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Volumn 232, Issue 2, 2014, Pages 99-102

Pathology in drug discovery and development

Author keywords

biomarkers; companion diagnostics; drug development; pathology

Indexed keywords

B RAF KINASE; BEVACIZUMAB; BIOLOGICAL MARKER; ONARTUZUMAB; PEMETREXED; RILOTUMUMAB; VASCULOTROPIN INHIBITOR;

EID: 84890283024     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4290     Document Type: Review
Times cited : (14)

References (38)
  • 1
    • 84890288893 scopus 로고    scopus 로고
    • Dendritic cells in IBD pathogenesis: An area of therapeutic opportunity?
    • Bates J, Diehl L,. Dendritic cells in IBD pathogenesis: an area of therapeutic opportunity? J Pathol 2014; 232: 112-120.
    • (2014) J Pathol , vol.232 , pp. 112-120
    • Bates, J.1    Diehl, L.2
  • 2
    • 84890291629 scopus 로고    scopus 로고
    • Advances in mouse tumour models to guide drug development and identify resistance mechanisms
    • Das Thakur M, Pryer NK, Singh M,. Advances in mouse tumour models to guide drug development and identify resistance mechanisms. J Pathol 2014; 232: 103-111.
    • (2014) J Pathol , vol.232 , pp. 103-111
    • Das Thakur, M.1    Pryer, N.K.2    Singh, M.3
  • 3
    • 84890295992 scopus 로고    scopus 로고
    • The evolving genomic classification of lung cancer
    • Shames DS, Wistuba II,. The evolving genomic classification of lung cancer. J Pathol 2014; 232: 121-133.
    • (2014) J Pathol , vol.232 , pp. 121-133
    • Shames, D.S.1    Wistuba, I.I.2
  • 4
    • 58149382583 scopus 로고    scopus 로고
    • A mouse model for EML4-ALK-positive lung cancer
    • Soda M, Takada S, Takeuchi K, et al., A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci USA 2008; 105: 19893-19897.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19893-19897
    • Soda, M.1    Takada, S.2    Takeuchi, K.3
  • 5
    • 84890283023 scopus 로고    scopus 로고
    • Developing biomarkers to predict benefit from HGF-MET pathway inhibitors
    • Koeppen H, Rost S, Yauch RL,. Developing biomarkers to predict benefit from HGF-MET pathway inhibitors. J Pathol 2014; 232: 210-218.
    • (2014) J Pathol , vol.232 , pp. 210-218
    • Koeppen, H.1    Rost, S.2    Yauch, R.L.3
  • 6
    • 84890284498 scopus 로고    scopus 로고
    • A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery
    • Smith NR, Womack C,. A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery. J Pathol 2014; 232: 190-198.
    • (2014) J Pathol , vol.232 , pp. 190-198
    • Smith, N.R.1    Womack, C.2
  • 7
    • 84890290450 scopus 로고    scopus 로고
    • New drug targets in metastatic melanoma
    • Homet B, Ribas A,. New drug targets in metastatic melanoma. J Pathol 2014; 232: 134-141.
    • (2014) J Pathol , vol.232 , pp. 134-141
    • Homet, B.1    Ribas, A.2
  • 8
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth
    • Hatzivassiliou G, Song K, Yen I, et al., RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010; 464: 431-435.
    • (2010) Nature , vol.464 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3
  • 9
    • 84890290279 scopus 로고    scopus 로고
    • Pathology is a necessary and informative tool in oncology clinical trials
    • Nagtegaal ID, West NP, van Krieken JHJM, et al., Pathology is a necessary and informative tool in oncology clinical trials. J Pathol 2014; 232: 185-189.
    • (2014) J Pathol , vol.232 , pp. 185-189
    • Nagtegaal, I.D.1    West, N.P.2    Van Krieken, J.3
  • 10
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P, Tsai J, et al., Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010; 467: 596-599.
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3
  • 11
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti GV, Parikh P, von Pawel J, et al., Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008; 26: 3543-3551.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.V.1    Parikh, P.2    Von Pawel, J.3
  • 12
    • 2942657615 scopus 로고    scopus 로고
    • Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer
    • Johnson DH, Fehrenbacher L, Novotny WF, et al., Randomized phase II trial comparing bevacizumab plus carboplatin and paclitaxel with carboplatin and paclitaxel alone in previously untreated locally advanced or metastatic non-small-cell lung cancer. J Clin Oncol 2004; 22: 2184-2191.
    • (2004) J Clin Oncol , vol.22 , pp. 2184-2191
    • Johnson, D.H.1    Fehrenbacher, L.2    Novotny, W.F.3
