Strength training alters MCT1-protein expression and exercise-induced translocation in erythrocytes of men with non-insulin-dependent type-2 diabetes

Canadian Journal of Physiology and Pharmacology

Volumn 92, Issue 3, 2014, Pages 259-262

  Opitz, David ^a   Kreutz, Thorsten ^a   Lenzen, Edward ^a   Dillkofer, Benedict ^a   Wahl, Patrick ^a   Montiel Garcia, Gracia ^a   Graf, Christine ^a   Bloch, Wilhelm ^a   Brixius, Klara ^a  

^a GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

Author keywords

CD147; MCT1; Strength training; Type 2 diabetes

Indexed keywords

CD147 ANTIGEN; MONOCARBOXYLATE TRANSPORTER 1;

ADULT; ARTICLE; BICYCLE ERGOMETER; BICYCLE ERGOMETRY; CELL MEMBRANE; CELLULAR DISTRIBUTION; CLINICAL ARTICLE; ERYTHROCYTE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RESISTANCE TRAINING;

AGED; ANTIGENS, CD147; DIABETES MELLITUS, TYPE 2; ERYTHROCYTES; HUMANS; INSULIN; MALE; MIDDLE AGED; MONOCARBOXYLIC ACID TRANSPORTERS; PROTEIN TRANSPORT; RESISTANCE TRAINING; SYMPORTERS;

EID: 84900353641     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0405     Document Type: Article

References (18)

1. Brinkmann, C., Blossfeld, J., Pesch, M., Krone, B., Wiesiollek, K., Capin, D., Montiel, G., Hellmich, M., Bloch, W., and Brixius, K. 2012. Lipid-peroxidation and peroxiredoxin-overoxidation in the erythrocytes of non-insulindependent type 2 diabetic men during acute exercise. Eur. J. Appl. Physiol. 112: 2277-2287. doi:10.1007/s00421-011-2203-x PMID:22005961
2. Brooks, G.A. 1991. Current concepts in lactate exchange. Med. Sci. Sports Exerc. 23: 895-906. doi:10.1249/00005768-199108000-00003 PMID:1956262
3. Brooks, G.A. 2009. Cell-cell and intracellular lactate shuttles. J. Physiol. 587: 5591-5600. doi:10.1113/jphysiol.2009.178350 PMID:19805739
4. Brun, J.F., Belhabas, H., Granat, M.Ch., Sagnes, C., Thoni, G., Micallef, J.P., and Mercier, J. 2002. Postexercise red cell aggregation is negatively correlated with blood lactate rate of disappearance. Clin. Hemorheol. Microcirc. 26: 231-239. PMID:12122228
5. Dubouchaud, H., Butterfield, G.E., Wolfel, E.E., Bergman, B.C., and Brooks, G.A. 2000. Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 278: 571-579. PMID:10751188
6. Halestrap, A.P., and Wilson, M.C. 2012. The monocarboxylate transporter family- role and regulation. IUBMB Life, 64: 109-119. doi:10.1002/iub.572 PMID:22162139
7. Hashimoto, T., Hussien, R., Oommen, S., Gohil, K., and Brooks, G.A. 2007. Lactate sensitive transcription network in L6 cells: activation of MCT1 and mitochondrial biogenesis. FASEB J. 21: 2602-2612. doi:10.1096/fj.07-8174com PMID: 17395833
8. Juel, C., Holten, M.K., and Dela, F. 2004. Effects of strength training on muscle lactate release and MCT1 and MCT4 content in healthy and type 2 diabetic humans. J. Physiol. 556: 297-304. doi:10.1113/jphysiol.2003.058222 PMID: 14724187
9. Kirk, P., Wilson, M.C., Heddle, C., Brown, M.H., Barclay, A.N., and Halestrap, A.P. 2000. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J. 19: 3896-3904. doi:10. 1093/emboj/19.15.3896 PMID:10921872
10. Koho, N.M., Vaihkonen, L.K., and Poso, A.R. 2002. Lactate transport in red blood cells by monocarboxylate transporters. Equine Vet. J. Suppl. 34: 555-559. doi:10.1111/j.2042-3306.2002.tb05482.x. PMID:12405750.
11. Metz, L., Vermaelen, M., Lambert, K., Broca, C., Sirvent, P., Raynaud, E., and Mercier, J. 2005a. Endurance training increases lactate transport in male Zucker fa/fa rats. Biochem. Biophys. Res. Commun. 331: 1338-1345. doi:10.1016/j.bbrc.2005.04.054 PMID:15883022
12. Metz, L., Sirvent, P., Py, G., Brun, J.F., Fedou, C., Raynaud, E., and Mercier, J. 2005b. Relationship between blood lactate concentration and substrate utilization during exercise in type 2 diabetic postmenopausal women. Metabolism, 54: 1102-1107. doi:10.1016/j.metabol.2005.03.015 PMID:16092062
13. Pilegaard, H., Bangsbo, J., Richter, E.A., and Juel, C. 1994. Lactate transport studied in sarcolemmal giant vesicles from human muscle biopsies: relation to training status. Eur. J. Appl. Physiol. 77: 1858-1862. PMID:7836210
14. Poole, R.C., and Halestrap, A.P. 1994. N-terminal protein sequence analysis of the rabbit erythrocyte lactate transporter suggests identity with the cloned monocarboxylate transport protein MCT1. Biochem. J. 303: 755-759. PMID:7980443
15. Sara, F., Hardy-Dessources, M.D., Marlin, L., Connes, P., and Hue, O. 2006. Lactate distribution in the blood compartments of sickle cell trait carriers during incremental exercise and recovery. Int. J. Sports Med. 27: 436-443. doi:10.1055/s-2005-865844 PMID:16767607
16. Shulman, R.G. 2005. Glycogen turnover forms lactate during exercise. Exerc. Sport Sci. Rev. 33: 157-162. doi:10.1097/00003677-200510000-00002 PMID:16239831
17. Thomas, C., Bishop, D.J., Lambert, K., Mercier, J., and Brooks, G.A. 2012. Effects of acute and chronic exercise on sarcolemmal MCT1 and MCT4 contents in human skeletal muscles: current status. Am. J. Physiol. 302: R1-R14. doi:10. 1152/ajpregu.00250.2011 PMID:22012699
18. Vaihkonen, L.K., Heinonen, O.J., Hyyppa, S., Nieminen, M., and Poso, A.R. 2001. Lactate-transport activity in RBCs of trained and untrained individuals from four racing species. Am. J. Physiol. 281: R19-R24. PMID:11404274