsorption and glomerular filtration

American Journal of Physiology - Renal Physiology

Volumn 296, Issue 5, 2009, Pages

  Deng, Aihua ^a   Thomson, Scott C ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Glomerulotubular balance; L glycine; Micropuncture; N methyl D aspartate receptors; Tubuloglomerular feedback

Indexed keywords

DIZOCILPINE; GLYCINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GLOMERULUS; GLOMERULUS FILTRATION; GLOMERULUS FILTRATION RATE; HEMODYNAMICS; HENLE LOOP; KIDNEY BLOOD FLOW; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE ABSORPTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 66049102132     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.90391.2008     Document Type: Article

References (31)

1. Blantz RC, Tucker BJ. Measurements of glomerular dynamics. In: Methods in Pharmacology, edited by Martinez-Maldonado M. New York: Plenum, 1978, p. 141-163.
2. Deng A, Valdivielso JM, Munger KA, Blantz RC, Thomson SC. Vasodilatory N-methyl-D-aspartate receptors are constitutively expressed in rat kidney. J Am Soc Nephrol 13: 1381-1384, 2002. (Pubitemid 34441420)
3. De Nicola L, Blantz RC, Gabbai FB. Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat. J Clin Invest 89: 1248-1256, 1992.
4. De Nicola L, Blantz RC, Gabbai FB. Renal functional reserve in the early stage of experimental diabetes. Diabetes 41: 267-273, 1992.
5. De Nicola L, Blantz RC, Gabbai FB. Renal functional reserve in treated and untreated hypertensive rats. Kidney Int 40: 406-412, 1991.
6. De Nicola L, Keiser JA, Blantz RC, Gabbai FB. Angiotensin II and renal functional reserve in rats with Goldblatt hypertension. Hypertension 19: 790-794, 1992.
7. De Nicola L, Peterson OW, Obagi S, Kaiser JA, Wilson CB, Gabbai FB. Renal functional reserve in experimental chronic glomerulonephritis. Nephrol Dial Transplant 9: 1383-1389, 1994. (Pubitemid 24310278)
8. De Nicola L, Thomson SC, Wead LM, Brown MR, Gabbai FB. Arginine feeding modifies cyclosporine nephrotoxicity in rats. J Clin Invest 92: 1859-1865, 1993. (Pubitemid 23304553)
9. Dingledine R, Borges K, Bowie D, Traynelis SF. The glutamate receptor ion channels. Pharmacol Rev 51: 8-61, 1999. (Pubitemid 29113865)
10. Gabbai FB, DeNicola L, Garcia GE, Blantz RC. Role of angiotensin in the regulation of renal response to proteins. Semin Nephrol 15: 396-404, 1995.
11. Leung JC, Travis BR, Verlander JW, Sandhu SK, Yang SG, Zea AH, Weiner ID, Silverstein DM. Expression and developmental regulation of the NMDA receptor subunits in the kidney and cardiovascular system. Am J Physiol Regul Integr Comp Physiol 283: R964-R971, 2002.
12. Miracle CM, Rieg T, Mansoury H, Vallon V, Thomson SC. Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt. Am J Physiol Renal Physiol 295: F995-F1002, 2008.
13. Neumann KH, Rector FC Jr. Mechanism of NaCl and water reabsorption in the proximal convoluted tubule of rat kidney. J Clin Invest 58: 1110-1118, 1976.
14. Papadia S, Hardingham GE. The dichotomy of NMDA receptor signaling. Neuroscientist 13: 572-579, 2007. (Pubitemid 350077306)
15. Parks LD, Barfuss DW. Transepithelial transport and metabolism of glycine in S1, S2, and S3 cell types of the rabbit proximal tubule. Am J Physiol Renal Physiol 283: F1208-F1215, 2002.
16. Parsons CG, Stöffler A, Danysz W. Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system too little activation is bad, too much is even worse. Neuropharmacology 53: 699-723, 2007. (Pubitemid 47532143)
17. Pitts RF. A renal reabsorptive mechanism in the dog common to glycin and creatine. Am J Physiol 140: 156-167, 1943.
18. Pitts RF. The effect of infusing glycine and varying the dietary protein intake on renal hemodynamics in the dog. Am J Physiol 142: 355-365, 1944.
19. Schnermann J, Briggs JP. Interaction between loop of Henle flow and arterial pressure as determinants of glomerular pressure. Am J Physiol Renal Fluid Electrolyte Physiol 256: F421-F429, 1989. (Pubitemid 19086449)
20. Slomowitz LA, Deng A, Hammes JS, Gabbai F, Thomson SC. Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats. Am J Physiol Regul Integr Comp Physiol 282: R1096-R1103, 2002. (Pubitemid 34664562)
21. Slomowitz LA, Gabbai FB, Khang SJ, Satriano J, Thareau S, Deng A, Thomson SC, Blantz RC, Munger KA. Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expression. Am J Physiol Regul Integr Comp Physiol 287: R1184-R1189, 2004. (Pubitemid 39391063)
22. Thomson S, Bao D, Deng A, Vallon V. Adenosine formed by 5′-nucleotidase mediates tubuloglomerular feedback. J Clin Invest 106: 289-298, 2000. (Pubitemid 30483133)
23. Thomson SC, Blantz RC. Glomerulotubular balance, tubuloglomerular feedback, and salt homeostasis. J Am Soc Nephrol 19: 2272-2275, 2008.
24. Thomson SC, Blantz RC. Homeostatic efficiency of tubuloglomerular feedback in hydropenia, euvolemia, and acute volume expansion. Am J Physiol Renal Fluid Electrolyte Physiol 264: F930-F936, 1993.
25. Thomson SC, Deng A. Cyclic GMP mediates influence of macula densa nitric oxide over tubuloglomerular feedback. Kidney Blood Press Res 26: 10-18, 2003. (Pubitemid 36438796)
26. Thomson SC, Deng A, Bao D, Satriano J, Blantz RC, Vallon V. Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes. J Clin Invest 107: 217-224, 2001. (Pubitemid 32096838)
27. Thomson SC, Deng A, Komine N, Hammes JS, Blantz RC, Gabbai FB. Early diabetes as a model for testing the regulation of juxtaglomerular NOS I. Am J Physiol Renal Physiol 287: F732-F738, 2004. (Pubitemid 39280508)
28. Thomson SC, Deng A, Wead L, Richter K, Blantz RC, Vallon V. An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest 116: 1110-1116, 2006.
29. Thomson S, Vallon V, Blantz RC. Asymmetry of tubuloglomerular feedback effector mechanism with respect to ambient tubular flow. Am J Physiol Renal Fluid Electrolyte Physiol 271: F1123-F1130, 1996. (Pubitemid 126831065)
30. Thomson SC, Vallon V, Blantz RC. Resetting protects efficiency of tubuloglomerular feedback. Kidney Int Suppl 67: S65-S70, 1998. (Pubitemid 28405683)
31. Yang CC, Chien CT, Wu MH, Ma MC, Chen CF. NMDA receptor blocker ameliorates ischemia-reperfusion-induced renal dysfunction in rat kidneys. Am J Physiol Renal Physiol 294: F1433-F1440, 2008.