Block copolymer/DNA vaccination induces a strong allergen-specific local response in a mouse model of house dust mite asthma

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Rolland Debord, Camille ^a,b   Lair, David ^a,b   Roussey Bihouée, Tiphaine ^a,b   Hassoun, Dorian ^a,b   Evrard, Justine ^a   Cheminant, Marie Aude ^a,b   Chesné, Julie ^a,b   Braza, Faouzi ^a,b   Mahay, Guillaume ^a,b   Portero, Vincent ^a,b   Sagan, Christine ^c   Pitard, Bruno ^a   Magnan, Antoine ^a,b  

^a CNRS   (France)

^b UNIVERSITÉ DE NANTES   (France)

^c NANTES UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COPOLYMER; CYTOKINE; DERMATOPHAGOIDES FARINAE ALLERGEN; GAMMA INTERFERON; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 5; MEMBRANE ANTIGEN; UNCLASSIFIED DRUG;

ALLERGENICITY; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DER F1 GENE; DERMATOPHAGOIDES FARINAE; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; GENE; IMMUNE RESPONSE; INFLAMMATION; LUNG ALVEOLUS CELL; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RESPIRATORY FUNCTION; RESPIRATORY TRACT ALLERGY; SKIN SENSITIZATION; SPLEEN CELL;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIGENS, DERMATOPHAGOIDES; ARTHROPOD PROTEINS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CD8-POSITIVE T-LYMPHOCYTES; CYSTEINE ENDOPEPTIDASES; CYTOKINES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSPOT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; POLYMERS; PYROGLYPHIDAE; SKIN; SPLEEN; VACCINATION; VACCINES, DNA;

EID: 84900333296     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0085976     Document Type: Article

References (20)

1. Global Initiative for Asthma (GINA) website. Global Strategy for Asthma Management and Prevention report Available: http://www.ginasthma.org/local/ uploads/files/GINA-Report-March13.pdf. Accessed 2013 Nov 15.
2. Pipet A, Botturi K, Pinot D, Vervloet D, Magnan A, et al. (2009) Allergen-specific immunotherapy in allergic rhinitis and asthma. Mechanisms and proof of efficacy. Respir Med 103(6): 800-812.
3. Akdis CA, Akdis M (2011) Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 127(1): 18-27.
4. Jarman ER, Lamb JR (2004) Reversal of established CD4+ type 2 T helper-mediated allergic airway inflammation and eosinophilia by therapeutic treatment with DNA vaccines limits progression towards chronic inflammation and remodelling. Immunology 112(4): 631-642. (Pubitemid 39061489)
5. Kim CH, Ahn JH, Kim SJ, Lee SY, Kim YK, et al. (2006) Co-administration of vaccination with DNA encoding T cell epitope on the Der p and BCG inhibited airway remodeling in a murine model of chronic asthma. J Asthma 43(5): 345-353. (Pubitemid 43995511)
6. McIlroy D, Barteau B, Cany J, Richard P, Gourden C, et al. (2009) DNA/ amphiphilic block copolymer nanospheres promote low-dose DNA vaccination. Mol Ther 17(8): 1473-1481.
7. Biliczki P, Girmatsion Z, Brandes RP, Harenkamp S, Pitard B, et al. (2009) Trafficking-deficient long QT syndrome mutation KCNQ1-T587M confers severe clinical phenotype by impairment of KCNH2 membrane localization: evidence for clinically significant IKr-IKs alpha-subunit interaction. Heart Rhythm 6(12): 1792-1801.
8. Pitard B, Bello-Roufaï M, Lambert O, Richard P, Desigaux L, et al. (2004) Negatively charged self-assembling DNA/poloxamine nanospheres for in vivo gene transfer. Nucleic Acids Res 32(20): e159.
9. Richard P, Pollard H, Lanctin C, Bello-Roufaï M, Désigaux L, et al. (2005) Inducible production of erythropoietin using intramuscular injection of block copolymer/DNA formulation. J Gene Med 7(1): 80-86.
10. Richard P, Bossard F, Desigaux L, Lanctin C, Bello-Roufai M, et al. (2005) Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles. Hum Gene Ther 16(11): 1318-1324. (Pubitemid 41611659)
11. Beilvert F, Tissot A, Langelot M, Mével M, Chatin B, et al. (2012) DNA/ amphiphilic block copolymer nanospheres reduce asthmatic response in a mouse model of allergic asthma. Hum Gene Ther. 23(6): 597-608.
12. Secrist H, Chelen CJ, Wen Y, Marshall JD, Umetsu DT, et al. (1993) Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 178(6): 2123-2130. (Pubitemid 23344869)
13. Jutel M, Akdis CA (2011) Immunological mechanisms of allergen-specific immunotherapy. Allergy 66(6): 725-732.
14. Mamessier E, Birnbaum J, Dupuy P, Vervloet D, Magnan A, et al. (2006) Ultrarush venom immunotherapy induces differential T cell activation and regulatory patterns according to the severity of allergy. Clin Exp Allergy 36(6): 704-713. (Pubitemid 43972965)
15. Akdis CA, Blesken T, Akdis M, Wüthrich B, Blaser K, et al. (1998) Role of interleukin 10 in specific immunotherapy. J Clin Invest 102(1): 98-106. (Pubitemid 28323835)
16. Fonseca DM, Wowk PF, Paula MO, Campos LW, Gembre AF, et al. (2012) Recombinant DNA immunotherapy ameliorate established airway allergy in a IL-10 dependent pathway. Clin Exp Allergy 42(1): 131-143.
17. Knutson KL, Disis ML (2005) Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol Immunother 54(8): 721-728. (Pubitemid 40977140)
18. Peng HJ, Su SN, Chang ZN, Chao PL, Kuo SW, et al. (2002) Induction of specific Th1 responses and suppression of IgE antibody formation by vaccination with plasmid DNA encoding Der f 11. Vaccine 20(13-14): 1761-1768.
19. Adel-Patient K, Pothelune L, Ah-Leung S, Wal JM, Créminon C, et al. (2010) Block copolymers have differing adjuvant effects on the primary immune response elicited by genetic immunization and on further induced allergy. Clin Vaccine Immunol 17(1): 36-42.
20. Jin H, Xiao C, Geng S, Hu Y, She R, et al. (2008) Protein/DNA vaccine-induced antigen-specific Treg confer protection against asthma. Eur J Immunol 38(9): 2451-2463.