  • 13
    • 84855297353 scopus 로고    scopus 로고
    • Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial
    • Gianni L, Pienkowski T, Im YH, et al., Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): a randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012; 13: 25-32.
    • (2012) Lancet Oncol , vol.13 , pp. 25-32
    • Gianni, L.1    Pienkowski, T.2    Im, Y.H.3
  • 14
    • 84862893473 scopus 로고    scopus 로고
    • Pathological complete response and accelerated drug approval in early breast cancer
    • Prowell TM, Pazdur R,. Pathological complete response and accelerated drug approval in early breast cancer. N Engl J Med 2012; 366: 2438-2441.
    • (2012) N Engl J Med , vol.366 , pp. 2438-2441
    • Prowell, T.M.1    Pazdur, R.2
  • 15
    • 79960463308 scopus 로고    scopus 로고
    • Preparing pathology for personalized medicine: Possibilities for improvement of the pre-analytical phase
    • Groenen PJ, Blokx WA, Diepenbroek C, et al., Preparing pathology for personalized medicine: possibilities for improvement of the pre-analytical phase. Histopathology 2011; 59: 1-7.
    • (2011) Histopathology , vol.59 , pp. 1-7
    • Groenen, P.J.1    Blokx, W.A.2    Diepenbroek, C.3
  • 16
    • 84871236047 scopus 로고    scopus 로고
    • Quality really matters: The need to improve specimen quality in biomedical research
    • Simeon-Dubach D, Burt AD, Hall PA,. Quality really matters: the need to improve specimen quality in biomedical research. J Pathol 2012; 228: 431-433.
    • (2012) J Pathol , vol.228 , pp. 431-433
    • Simeon-Dubach, D.1    Burt, A.D.2    Hall, P.A.3
  • 17
    • 84890275820 scopus 로고    scopus 로고
    • Mechanisms of age-related macular degeneration and therapeutic opportunities
    • van Lookeren Campagne M, LeCouter J, Yaspan BL, et al., Mechanisms of age-related macular degeneration and therapeutic opportunities. J Pathol 2014; 232: 151-164.
    • (2014) J Pathol , vol.232 , pp. 151-164
    • Van Lookeren, C.M.1    Lecouter, J.2    Yaspan, B.L.3
  • 18
    • 84880706152 scopus 로고    scopus 로고
    • Oncology meets immunology: The cancer-immunity cycle
    • Chen DS, Mellman I,. Oncology meets immunology: the cancer-immunity cycle. Immunity 2013; 39: 1-10.
    • (2013) Immunity , vol.39 , pp. 1-10
    • Chen, D.S.1    Mellman, I.2
  • 19
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • Topalian SL, Hodi FS, Brahmer JR, et al., Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 2012; 366: 2443-2454.
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 20
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O, Robert C, Daud A, et al., Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369: 134-144.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 21
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok JD, Kluger H, Callahan MK, et al., Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med 2013; 369: 122-133.
    • (2013) N Engl J Med , vol.369 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 22
    • 84890280907 scopus 로고    scopus 로고
    • Towards the introduction of the Immunoscore in the classification of malignant tumours
    • Galon J, Mlecnik B, Bindea G, et al., Towards the introduction of the Immunoscore in the classification of malignant tumours. J Pathol 2014; 232: 199-209.
    • (2014) J Pathol , vol.232 , pp. 199-209
    • Galon, J.1    Mlecnik, B.2    Bindea, G.3
  • 23
    • 84890280905 scopus 로고    scopus 로고
    • Biomarkers of drugs targeting HER-family signalling in cancer
    • Montemurro F, Scaltriti M,. Biomarkers of drugs targeting HER-family signalling in cancer. J Pathol 2014; 232: 219-229.
    • (2014) J Pathol , vol.232 , pp. 219-229
    • Montemurro, F.1    Scaltriti, M.2
  • 24
    • 84890283025 scopus 로고    scopus 로고
    • Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes
    • Lehmann BD, Pietenpol JA,. Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes. J Pathol 2014; 232: 142-150.
    • (2014) J Pathol , vol.232 , pp. 142-150
    • Lehmann, B.D.1    Pietenpol, J.A.2
  • 25
    • 84890275818 scopus 로고    scopus 로고
    • Using the molecular classification of glioblastoma to inform personalized treatment
    • Olar A, Aldape KD,. Using the molecular classification of glioblastoma to inform personalized treatment. J Pathol 2014; 232: 165-177.
    • (2014) J Pathol , vol.232 , pp. 165-177
    • Olar, A.1    Aldape, K.D.2
  • 26
