Integrating pathology into human disease modelling - How to eat the elephant

DMM Disease Models and Mechanisms

Volumn 7, Issue 5, 2014, Pages 495-497

  Scudamore, Cheryl L ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

Author keywords

IMPC; Mouse; Pathology; Phenotyping

Indexed keywords

ANIMAL MODEL; DISEASE MODEL; DRUG INDUSTRY; EXPERIMENTAL ANIMAL; FUNDING; HISTOPATHOLOGY; HUMAN; NONHUMAN; PATHOLOGY; PHENOTYPE; PRIORITY JOURNAL; REVIEW; ANIMAL; MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MICE; PATHOLOGY;

EID: 84900390492     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.016394     Document Type: Review

References (13)

1. Adissu, H. A., Estabel, J., Sunter, D., Tuck, E., Hooks, Y., Carragher, D. M., Clarke, K., Karp, N. A., Sanger Mouse Genetics Project, Newbigging, S., Jones, N., Morikawa, L., White, J. K. and McKerlie, C. (2014). Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Dis. Mod. Mech. 7, 515-524.
2. Brayton, C. F., Treuting, P. M. and Ward, J. M. (2012). Pathobiology of aging mice and GEM: background strains and experimental design. Vet. Pathol. 49, 85-105.
3. Brown, S. D. M. and Moore, M. W. (2012). Towards an encyclopaedia of mammalian gene function: the International Mouse Phenotyping Consortium. Dis. Model. Mech. 5, 289-292.
4. Cardiff, R. D., Ward, J. M. and Barthold, S. W. (2008). 'One medicine - one pathology': are veterinary and human pathology prepared? Lab. Invest. 88, 18-26.
5. ICH (2009). Guidance on nonclinical safety studies for the conduct of human trials and marketing authorisation for human pharmaceuticals M3 (R2). http://www.ich.org/fileadmin/Public-Web-Site/ICH-Products/Guidelines/ Multidisciplinary/M3-R2/Step4/M3-R2-Guideline.pdf.
6. Jubb, A. M., Koeppen, H. and Reis-Filho, J. S. (2014). Pathology in drug discovery and development. J. Pathol. 232, 99-102.
7. Ladiges, W., Ikeno, Y., Liggitt, D. and Treuting, P. M. (2013). Pathology is a critical aspect of preclinical aging studies. Pathobiology of Aging & Age-related Diseases 3, 1-4.
8. Schofield, P. N., Vogel, P., Gkoutos, G. V. and Sundberg, J. P. (2012). Exploring the elephant: histopathology in high-throughput phenotyping of mutant mice. Dis. Model. Mech. 5, 19-25.
9. Scudamore, C. L. (2014). Chapter 2. Practical approaches to reviewing and recording pathology data. In A Practical Guide to Histology of the Mouse (ed. C. L. Scudamore), pp. 25-42. Chichester, UK: Wiley-Blackwell.
10. Sundberg, J. P., Haschek, W. M., Hackman, R. C. and HogenEsch, H. (2004). Developing a comprehensive mouse pathology program. Comp. Med. 54, 617-621. (Pubitemid 44204195)
11. Turner, P. V., Haschek, W. M., Bolon, B., Diegel, K., Hayes, M. A., McEwen, B., Sargeant, A. M., Scudamore, C. L., Stalker, M., Beust, B. V. et al. (2014). Commentary: the role of the toxicologic pathologist in academia. Vet. Pathol. [Epub ahead of print] doi: 10.1177/0300985813519652.
12. van den Tweel, J. G. and Taylor, C. R. (2010). A brief history of pathology: Preface to a forthcoming series that highlights milestones in the evolution of pathology as a discipline. Virchows Arch. 457, 3-10.
13. Warren, M. V., Studley, M. L., Dubus, P., Fiette, L., Rozell, B., Quintanilla-Martinez, L., Raspa, M., Breuer, M., Song, J. Y., Gates, H. et al. (2009). An impending crisis in the provision of histopathology expertise for mouse functional genomics. J. Pathol. 217, 4-13.