Prognostic factors of 'High-Grade' Ta bladder cancers according to the WHO 2004 classification: Are these equivalent to 'High-Risk' non-muscle-invasive bladder cancer?

Urologia Internationalis

Volumn 92, Issue 2, 2014, Pages 136-142

  Gontero, Paolo ^a   Gillo, Arianna ^a   Fiorito, Chiara ^a   Oderda, Marco ^a   Pacchioni, Donatella ^b   Casetta, Giovanni ^a   Peraldo, Francesca ^a   Zitella, Andrea ^a   Tizzani, Alessandro ^a   Ricceri, Fulvio ^a,c  

^a UNIVERSITY OF TURIN   (Italy)

^b Departments of Biomedical Sciences and Human Oncology   (Italy)

^c Human Genetics Foundation   (Italy)

Author keywords

Bladder cancer; Grading; Non muscle invasive bladder cancer; Ta; WHO

Indexed keywords

AGED; ARTICLE; CANCER CLASSIFICATION; CANCER GROWTH; CANCER PROGNOSIS; CANCER RECURRENCE; CANCER SURGERY; FEMALE; HIGH RISK PATIENT; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MEDICAL SOCIETY; NON MUSCLE INVASIVE BLADDER CANCER; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; TRANSURETHRAL RESECTION; BLADDER; CANCER GRADING; CLASSIFICATION; COHORT ANALYSIS; DISEASE COURSE; DISEASE FREE SURVIVAL; FOLLOW UP; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; MIDDLE AGED; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; RISK; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TUMOR INVASION; TUMOR RECURRENCE; URINARY BLADDER NEOPLASMS; WORLD HEALTH ORGANIZATION; CANCER CHEMOTHERAPY; CANCER RISK; CANCER SURVIVAL; PREDICTION;

AGED; COHORT STUDIES; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; RISK; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; URINARY BLADDER; URINARY BLADDER NEOPLASMS; WORLD HEALTH ORGANIZATION;

KI 67 ANTIGEN;

EID: 84900373050     PISSN: 00421138     EISSN: 14230399     Source Type: Journal    
DOI: 10.1159/000351961     Document Type: Article

References (19)

1. Babjuk M, Oosterlinck W, Sylvester R, Kaasinen E, Bohle A, Palou-Redorta J: EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder. Eur Urol 2008; 54: 303-314.
2. Miyamoto H, Miller JS, Fajardo DA, Lee TK, Netto GJ, Epstein JI: Non-invasive papillary urothelial neoplasms: the 2004 WHO/ISUP classification system. Pathol Int 2010; 60: 1-8.
3. Mostofi FK, Sobin LH, Torloni H: Histological Typing of Urinary Bladder Tumours. International Classification of Tumours 10. Geneva, World Health Organization, 1973.
4. MacLennan GT, Kirkali Z, Cheng L: Histologic grading of noninvasive papillary urothelial neoplasms. Eur Urol 2007; 51: 889-897.
5. Epstein JI, Amin MB, Reuter VR, Mostofi FK: The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am J Surg Pathol 1998; 22: 1435-1448. (Pubitemid 28550639)
6. Eble JN, Sauter G, Epstein JI, Sesterhenn IA: World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. Lyon, IARC Press, 2004.
7. Holmang S, Andius P, Hedelin H, Wester K, Busch C, Johansson SL: Stage progression in Ta papillary urothelial tumors: relationship to grade, immunohistochemical expression of tumor markers, mitotic frequency and DNA ploidy. J Urol 2001; 165: 1124-1128. (Pubitemid 32210217)
8. Samaratunga H, Makarov DV, Epstein JI: Comparison of WHO/ISUP and WHO classification of noninvasive papillary urothelial neoplasms for risk of progression. Urology 2002; 60: 315-319. (Pubitemid 34831779)
9. Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F: Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. J Clin Pathol 2002; 55: 900-905. (Pubitemid 35454490)
10. Schned AR, Andrew AS, Marsit CJ, Zens MS, Kelsey KT, Karagas MR. Survival following the diagnosis of noninvasive bladder cancer: WHO/International Society of Urological Pathology versus WHO classification systems. J Urol 2007; 178: 1196-1200. (Pubitemid 47368390)
11. Pan CC, Chang YH, Chen KK, Yu HJ, Sun CH, Ho DM: Prognostic significance of the 2004 WHO/ISUP classification for prediction of recurrence, progression, and cancer-specific mortality of non-muscle-invasive urothelial tumors of the urinary bladder: a clinicopathologic study of 1,515 cases. Am J Clin Pathol 2010; 133: 788-795.
12. van Rhijn BW, Zuiverloon TC, Vis AN, Radvanyi F, van Leenders GJ, Ooms BC, Kirkels WJ, Lockwood GA, Boeve ER, Jöbsis AC, Zwarthoff EC, van der Kwast T: Molecular grade (FGFR3/MIB-1) and EORTC risk scores are predictive in primary non-muscleinvasive bladder cancer. Eur Urol 2010; 58; 433-441.
13. Schmitz-Drager BJ, Goebell PJ, Ebert T, Fradet Y: p53 immunohistochemistry as a prognostic marker in bladder cancer: playground for urology scientists? Eur Urol 2000; 38: 691-700.
14. Lacombe L, Dalbagni G, Zhang ZF, Cordon-Cardo C, Fair WR, Herr HW: Overexpression of p53 protein in a high-risk population of patients with superficial bladder cancer before and after Bacillus Calmette-Guérin therapy: correlation to clinical outcome. J Clin Oncol 1996; 14: 2646-2652. (Pubitemid 26329648)
15. Epstein JI: The new World Health Organization/International Society of Urological Pathology (WHO/ISUP) classification for TA, T1 bladder tumors: is it an improvement? Crit Rev Oncol Hematol 2003; 47: 83-89. (Pubitemid 36945309)
16. Sylvester R, van der Meijden APM, Oosterlinck W, Witjes JA, Bouffioux C, Denis L, Newling DWW, Kurth K: Predicting recurrence and progression in individual patients with stage Ta T1 bladder cancer using EORTC risk tables: a combined analysis of 2596 patients from seven EORTC trials. Eur Urol 2006; 49: 466-477.
17. Humphrey PA: Urinary bladder pathology 2004: an update. Ann Diagn Pathol 2004; 8: 380-389. (Pubitemid 40017963)
18. Hall MC, Chang SS, Dalbagni G, Pruthi RS, Seigne JD, Skinner EC, Wolf JS Jr, Schellhammer PF: Guideline for the management of nonmuscle invasive bladder cancer (stages Ta, T1, and Tis): 2007 update. J Urol 2007; 178: 2314-2330. (Pubitemid 350080987)
19. Gontero P, Bohle A, Malmstrom PU, O'Donnell MA, Oderda M, Sylvester R, Witjes F: The role of Bacillus Calmette-Guérin in the treatment of non-muscle-invasive bladder cancer. Eur Urol 2010; 57: 410-429.