    • 84890259591 scopus 로고    scopus 로고
    • Molecular pathology and prostate cancer therapeutics: From biology to bedside
    • Rodrigues DN, Butler LM, Llorente D, et al., Molecular pathology and prostate cancer therapeutics: from biology to bedside. J Pathol 2014; 232: 178-184.
    • (2014) J Pathol , vol.232 , pp. 178-184
    • Rodrigues, D.N.1    Butler, L.M.2    Llorente, D.3
  • 27
    • 84890300368 scopus 로고    scopus 로고
    • The impact of germline mutations on targeted therapy
    • Smith SA, French T, Hollingsworth SJ,. The impact of germline mutations on targeted therapy. J Pathol 2014; 232: 230-243.
    • (2014) J Pathol , vol.232 , pp. 230-243
    • Smith, S.A.1    French, T.2    Hollingsworth, S.J.3
  • 28
    • 84858258851 scopus 로고    scopus 로고
    • Development and use of integral assays in clinical trials
    • Schilsky RL, Doroshow JH, Leblanc M, et al., Development and use of integral assays in clinical trials. Clin Cancer Res 2012; 18: 1540-1546.
    • (2012) Clin Cancer Res , vol.18 , pp. 1540-1546
    • Schilsky, R.L.1    Doroshow, J.H.2    Leblanc, M.3
  • 29
    • 82355191818 scopus 로고    scopus 로고
    • Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
    • Sequist LV, Heist RS, Shaw AT, et al., Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice. Ann Oncol 2011; 22: 2616-2624.
    • (2011) Ann Oncol , vol.22 , pp. 2616-2624
    • Sequist, L.V.1    Heist, R.S.2    Shaw, A.T.3
  • 31
    • 84865833740 scopus 로고    scopus 로고
    • High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing
    • Wagle N, Berger MF, Davis MJ, et al., High-throughput detection of actionable genomic alterations in clinical tumor samples by targeted, massively parallel sequencing. Cancer Discov 2012; 2: 82-93.
    • (2012) Cancer Discov , vol.2 , pp. 82-93
    • Wagle, N.1    Berger, M.F.2    Davis, M.J.3
  • 32
    • 84868224906 scopus 로고    scopus 로고
    • Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
    • Flaherty KT, Infante JR, Daud A, et al., Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 2012; 367: 1694-1703.
    • (2012) N Engl J Med , vol.367 , pp. 1694-1703
    • Flaherty, K.T.1    Infante, J.R.2    Daud, A.3
  • 33
    • 84890285771 scopus 로고    scopus 로고
    • Somatic alterations as the basis for resistance to targeted therapies
    • Blair BG, Bardelli A, Park BH,. Somatic alterations as the basis for resistance to targeted therapies. J Pathol 2014; 232: 244-254.
    • (2014) J Pathol , vol.232 , pp. 244-254
    • Blair, B.G.1    Bardelli, A.2    Park, B.H.3
  • 34
    • 84890282746 scopus 로고    scopus 로고
    • Epistatic interactions and drug response
    • Weigelt B, Reis-Filho JS,. Epistatic interactions and drug response. J Pathol 2014; 232: 255-263.
    • (2014) J Pathol , vol.232 , pp. 255-263
    • Weigelt, B.1    Reis-Filho, J.S.2
  • 35
    • 84890282111 scopus 로고    scopus 로고
    • The genetic complexity of common cancers and the promise of personalized medicine: Is there any hope?
    • Arnedos M, Viehl P, Soria JC, et al., The genetic complexity of common cancers and the promise of personalized medicine: is there any hope? J Pathol 2014; 232: 274-282.
    • (2014) J Pathol , vol.232 , pp. 274-282
    • Arnedos, M.1    Viehl, P.2    Soria, J.C.3
  • 36
    • 84890294470 scopus 로고    scopus 로고
    • Implications of intratumour heterogeneity for treatment stratification
    • 2014.
    • Crockford A, Jamal-Hanjani M, Hicks J, et al., Implications of intratumour heterogeneity for treatment stratification. J Pathol 2014; 232: 264-273.
    • J Pathol , vol.232 , pp. 264-273
    • Crockford, A.1    Jamal-Hanjani, M.2    Hicks, J.3
  • 37
    • 84860217696 scopus 로고    scopus 로고
    • Cancer imaging by optical coherence tomography: Preclinical progress and clinical potential
    • Vakoc BJ, Fukumura D, Jain RK, et al., Cancer imaging by optical coherence tomography: preclinical progress and clinical potential. Nat Rev Cancer 2012; 12: 363-368.
    • (2012) Nat Rev Cancer , vol.12 , pp. 363-368
    • Vakoc, B.J.1    Fukumura, D.2    Jain, R.K.3
  • 38
    • 84862999938 scopus 로고    scopus 로고
    • Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
    • Misale S, Yaeger R, Hobor S, et al., Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature 2012; 486: 532-536.
    • (2012) Nature , vol.486 , pp. 532-536
    • Misale, S.1    Yaeger, R.2    Hobor, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.